Effects of mechanical forces on signal transduction and gene expression in endothelial cells

Hypertension

Volumn 31, Issue 1 II SUPPL., 1998, Pages 162-169

  Chien, Shu ^a   Li, Song ^a   Shyy, John Y J ^a  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

Endothelial cells; Hemodynamic forces; Mechanical strain; Mechanotransduction; Shear stress; Vascular biology

Indexed keywords

BASIC FIBROBLAST GROWTH FACTOR; ENDOTHELIN 1; EPIDERMAL GROWTH FACTOR; GROWTH FACTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE TRIPHOSPHATASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; NITRIC OXIDE; PLATELET DERIVED GROWTH FACTOR A; PLATELET DERIVED GROWTH FACTOR B; PROTEIN TYROSINE KINASE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR SP1; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL CELL; CONFERENCE PAPER; ENDOTHELIUM CELL; GENE EXPRESSION; HEMODYNAMIC PARAMETERS; HYPERTENSION; MECHANICAL STRESS; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; SHEAR STRESS; SIGNAL TRANSDUCTION; VASCULAR ENDOTHELIUM; ANIMAL; BLOOD VESSEL; GENE EXPRESSION REGULATION; HOMEOSTASIS; HUMAN; PHYSIOLOGY; REVIEW;

ANIMALS; BLOOD VESSELS; ENDOTHELIUM, VASCULAR; GENE EXPRESSION REGULATION; HOMEOSTASIS; HUMANS; SIGNAL TRANSDUCTION; STRESS, MECHANICAL;

EID: 0031601849     PISSN: 0194911X     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.hyp.31.1.162     Document Type: Conference Paper

References (89)

1. Davies PF. Flow-mediated endothelial mechanotransduction. Physiol. Rev. 1995;75:519-560.
2. Kuchan MJ, Jo H, Frangos JA. Role of G proteins in shear stress-mediated nitric oxide production by endothelial cells. Am J Physiol. 1994;267: C753-C758.
3. Uematsu M, Ohara Y, Navas JP, Nishida K, Murphy TJ, Alexander RW, Nerem RM, Harrison DG. Regulation of endothelial cell nitric oxide synthase mRNA expression by shear stress. Am J Physiol. 1995;269: C1371-C1378.
4. Ranjan V, Xiao Z, Diamond SL. Constitutive NOS expression in cultured endothelial cells is elevated by fluid shear stress. Am J Physiol. 1995;269: H550-H555.
5. Yoshizumi M, Kunhara H, Sugiyama T, Takaku F, Yanagisawa M, Masaki T, Yazaki Y. Hemodynamic shear stress stimulates endothelin production by cultured endothelial cells. Biochem Biophys Res Commun. 1989;161: 859-864.
6. Sharefkin JB, Diamond SL, Eskin SG, McIntire LV, Dieffenbach CW. Fluid flow decreases preproendothelin mRNA levels and suppresses endothelin-1 peptide release in cultured human endothelial cells. J Vasc Surg. 1991;14:1-9.
7. Malek A, Izumo S. Physiological fluid shear stress causes downregulation of endothelin-1 mRNA in bovine aortic endothelium. Am J Physiol. 1992; 263:C389-C396.
8. Morita T, Kurihara H, Maemura K, Yoshizumi M, Yazaki Y. Disruption of cytoskeletal structures mediates shear stress-induced endothelin-1 gene expression in cultured porcine aortic endothelial cells. J Clin Invest. 1993; 92:1706-1712.
9. Kuchan MJ, Frangos JA. Shear stress regulates endothelin-1 release via protein kinase C and cGMP in cultured endothelial cells. Am J Physiol. 1993;264:H150-H156.
10. Frangos JA, Eskin SG, McIntire LV, Ives CL. Flow effects on prostacyclin production by cultured human endothelial cells. Science. 1985;227: 1477-1479.
11. Grabowski EF, Jaffe EA, Weksler BB. Prostacyclin production by cultured endothelial cell monolayers exposed to step increases in shear stress. J Lab Clin Med. 1985;105:36-43.
12. Okahara K, Kambayashi J, Ohnishi T, Fujiwara Y, Kawasaki T, Monden M. Shear stress induces expression of CNP gene in human endothelial cells. FEBS Lett. 1995;373:108-110.
13. Chun TH, Itoh H, Ogawa Y, Tamura N, Takaya K, Igaki T, Yamashita J, Doi K, Inoue M, Masatsugu K, Korenaga R, Ando J, Nakao K. Shear stress augments expression of C-type natriuretic peptide and adrenomedullin. Hypertension. 1997;29:1296-1302.
14. Hsieh HJ, Li NQ, Frangos JA. Shear stress increases endothelial platelet-derived growth factor mRNA levels. Am J Physiol. 1991;260:H642-H646.
15. Hsieh HJ, Li NQ, Frangos JA. Pulsatile and steady flow induces c-fos expression in human endothelial cells. J Cell Physiol. 1993;154:143-151.
16. Khachigian LM, Anderson KR, Halnon NJ, Gimbrone MAJ, Resnick N, Collins T. Shear induced endothelial platelet-derived growth factor-A chain gene expression involves Egr-1. FASEB J. 1996;10:A1002. Abstract.
17. Resnick N, Collins T, Atkinson W, Bonthron DT, Dewey CJ, Gimbron MJ. Platelet-derived growth factor B chain promoter contains a cis-acting fluid shear-stress-responsive element. Proc Natl Acad Sci U S A. 1993; 90:7908.
18. Khachigian LM, Resnick N, Gimbrone MJ, Collins T. Nuclear factor-kappa B interacts functionally with the platelet-derived growth factor B-chain shear-stress response element in vascular endothelial cells exposed to fluid shear stress. J Clin Invest. 1995;96:1169-1175.
19. Malek AM, Gibbons GH, Dzau VJ, Izumo S. Fluid shear stress differentially modulates expression of genes encoding basic fibroblast growth factor and platelet-derived growth factor B chain in vascular endothelium. J Clin Invest. 1993;92:2013-2021.
20. Ohno M, Cooke JP, Dzau VJ, Gibbons GH. Fluid shear stress induces endothelial transforming growth factor beta-1 transcription and production: modulation by potassium channel blockade. J Clin Invest. 1995;95: 1363-1369.
21. Morita T, Yoshizumi M, Kurihara H, Maemura K, Nagai R, Yazaki Y. Shear stress increases heparin-binding epidermal growth factor-like growth factor mRNA levels in human vascular endothelial cells. Biochem Biophys Res Commun. 1993;197:256-262.
22. Nagel T, Resnick N, Atkinson WJ, Dewey CJ, Gimbrone MJ. Shear stress selectively upregulates intercellular adhesion molecule-1 expression in cultured human vascular endothelial cells. J Clin Invest. 1994;94:885-891.
23. Tsuboi H, Ando J, Korenaga R, Takada Y, Kamiya A. Flow stimulates ICAM-1 expression time and shear stress dependency in cultured human endothelial cells. Biochem Biophys Res Commun. 1995;206:988-996.
24. Sampath R, Kukielka GL, Smith CW, Eskin SG, Mclntire LV. Shear stress-mediated changes in the expression of leukocyte adhesion receptors on human umbilical vein endothelial cells in vitro. Ann Biomed Eng. 1995;23:247-256.
25. Ohtsuka A, Ando J, Korenaga R, Kamiya A, Toyama SN, Miyasaka M. The effect of flow on the expression of vascular adhesion molecule-1 by cultured mouse endothelial cells. Biochem Biophys Res Commun. 1993;193: 303-310.
26. Ando J, Tsuboi H, Korenaga R, Takada Y, Toyama SN, Miyasaka M, Kamiya A. Shear stress inhibits adhesion of cultured mouse endothelial cells to lymphocytes by downregulating VCAM-1 expression. Am J Physiol. 1994;267:C679-C687.
27. Shyy YJ, Hsieh HJ, Usami S, Chien S. Fluid shear stress induces a biphasic response of human monocyte chemotactic protein 1 gene expression in vascular endothelium. Proc Natl Acad Sci U S A. 1994;91:4678-4682.
28. Shyy JY, Lin MC, Han J, Lu Y, Petrime M, Chien S. The cis-acting phorbol ester "12-O-tetradecanoylphorbol 13-acetate"-responsive element is involved in shear stress-induced monocyte chemotactic protein 1 gene expression. Proc Natl Acad Sci U S A. 1995;92:8069-8073.
29. Lin MC, Almus JF, Chen HH, Parry GC, Mackman N, Shyy JY, Chien S. Shear stress induction of the tissue factor gene. J Clin Invest. 1997;99: 737-744.
30. Diamond SL, Sharefkin JB, Dieffenbach C, Frasier SK, McIntire LV, Eskin SG. Tissue plasminogen activator messenger RNA levels increase in cultured human endothelial cells exposed to laminar shear stress. J Cell Physiol. 1990;143:364-371.
31. Malek AM, Jackman R, Rosenberg RD, Izumo S. Endothelial expression of thrombomodulin is reversibly regulated by fluid shear stress. Circ Res. 1994;74:852-860.
32. Takada Y, Shinkai F, Kondo S, Yamamoto S, Tsuboi H, Korenaga R, Ando J. Fluid shear stress increases the expression of thrombomodulin by cultured human endothelial cells. Biochem Biophys Res Commun. 1994;205: 1345-1352.
33. Topper JN, Cai J, Falb D, Gimbrone MJ. Identification of vascular endothelial genes differentially responsive to fluid mechanical stimuli: cyclooxygenase-2, manganese superoxide dismutase, and endothelial cell nitric oxide synthase are selectively up-regulated by steady laminar shear stress. Proc Natl Acad Sci U S A. 1996;93:10417-10422.
34. Inoue N, Ramasamy S, Fukai T, Nerem RM, Harrison DG. Shear stress modulates expression of Cu/Zn superoxide dismutase in human aortic endothelial cells. Circ Res. 1996;79:32-37.
35. Ranjan V, Diamond SL. Fluid shear stress induces synthesis and nuclear localization of c-fos in cultured human endothelial cells. Biochem Biophys Res Commun. 1993;196:79-84.
36. Wang W, Diamond SL. Does elevated nitric oxide production enhance the release of prostacyclin from shear stressed aortic endothelial cells? Biochem Biophys Res Commun. 1997;233:748-751.
37. Tsao PS, Lewis NP, Alpert S, Cooke JP. Exposure to shear stress alters endothelial adhesiveness: role of nitric oxide. Circulation. 1995;92: 3513-3519.
38. Morigi M, Zoja C, Figliuzzi M, Foppolo M, Micheletti G, Bontempelli M, Saronni M, Remuzzi G, Remuzzi A. Fluid shear stress modulates surface expression of adhesion molecules by endothelial cells. Blood. 1995;85: 1696-1703.
39. Lan Q, Mercurius KO, Davies PF. Stimulation of transcription factors NFKB and API in endothelial cells subjected to shear stress. Biochem Biophys Res Commun. 1994;201:950-956.
40. Karin M, Liu ZG, Zandi E. AP-1 function and regulation. Curr Opin Cell Biol. 1997;9:240-246.
41. Robinson MJ, Cobb MH. Mitogen-activated protein kinase pathways. Curr Opin Cell Biol. 1997;9:180-186.
42. Li YS, Shyy JY, Li S, Lee J, Su B, Karin M, Chien S. The Ras-JNK pathway is involved in shear-induced gene expression. Mol Cell Biol. 1996;16:5947-5954.
43. + current in vascular endothelial cells. Nature. 1988;331:168-170.
44. Gudi SR, Clark CB, Frangos JA. Fluid flow rapidly activates G proteins in human endothelial cells: involvement of G proteins in mechanochemical signal transduction. Circ Res. 1996;79:834-839.
45. Ando J, Komatsuda T, Kamiya A. Cytoplasmic calcium response to fluid shear stress in cultured vascular endothelial cells. In Vitro Cell Dev Biol. 1988;24:871-877.
46. Reich KM, Gay CV, Frangos JA. Fluid shear stress as a mediator of osteoblast cyclic adenosine monophosphate production. J Cell Physiol. 1990;143:100-104.
47. Ohno M, Gibbons GH, Dzau VJ, Cooke JP. Shear stress elevates endothelial cGMP: role of a potassium channel and G protein coupling. Circulation. 1993;88:193-197.
48. Nollert MU, Eskin SG, Mclntire LV. Shear stress increases inositol trisphosphate levels in human endothelial cells. Biochem Biophys Res Commun. 1990;170:281-287.
49. Tseng H, Peterson TE, Berk BC. Fluid shear stress stimulates mitogen-activated protein kinase in endothelial cells. Cir Res. 1995;77:869-878.
50. Ishida T, Peterson TE, Kovach NL, Berk BC. MAP kinase activation by flow in endothelial cells: role of beta 1 integrins and tyrosine kinases. Circ Res. 1996;79:310-316.
51. Li S, Kim M, Hu Y-L, Jalali S, Schlaepfer DD, Hunter T, Chien S, Shyy JY-J. Fluid shear stress activation of FAK: :Linking to MAPKs. J Biol Chem. 1997;272:30455-30462.
52. Hsieh HJ, Li NQ, Frangos JA. Shear-induced platelet-derived growth factor gene expression in human endothelial cells is mediated by protein kinase C. J Cell Physiol. 1992;150:552-558.
53. Frangos JA, Gudi SRP. Shear stress activates reconstituted G proteins in the absence of protein receptors by modulating lipid bilayer fluidity. FASEB J. 1997;11:A521. Abstract.
54. Franke RP, Grafe M, Schnittler H, Seiffge D, Mittermayer C, Drenckhahn D. Induction of human vascular endothelial stress fibres by fluid shear stress. Nature. 1984;307:648-649.
55. Davies PF, Robotewskyj A, Griem ML. Quantitative studies of endothelial cell adhesion: directional remodeling of focal adhesion sites in response to flow forces. J Clin Invest. 1994;93:2031-2038.
56. Knudsen HL, Frangos JA. Role of cytoskeleton in shear stress-induced endothelial nitric oxide production. Am J Physiol. 1997;273:H347-H355.
57. Jalali S, Li Y-S, Sotoudeh M, Yuan S, Li S, Chien S, Shyy JY-J. Shear stress activates p60src-Ras-MAPKs signaling pathways in vascular endothelial cells. Arterioscler Thromb Vasc Biol. 1998; in press.
58. Jo H, Sipos K, Go YM, Law R, Rong J, McDonald JM. Differential effect of shear stress on extracellular signal-regulated kinase and N-terminal Jun kinase in endothelial cells. Gi2- and Gbeta/gamma-dependent signaling pathways. J Biol Chem. 1997;272:1395-1401.
59. Tapon N, Hall A. Rho, Rac, and Cdc42 GTPases regulate the organization of the actin cytoskeleton. Curr Opin Cell Biol. 1997;9:86-92.
60. Lim L, Manser E, Leung T, Hall C. Regulation of phosphorylation pathways by p21 GTPases: the p21 Ras-related Rho subfamily and its role in phosphorylation signalling pathways. Eur J Biochem. 1996;242:171-185.
61. Chardin P, Camonis JH, Gale NW, van AL, Schlessinger J, Wigler MH, Bar-Sagi SD. Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2. Science. 1993;260:1338-1343.
62. Nobes CD, Hall A. Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular filopodia. Cell. 1995b;81:53-62.
63. Nobes CD, Hawkins P, Stephens L, Hall A. Activation of the small GTP-binding proteins rho and rac by growth factor receptors. J Cell Sci. 1995a;225-233:.
64. Sah VP, Hoshijima M, Chien KR, Brown JH. Rho is required for Galphaq and alpha 1-adrenergic receptor signaling in cardiomyocytes: dissociation of Ras and Rho pathways. J Biol Chem. 1996;271:31185-31190.
65. Gudi SRP, Huver IV, Taliana AP, Boss GR, Frangos JA. Fluid flow-induced Ras activation is mediated by Gαq in human vascular endothelial cells. FASEB J. 1997;11:A223. Abstract.
66. Takahashi M, Berk BC. Mitogen-activated protein kinase (ERK1/2) activation by shear stress and adhesion in endothelial cells: essential role for a herbimycin-sensitive kinase. J Clin Invest. 1996;98:2623-2631.
67. Malek AM, Izumo S. Mechanism of endothelial cell shape change and cytoskeletal remodeling in response to fluid shear stress. J Cell Sci. 1996; 109:713-726.
68. Corson MA, James NL, Latta SE, Nerem RM, Berk BC, Harrison DG. Phosphorylation of endothelial nitric oxide synthase in response to fluid shear stress. Circ Res. 1996;79:984-991.
69. Schaller MD, Parsons JT. Focal adhesion kinase and associated proteins. Curr Opin Cell Biol. 1994;6:705-710.
70. Muller JM, Chilian WM, Davis MJ. Integrin signaling transduces shear stress-dependent vasodilation of coronary arterioles. Circ Res. 1997;80: 320-326.
71. Awolesi MA, Sessa WC, Sumpio BE. Cyclic strain upregulates nitric oxide synthase in cultured bovine aortic endothelial cells. J Clin Invest. 1995;96: 1449-1454.
72. Wang DL, Wung BS, Shyy YJ, Lin CF, Chao YJ, Usami S, Chien S. Mechanical strain induces monocyte chemotactic protein-1 gene expression in endothelial cells: effects of mechanical strain on monocyte adhesion to endothelial cells. Circ Res. 1995;77:294-302.
73. Carosi JA, Eskin SG, McIntire LV. Cyclical strain effects on production of vasoactive materials in cultured endothelial cells. J Cell Physiol. 1992;151: 29-36.
74. Wang DL, Wung BS, Peng YC, Wang JJ. Mechanical strain increases endothelin-1 gene expression via protein kinase C pathway in human endothelial cells. J Cell Physiol. 1995;163:400-406.
75. ChengJJ, Wung BS, Chao YJ, Wang DL. Cyclic strain enhances adhesion of monocytes to endothelial cells by increasing intercellular adhesion molecule-1 expression. Hypertension. 1996;28:386-391.
76. ChengJJ, Chao YJ, Wung BS, Wang DL. Cyclic strain-induced plasminogen activator inhibitor-1 (PAI-1) release from endothelial cells involves reactive oxygen species. Biochem Biophys Res Commun. 1996;225:100-105.
77. 2+ mobilization to mechanical stretch in endothelial cells. Am J Physiol. 1993;264:C1037-C1044.
78. Rosales OR, Sumpio BE. Changes in cyclic strain increase inositol trisphosphate and diacylglycerol in endothelial cells. Am J Physiol. 1992; 262:C956-C962.
79. Rosales OR, Sumpio BE. Protein kinase C is a mediator of the adaptation of vascular endothelial cells to cyclic strain in vitro. Surgery. 1992;112: 459-466.
80. Letsou GV, Rosales O, Maitz S, Vogt A, Sumpio BE. Stimulation of adenylate cyclase activity in cultured endothelial cells subjected to cyclic stretch. J Cardiovasc Surg. 1990;31:634-639.
81. Cohen CR, Mills I, Du W, Kamal K, Sumpio BE. Activation of the adenylyl cyclase/cyclic AMP/protein kinase A pathway in endothelial cells exposed to cyclic strain. Exp Cell Res. 1997;231:184-189.
82. Howard AB, Alexander RW, Nerem RM, Griendling KK, Taylor WR. Cyclic strain induces an oxidative stress in endothelial cells. Am J Physiol. 1997;272:C421-C427.
83. Wung BS, Cheng JJ, Hsieh H, Shyy YJ, Wang DL. Cyclic strain-induced monocyte chemotactic protein-1 gene expression in endothelial cells involves reactive oxygen species activation of activator protein 1. Circ Res. 1997;81:1-7.
84. Yano Y, Geibel J, Sumpio BE. Tyrosine phosphorylation of pp125FAK and paxillin in aortic endothelial cells induced by mechanical strain. Am J Physiol. 1996;271:C635-C649.
85. Yano Y, Saito Y, Narumiya S, Sumpio BE. Involvement of rho p21 in cyclic strain-induced tyrosine phosphorylation of focal adhesion kinase (pp125FAK), morphological changes and migration of endothelial cells. Biochem Biophys Res Commun. 1996;224:508-515.
86. Du W, Mills I, Sumpio BE. Cyclic strain causes heterogeneous induction of transcription factors, AP-1, CRE binding protein and NF-κB, in endothelial cells: species and vascular bed diversity. J Biomech. 1995;28: 1485-1491.
87. Yano Y, Geibel J, Sumpio BE. Cyclic strain induces reorganization of integrin alpha 5 beta 1 and alpha 2 beta 1 in human umbilical vein endothelial cells. J Cell Biochem. 1997;64:505-513.
88. Resnick N, Gimbrone MA Jr. Hemodynamic forces are complex regulators of endothelial gene expression. FASEB J. 1995;9:874-882.
89. Davies PF, Barbee KA, Volin MV, Robotewskyj A, Chen J, Joseph L, Griem ML, Wemick MN, Jacobs E, Polacek DC, DePaola N, Barakat AI. Spatial relationships in early signaling events of flow-mediated endothelial mechanotransduction. Annu. Rev. Physiol. 1997;59:527-49.