Molecular mechanisms that control endothelial cell contacts

Journal of Pathology

Volumn 190, Issue 3, 2000, Pages 281-291

  Vestweber, Dietmar ^a  

^a UNIVERSITY OF MÜNSTER   (Germany)

Author keywords

Angiogenesis; Cadherins; Cell adhesion; Inflammation; Junctions

Indexed keywords

CELL SURFACE PROTEIN; CYTOSKELETON PROTEIN;

ANGIOGENESIS; BLOOD VESSEL PERMEABILITY; CELL INTERACTION; CELL MIGRATION; CELL SWELLING; ENDOTHELIUM CELL; INFLAMMATION; LEUKOCYTE ADHERENCE; PRIORITY JOURNAL; REVIEW;

CELL ADHESION; CELL COMMUNICATION; CELL MEMBRANE PERMEABILITY; CELL MOVEMENT; CONNEXINS; ENDOTHELIUM, VASCULAR; GAP JUNCTIONS; HUMANS; LEUKOCYTES; NEOVASCULARIZATION, PHYSIOLOGIC;

EID: 0034091764     PISSN: 00223417     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1096-9896(200002)190:3<281::AID-PATH527>3.0.CO;2-Z     Document Type: Review

References (151)

1. Farquhar MG, Palade GE. Junctional complexes in various epithelia. J Cell Biol 1963; 17: 375-412.
2. Gumbiner BM. Cell adhesion: the molecular basis of tissue architecture and morphogenesis. Cell 1996; 84: 345-357.
3. Anderson JM, Van Itallie CM. Tight junctions and the molecular basis for regulation of paracellular permeability. Am J Physiol 1995; 269: 467-475.
4. Simionescu N, Simionescu M. Endothelial transport of macromolecules: transcytosis and endocytosis. A look from cell biology. Cell Biol Rev 1991; 25: 5-80.
5. Schmelz M, Franke WW. Complexus adhaerentes, a new group of desmoplakin-containing junctions in endothelial cells: the syndesmos connecting retothelial cell of lymph nodes. Em J Cell Biol 1993; 61: 274-289.
6. Schmelz M, Moll R, Kühn C, Franke WW. Complexus adhaerentes, a new group of desmoplakin-containing junctions in endothelial cells: II. Different types of lymphatic vessels. Differentiation 1994; 57: 97-117.
7. Franke WW, Cowin P, Grund C, Kuhn C, Kapprell H-C. In Endothelial Cell Biology in Health and Disease, Simionescu N, Simionescu M (eds). Plenum Press: New York, 1988; 147-166.
8. Kowalczyk AP, Navarro P, Dejana E, et al. VE-cadherin and desmoplakin are assembled into dermal microvascular endothelial intercellular junctions: a pivotal role for plakoglobin in the recruitment of desmoplakin to intercellular junctions. J Cell Sci 1998; 111: 3045-3057.
9. Takeichi M. Morphogenetic roles of classic cadherins. Curr Opin Cell Biol 1995; 7: 619-627.
10. Boiler K, Vestweber D, Kemler R. Cell-adhesion molecule uvomorulin is localized in the intermediate junctions of adult intestinal epithelial cells. J Cell Biol 1985; 100: 327-332.
11. Huber O, Bierkamp C, Kemler R. Cadherins and catenins in development. Curr Opin Cell Biol 1996; 8: 685-691.
12. Aberle H, Schwartz H, Kemler R. Cadherin catenin complex: protein interactions and their implications for cadherin function. J Cell Biochem 1996; 61: 514-523.
13. Tsukita S, Furuse M. Occludin and claudins in tight junction strands: leading or supporting players? Trends Cell Biol 1999; 9: 268-273.
14. Newman PJ. The biology of PECAM-1. J Clin Invest 1997; 99: 3-7.
15. Kemler R. Classical cadherins. Semin Cell Biol 1992; 3: 149-155.
16. Takeichi M. Cadherin cell adhesion receptors as a morphogenetic regulator. Science 1991; 251: 1451-1455.
17. Kemler R. From cadherins to catenins: cytoplasmic protein interactions and regulation of cell adhesion. Trends Genet 1993; 9: 317-321.
18. Barth AI, Nathke IS, Nelson WJ. Cadherins, catenins and APC protein: interplay between cytoskeletal complexes and signalling pathways. Curr Opin Cell Biol 1997; 9: 683-690.
19. Behrens J, von Kries JP, Kuhl M, et al. Functional interaction of beta-catenin with the transcription factor LEF-1. Nature 1996; 382: 638-642.
20. Huber O, Korn R, McLaughlin J, Ohsugi M, Herrmann BG, Kemler R. Nuclear localization of beta-catenin by interaction with transcription factor LEF-1. Mech Der 1996; 59: 3-10.
21. Suzuki ST. Protocadherins and diversity of the cadherin superfamily. J Cell Sci 1996; 109: 2609-2611.
22. Vestweber D, Kemler R. Identification of a putative cell adhesion domain of uvomorulin. EMBO J 1985; 4: 3393-3398.
23. Benson DL, Tanaka H. N-cadherin redistribution during synaptogenesis in hippocampal neurons. J Neurosci 1998; 18: 6892-6904.
24. Tang L, Hung CP, Schuman EM. A role for the cadherin family of cell adhesion molecules in hippocampal long-term potentiation. Neuron 1998; 20: 1165-1175.
25. Yap AS, Brieher WM, Pruschy M, Gumbiner BM. Lateral clustering of the adhesive ectodomain: a fundamental determinant of cadherin function. Curr Biol 1997; 7: 308-315.
26. Shapiro L, Fannon AM, Kwong PD, et al. Structural basis of cell-cell adhesion by cadherins. Nature 1995; 374: 327-337.
27. Nagar B, Overduin M, Ikura M, Rini JM. Structural basis of calcium-induced E-cadherin rigidification and dimerization. Nature 1996; 380: 360-364.
28. Koch AW, Bozic D, Pertz O, Engel J. Homophilic adhesion by cadherins. Curr Opin Struct Biol 1999; 9: 275-281.
29. 2+ dependence and mutational analysis reveal molecular details of E-cadherin homoassociation. EMBO J 1999; 18: 1738-1747.
30. Suzuki S, Sano K, Tanihara H. Diversity of the cadherin family: evidence for eight new cadherins in nervous tissue. Cell Regul 1991; 2: 261-270.
31. Lampugnani MG, Resnati M, Raiteri M, et al. A novel endothelial specific membrane protein is a marker of cell-cell contacts. J Cell Biol 1992; 118: 1511-1522.
32. Breier G, Breviario F, Caveda L, et al. Molecular cloning and expression of murine vascular endothelial-cadherin in early stage development of cardiovascular system. Blood 1996; 87: 630-641.
33. Huber P, Dalmon J, Engiles J, et al. Genomic structure and chromosomal mapping of the mouse VE-cadherin gene (Cdh5). Genomics 1996; 32: 21-28.
34. Gory S, Vernet M, Laurent M, Dejana E, Dalmon J, Huber P. The vascular endothelial-cadherin promoter directs endothelial-specific expression in transgenic mice. Blood 1999; 93: 184-192.
35. Gotsch U, Borges E, Bosse R, et al. VE-cadherin antibody accelerates neutrophil recruitment in vivo. J Cell Sci 1997; 110: 583-588.
36. Rimm DL, Koslov ER. Kebriaei P, Cianci CD, Morrow JS. Alpha 1(E)-catenin is an actin-binding and -bundling protein mediating the attachment of F-actin to the membrane adhesion complex. Proc Natl Acad Sci U S A 1995; 92: 8813-8817.
37. Nieset JE, Redfield AR, Jin F, Knudsen KA, Johnson KR, Wheclock MJ. Characterization of the interactions of alpha-catenin with alpha-actinin and beta-catenin/plakoglobin. J Cell Sci 1997; 110: 1013-1022.
38. Itoh M, Nagafuchi A, Moroi S, Tsukita S. Involvement of ZO-1 in cadherin-based cell adhesion through its direct binding to α-catenin and actin filaments. J Cell Biol 1997; 138: 181-192.
39. Ozawa M, Baribault H, Kemler R. The cytoplasmic domain of the cell adhesion molecule uvomorulin associates with three independent proteins structurally related in different species. EMBO J 1989; 8: 1711-1717.
40. Ozawa M, Ringwald M, Kemler R. Uvomorulin catenin complex formation is regulated by a specific domain in the cytoplasmic region of the cell adhesion molecule. Proc Natl Acad Sci U S A 1990; 87: 4246-4250.
41. Hirano S, Kimoto N, Shimoyama Y, Hirohashi S, Takeichi M. Identification of a neural alpha-catenin as a key regulator of cadherin function and multicellular organization. Cell 1992; 70: 293-301.
42. Navarro P, Caveda L, Breciario F, Mandoteanu I, Lampugnani MG, Dejana E. Catenin-dependent and -independent functions of vascular endothelial cadherin. J Biol Chem 1995; 270: 30965-30970.
43. Ozawa M, Kemler R. The membrane-proximal region of the E-cadherin cytoplasmic domain prevents dimerization and negatively regulates adhesion activity. J Cell Biol 1998; 142: 1605-1613.
44. Lampugnani MG, Corada M. Andriopoulou P, Esser S, Risau W, Dejana E. Cell confluence regulates tyrosine phosphorylation of adherens junction components in endothelial cells. J Cell Sei 1997; 110: 2065-2077.
45. Shibamoto S, Hayakawa M, Takeuchi K, et al. Association of pi20, a tyrosine kinase substrate, with E-cadherin/catenin complexes. J Cell Biol 1995; 128: 949-957.
46. Lampugnani MG, Corada M, Caveda L, et al. The molecular organization of endothelial cell to cell junctions: differential association of plakoglobin, β-catenin, and α-catenin with vascular endothelial cadherin (VE-cadherin). J Cell Biol 1995; 129: 203-217.
47. Behrens J, Vakaet L, Friis R, et al. Loss of epithelial differentiation and gain of invasiveness correlate with tyrosine phosphorylation of the E-cadherin/β-catenin complex in cells transformed with a temperature-sensitive v-src gene. J Cell Biol 1993; 120: 757-766.
48. Hoschuetzky H, Aberle H, Kemler R. β-catenin mediates the interaction of the cadherin catenin complex with epidermal growth factor receptor. J Cell Biol 1994; 127: 1375-1380.
49. Esser S, Lampugnani MG, Corada M, Dejana E, Risau W. Vascular endothelial growth factor induces VE-cadherin tyrosine phosphorylation in endothelial cells. J Cell Sci 1998; 111: 1853-1865.
50. Navarro P, Ruco L, Dejana E. Differential localization of VE- and N-cadherins in human endothelial cells: VE-cadherin competes with N-cadherin for junctional localization. J Cell Biol 1998; 140: 1475-1484.
51. Haselton FR, Heimark RL. Role of cadherins 5 and 13 in the aortic endothelial barrier. J Cell Physiol 1997; 171: 243-251.
52. Telo P, Breviario F, Huber P, Panzeri C, Dejana E. Identification of a novel cadherin (vascular endothelial cadherin-2) located at intercellular junctions in endothelial cells. J Biol Chem 1998; 273: 17565-17572.
53. Sano K, Tanihara H, Heimark RL, et al. Protocadherins: a large family of cadherin-related molecules in central nervous system. EMBO J 1993; 12: 2249-2256.
54. Furuse M, Hirase T, Itoh M, et al. Occludin: a novel integral membrane protein localizing at tight junctions. J Cell Biol 1993; 123: 1777-1788.
55. Hirase T, Staddon JM, Saitou M. et al. Occludin as a possible determinant of tight junction permeability in endothelial cells. J Cell Sci 1997; 110: 1603-1613.
56. Saitou M, Ando-Akatsuka Y. Itoh M, et al. Mammalian occludin in epithelial cells: its expression and subcellular distribution. Em J Cell Biol 1997; 73: 222-231.
57. Balda MS, Whitney JA, Flores C, Gonzalez S, Cereijido M, Matter K. Functional dissociation of paracellular permeability and transepithelial electrical resistance and disruption of the apical-basolateral intramembrane diffusion barrier by expression of a mutant tight junction membrane protein. J Cell Biol 1996; 134: 1031-1049.
58. Chen Y, Merzdorf C, Paul DL, Goodenough DA. COOH terminus of occludin is required for light junction barrier function in early Xenopus embryos. J Cell Biol 1997; 138: 891-899.
59. Bamforth SD, Kniesel U, Wolburg H, Engelhardt B, Risau W. A dominant mutant of occludin disrupts tight junction structure and function. J Cell Sci 1999; 112: 1879-1888.
60. Wong V, Gumbiner BM. A synthetic peptide corresponding to the extracellular domain of occludin perturbs the tight junction permeability barrier. J Cell Biol 1997; 136: 399-409.
61. Saitou M, Fujimoto K, Doi Y, et al. Occludin-deficient embryonic stem cells can differentiate into polarized epithelial cells bearing tight junctions. J Cell Biol 1998; 141: 397-408.
62. Furuse M, Fujita K, Hiiragi T, Fujimoto K, Tsukita S. Claudin-1 and -2: novel integral membrane proteins localizing at tight junctions with no sequence similarity to occludin. J Cell Biol 1998; 141: 1539-1550.
63. Furuse M, Sasaki H, Fujimoto K, Tsukita S. A single gene product, claudin-1 or-2, reconstitutes tight junction strands and recruits occludin in fibroblasts. J Cell Biol 1998; 143: 391-401.
64. Morita K, Furuse M, Fujimoto K, Tsukita S. Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands. Proc Natl Acad Sci U S A 1999; 96: 511-516.
65. Briehl MM, Miesfeld RL. Isolation and characterization of transcripts induced by androgen withdrawal and apoptotic cell death in the rat ventral prostate. Mol Endocrinol 1991; 5: 1381-1388.
66. Katahira J, Inoue N, Horiguchi Y, Matsuda M, Sugimoto N. Molecular cloning and functional characterization of the receptor for Clostridium perfringens enterotoxin. J Cell Biol 1997; 136: 1239-1247.
67. Sirotkin H, Morrow B, Saint-Jore B, et al. Identification, characterization, and precise mapping of a human gene encoding a novel membrane-spanning protein from the 22q11 region deleted in velo-cardio-facial syndrome. Genomics 1997; 42: 245-251.
68. Stevenson BR, Siciliano JD, Mooseker MS, Goodenough DA. Identification of ZO-1: a high molecular weight polypeptide associated with the tight junction (zonula occludens) in a variety of epithelia. J Cell Biol 1986; 103: 755-766.
69. Gumbiner B, Lowenkopf T, Apatira D. Identification of a 160 kDa polypeptide that binds to the tight junction protein ZO-1. Proc Natl Acad Sci U S A 1991; 88: 3460-3464.
70. Jesaitis LA, Goodenough DA. Molecular characterization and tissue distribution of ZO-2. a tight junction protein homologous to ZO-1 and the Drosophila discs-large tumor suppressor protein. J Cell Biol 1994; 124: 949-961.
71. Haskins J, Gu L, Wittchen ES, Hibbard J, Stevenson BR. ZO-3, a novel member of the MAGUK protein family found at the tight junction, interacts with ZO-1 and occludin. J Cell Biol 1998; 141: 199-208.
72. Anderson JM. Cell signalling: MAGUK magic. Curr Biol 1996; 6: 382-384.
73. Fanning AS, Anderson JM. PDZ domains: fundamental building blocks in the organization of protein complexes at the plasma membrane. J Clin Invest 1999; 103: 767-772.
74. Itoh M, Morita K, Tsukita S. Characterization of ZO-2 as a MAGUK family member associated with tight as well as adherens junctions with a binding affinity to occludin and catenin. J Biol Chem 1999; 274: 5981-5986.
75. Furuse M, Itoh M, Hirase T, et al. Direct association of occludin with ZO-1 and its possible involvement in the localization of occludin at tight junctions. J Cell Biol 1994; 127: 1617-1626.
76. Citi S, Sabany H, Jakes R, Geiger B, Kendrick-Jones J. Cingulin, a new peripheral component of tight junctions. Nature 1988; 333: 272-276.
77. Zhong Y, Saitoh T, Minase T, Sawada N, Enomoto K, Mori M. Monoclonal antibody 7H6 reacts with a novel tight junction-associated protein distinct from ZO-1, cingulin, and ZO-2. J Cell Biol 1993; 120: 477-483.
78. Keon BH, Schäfer S, Kühn C, Grund C, Franke WW. Symplekin, a novel type of tight junction plaque protein. J Cell Biol 1996; 134: 1003-1018.
79. Yamamoto T, Harada N, Kano K, et al. The Ras target AF-6 interacts with ZO-1 and serves as a peripheral component of tight junctions in epithelial cells. J Cell Biol 1997; 139: 785-795.
80. Van Itallie CM, Balda MS, Anderrson JM. Epidermal growth factor induces tyrosine phosphorylation and reorganization of the tight junction protein ZO-1 in A431 cells. J Cell Sci 1995; 108: 1735-1742.
81. Buchert M, Schneider S, Meskenaite V, et al. The junction-associated protein AF-6 interacts and clusters with specific Eph receptor tyrosine kinases at specialized sites of cell-cell contact in the brain. J Cell Biol 1999; 144: 361-371.
82. Martin-Padura I, Lostaglio S, Schneemann M, et al. Junctional adhesion molecule, a novel member of the immunoglobulin superfamily that distributes at intercellular junctions and modulates monocyte transmigration. J Cell Biol 1998; 142: 117-127.
83. Malergue F, Galland F, Martin F, Mansuelle P, Aurrand-Lions M, Naquet P. A novel immunoglobulin superfamily junctional molecule expressed by antigen presenting cells, endothelial cells and platelets. Mol Immunol 1998; 35: 1111-1119.
84. Ozaki H, Ishii K, Horiuchi H, et al. Combined treatment of TNF-alpha and IFN-gamma causes redistribution of junctional adhesion molecule in human endothelial cells. J Immunol 1999; 163: 553-557.
85. Romer LH, McLean NV, Van HC, Daise M, Sun J, DeLisser HM. IFN-gamma and TNF-alpha induce redistribution of PECAM-1 (CD31) on human endothelial cells. J Immunol 1995; 154: 6582-6592.
86. Rival Y, Del Maschio A, Rabiet MJ, Dejana E, Duperray A. Inhibition of platelet endothelial cell adhesion molecule-1 synthesis and leukocyte transmigration in endothelial cells by the combined action of TNF-alpha and IFN-gamma. J Immunol 1996; 157: 1233-1241.
87. Heath JK, White SJ, Johnstone CN, et al. The human A33 antigen is a transmembrane glycoprotein and a novel member of the immunoglobulin superfamily. Proc Natl Acad Sci U S A 1997; 94: 469-474.
88. Schwarz MA, Owaribe K, Kartenbeck J, Franke WW. Desmosomes and hemidesmosomes: constitutive molecular components. Annu Rev Cell Biol 1990; 6: 461-491.
89. Schmidt A, Heid HW, Schafer S, Nuber UA, Zimbelmann R, Franke WW. Desmosomes and cytoskeletal architecture in epithelial differentiation: cell type-specific plaque components and intermediate filament anchorage. Eur J Cell Biol 1994; 65: 229-245.
90. Simon AM. Gap junctions: more roles and new structural data. Trends Cell Biol 1999; 9: 169-170.
91. Muller WA, Ratti CM, McDonnell SL, Cohn ZA. A human endothelial cell-restricted externally disposed plasmalemmal protein enriched in intercellular junctions. J Exp Med 1989; 170; 399-414.
92. Albelda SM, Oliver PD, Romer LH, Buck CA. Endo-CAM: a novel endothelial cell-cell adhesion molecule. J Cell Biol 1990; 110: 1227-1237.
93. Newman PJ, Berndt MC, Gorski J, et al. PECAM-1 (CD31) cloning and relation to adhesion molecules of the immunoglobulin gene superfamily. Science 1990; 247: 1219-1222.
94. Albelda SM, Muller WA, Buck CA, Newman PJ. Molecular and cellular properties of PECAM-1 (endoCAM/CD31): a novel vascular cell adhesion molecule. J Cell Biol 1991; 114: 1059-1068.
95. Matsumura T, Wolff K, Petzelbauer P. Endothelial cell tube formation depends on cadherin 5 and CD31 interactions with filamentous actin. J Immunol 1997; 158: 3408-3416.
96. Muller WA, Weigl SA, Deng X, Phillips DM. PECAM-1 is required for transendothelial migration of leukocytes. J Exp Med 1993; 178: 449-460.
97. Vaporciyan AA, DeLisser HM, Van H-C, et al. Involvement of platelet-endothelial cell adhesion molecule-1 in neutrophil recruitment in vivo. Science 1993; 262: 1059-1064.
98. Liao F, Ali J, Greene T, Muller WA. Soluble domain 1 of platelet endothelial cell adhesion molecule (PECAM) is sufficient to block transendothelial migration in vitro and in vivo. J Exp Med 1997; 185: 1349-1357.
99. Liai F, Huynh HK, Eiroa A. Greene T, Polizzi E, Muller WA. Migration of monocytes across endothelium and passage through extracellular matrix involve separate molecular domains of PECAM-1. J Exp Med 1995; 182: 1337-1343.
100. Wakelin MW, Sanz MJ, Dewar A, et al. An anti-platelet-endothelial cell adhesion molecule-1 antibody inhibits leukocyte extravasation from mesenteric microvessels in vivo by blocking the passage through the basement membrane. J Exp Med 1996; 184: 229-239.
101. Duncan GS, Andrew DP, Takimoto H, et al. Genetic evidence for functional redundancy of platelet/endothelial cell adhesion molecule-l (PECAM-1): CD31-deficient mice reveal PECAM-1-dependent and PECAM-1-independent functions. J Immunol 1999; 162: 3022-3030.
102. Newman PJ. Switched at birth: a new family for PECAM-1. J Clin Invest 1999; 103: 5-9.
103. Vivier E, Daeron M. Immunoreceptor tyrosine-based inhibition motifs. Immunol Today 1997; 18: 286-291.
104. Cambier JC. Inhibitory receptors abound? Proc Natl Acad Sci U S A 1997; 94: 5993-5995.
105. Jackson DE, Ward CM, Wang R, Newman PJ. The protein-tyrosine phosphatase SHP-2 binds platelet/endothelial cell adhesion molecule-1 (PECAM-1) and forms a distinct signalling complex during platelet aggregation. Evidence for a mechanistic link between PECAM-1- and integrin-mediated cellular signalling. J Biol Chem 1997; 272: 6986-6993.
106. Sagawa K, Kimura T, Swieter M, Siraganian RP. The protein-tyrosine phosphatase SHP-2 associates with tyrosine phosphorylated adhesion molecule PECAM-1 (CD31). J Biol Chem 1997; 272: 31086-31091.
107. Cao MY, Huber M, Beauchemin N, Famiglietti J, Albelda SM, Veillette A. Regulation of mouse PECAM-1 tyrosine phosphorylation by the Src and Csk families of protein-tyrosine kinases. J Biol Chem 1998; 273: 15765-15772.
108. Hua CT, Gamble JR, Vadas MA, Jackson DE. Recruitment and activation of SHP-1 protein-tyrosine phosphatase by human platelet endothelial cell adhesion molecule-1 (PECAM-1). Identification of immunoreceptor tyrosine-based inhibitory motif-like binding motifs and substrates. J Biol Chem 1998; 273: 28332-28340.
109. Pumphrey NJ, Taylor V, Freeman S, et al. Differential association of cytoplasmic signalling molecules SHP-1, SHP-2, SHIP and phospholipase C-gamma 1 with PECAM-1/CD31. FEBS Lett 1999; 450: 77-83.
110. Osawa M, Masuda M, Harada N, Lopes RB, Fujiwara K. Tyrosine phosphorylation of platelet endothelial cell adhesion molecule-1 (PECAM-1, CD31) in mechanically stimulated vascular endothelial cells. Eur J Cell Biol 1997; 72: 229-237.
111. Sagawa K, Swaim W, Zhang J, Unsworth E. Siraganian RP. Aggregation of the high affinity IgE receptor results in the tyrosine phosphorylation of the surface adhesion protein PECAM-1 (CD31). J Biol Chem 1997; 272: 13412-13418.
112. Varon D, Jackson DE, Shenkman B, et al. Platelet/endothelial cell adhesion molecule-1 serves as a costimulatory agonist receptor that modulates integrin-dependent adhesion and aggregation of human platelets. Blood 1998; 91: 500-507.
113. Tanaka Y, Albelda SM, Horgan KJ, et al. CD31 expressed on distinctive T cell subsets is a preferential amplifier of beta 1 integrin-mediated adhesion. J Exp Med 1992; 176: 245-253.
114. Piali L, Albelda SM, Baldwin HS, Hammel P, Gisler RH, Imhof BA. Murine platelet endothelial cell adhesion molecule (PECAM-1)/CD31 modulates beta 2 integrins on lymphokine-activated killer cells. Eur J Immunol 1993; 23: 2464-2471.
115. Berman ME, Muller WA. Ligation of platelet/endothelial cell adhesion molecule l (PECAM-1/CD31) on monocytes and neutrophils increases binding capacity of leukocyte CR3 (CD11b/CD18). J Immunol 1995; 154: 299-307.
116. Berman ME, Xie Y, Muller WA. Roles of platelet/endothelial cell adhesion molecule-1 (PECAM-1, CD31) in natural killer cell transendothelial migation and beta 2-integrin activation. J Immunol 1996; 156: 1515-1524.
117. Schimmenti LA, Yan H-C, Madri JA, Albelda SM. Platelet endothelial cell adhesion molecule, PECAM-1, modulates cell migration. J Cell Physiol 1992; 153: 417-428.
118. Eliceiri BP, Cheresh DA. The role of alpha v integrins during angiogenesis: insights into potential mechanisms of action and clinical development. J Clin Invest 1999; 103: 1227-1230.
119. Hodivala-Dilke KM, McHugh KP, Tsakiris DA, et al. Beta 3-integrin-deficient mice are a model for Glanzmann thrombasthenia showing placental defects and reduced survival. J Clin Invest 1999; 103: 229-238.
120. Bader BL, Rayburn H, Crowley D, Hynes RO. Extensive vasculogenesis, angiogenesis, and organogenesis precede lethality in mice lacking all alpha v integrins. Cell 1998; 95: 507-519.
121. Hynes RO, Bader BL, Hodivala-Dilke K. Integrins in vascular development. Braz J Med Biob Res 1999; 32: 501-510.
122. Laruc L, Ohsugi M, Hirchenhain J, Kemler R. E-cadherin null mutant embryos fail to form a trophectoderm epithelium. Proc Natl Acad Sci U S A 1994; 91: 8263-8267.
123. Carmeliet P, Lampugnani M-G, Moons L, et al. Targeted deficiency or cytosolic truncation of the VE-cadherin gene in mice impairs VEGF-mediated endothelial survival and angiogenesis. Cell 1999; 98: 147-157.
124. Gory-Faure S, Prandini MH, Pointu H, et al. Role of vascular endothelial-cadherin in vascular morphogenesis. Development 1999; 126: 2093-2102.
125. Vittet D, Buchou T, Schweitzer A, Dejana E, Huber P. Targeted null-mutation in the vascular endothelial-cadherin gene impairs the organization of vascular-like structures in embryoid bodies. Proc Natl Acad Sci U S A 1997; 94: 6273-6278.
126. Bach TL, Barsigian C, Chalupowicz DG, et al. VE-cadherin mediates endothelial cell capillary tube formation in fibrin and collagen gels. Exp Cell Res 1998; 238: 324-334.
127. Bach TL, Barsigian C, Yaen CH, Martinez J. Endothelial cell VE-cadherin functions as a receptor for the beta 15-42 sequence of fibrin. J Biol Chem 1998; 273: 30719-30728.
128. Springer TA. Traffic signals on endothelium for lymphocyte recirculation and leukocyte emigration. Annu Rev Physiol 1995; 57: 827-872.
129. Vestweber D, Blanks JE. Mechanisms that regulate the function of the selectins and their ligands. Physiol Rev 1999; 79: 181-213.
130. Florey H, Grant L. Leukocyte migration from small blood vessels stimulated with ultraviolet light: an electron microscopic study. J Pathol Bacteriol 1961; 82: 13-17.
131. Movat H, Fernando N. Acute inflammation. The earliest fine structural changes at the blood tissue barrier. Lab Invest 1963; 12: 895-910.
132. Williamson J, Grisham J. Electron microscopy of leukocytic margination and emigration in acute inflammation in dog pancreas. Am J Pathol 1961; 39: 239-256.
133. Marchesi V. The site of leukocyte emigration during inflammation. Q J Exp Physiol Cogn Med Sci 1961; 46: 115-118.
134. Hurley J, Xeros N. Electron microscopic observation on the emigration of leukocytes. Aust J Exp Biol 1961; 39: 609-624.
135. Hammersen F, Hammersen E. The ultrastructure of endothelial gap-formation and leukocyte emigration. Prog Appl Microcirc 1987; 12: 1-34.
136. Bamforth SD, Lightman SL, Greenwood J. Ultrastructural analysis of interleukin-1 beta-induced leukocyte recruitment to the rat retina. Invest Ophthalmol Vis Sci 1997; 38: 25-35.
137. Feng D, Nagy JA, Pyne K, Dvorak HF, Dvorak AM. Neutrophils emigrate from venules by a transendothelial cell pathway in response to FMLP. J Exp Med 1998; 187: 903-915.
138. Huang A, Manning JE, Bandak TM, Ratau MC, Hanser KR, Silverstein SC. Endothelial cell cytosolic free calcium regulates neutrophil migration across monolayers of endothelial cells. J Cell Biol 1993; 120: 1371-1380.
139. Hixenbaugh EA, Goeckeler ZM, Papaiya NN, Wysolmerski RB, Silverstein SC, Huang AJ. Stimulated neutrophils induce myosin light chain phosphorylation and isometric tension in endothelial cells. Am J Physiol 1997; 273: H981-H988.
140. Lorenzon P, Vecile E, Nardon E, et al. Endothelial E- and P-selectin and vascular cell adhesion molecule-1 function as signalling receptors. J Cell Biol 1998; 142: 1381-1391.
141. Rotrosen D, Gallin JI. Histamine type I receptor occupancy increases endothelial cytosolic calcium, reduces F-actin, and promotes albumin diffusion across cultured endothelial monolayers. J Cell Biol 1986; 103: 2379-2387.
142. Laposata M, Dovnarsky DK, Shin HS. Thrombin-induced gap formation in confluent endothelial cell monolayers in vitro. Blood 1983; 62: 549-556.
143. Kevil CG, Payne DK, Mire E, Alexander JS. Vascular permeability factor/vascular endothelial cell growth factor-mediated permeability occurs through disorganization of endothelial junctional proteins. J Biol Chem 1998; 273: 15099-15103.
144. Rabiet MJ, Plantier JL, Rival Y, Genoux Y, Lampugnani MG, Dejana E. Thrombin-induced increase in endothelial permeability is associated with changes in cell-to-cell junction organization. Arterioscler Thromb Vasc Biol 1996; 16: 488-496.
145. Braga VMM, Machesky LM, Hall A, Hotchin NA. The small GTPases Rho and Rac are required for the establishment of cadherin-dependent cell cell contacts. J Cell Biol 1997; 137: 1421-1431.
146. Braga VMM, Del Maschio A, Machesky L, Dejana E. Regulation of cadherin function by Rho and Rac: modulation by junction maturation and cellular context. Mol Biol Cell 1999; 10: 9-22.
147. Del Maschio A, Zanetti A, Corada M, et al. Polymorpho-nuclear leukocyte adhesion triggers the disorganization of endothelial cell-to-cell adherens junctions. J Cell Biol 1996; 135: 497-510.
148. Allport JR, Ding H, Collins T, Gerritsen ME, Luscinskas FW. Endothelial-dependent mechanisms regulate leukocyte transmigration: a process involving the proteasome and disruption of the VE-cadherin complex at endothelial cell-to-cell junctions. J Exp Med 1997; 186: 517-527.
149. Moll T, Dejana E, Vestweber D. In vitro degradation of endothelial catenins by a neutrophil protease. J Cell Biol 1998; 140: 403-407.
150. Wong RK, Baldwin AL, Heimark RL. Cadherin-5 redistribution at sites of TNF-alpha and IFN-gamma-induced permeability in mesenteric venules. Am J Physiol 1999; 276: H736-H748.
151. Morita K, Hiroyuki S, Furuse M, Tsukita S. Endothelial claudin: claudin-5/TMVCF constitutes tight junction strands in endothelial cells. J Cell Biol 1999; 147: 185-194.