메뉴 건너뛰기




Volumn 17, Issue 1, 1998, Pages 81-92

The catalytic activity of Src is dispensable for translocation to focal adhesions but controls the turnover of these structures during cell motility

Author keywords

Focal adhesions; Motility; Src; Tyrosine kinase

Indexed keywords

ACTIN; MUTANT PROTEIN; ONCOPROTEIN; PROTEIN TYROSINE KINASE;

EID: 0032472411     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/17.1.81     Document Type: Article
Times cited : (266)

References (45)
  • 1
    • 0018139183 scopus 로고
    • Differential expression of Rous sarcoma virus-specific transformation parameters in enucleated cells
    • Beug, H., Claviez, M., Jockusch, B.M. and Graf, T. (1978) Differential expression of Rous sarcoma virus-specific transformation parameters in enucleated cells. Cell, 14, 843-856.
    • (1978) Cell , vol.14 , pp. 843-856
    • Beug, H.1    Claviez, M.2    Jockusch, B.M.3    Graf, T.4
  • 2
    • 0024150623 scopus 로고
    • Focal adhesions-transmembrane junctions between the extracellular-matrix and the cytoskeleton
    • Burridge, K., Fath, K., Kelly, T., Nuckolls, G. and Turner, C. (1988) Focal adhesions-transmembrane junctions between the extracellular-matrix and the cytoskeleton. Annu. Rev. Cell Biol., 4, 487-525.
    • (1988) Annu. Rev. Cell Biol. , vol.4 , pp. 487-525
    • Burridge, K.1    Fath, K.2    Kelly, T.3    Nuckolls, G.4    Turner, C.5
  • 3
    • 0026445719 scopus 로고
    • Tyrosine phosphorylation of paxillin and pp125(FAK) accompanies cell-adhesion to extracellular-matrix - A role in cytoskeletal assembly
    • Burridge, K., Turner, C.E. and Romer, L.H. (1992) Tyrosine phosphorylation of paxillin and pp125(FAK) accompanies cell-adhesion to extracellular-matrix - a role in cytoskeletal assembly. J. Cell Biol., 119, 893-903.
    • (1992) J. Cell Biol. , vol.119 , pp. 893-903
    • Burridge, K.1    Turner, C.E.2    Romer, L.H.3
  • 4
    • 0029948080 scopus 로고    scopus 로고
    • Stimulation of cell-migration by overexpression of focal adhesion kinase and its association with src and fyn
    • Cary, L.A., Chang, J.F. and Guan, J.-L. (1996) Stimulation of cell-migration by overexpression of focal adhesion kinase and its association with src and fyn. J. Cell Sci., 109, 1787-1794.
    • (1996) J. Cell Sci. , vol.109 , pp. 1787-1794
    • Cary, L.A.1    Chang, J.F.2    Guan, J.-L.3
  • 5
    • 0027295851 scopus 로고
    • Mitogenesis of quiescent chick fibroblasts by v-Src: Dependence on events at the membrane leading to early changes in AP-1
    • Catling, A.D., Wyke, J.A. and Frame, M.C. (1993) Mitogenesis of quiescent chick fibroblasts by v-Src: dependence on events at the membrane leading to early changes in AP-1. Oncogene, 8, 1875-1886.
    • (1993) Oncogene , vol.8 , pp. 1875-1886
    • Catling, A.D.1    Wyke, J.A.2    Frame, M.C.3
  • 6
    • 0029995797 scopus 로고    scopus 로고
    • Rho-stimulated contractility drives the formation of stress fibres and focal adhesions
    • Chrzanowska-Wodnicka, M. and Burridge, K. (1996) Rho-stimulated contractility drives the formation of stress fibres and focal adhesions. J. Cell Biol., 133, 1403-1415.
    • (1996) J. Cell Biol. , vol.133 , pp. 1403-1415
    • Chrzanowska-Wodnicka, M.1    Burridge, K.2
  • 7
    • 85053099623 scopus 로고
    • The Src family of protein-tyrosine kinases
    • Kemp, B. and Alewood, P.F. (eds), CRC Press, Boca Raton, FL
    • Cooper, J.A. (1989) The Src family of protein-tyrosine kinases. In Kemp, B. and Alewood, P.F. (eds), Peptides and Protein Phosphorylation. CRC Press, Boca Raton, FL, pp. 85-113.
    • (1989) Peptides and Protein Phosphorylation , pp. 85-113
    • Cooper, J.A.1
  • 8
    • 0028492201 scopus 로고
    • Protein tyrosine kinases, with emphasis on the Src family
    • Courtneidge, S.A. (1994) Protein tyrosine kinases, with emphasis on the Src family. Semin. Cancer Biol., 5, 239-246.
    • (1994) Semin. Cancer Biol. , vol.5 , pp. 239-246
    • Courtneidge, S.A.1
  • 11
    • 0025605786 scopus 로고
    • Immunolocalisation of the cellular Src protein in interphase and mitotic NIH c-Src overexpressed cells
    • David-Pfeuty, T. and Nouvian-Dooghe, Y. (1990) Immunolocalisation of the cellular Src protein in interphase and mitotic NIH c-Src overexpressed cells. J. Cell Biol., 111, 3097-3116.
    • (1990) J. Cell Biol. , vol.111 , pp. 3097-3116
    • David-Pfeuty, T.1    Nouvian-Dooghe, Y.2
  • 12
    • 0028988989 scopus 로고
    • v-Src-induced degradation of focal adhesion kinase during morphological transformation of chicken-embryo fibroblasts
    • Fincham, V.J., Wyke, J.A. and Frame, M.C. (1995) v-Src-induced degradation of focal adhesion kinase during morphological transformation of chicken-embryo fibroblasts. Oncogene, 10, 2247-2252.
    • (1995) Oncogene , vol.10 , pp. 2247-2252
    • Fincham, V.J.1    Wyke, J.A.2    Frame, M.C.3
  • 13
    • 0030482560 scopus 로고    scopus 로고
    • Translocation of Src kinase to the cell periphery is mediated by the actin cytoskeleton under the control of the Rho family of small G proteins
    • Fincham, V.J., Unlu, M., Brunton, V.G., Pitts, J.D., Wyke, J.A. and Frame, M.C. (1996) Translocation of Src kinase to the cell periphery is mediated by the actin cytoskeleton under the control of the Rho family of small G proteins. J. Cell Biol., 135, 1551-1564.
    • (1996) J. Cell Biol. , vol.135 , pp. 1551-1564
    • Fincham, V.J.1    Unlu, M.2    Brunton, V.G.3    Pitts, J.D.4    Wyke, J.A.5    Frame, M.C.6
  • 14
    • 0028117945 scopus 로고
    • Separation of v-Src-induced mitogenesis and morphological transformation by inhibition of AP-1
    • Frame, M.C., Simpson, K., Fincham, V.J. and Crouch, D.H. (1994) Separation of v-Src-induced mitogenesis and morphological transformation by inhibition of AP-1. Mol. Cell. Biol., 5, 1177-1184.
    • (1994) Mol. Cell. Biol. , vol.5 , pp. 1177-1184
    • Frame, M.C.1    Simpson, K.2    Fincham, V.J.3    Crouch, D.H.4
  • 15
    • 0029741102 scopus 로고    scopus 로고
    • Inhibition of focal adhesion kinase (FAK) signalling in focal adhesions decreases cell motility and proliferation
    • Gilmore, A.P. and Romer, L.H. (1996) Inhibition of focal adhesion kinase (FAK) signalling in focal adhesions decreases cell motility and proliferation. Mol. Biol. Cell, 7, 1209-1224.
    • (1996) Mol. Biol. Cell , vol.7 , pp. 1209-1224
    • Gilmore, A.P.1    Romer, L.H.2
  • 16
    • 0026759309 scopus 로고
    • Regulation of focal adhesion-associated protein tyrosine kinase by both cellular adhesion and oncogenic transformation
    • Guan, J.-L. and Shalloway, D. (1992) Regulation of focal adhesion-associated protein tyrosine kinase by both cellular adhesion and oncogenic transformation. Nature, 358, 690-692.
    • (1992) Nature , vol.358 , pp. 690-692
    • Guan, J.-L.1    Shalloway, D.2
  • 17
    • 0029838320 scopus 로고    scopus 로고
    • Pp60(c-src) is required for cell locomotion regulated by the hyaluronan receptor RHAMM
    • Hall, C.L., Lange, L.A., Prober, D.A., Zhang, S. and Turley, E.A. (1996) Pp60(c-src) is required for cell locomotion regulated by the hyaluronan receptor RHAMM. Oncogene, 13, 2213-2224.
    • (1996) Oncogene , vol.13 , pp. 2213-2224
    • Hall, C.L.1    Lange, L.A.2    Prober, D.A.3    Zhang, S.4    Turley, E.A.5
  • 18
    • 0026674919 scopus 로고
    • Focal adhesion protein-tyrosine kinase is phosphorylated in response to cell attachment to fibronectin
    • Hanks, S.K., Calalb, M.B., Harper, M.C. and Patel, S.K. (1992) Focal adhesion protein-tyrosine kinase is phosphorylated in response to cell attachment to fibronectin. Proc. Natl Acad. Sci. USA, 89, 8487-8491.
    • (1992) Proc. Natl Acad. Sci. USA , vol.89 , pp. 8487-8491
    • Hanks, S.K.1    Calalb, M.B.2    Harper, M.C.3    Patel, S.K.4
  • 19
    • 0027428367 scopus 로고
    • Identification of sequences required for the efficient localisation of the focal adhesion kinase, pp125(FAK), to cellular focal adhesions
    • Hildebrand, J.D., Schaller, M.D. and Parsons, J.T. (1993) Identification of sequences required for the efficient localisation of the focal adhesion kinase, pp125(FAK), to cellular focal adhesions. J. Cell Biol., 123, 993-1005.
    • (1993) J. Cell Biol. , vol.123 , pp. 993-1005
    • Hildebrand, J.D.1    Schaller, M.D.2    Parsons, J.T.3
  • 20
    • 0029120440 scopus 로고
    • Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice
    • Ilic, D. et al. (1995) Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice. Nature, 377, 539-544.
    • (1995) Nature , vol.377 , pp. 539-544
    • Ilic, D.1
  • 22
    • 0025376378 scopus 로고
    • Monoclonal-antibodies to individual tyrosine-phosphorylated protein substrates of oncogene-encoded tyrosine kinases
    • Kanner, S.B., Reynolds, A.B., Vines, R.R. and Parsons, T. (1990) Monoclonal-antibodies to individual tyrosine-phosphorylated protein substrates of oncogene-encoded tyrosine kinases. Proc. Natl Acad. Sd. USA, 87, 3328-3332.
    • (1990) Proc. Natl Acad. Sd. USA , vol.87 , pp. 3328-3332
    • Kanner, S.B.1    Reynolds, A.B.2    Vines, R.R.3    Parsons, T.4
  • 24
    • 0028151515 scopus 로고
    • Association of the amino-terminal half of c-Src with focal adhesions alters their properties and is regulated by phosphorylation of tyrosine 527
    • Kaplan, K.B., Bibbins, K.B., Swedlow, J.R., Arnaud, M., Morgan, D.O. and Varmus, H.E. (1994) Association of the amino-terminal half of c-Src with focal adhesions alters their properties and is regulated by phosphorylation of tyrosine 527. EMBO J., 13, 4745-4756.
    • (1994) EMBO J. , vol.13 , pp. 4745-4756
    • Kaplan, K.B.1    Bibbins, K.B.2    Swedlow, J.R.3    Arnaud, M.4    Morgan, D.O.5    Varmus, H.E.6
  • 26
    • 0027055575 scopus 로고
    • Cell-adhesion or integrin clustering increases phosphorylation of a focal adhesion-associated tyrosine kinase
    • Kornberg, L., Earp, H.S., Parsons, J.T., Schaller, M. and Juliano, R.L. (1992) Cell-adhesion or integrin clustering increases phosphorylation of a focal adhesion-associated tyrosine kinase. J. Biol. Chem., 267, 23439-23442.
    • (1992) J. Biol. Chem. , vol.267 , pp. 23439-23442
    • Kornberg, L.1    Earp, H.S.2    Parsons, J.T.3    Schaller, M.4    Juliano, R.L.5
  • 27
    • 0021288579 scopus 로고
    • src proteins of recovered avian sarcoma virus interact with adhesion plaques as peripheral membrane proteins: Effects on cell transformation
    • src proteins of recovered avian sarcoma virus interact with adhesion plaques as peripheral membrane proteins: effects on cell transformation. Mol. Cell. Biol., 4, 454-467.
    • (1984) Mol. Cell. Biol. , vol.4 , pp. 454-467
    • Krueger, J.G.1    Garber, E.A.2    Chin, S.S.M.3    Hanafusa, H.4
  • 28
    • 0028281170 scopus 로고
    • Excess early signalling activity inhibits cellular chemotaxis toward PDGF-BB
    • Kundra, V., Soker, S. and Zetter, B.R. (1994) Excess early signalling activity inhibits cellular chemotaxis toward PDGF-BB. Oncogene, 9, 1429-1435.
    • (1994) Oncogene , vol.9 , pp. 1429-1435
    • Kundra, V.1    Soker, S.2    Zetter, B.R.3
  • 29
    • 0030045346 scopus 로고    scopus 로고
    • Cell-migration - A physically integrated molecular process
    • Lauffenburger, D.A. and Horwitz, A.F. (1996) Cell-migration - a physically integrated molecular process. Cell, 84, 359-369.
    • (1996) Cell , vol.84 , pp. 359-369
    • Lauffenburger, D.A.1    Horwitz, A.F.2
  • 31
    • 0027507115 scopus 로고
    • Signalling through SH2 and SH3 domains
    • Mayer, B.J. and Baltimore, D. (1993) Signalling through SH2 and SH3 domains. Trends Cell Biol., 3, 8-13.
    • (1993) Trends Cell Biol. , vol.3 , pp. 8-13
    • Mayer, B.J.1    Baltimore, D.2
  • 32
    • 0020189847 scopus 로고
    • Immunofluorescent localisation of the transforming protein of Roussarcoma virus with antibodies against a synthetic Src peptide
    • Nigg, E.A., Sefton, B.M., Hunter, T., Walter, G. and Singer, S.J. (1982) Immunofluorescent localisation of the transforming protein of Roussarcoma virus with antibodies against a synthetic Src peptide. Proc. Natl Acad. Sci. USA, 79, 5322-5326.
    • (1982) Proc. Natl Acad. Sci. USA , vol.79 , pp. 5322-5326
    • Nigg, E.A.1    Sefton, B.M.2    Hunter, T.3    Walter, G.4    Singer, S.J.5
  • 35
    • 0026778133 scopus 로고
    • The small GTP-binding protein Rho regulates the assembly of focal adhesions and actin stress fibres in response to growth factors
    • Ridley, A.J. and Hall, A. (1992) The small GTP-binding protein Rho regulates the assembly of focal adhesions and actin stress fibres in response to growth factors. Cell, 70, 389-399.
    • (1992) Cell , vol.70 , pp. 389-399
    • Ridley, A.J.1    Hall, A.2
  • 36
    • 0026654125 scopus 로고
    • The small GTP-binding protein Rac regulates growth factor-induced membrane ruffling
    • Ridley, A.J., Paterson, H.F., Johnston, C.L., Diekmann, D. and Hall, A. (1992) The small GTP-binding protein Rac regulates growth factor-induced membrane ruffling. Cell, 70, 401-410.
    • (1992) Cell , vol.70 , pp. 401-410
    • Ridley, A.J.1    Paterson, H.F.2    Johnston, C.L.3    Diekmann, D.4    Hall, A.5
  • 37
    • 0028971036 scopus 로고
    • Pp60(c-src) is a positive regulator of growth factor-induced cell scattering in a rat bladder-carcinoma cell-line
    • Rodier, J.-M, Vallés, A.M., Denoyelle, M., Thiery, J.P. and Boyer, B. (1995) Pp60(c-src) is a positive regulator of growth factor-induced cell scattering in a rat bladder-carcinoma cell-line. J. Cell Biol., 131, 761-773.
    • (1995) J. Cell Biol. , vol.131 , pp. 761-773
    • Rodier, J.-M.1    Vallés, A.M.2    Denoyelle, M.3    Thiery, J.P.4    Boyer, B.5
  • 38
    • 0018349213 scopus 로고
    • Immunofluorescence on avian sarcoma virus-transformed cell: Localisation of the src gene product
    • Rohrschneider, J.R. (1979) Immunofluorescence on avian sarcoma virus-transformed cell: localisation of the src gene product. Cell, 16, 11-24.
    • (1979) Cell , vol.16 , pp. 11-24
    • Rohrschneider, J.R.1
  • 40
    • 0028350859 scopus 로고
    • Autophosphorylation of the focal adhesion kinase, pp125(FAK), directs SH2 dependent binding of pp60(SRC)
    • Schaller, M.D., Hildebrand, J.D., Shannon, J.D., Fox, J.X., Vines, R.R. and Parsons, J.T. (1994) Autophosphorylation of the focal adhesion kinase, pp125(FAK), directs SH2 dependent binding of pp60(SRC). Mol. Cell. Biol. 14, 1680-1688.
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 1680-1688
    • Schaller, M.D.1    Hildebrand, J.D.2    Shannon, J.D.3    Fox, J.X.4    Vines, R.R.5    Parsons, J.T.6
  • 41
    • 0028609382 scopus 로고
    • Integrin-mediated signal-transduction is linked to the Ras pathway by GRB2 binding to focal adhesion kinase
    • Schlaepfer, D.D., Hanks, S.K., Hunter, T. and van der Geer, P. (1994) Integrin-mediated signal-transduction is linked to the Ras pathway by GRB2 binding to focal adhesion kinase. Nature, 372, 786-791.
    • (1994) Nature , vol.372 , pp. 786-791
    • Schlaepfer, D.D.1    Hanks, S.K.2    Hunter, T.3    Van Der Geer, P.4
  • 42
    • 0031148599 scopus 로고    scopus 로고
    • Cell migration: May the force be with you
    • Schwarzbauer, J.E. (1997) Cell migration: may the force be with you. Curr. Biol., 7, 292-294.
    • (1997) Curr. Biol. , vol.7 , pp. 292-294
    • Schwarzbauer, J.E.1
  • 43
    • 0026245786 scopus 로고
    • Transmembrane molecular assemblies in cell-extracellular matrix interactions
    • Turner, C.E. and Burridge, K. (1991) Transmembrane molecular assemblies in cell-extracellular matrix interactions. Curr. Opin. Cell Biol., 3, 849-853.
    • (1991) Curr. Opin. Cell Biol. , vol.3 , pp. 849-853
    • Turner, C.E.1    Burridge, K.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.