Structure and function in rhodopsin. Single cysteine substitution mutants in the cytoplasmic interhelical E-F loop region show position- specific effects in transducin activation

Biochemistry

Volumn 35, Issue 38, 1996, Pages 12464-12469

  Yang, Ke ^a,c   Farrens, David L ^a   Hubbell, Wayne L ^b   Gobind Khorana, H ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^b JULES STEIN EYE INSTITUTE   (United States)

^c MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

11 CIS RETINAL; CYSTEINE; GUANINE NUCLEOTIDE BINDING PROTEIN; MEMBRANE PROTEIN; MUTANT PROTEIN; N ETHYLMALEIMIDE; RHODOPSIN; TRANSDUCIN;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; GENE EXPRESSION; NONHUMAN; PHOTORECEPTOR; PRIORITY JOURNAL; PROTEIN PURIFICATION; PROTEIN STRUCTURE; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; ANIMALS; CATTLE; COS CELLS; CYSTEINE; ETHYLMALEIMIDE; FLUORESCENCE; GENE EXPRESSION; GUANOSINE TRIPHOSPHATE; LIGHT; MOLECULAR SEQUENCE DATA; MUTAGENESIS; OPSIN; RECOMBINANT PROTEINS; RHODOPSIN; SPECTROPHOTOMETRY; TRANSDUCIN;

EID: 0029818639     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi960848t     Document Type: Article

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