메뉴 건너뛰기




Volumn 19, Issue 12, 2000, Pages 2911-2923

Active ERK/MAP kinase is targeted to newly forming cell-matrix adhesions by integrin engagement and v-Src

Author keywords

Cell adhesion; Integrins; MAP kinase; Signalling; Src

Indexed keywords

INTEGRIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; PROTEIN KINASE P60;

EID: 0034660524     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/19.12.2911     Document Type: Article
Times cited : (290)

References (69)
  • 1
    • 0033000286 scopus 로고    scopus 로고
    • Integrin and cytoskeletal regulation of growth factor signaling to the MAP kinase pathway
    • Aplin, A.E. and Juliano, R.L. (1999) Integrin and cytoskeletal regulation of growth factor signaling to the MAP kinase pathway. J. Cell Sci., 112, 695-706.
    • (1999) J. Cell Sci. , vol.112 , pp. 695-706
    • Aplin, A.E.1    Juliano, R.L.2
  • 2
    • 0031745571 scopus 로고    scopus 로고
    • Signal transduction and cell modulation by cell adhesion receptors: The role of integrins, cadherins, immunoglobulin-cell adhesion molecules and selectins
    • Aplin, A.E., Howe, A., Alahari, S.K. and Juliano, R.L. (1998) Signal transduction and cell modulation by cell adhesion receptors: the role of integrins, cadherins, immunoglobulin-cell adhesion molecules and selectins. Pharmacol. Rev., 50, 197-262.
    • (1998) Pharmacol. Rev. , vol.50 , pp. 197-262
    • Aplin, A.E.1    Howe, A.2    Alahari, S.K.3    Juliano, R.L.4
  • 3
    • 0033081066 scopus 로고    scopus 로고
    • Nuclear translocation of p42/p44 mitogen-activated protein kinase is required for growth factor-induced gene expression and cell cycle entry
    • Brunet, A., Roux, D., Lenormand, P., Dowd, S., Keyse, S. and Pouyssegur, J. (1999) Nuclear translocation of p42/p44 mitogen-activated protein kinase is required for growth factor-induced gene expression and cell cycle entry. EMBO J., 18, 664-674.
    • (1999) EMBO J. , vol.18 , pp. 664-674
    • Brunet, A.1    Roux, D.2    Lenormand, P.3    Dowd, S.4    Keyse, S.5    Pouyssegur, J.6
  • 5
    • 0028877919 scopus 로고
    • Tyrosine phosphorylation of focal adhesion kinase at sites in the catalytic domain regulates kinase activity: A role for Src family kinases
    • Calalb, M.B., Polte, T.R. and Hanks, S.K. (1995) Tyrosine phosphorylation of focal adhesion kinase at sites in the catalytic domain regulates kinase activity: a role for Src family kinases. Mol. Cell. Biol., 15, 954-963.
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 954-963
    • Calalb, M.B.1    Polte, T.R.2    Hanks, S.K.3
  • 6
    • 0027939187 scopus 로고
    • Integrin-mediated cell adhesion activates mitogen-activated protein kinases
    • Chen, Q., Kinch, M.S., Lin, T.H., Burridge, K. and Juliano, R.L. (1994) Integrin-mediated cell adhesion activates mitogen-activated protein kinases J Biol. Chem., 269, 26602-26605.
    • (1994) J Biol. Chem. , vol.269 , pp. 26602-26605
    • Chen, Q.1    Kinch, M.S.2    Lin, T.H.3    Burridge, K.4    Juliano, R.L.5
  • 7
    • 0029994358 scopus 로고    scopus 로고
    • Integrin-mediated activation of MEK and MAP kinases is independent of Ras
    • Chen, Q., Lin, T.H., Der, C.J. and Juliano, R.L. (1996) Integrin-mediated activation of MEK and MAP kinases is independent of Ras J. Biol. Chem., 271, 18122-18127.
    • (1996) J. Biol. Chem. , vol.271 , pp. 18122-18127
    • Chen, Q.1    Lin, T.H.2    Der, C.J.3    Juliano, R.L.4
  • 8
    • 0033046706 scopus 로고    scopus 로고
    • MEKK1 interacts with α-actinin and localizes to stress fibers and focal adhesions
    • Christerson, L.B., Venderbilt, C.A. and Cobb, M.H. (1999) MEKK1 interacts with α-actinin and localizes to stress fibers and focal adhesions. Cell Motil. Cytoskel., 43, 186-198.
    • (1999) Cell Motil. Cytoskel. , vol.43 , pp. 186-198
    • Christerson, L.B.1    Venderbilt, C.A.2    Cobb, M.H.3
  • 9
    • 0029995797 scopus 로고    scopus 로고
    • Rho-stimulated contractility drives the formation of stress fibres and focal adhesions
    • Chrzanowska-Wodnicka, M. and Burridge, K. (1996) Rho-stimulated contractility drives the formation of stress fibres and focal adhesions J. Cell Biol., 133, 1403-1415.
    • (1996) J. Cell Biol. , vol.133 , pp. 1403-1415
    • Chrzanowska-Wodnicka, M.1    Burridge, K.2
  • 10
    • 17544364168 scopus 로고    scopus 로고
    • Ras activation is necessary for integrin-mediated activation of extracellular signal-regulated kinase 2 and cytosolic phospholipase A2 but not for cytoskeletal organization
    • Clark, E.A. and Hynes, R.O. (1996) Ras activation is necessary for integrin-mediated activation of extracellular signal-regulated kinase 2 and cytosolic phospholipase A2 but not for cytoskeletal organization. J. Biol. Chem., 271, 14814-14818.
    • (1996) J. Biol. Chem. , vol.271 , pp. 14814-14818
    • Clark, E.A.1    Hynes, R.O.2
  • 11
    • 0028228616 scopus 로고
    • Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of N1H3T3 cells
    • Cowley, S., Paterson, H., Kemp, P. and Marshal, C.J. (1994) Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of N1H3T3 cells. Cell, 77, 841-852.
    • (1994) Cell , vol.77 , pp. 841-852
    • Cowley, S.1    Paterson, H.2    Kemp, P.3    Marshal, C.J.4
  • 12
    • 0028786336 scopus 로고
    • Transcriptional regulation by MAP kinases
    • Davis, R.J. (1995) Transcriptional regulation by MAP kinases. Mol. Reprod. Dev., 42, 459-467.
    • (1995) Mol. Reprod. Dev. , vol.42 , pp. 459-467
    • Davis, R.J.1
  • 13
    • 0025874695 scopus 로고
    • Accumulation of talin in nodes at the edge of the lamellipodium and separate incorporation into adhesion plaques at focal contacts in fibroblasts
    • DePasquale, J.A. and Izzard, C.S. (1991) Accumulation of talin in nodes at the edge of the lamellipodium and separate incorporation into adhesion plaques at focal contacts in fibroblasts. J. Cell Biol., 113, 1351-1359.
    • (1991) J. Cell Biol. , vol.113 , pp. 1351-1359
    • Depasquale, J.A.1    Izzard, C.S.2
  • 15
    • 14444279192 scopus 로고    scopus 로고
    • Identification of a novel inhibitor of mitogen-activated protein kinase kinase
    • Favata, M.F. et al. (1998) Identification of a novel inhibitor of mitogen-activated protein kinase kinase. J. Biol. Chem., 273, 18623-18632.
    • (1998) J. Biol. Chem. , vol.273 , pp. 18623-18632
    • Favata, M.F.1
  • 16
    • 0032472411 scopus 로고    scopus 로고
    • The catalytic activity of Src is dispensable for translocation to focal adhesions but controls the turnover of these structures during cell motility
    • Fincham, V.J. and Frame, M.C. (1998) The catalytic activity of Src is dispensable for translocation to focal adhesions but controls the turnover of these structures during cell motility EMBO J., 17, 81-92.
    • (1998) EMBO J. , vol.17 , pp. 81-92
    • Fincham, V.J.1    Frame, M.C.2
  • 17
    • 0028988989 scopus 로고
    • V-Src-induced degradation of focal adhesion kinase during morphological transformation of chicken embryo fibroblasts
    • Erratum: Oncogene, 1995, 11, 2185
    • Fincham, V.J., Wyke, J.A. and Frame, M.C. (1995) v-Src-induced degradation of focal adhesion kinase during morphological transformation of chicken embryo fibroblasts. Oncogene, 10, 2247-2252. [Erratum: Oncogene, 1995, 11, 2185.]
    • (1995) Oncogene , vol.10 , pp. 2247-2252
    • Fincham, V.J.1    Wyke, J.A.2    Frame, M.C.3
  • 18
    • 0030482560 scopus 로고    scopus 로고
    • Translocation of Src kinase to the cell periphery is mediated by the actin cytoskeleton under the control of the Rho family of small G proteins
    • Fincham, V.J., Unulu, M., Brunton, V.G., Pitts, J.D., Wyke, J.A. and Frame, M.C. (1996) Translocation of Src kinase to the cell periphery is mediated by the actin cytoskeleton under the control of the Rho family of small G proteins. J. Cell Biol., 135, 1551-1564.
    • (1996) J. Cell Biol. , vol.135 , pp. 1551-1564
    • Fincham, V.J.1    Unulu, M.2    Brunton, V.G.3    Pitts, J.D.4    Wyke, J.A.5    Frame, M.C.6
  • 19
    • 0032959561 scopus 로고    scopus 로고
    • Regulation of pl90 Rho-GAP by v-Src is linked to cytoskeletal disruption during transformation
    • Fincham, V.J., Chudliegh, A. and Frame, M.C. (1999) Regulation of pl90 Rho-GAP by v-Src is linked to cytoskeletal disruption during transformation. J. Cell Sci., 112, 947-956.
    • (1999) J. Cell Sci. , vol.112 , pp. 947-956
    • Fincham, V.J.1    Chudliegh, A.2    Frame, M.C.3
  • 20
    • 0029741102 scopus 로고    scopus 로고
    • Inhibition of focal adhesion kinase (FAK) signaling in focal adhesions decreases cell motility and proliferation
    • Gilmore, A.P. and Romer, L.H. (1996) Inhibition of focal adhesion kinase (FAK) signaling in focal adhesions decreases cell motility and proliferation. Mol. Biol. Cell, 7, 1209-1224.
    • (1996) Mol. Biol. Cell , vol.7 , pp. 1209-1224
    • Gilmore, A.P.1    Romer, L.H.2
  • 21
    • 0027225936 scopus 로고
    • Serum-induced translocation of mitogen-activated protein kinase to the cell surface ruffling membrane and the nucleus
    • Gonzalez, F.A., Seth, A., Raden, D.L., Bowman, D.S., Fay, F.S. and Davis, R.J. (1993) Serum-induced translocation of mitogen-activated protein kinase to the cell surface ruffling membrane and the nucleus. J. Cell Biol., 122, 1089-1101.
    • (1993) J. Cell Biol. , vol.122 , pp. 1089-1101
    • Gonzalez, F.A.1    Seth, A.2    Raden, D.L.3    Bowman, D.S.4    Fay, F.S.5    Davis, R.J.6
  • 22
    • 0031005028 scopus 로고    scopus 로고
    • Evidence for MEK-independent pathways regulating the prolonged activation of the ERK-MAP kinases
    • Grammer, T.C. and Blenis, J. (1997) Evidence for MEK-independent pathways regulating the prolonged activation of the ERK-MAP kinases. Oncogene, 14, 1635-1642.
    • (1997) Oncogene , vol.14 , pp. 1635-1642
    • Grammer, T.C.1    Blenis, J.2
  • 23
    • 0029918793 scopus 로고    scopus 로고
    • Delay in serum stimulation of Erk activity caused by oncogenic transformation
    • Greulich, H., Reichman, C. and Hanafusa, H. (1996) Delay in serum stimulation of Erk activity caused by oncogenic transformation. Oncogene, 12, 1689-1695.
    • (1996) Oncogene , vol.12 , pp. 1689-1695
    • Greulich, H.1    Reichman, C.2    Hanafusa, H.3
  • 24
    • 0026759309 scopus 로고
    • Regulation of focal adhesion-associated protein tyrosine kinase by both cellular adhesion and oncogenic transformation
    • Guan, J.L. and Shalloway, D. (1992) Regulation of focal adhesion-associated protein tyrosine kinase by both cellular adhesion and oncogenic transformation. Nature, 358, 690-692.
    • (1992) Nature , vol.358 , pp. 690-692
    • Guan, J.L.1    Shalloway, D.2
  • 25
    • 0026674919 scopus 로고
    • Focal adhesion protein-tyrosine kinase phosphorylated in response to cell attachment to fibronectin
    • Hanks, S.K., Calalb, M.B., Harper, M.C. and Patel, S.K. (1992) Focal adhesion protein-tyrosine kinase phosphorylated in response to cell attachment to fibronectin. Proc. Natl Acad. Sci. USA, 89, 8487-8491.
    • (1992) Proc. Natl Acad. Sci. USA , vol.89 , pp. 8487-8491
    • Hanks, S.K.1    Calalb, M.B.2    Harper, M.C.3    Patel, S.K.4
  • 26
    • 0033526098 scopus 로고    scopus 로고
    • Direct observations of the mechanical behaviors of the cytoskeleton in living fibroblasts
    • Heidemann, S.R., Kaech, S., Buxbaum, R.E. and Matus, A. (1999) Direct observations of the mechanical behaviors of the cytoskeleton in living fibroblasts. J. Cell Biol., 145, 109-122.
    • (1999) J. Cell Biol. , vol.145 , pp. 109-122
    • Heidemann, S.R.1    Kaech, S.2    Buxbaum, R.E.3    Matus, A.4
  • 27
    • 0024602815 scopus 로고
    • Butanedione monoxime suppresses contraction and ATPase activity of rabbit skeletal muscle
    • Higuchi, H. and Takemori, S. (1989) Butanedione monoxime suppresses contraction and ATPase activity of rabbit skeletal muscle. J. Biochem., 105, 638-43.
    • (1989) J. Biochem. , vol.105 , pp. 638-643
    • Higuchi, H.1    Takemori, S.2
  • 28
    • 0029562867 scopus 로고
    • The assembly of integrin adhesion complexes requires both extracellular matrix and intracellular rho/rac GTPases
    • Hotchin, N.A. and Hall, A. (1995) The assembly of integrin adhesion complexes requires both extracellular matrix and intracellular rho/rac GTPases. J. Cell Biol., 131, 1857-1865.
    • (1995) J. Cell Biol. , vol.131 , pp. 1857-1865
    • Hotchin, N.A.1    Hall, A.2
  • 29
    • 0030909050 scopus 로고    scopus 로고
    • Suppression of integrin activation: A novel function of a Ras/Raf-initiated MAP kinase pathway
    • Hughes, P.E., Renshaw, M.W., Pfaff, M., Forsyth, J., Keivens, V.E., Schwartz, M.A. and Ginsberg, MH. (1997) Suppression of integrin activation: a novel function of a Ras/Raf-initiated MAP kinase pathway. Cell, 88, 521-530.
    • (1997) Cell , vol.88 , pp. 521-530
    • Hughes, P.E.1    Renshaw, M.W.2    Pfaff, M.3    Forsyth, J.4    Keivens, V.E.5    Schwartz, M.A.6    Ginsberg, M.H.7
  • 30
    • 0026770377 scopus 로고
    • Integrins: Versatility, modulation and signaling in cell adhesion
    • Hynes, R.O. (1992) Integrins: versatility, modulation and signaling in cell adhesion. Cell, 69, 11-25.
    • (1992) Cell , vol.69 , pp. 11-25
    • Hynes, R.O.1
  • 31
    • 0022410257 scopus 로고
    • Phosphorylation of smooth muscle myosin at two distinct sites by myosin light chain kinase
    • Ikebe, M. and Hartshorne, D.J. (1985) Phosphorylation of smooth muscle myosin at two distinct sites by myosin light chain kinase. J. Biol. Chem., 260, 10027-10031.
    • (1985) J. Biol. Chem. , vol.260 , pp. 10027-10031
    • Ikebe, M.1    Hartshorne, D.J.2
  • 32
    • 0029120440 scopus 로고
    • Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice
    • Ilic, D. et al. (1995) Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice. Nature, 377, 539-544.
    • (1995) Nature , vol.377 , pp. 539-544
    • Ilic, D.1
  • 33
    • 13344270369 scopus 로고
    • The molecular architecture of focal adhesions
    • Jockusch, B.M. et al. (1995) The molecular architecture of focal adhesions. Annu. Rev. Cell. Dev. Biol., 11, 379-416.
    • (1995) Annu. Rev. Cell. Dev. Biol. , vol.11 , pp. 379-416
    • Jockusch, B.M.1
  • 35
    • 0033544953 scopus 로고    scopus 로고
    • Dynamin is required for the activation of mitogen-activated protein (MAP) kinase by MAP kinase kinase
    • Kranenburg, O., Veerlan, I. and Moolenaar, W.H. (1999) Dynamin is required for the activation of mitogen-activated protein (MAP) kinase by MAP kinase kinase. J. Biol. Chem., 274, 35301-35304.
    • (1999) J. Biol. Chem. , vol.274 , pp. 35301-35304
    • Kranenburg, O.1    Veerlan, I.2    Moolenaar, W.H.3
  • 36
    • 0030874021 scopus 로고    scopus 로고
    • Integrin-mediated activation of MAP kinase is independent of FAK: Evidence for dual integrin signaling pathways in fibroblasts
    • Lin, T.H., Aplin, A.E., Shen, Y., Chen, Q., Schaller, M., Romer, L., Aukhil, I. and Juliano, R.L. (1997) Integrin-mediated activation of MAP kinase is independent of FAK: evidence for dual integrin signaling pathways in fibroblasts. J. Cell Biol., 136, 1385-1395.
    • (1997) J. Cell Biol. , vol.136 , pp. 1385-1395
    • Lin, T.H.1    Aplin, A.E.2    Shen, Y.3    Chen, Q.4    Schaller, M.5    Romer, L.6    Aukhil, I.7    Juliano, R.L.8
  • 37
    • 0029006126 scopus 로고
    • Ras recruits Raf-1 to the plasma membrane for activation by tyrosine phosphorylation
    • Marais, R., Light, Y., Paterson, H.F. and Marshall, C.J. (1995) Ras recruits Raf-1 to the plasma membrane for activation by tyrosine phosphorylation. EMBO J., 14, 3136-3145.
    • (1995) EMBO J. , vol.14 , pp. 3136-3145
    • Marais, R.1    Light, Y.2    Paterson, H.F.3    Marshall, C.J.4
  • 38
    • 0028365439 scopus 로고
    • The influence of 2.3-butanedione 2-monoxime (BDM) on the interaction between actin and myosin in solution and in skinned muscle fibres
    • McKillop, D.F., Fortune, N.S., Ratunga, K.W. and Geeves, M.A. (1994) The influence of 2.3-butanedione 2-monoxime (BDM) on the interaction between actin and myosin in solution and in skinned muscle fibres. J. Muscle Res. Cell Motil., 15, 309-18.
    • (1994) J. Muscle Res. Cell Motil. , vol.15 , pp. 309-318
    • McKillop, D.F.1    Fortune, N.S.2    Ratunga, K.W.3    Geeves, M.A.4
  • 40
    • 0028954797 scopus 로고
    • Synergistic roles of receptor occupancy and aggregation in integrin transmembrane function
    • Miyamoto, S., Akiyama, S.K. and Yamada, K.M. (1995a) Synergistic roles of receptor occupancy and aggregation in integrin transmembrane function. Science, 267, 883-885.
    • (1995) Science , vol.267 , pp. 883-885
    • Miyamoto, S.1    Akiyama, S.K.2    Yamada, K.M.3
  • 42
    • 0030453194 scopus 로고    scopus 로고
    • Integrins can collaborate with growth factors for phosphorylation of receptor tyrosine kinases and MAP kinase activation: Roles of integrin aggregation and occupancy of receptors
    • Miyamoto, S., Teramoto, H., Gutkind, J.S. and Yamada, K.M. (1996) Integrins can collaborate with growth factors for phosphorylation of receptor tyrosine kinases and MAP kinase activation: roles of integrin aggregation and occupancy of receptors. J. Cell Biol., 135, 1633-1642.
    • (1996) J. Cell Biol. , vol.135 , pp. 1633-1642
    • Miyamoto, S.1    Teramoto, H.2    Gutkind, J.S.3    Yamada, K.M.4
  • 44
    • 0030340292 scopus 로고    scopus 로고
    • Phosphorylation and activation of smooth muscle myosin light chain kinase by MAP kinase and cyclin-dependent kinase-1
    • Morrison, D.L., Sanghera, J.S., Stewart, J., Sutherland, C., Walsh, M.P. and Pelech, S.L. (1996) Phosphorylation and activation of smooth muscle myosin light chain kinase by MAP kinase and cyclin-dependent kinase-1. Biochem. Cell Biol., 74, 549-558.
    • (1996) Biochem. Cell Biol. , vol.74 , pp. 549-558
    • Morrison, D.L.1    Sanghera, J.S.2    Stewart, J.3    Sutherland, C.4    Walsh, M.P.5    Pelech, S.L.6
  • 45
    • 0033549558 scopus 로고    scopus 로고
    • Myosin light chain kinase functions downstream of Ras/ERK to promote migration of urokinase-type plasminogen activator-stimulated cells in an integrin-selective manner
    • Nguyen, D.H., Catling, A.D., Webb, D.J., Sankovic, M., Walker, L.A., Somlyo, A.V., Weber, M.J. and Gonias, S.L. (1999) Myosin light chain kinase functions downstream of Ras/ERK to promote migration of urokinase-type plasminogen activator-stimulated cells in an integrin-selective manner. J. Cell Biol., 146, 149-164.
    • (1999) J. Cell Biol. , vol.146 , pp. 149-164
    • Nguyen, D.H.1    Catling, A.D.2    Webb, D.J.3    Sankovic, M.4    Walker, L.A.5    Somlyo, A.V.6    Weber, M.J.7    Gonias, S.L.8
  • 46
    • 0022595998 scopus 로고
    • Cytoskeletal organisation, vinculin-phosphorylation, and fibronectin expression in transformed fibroblasts with different cell morphologies
    • Nigg, E.A., Sefton, B.M., Singer, S.J. and Vogt, P.K. (1986) Cytoskeletal organisation, vinculin-phosphorylation, and fibronectin expression in transformed fibroblasts with different cell morphologies. Virology, 151, 50-65.
    • (1986) Virology , vol.151 , pp. 50-65
    • Nigg, E.A.1    Sefton, B.M.2    Singer, S.J.3    Vogt, P.K.4
  • 47
    • 0025734407 scopus 로고
    • Disruption of the actin cytoskeleton after microinjection of proteolytic fragments of α-actinin
    • Pavalko, F.M. and Burridge, K. (1991) Disruption of the actin cytoskeleton after microinjection of proteolytic fragments of α-actinin. J. Cell Biol., 114, 481-191.
    • (1991) J. Cell Biol. , vol.114 , pp. 481-1191
    • Pavalko, F.M.1    Burridge, K.2
  • 48
    • 0028817908 scopus 로고
    • Convergence of integrin and growth factor receptor signaling pathways within the focal adhesion complex
    • Plopper, G.E., McNamee, H.P., Dike, L.E., Bojanowski, K. and Ingber, D.E. (1995) Convergence of integrin and growth factor receptor signaling pathways within the focal adhesion complex. Mol. Biol. Cell, 6, 1349-1365.
    • (1995) Mol. Biol. Cell , vol.6 , pp. 1349-1365
    • Plopper, G.E.1    McNamee, H.P.2    Dike, L.E.3    Bojanowski, K.4    Ingber, D.E.5
  • 49
    • 0032563558 scopus 로고    scopus 로고
    • Disruption of the talin gene compromises focal adhesion assembly in undifferentiated but not differentiated embryonic stem cells
    • Priddle, H., Hemmings, L., Monkley, S., Woods, A., Patel, B., Sutton, D., Dunn, G., Zicha, D. and Critchley, D. (1998) Disruption of the talin gene compromises focal adhesion assembly in undifferentiated but not differentiated embryonic stem cells. J. Cell Biol., 142, 1121-1133.
    • (1998) J. Cell Biol. , vol.142 , pp. 1121-1133
    • Priddle, H.1    Hemmings, L.2    Monkley, S.3    Woods, A.4    Patel, B.5    Sutton, D.6    Dunn, G.7    Zicha, D.8    Critchley, D.9
  • 50
    • 0029828456 scopus 로고    scopus 로고
    • Involvement of the small GTPase Rho in integrin-mediated activation of mitogen-activated protein kinase
    • Renshaw, M.W., Toksoz, D. and Schwartz, M.A. (1996) Involvement of the small GTPase Rho in integrin-mediated activation of mitogen-activated protein kinase J. Biol. Chem., 271, 21691-21694.
    • (1996) J. Biol. Chem. , vol.271 , pp. 21691-21694
    • Renshaw, M.W.1    Toksoz, D.2    Schwartz, M.A.3
  • 51
    • 0030766846 scopus 로고    scopus 로고
    • Growth factor activation of MAP kinase requires cell adhesion
    • Renshaw, M.W., Ren, X.-D. and Schwartz, M.A. (1997) Growth factor activation of MAP kinase requires cell adhesion EMBO J., 16, 5592-5599.
    • (1997) EMBO J. , vol.16 , pp. 5592-5599
    • Renshaw, M.W.1    Ren, X.-D.2    Schwartz, M.A.3
  • 52
    • 0026778133 scopus 로고
    • The small GTP-binding protein Rho regulates the assembly of focal adhesions and actin stress fibres in response to growth
    • Ridley, A.J. and Hall, A. (1992) The small GTP-binding protein Rho regulates the assembly of focal adhesions and actin stress fibres in response to growth. Cell, 70, 389-399.
    • (1992) Cell , vol.70 , pp. 389-399
    • Ridley, A.J.1    Hall, A.2
  • 53
    • 0023644877 scopus 로고
    • Selective inhibition of catalytic activity of smooth muscle myosin light chain kinase
    • Saitoh, M., Ishikawa, T., Matsushima, S., Naka, M. and Hidaka, H. (1987) Selective inhibition of catalytic activity of smooth muscle myosin light chain kinase. J. Biol. Chem., 262, 7796-7801.
    • (1987) J. Biol. Chem. , vol.262 , pp. 7796-7801
    • Saitoh, M.1    Ishikawa, T.2    Matsushima, S.3    Naka, M.4    Hidaka, H.5
  • 54
    • 0031745490 scopus 로고    scopus 로고
    • Dynamics of myosin light chain phosphorylation at Ser19 and Thr18/Ser19 in smooth muscle cells in culture
    • Sakurada, K., Seto, M. and Sasaki, Y. (1998) Dynamics of myosin light chain phosphorylation at Ser19 and Thr18/Ser19 in smooth muscle cells in culture. Am. J. Physiol., 274, C1563-1572.
    • (1998) Am. J. Physiol. , vol.274
    • Sakurada, K.1    Seto, M.2    Sasaki, Y.3
  • 55
    • 0027057659 scopus 로고
    • Immunological characterisation of avian MAP kinases: Evidence for nuclear localisation
    • Sanghera, J.S., Peter, M., Nigg, E.A. and Pelech, S.L. (1992) Immunological characterisation of avian MAP kinases: evidence for nuclear localisation. Mol. Biol. Cell, 3, 775-787.
    • (1992) Mol. Biol. Cell , vol.3 , pp. 775-787
    • Sanghera, J.S.1    Peter, M.2    Nigg, E.A.3    Pelech, S.L.4
  • 57
    • 0028609382 scopus 로고
    • Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase
    • Schlaepfer, D.D., Hanks, S., Hunter, T. and vanderGreer, P. (1994) Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase Nature, 372, 786-791.
    • (1994) Nature , vol.372 , pp. 786-791
    • Schlaepfer, D.D.1    Hanks, S.2    Hunter, T.3    Vandergreer, P.4
  • 58
    • 0031921101 scopus 로고    scopus 로고
    • Multiple Grb2-mediated integrin-stimulated signaling pathways to ERK2/mitogen-activated protein kinase: Summation of both c-Src-and focal adhesion kinase-initiated tyrosine phosphorylation events
    • Schlaepfer, D.D., Jones, K.C. and Hunter, T. (1998) Multiple Grb2-mediated integrin-stimulated signaling pathways to ERK2/mitogen-activated protein kinase: summation of both c-Src-and focal adhesion kinase-initiated tyrosine phosphorylation events. Mol. Cell. Biol., 18, 2571-2585.
    • (1998) Mol. Cell. Biol. , vol.18 , pp. 2571-2585
    • Schlaepfer, D.D.1    Jones, K.C.2    Hunter, T.3
  • 59
    • 0032911020 scopus 로고    scopus 로고
    • Bidirectional signaling between the cytoskeleton and integrins
    • Schoenwaelder, S.M. and Burridge, K. (1999) Bidirectional signaling between the cytoskeleton and integrins. Curr. Opin. Cell Biol., 11, 274-286.
    • (1999) Curr. Opin. Cell Biol. , vol.11 , pp. 274-286
    • Schoenwaelder, S.M.1    Burridge, K.2
  • 60
    • 0031042493 scopus 로고    scopus 로고
    • Rho, Rac and Cdc42 GTPases regulate the organisation of the actin cytoskeleton
    • Tapon, N. and Hall, A. (1997) Rho, Rac and Cdc42 GTPases regulate the organisation of the actin cytoskeleton. Curr. Opin. Cell Biol., 9, 86-92.
    • (1997) Curr. Opin. Cell Biol. , vol.9 , pp. 86-92
    • Tapon, N.1    Hall, A.2
  • 61
    • 0027966390 scopus 로고
    • Paxillin: A cytoskeletal target for tyrosine kinases
    • Turner, C.E. (1994) Paxillin: a cytoskeletal target for tyrosine kinases. BioEssays, 16, 47-52.
    • (1994) BioEssays , vol.16 , pp. 47-52
    • Turner, C.E.1
  • 63
    • 0028818253 scopus 로고
    • Myosin-II assemblies in the active lamella of fibroblasts - Their morphogenesis and role in the formation of actin filament bundles
    • Verkhovsky, A.B., Svitkina, T.M. and Borisy, G. (1995) Myosin-II assemblies in the active lamella of fibroblasts - their morphogenesis and role in the formation of actin filament bundles. J. Cell Biol., 131, 989-1002.
    • (1995) J. Cell Biol. , vol.131 , pp. 989-1002
    • Verkhovsky, A.B.1    Svitkina, T.M.2    Borisy, G.3
  • 64
    • 0029664531 scopus 로고    scopus 로고
    • cas signaling complex formation upon integrin-mediated cell adhesion: A role for src family kinases
    • cas signaling complex formation upon integrin-mediated cell adhesion: a role for Src family kinases. Mol. Cell. Biol., 16, 2606-2613.
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 2606-2613
    • Vuori, K.1    Hirai, H.2    Aizawa, S.3    Ruoslahti, E.4
  • 65
    • 0027073111 scopus 로고
    • Activation of protein serine-threonine kinases p42, p63, and p87 in Rous sarcoma virus-transformed cells: Signal transduction/transformation-dependent MBP kinases
    • Wang, H.-C.R. and Erickson, R.L. (1992) Activation of protein serine-threonine kinases p42, p63, and p87 in Rous sarcoma virus-transformed cells: signal transduction/transformation-dependent MBP kinases. Mol. Biol. Cell, 3, 1329-1337.
    • (1992) Mol. Biol. Cell , vol.3 , pp. 1329-1337
    • Wang, H.-C.R.1    Erickson, R.L.2
  • 66
    • 0033160196 scopus 로고    scopus 로고
    • Cooperation between mDial and ROCK in Rho-induced actin reorganization
    • Watanabe, N., Kato, T., Fujita, A., Ishizaki, T. and Narumiya, S. (1999) Cooperation between mDial and ROCK in Rho-induced actin reorganization. Nature Cell Biol., 1, 136-143.
    • (1999) Nature Cell Biol. , vol.1 , pp. 136-143
    • Watanabe, N.1    Kato, T.2    Fujita, A.3    Ishizaki, T.4    Narumiya, S.5
  • 68
    • 0028838340 scopus 로고
    • 1 of classical immediate early AP-1 and mitogen-activated protein-kinase responses that parallel the need for the oncoprotein
    • 1 of classical immediate early AP-1 and mitogen-activated protein-kinase responses that parallel the need for the oncoprotein. Cell Growth Diff., 6, 1225-1234.
    • (1995) Cell Growth Diff. , vol.6 , pp. 1225-1234
    • Wyke, A.W.1    Frame, M.C.2    Gillespie, D.A.F.3    Chudleigh, A.4    Wyke, J.A.5
  • 69
    • 0028904784 scopus 로고
    • Integrin-dependent activation of MAP kinase: A link to shape-dependent cell proliferation
    • Zhu, X. and Assoian, R.K. (1995) Integrin-dependent activation of MAP kinase: a link to shape-dependent cell proliferation Mol. Biol. Cell, 6, 273-282.
    • (1995) Mol. Biol. Cell , vol.6 , pp. 273-282
    • Zhu, X.1    Assoian, R.K.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.