Clnk, a novel SLP-76-related adaptor molecule expressed in cytokine- stimulated hemopoietic cells

Journal of Experimental Medicine

Volumn 190, Issue 10, 1999, Pages 1527-1534

  Cao, Ming Yu ^a   Davidson, Dominique ^a   Yu, Jie ^a   Latour, Sylvain ^a   Veillette, André ^a,b  

^a MCGILL UNIVERSITY   (Canada)

^b MCGILL UNIVERSITY   (Canada)

Author keywords

Adaptor; Blnk; Lymphocytes; Signaling; SLP 76

Indexed keywords

ADAPTOR PROTEIN; INTERLEUKIN 2; INTERLEUKIN 3; LINK PROTEIN; TYROSINE;

ANIMAL CELL; ARTICLE; HEMATOPOIETIC CELL; MAST CELL; MOLECULAR CLONING; MOUSE; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; T LYMPHOCYTE;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AMINO ACID SEQUENCE; ANIMALS; CARRIER PROTEINS; CELL LINE; CYTOKINES; DNA, COMPLEMENTARY; DNA-BINDING PROTEINS; HEMATOPOIETIC SYSTEM; MICE; MICE, INBRED C57BL; MOLECULAR SEQUENCE DATA; NFATC TRANSCRIPTION FACTORS; NUCLEAR PROTEINS; PHOSPHOPROTEINS; PROMOTER REGIONS (GENETICS); RECEPTORS, IMMUNOLOGIC; SRC HOMOLOGY DOMAINS; TRANSCRIPTION FACTOR AP-1; TRANSCRIPTION FACTORS;

EID: 0001000138     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.190.10.1527     Document Type: Article

References (36)

1. Fu, C., C.W. Turck, T. Kurosaki, and A.C. Chan. 1998. BLNK: a central linker protein in B cell activation. Immunity. 9:93-103.
2. Wienands, J., J. Schweikert, B. Wollscheid, H. Jumaa, P.J. Nielsen, and M. Reth. 1998. SLP-65: a new signaling component in B lymphocytes which requires expression of the antigen receptor for phosphorylation. J. Exp. Med. 188: 791-795.
3. Jackman, J.K., D.G. Motto, Q. Sun, M. Tanemoto, C.W. Turck, G.A. Peltz, G.A. Koretzky, and P.R. Findell. 1995. Molecular cloning of SLP-76, a 76-kDa tyrosine phosphoprotein associated with Grb2 in T cells. J. Biol. Chem. 270: 7029-7032.
4. Goitsuka, R., Y. Fujimura, H. Mamada, A. Umeda, T. Morimura, K. Uetsuka, K. Doi, S. Tsuji, and D. Kitamura. 1998. BASH, a novel signaling molecule preferentially expressed in B cells of the bursa of Fabricius. J. Immunol. 161: 5804-5808.
5. Clements, J.L., S.E. Ross-Barta, L.T. Tygrett, T.J. Waldschmidt, and G.A. Koretzky. 1998. SLP-76 expression is restricted to hemopoietic cells of monocyte, granulocyte, and T lymphocyte lineage and is regulated during T cell maturation and activation. J. Immunol. 161:3880-3889.
6. Clements, J.L., B. Yang, S.E. Ross-Barta, S.L. Eliason, R.F. Hrstka, R.A. Williamson, and G.A. Koretzky. 1998. Requirement for the leukocyte-specific adapter protein SLP-76 for normal T cell development. Science. 281:416-419.
7. Pivniouk, V., E. Tsitsikov, P. Swinton, G. Rathbun, F.W. Alt, and R.S. Geha. 1998. Impaired viability and profound block in thymocyte development in mice lacking the adaptor protein SLP-76. Cell. 94:229-238.
8. Clements, J.L., J.R. Lee, B. Gross, B. Yang, J.D Olson, A. Sandra, S.P. Watson, S.R. Lentz, and G.A. Koretzky. 1999. Fetal hemorrhage and platelet dysfunction in SLP-76-deficient mice. J. Clin. Invest. 103:19-25.
9. Pivniouk, V.I., T.R. Martin, J.M. Lu-Kuo, H.R. Katz, H.C. Oettgen, and R.S. Geha. 1999. SLP-76 deficiency impairs signaling via the high-affinity IgE receptor in mast cells. J. Clin. Invest. 103:1737-1743.
10. Yablonski, D., M.R. Kuhne, T. Kadlecek, and A. Weiss. 1998. Uncoupling of nonreceptor tyrosine kinases from PLC-γ1 in an SLP-76-deficient T cell. Science. 281:413-416.
11. Ishiai, M., M. Kurosaki, R. Pappu, K. Okawa, I. Ronko, C. Fu, M. Shibata, A. Iwamatsu, A.C. Chan, and T. Kurosaki. 1999. BLNK required for coupling Syk to PLC gamma 2 and Rac1-JNK in B cells. Immunity. 10:117-125.
12. Bubeck Wardenburg, J., R. Pappu, J.Y. Bu, B. Mayer, J. Chernoff, D. Straus, and A.C. Chan. 1998. Regulation of PAK activation and the T cell cytoskeleton by the linker protein SLP-76. Immunity. 9:607-616.
13. da Silva, A.J., Z. Li, C. de Vera, E. Canto, P. Findell, and C.E. Rudd. 1997. Cloning of a novel T-cell protein FYB that binds FYN and SH2-domain-containing leukocyte protein 76 and modulates interleukin 2 production. Proc. Natl. Acad. Sci. USA. 94:7493-7498.
14. Law, C.L., M.K. Ewings, P.M. Chaudhary, S.A. Solow, T.J. Yun, A.J. Marshall, L. Hood, and E.A. Clark. 1999. GrpL, a Grb2-related adaptor protein, interacts with SLP-76 to regulate nuclear factor of activated T cell activation. J. Exp. Med. 189:1243-1253.
15. Liu, S.K., N. Fang, G.A. Koretzky, and C.J. McGlade. 1999. The hematopoietic-specific adaptor protein Gads functions in T-cell signaling via interactions with the SLP-76 and LAT adaptors. Curr. Biol. 9:67-75.
16. Musci, M.A., L.R. Hendricks-Taylor, D.G. Motto, M. Paskind, J. Kamens, C.W. Turck, and G.A. Koretzky. 1997. Molecular cloning of SLAP-130, an SLP-76-associated substrate of the T cell antigen receptor-stimulated protein tyrosine kinases. J. Biol. Chem. 272:11674-11677.
17. vav associates with tyrosine-phosphorylated SLP-76 in antigen-stimulated T cells. J. Exp. Med. 184:1161-1166.
18. Wu, J., D.G. Motto, G.A. Koretzky, and A. Weiss. 1996. Vav and SLP-76 interact and functionally cooperate in IL-2 gene activation. Immunity. 4:593-602.
19. Wunderlich, L., A. Farago, J. Downward, and L. Buday. 1999. Association of Nck with tyrosine-phosphorylated SLP-76 in activated T lymphocytes. Eur. J. Immunol. 29:1068-1075.
20. Chow, L.M., D. Davidson, M. Fournel, P. Gosselin, S. Lemieux, M.S. Lyu, C.A. Kozak, L.A. Matis, and A. Veillette. 1994. Two distinct protein isoforms are encoded by ntk, a csk-related tyrosine protein kinase gene. Oncogene. 9:3437-3448.
21. Damen, J.E., L. Liu, P. Rosten, R.K. Humphries, A.B. Jefferson, P.W. Majerus, and G. Krystal. 1996. The 145-kDa protein induced to associate with Shc by multiple cytokines is an inositol tetraphosphate and phosphatidylinositol 3,4,5-triphosphate 5-phosphatase. Proc. Natl. Acad. Sci. USA. 93: 1689-1693.
22. lck with CD4 inhibits the induction of growth through the alpha beta T-cell receptor. Nature. 358:328-331.
23. Leo, O., M. Foo, D.H. Sachs, L.E. Samelson, and J.A. Bluestone. 1987. Identification of a monoclonal antibody specific for a murine T3 polypeptide. Proc. Natl. Acad. Sci. USA. 84: 1374-1378.
24. 2a production. Eur. J. Immunol. 20: 1781-1787.
25. Chow, L.M., M.J. Ratcliffe, and A. Veillette. 1992. tkl is the avian homolog of the mammalian lck tyrosine protein kinase gene. Mol. Cell. Biol. 12:1226-1233.
26. lck in resting T-lymphocytes. J. Biol. Chem. 269:22830-22838.
27. csk with protein tyrosine phosphatase PEP in T cells and other hemopoietic cells. EMBO (Eur. Mol. Biol. Organ.) J. 15:4909-4918.
28. lck. Cell. 55:301-308.
29. c-cbl in T lymphocytes. J. Exp. Med. 183:301-306.
30. Cao, M.Y., M. Huber, N. Beauchemin, J. Famiglietti, S.M. Albelda, and A. Veillette. 1998. Regulation of mouse PECAM-1 tyrosine phosphorylation by the Src and Csk families of protein-tyrosine kinases. J. Biol. Chem. 273:15765-15772.
31. Newman, P.J., M.C. Berndt, J. Gorski, G.C. White II, S. Lyman, C. Paddock, and W.A. Muller. 1990. PECAM-1 (CD31) cloning and relation to adhesion molecules of the immunoglobulin gene superfamily. Science. 247:1219-1222.
32. Motto, D.G., S.E. Ross, J. Wu, L.R. Hendricks-Taylor, and G.A. Koretzky. 1996. Implication of the GRB2-associated phosphoprotein SLP-76 in T cell receptor-mediated interleukin 2 production. J. Exp. Med. 183:1937-1943.
33. Raab, M., A.J. da Silva, P.R. Findell, and C.E. Rudd. 1997. Regulation of Vav-SLP-76 binding by ZAP-70 and its relevance to TCR zeta/CD3 induction of interleukin-2. Immunity. 6:155-164.
34. Piao, X., R. Paulson, P. van der Geer, T. Pawson, and A. Bernstein. 1996. Oncogenic mutation in the Kit receptor tyrosine kinase alters substrate specificity and induces degradation of the protein tyrosine phosphatase SHP-1. Proc. Natl. Acad. Sci. USA. 93:14665-14669.
35. Peterson, E.J., J.L. Clements, Z.K. Ballas, and G.A. Koretzky. 1999. NK cytokine secretion and cytotoxicity occur independently of the SLP-76 adaptor protein. Eur. J. Immunol. 29:2223-2232.
36. Fang, N., and G.A. Koretzky. 1999. SLP-76 and Vav function in separate, but overlapping pathways to augment interleukin-2 promoter activity. J. Biol. Chem. 274:16206-16212.