Phospholipase C-γ as a signal-transducing element

Experimental Cell Research

Volumn 253, Issue 1, 1999, Pages 15-24

  Carpenter, Graham ^a   Ji, Qun Sheng ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Growth factors; Phospholipase C; Phosphotyrosine

Indexed keywords

ADAPTOR PROTEIN; CALCIUM; DIACYLGLYCEROL; INOSITOL 1,4,5 TRISPHOSPHATE; ISOENZYME; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE; PHOSPHOLIPASE C; PROTEIN KINASE C; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE PHOSPHATASE;

BIOCHEMISTRY; CALCIUM CELL LEVEL; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; FERTILIZATION; GENETIC REGULATION; HORMONE RESPONSE; MITOGENESIS; PRIORITY JOURNAL; PROTEIN DOMAIN; REVIEW; SECOND MESSENGER; SIGNAL TRANSDUCTION;

EID: 0033604513     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1006/excr.1999.4671     Document Type: Article

References (123)

1. Nishizuka Y. The role of protein kinase C in cell surface signal transduction and tumor promotion. Nature. 308:1984;693-697.
2. Berridge M. J., Irvine R. F. Inositol trisphosphate, a novel second messenger in cellular signal transduction. Nature. 312:1984;315-321.
3. Rhee S. G., Bae Y. S. Regulation of phosphoinositide-specific phospholipase C isozymes. J. Biol. Chem. 272:1997;15045-15048.
4. Essen L.-O., Perisic O., Cheung R., Katan M., Williams R. L. Crystal structure of a mammalian phosphoinositide-specific phospholipase Cδ Nature. 380:1996;595-602.
5. Ellis M. V., James S. R., Perisic O., Downes C. P., Williams R. L., Katan M. Catalytic domain of phosphoinositide-specific phospholipase C (PLC). Mutational analysis of residues within the active site and hydrophobic ridge of PLC-δ1. J. Biol. Chem. 273:1998;11650-11659.
6. Heinz D. W., Essen L.-O., Williams R. L. Structural and mechanistic comparison of prokaryotic and eukaryotic phosphoinositide-specific phospholipases C. J. Mol. Biol. 275:1998;635-650.
7. Smith M. R., Liu Y.-L., Matthews N. T., Rhee S. G., Sung W. K., Kung H.-F. Phospholipase C-γ1 can induce DNA synthesis by a mechanism independent of its lipase activity. Proc. Natl. Acad. Sci. USA. 91:1994;6554-6558.
8. Kamat A.m, Carpenter G. Phospholipase C-γ1: Regulation of enzyme function and role in growth factor-dependent signal transduction. Cytokine Growth Factor Rev. 8:1997;109-117.
9. Horstman D. A., DeStefano K., Carpenter G. Enhanced phospholipase C-γ1 activity produced by association of independently expressed X and Y domain polypeptides. Proc. Nat. Acad. Sci. USA. 93:1996;7518-7521.
10. Zhou C., Horstman D., Carpenter G.m, Roberts M. F. Action of phosphatidylinositol-specific phospholipase Cγ1 on soluble and micellar substrates: Separating effects on catalysis from modulation of the surface. J. Biol. Chem. 274:1999;2786-2793.
11. Hof P., Pluskey S., Dhe-Paganon S., Eck M. J., Shoelson S. E. Crystal structure of the tyrosine phosphatase SHP-2. Cell. 92:1998;441-450.
12. Katan M., Allen V. L. Modular PH and C2 domains in membrane attachment and other functions. FEBS Lett. 452:1999;36-40.
13. Katan M. Families of phosphoinositide-specific phospholipase C: Structure and function. Biochim. Biophys. Acta. 1436:1998;5-17.
14. Ji Q.-s., Winnier G. E., Niswender K. D., Horstman D., Wisdom R., Magnuson M. A., Carpenter G. Essential role of the tyrosine kinase substrate phospholipase C-γ1 in mammalian growth and development. Proc. Natl. Acad. Sci. USA. 94:1997;2999-3003.
15. Kim D., Jun K. S., Lee S. B., Kang N.-G., Min D. S., Kim Y.-H., Ryu S. H., Suh P.-G., Shin H.-S. Phospholipase C isozymes selectively couple to specific neurotransmitter receptors. Nature. 389:1997;290-293.
16. Jiang H., Lyubarsky A., Dodd R., Vardi N., Pugh E., Baylor D., Simon M. I., Wu D. Phospholipase C β4 is involved in modulating the visual response in mice. Proc. Natl. Acad. Sci. USA. 93:1996;14598-14601.
17. Jiang H., Kuang Y., Wu Y., Xie W., Simon M. I., Wu D. Roles of phospholipase Cβ2 in chemoattractant-elicited responses. Proc. Natl. Acad. Sci. USA. 94:1997;7971-7975.
18. Wang S., Gebre-Medhin S., Betsholtz C., Stålberg P., Zhou Y., Larsson C., Weber G., Feinstein R., Öberg K., Gobl A., Skogseid B. Targeted disruption of the mouse phospholipase C β3 gene results in early embryonic lethality. FEBS Lett. 441:1998;261-265.
19. Thackeray J. R., Gaines P. C. W., Ebert P., Carlson J. R. small wing encodes a phospholipase C-γ that acts as a negative regulator of R7 development in Drosophila. Development. 125:1998;5033-5042.
20. Ji Q.-s., Ermini S., Baulida J., Sun F.-l., Carpenter G. Epidermal growth factor signaling and mitogenesis in Plcg1 null mouse embryonic fibroblasts. Mol. Biol. Cell. 9:1998;749-757.
21. Hess J. A., Ji Q.-s., Carpenter G., Exton J. H. Analysis of platelet-derived growth factor-induced phospholipase D activation in mouse embryo fibroblasts lacking phospholipase C-γ1. J. Biol. Chem. 273:1998;20517-20524.
22. 2+/calmodulin-dependent protein kinase II are involved in platelet-derived growth factor-induced phosphorylation of Tiam1. FEBS Lett. 429:1998;229-233.
23. Xie Z., Bikle D. D. Phospholipase C-γ1 is required for calcium-induced keratinocyte differentiation. J. Biol. Chem. 274:1999;20421-20424.
24. Nebigil C. G. Suppression of phospholipase C β, γ, and δ families alters cell growth and phosphatidylinositol 4,5-bisphosphate levels. Biochemistry. 36:1997;15949-15958.
25. Takata M., Homma Y., Kurosaki T. Requirement of phospholipase C-γ2 activation in surface immunoglobulin M-induced B cell apoptosis. J. Exp. Med. 182:1995;907-914.
26. Kim J. W., Sim S. S., Kim Y.-H., Nishibe S., Wahl M. I., Carpenter G., Rhee S. G. Tyrosine residues in bovine phospholipase C-γ phosphorylated by the epidermal growth factor receptor in vitro. J. Biol. Chem. 265:1990;3940-3943.
27. Wahl M. I., Nishibe S., Kim J. W., Kim H., Rhee S. G., Carpenter G. Identification of two epidermal growth factor-sensitive tyrosine phosphorylation sites of phospholipase C-γ in intact HSC-1 cells. J. Biol. Chem. 265:1990;3944-3948.
28. Kim H. K., Kim J. W., Zilberstein A., Margolis B., Kim J. G., Schlessinger J., Rhee S. G. PDGF stimulation of inositol phospholipid hydrolysis requires PLC-γ1 phosphorylation on tyrosine residues 783 and 1254. Cell. 65:1991;435-441.
29. Nishibe S., Wahl M. I., Hernández-Sotomayor S. M. T., Tonks N. K., Rhee S. G., Carpenter G. Increase of the catalytic activity of phospholipase C-γ1 by tyrosine phosphorylation. Science. 250:1990;1253-1256.
30. Anderson D., Koch C. A., Grey L., Ellis C., Moran M. F., Pawson T. Binding of SH2 domains of phospholipase Cγ1, GAP, and Src to activated growth factor receptors. Science. 250:1990;979-982.
31. Rönnstrand L., Mori S., Arridsson A.-K., Eriksson A., Wernstedt C., Hellman U., Claesson-Welsh L., Heldin C.-H. Identification of two C-terminal autophosphorylation sites in the PDGF β-receptor: Involvement in the interaction with phospholipase C-γ EMBO J. 11:1992;3911-3919.
32. Valius M., Bazenet C., Kazlauskas A. Tyrosines 1021 and 1009 are phosphorylation sites in the carboxy terminus of the platelet-derived growth factor receptor β subunit and are required for binding of phospholipase Cγ and a 64-Kilodalton protein, respectively. Mol. Cell. Biol. 13:1993;133-143.
33. Larose L., Gish G., Shoelson S., Pawson T. Identification of residues in the β platelet-derived growth factor receptor that confer specificity for binding to phospholipase C-γ1. Oncogene. 8:1993;2493-2499.
34. 2+ flux but not mitogenesis. Nature. 358:1992;678-681.
35. Mohammadi M., Dionne C. A., Li W., Li N., Spivak T., Honegger A. M., Jaye M., Schlessinger J. Point mutation in FGF receptor eliminates phosphatidylinositol hydrolysis without affecting mitogenesis. Nature. 358:1992;681-684.
36. Obermeier A., Halfter H., Wiesmüller K.-H., Jung G., Schlessinger J., Ullrich A. Tyrosine 785 is a major determinant of Trk-substrate interaction. EMBO J. 12:1993;933-941.
37. Middlemas D. S., Meisenhelder J., Hunter T. Identification of TrkB autophosphorylation sites and evidence that phospholipase C-γ1 is a substrate of the TrkB receptor. J. Biol. Chem. 269:1994;5458-5466.
38. Soler C., Beguinot L., Carpenter G. Individual epidermal growth actor receptor autophosphorylation sites do not stringently define association motifs for several SH2-containing proteins. J. Biol. Chem. 269:1994;12320-12324.
39. Rotin D., Margolis B., Mohammadi M., Daly R. J., Daum G., Li N., Fischer E. H., Burgess W. H., Ullrich A., Schlessinger J. SH2 domains prevent tyrosine dephosphorylation of the EGF receptor: Identification of Tyr992 as the high-affinity binding site for SH2 domains of phospholipase Cγ EMBO J. 11:1992;559-567.
40. Chattopadhyay A., Vecchi M., Ji Q.-S., Mernaugh R., Carpenter G. The role of individual SH2 domains in mediating association of phospholipase C-γ1 with the activated EGF receptor. J. Biol. Chem. 274:1999;26091-26097.
41. Ji Q.-s., Chattopadhyay A., Vecchi M., Carpenter G. Physiological requirement for both SH2 domains for phospholipase C-γ1 function and interaction with platelet-derived growth factor receptors. Mol. Cell. Biol. 19:1999;4961-4970.
42. Todderud G., Wahl M. I., Rhee S. G., Carpenter G. Stimulation of phospholipase C-γ1 membrane association by epidermal growth factor. Science. 249:1990;296-298.
43. Kumjian D. A., Barnstein A., Rhee S. G., Daniel T. O. Phospholipase Cγ complexes with ligand-activated platelet-derived growth factor receptors. An intermediate implicated in phospholipase activation. J. Biol. Chem. 266:1991;3973-3980.
44. Vega Q. C., Cochet C., Filhol O., Chang C.-P., Rhee S. G., Gill G. N. A site of tyrosine phosphorylation in the C terminus of the epidermal growth factor receptor is required to activated phospholipase C. Mol. Cell. Biol. 12:1992;128-135.
45. Koblan K. S., Schaber M. D., Edwards G., Gibbs J. B., Pompliano D. L. src-homology 2 (SH2) domain ligation as an allosteric regulator: Modulation of phosphoinositide-specific phospholipase Cγ1 structure and activity. Biochem. J. 305:1995;745-751.
46. Barford D., Neel B. G. Revealing mechanisms for SH2 domain mediated regulation of the protein tyrosine phosphatase SHP-2. Structure. 6:1998;249-254.
47. Falasca M., Logan S. K., Lehto V. P., Baccante G., Lemmon M. A., Schlessinger J. Activation of phospholipase Cγ by PI 3-kinase-induced PH domain-mediated membrane targeting. EMBO J. 17:1998;414-422.
48. Kavran J. M., Klein D. E., Lee A., Falasea M., Isakoff S. J., Skolnik E. Y., Lemmon M. A. Specificity and promiscuity in phosphoinositide binding by pleckstrin homology domains. J. Biol. Chem. 273:1998;30497-30508.
49. 3 interacts with SH2 domains and modulates PI 3-kinase association with tyrosine-phosphorylated proteins. Cell. 83:1995;821-830.
50. Bae Y. S., Cantley L. G., Chen C.-S., Kim S.-R., Kwon K.-S., Rhee S. G. Activation of phospholipase C-γ by phosphatidylinositol 3,4,5-trisphosphate. J. Biol. Chem. 273:1998;4465-4469.
51. Rameh L. E., Rhee S. G., Spokes K., Kazlauskas A., Cantley L. C., Cantley L. G. Phosphoinositide 3-kinase regulates phospholipase Cγ-mediated calcium signaling. J. Biol. Chem. 273:1998;23750-23757.
52. Sekiya F., Bae Y. S., Rhee S. G. Regulation of phospholipase C isozymes: Activation of phospholipase Cγ in the absence of tyrosine-phosphorylation. Chem. Phys. Lipids. 98:1999;3-11.
53. Duckworth B. C., Cantley L. C. Conditional inhibition of the mitogen-activated protein kinase cascade by Wortmannin: Dependence on signal strength. J. Biol. Chem. 272:1997;27665-27670.
54. Wennström S., Downward J. Role of phosphoinositide 3-kinase in activation of Ras and mitogen-activated protein kinase by epidermal growth factor. Mol. Cell. Biol. 19:1999;4279-4288.
55. Roche S., McGlade J., Jones M., Gish G. D., Pawson T., Courtneidge S. A. Requirement of phospholipase Cγ, the tyrosine phosphatase Syp and the adaptor proteins Shc and Nck for PDGF-induced DNA synthesis: evidence for Ras-independent pathways. EMBO J. 15:1996;4940-4948.
56. Wang Z., Glück S., Zhang L., Moran M. F. Requirement for phospholipase C-γ1 enzymatic activity in growth factor-induced mitogenesis. Mol. Cell. Biol. 18:1998;590-597.
57. Valius M., Kazlauskas A. Phospholipase C-γ1 and phosphatidylinositol 3 kinase are the downstream mediators of the PDGF receptor's mitogenic signal. Cell. 73:1993;321-334.
58. Montmayeur J.-P, Valius M., Vandenheede J., Kazlauskas A. The platelet-derived growth factor β receptor triggers multiple cytoplasmic signaling cascades that arrive at the nucleus as distinguishable inputs. J. Biol. Chem. 272:1997;32670-32678.
59. Borrello M. G., Alberti L., Arighi E., Bongarzone I., Battistini C., Bardelli A., Pasini B., Piutti C., Rizzetti M. G., Mondellini P., Radice T., Pierotti M. A. The full oncogenic activity of Ret/ptc2 depends on tyrosine 539, a docking site for phospholipase Cγ Mol. Cell. Biol. 16:1996;2151-2163.
60. DeMali K. A., Whiteford C. C., Ulug E. T., Kazlauskas A. Platelet-derived growth factor-dependent cellular transformation requires either phospholipase Cγ or phosphatidylinositol 3 kinase. J. Biol. Chem. 272:1997;9011-9018.
61. Chang J.-S., Noh D. Y., Park I. A., Kim M. J., Song H., Ryu S. H., Suh P.-G. Overexpression of phospholipase C-γ1 in rat 3Y1 fibroblast cells leads to malignant transformation. Cancer Res. 57:1997;5465-5468.
62. Smith M. R., Court D. W., Kim H.-k., Park J. B., Rhee S. G., Rhim J. S., Kung H.-f. Overexpression of phosphoinositide-specific phospholipase Cγ in NIH 3T3 cells promotes transformation and tumorigenicity. Carcinogenesis. 19:1998;177-185.
63. Yu J.-C., Li W., Wang L. M., Uren A., Pierce J. H., Heidaran M. A. Differential requirement of a motif within the carboxyl-terminal domain of α-platelet-derived growth factor (αPDGF) receptor for PDGF focus forming activity, chemotaxis, or growth factor. J. Biol. Chem. 270:1995;7033-7036.
64. Khoshyomn S., Penar P. L., Rossi J., Wells A., Abramson D. L., Bhushan A. Inhibition of phospholipase C-γ1 activation blocks glioma cell motility and invasion of fetal rat brain aggregates. Neurosurgery. 44:1999;568-578.
65. Rönnstrand L., Siegbahn A., Rorsman C., Johnell M., Hansen K., Heldin C.-H. Overactivation of phospholipase C-γ1 renders platelet-derived growth factor β-receptor-expressing cells independent of the phosphatidylinositol 3-kinase pathway for chemotaxis. J. Biol. Chem. 274:1999;22089-22094.
66. Kundra V., Escobedo J. A., Kazlauskas A., Kim H. K., Rhee S. G., Williams L. T., Zetter B. R. Regulation of chemotaxis by the platelet-derived growth factor receptor-β Nature. 367:1994;474-476.
67. Ming G.-l., Song H.-j., Berninger B., Inagaki N., Tessier-Lavigne M., Poo M.-m. Phospholipase C-γ and phosphoinositide 3-kinase mediate cytoplasmic signaling in nerve growth cone guidance. Neuron. 23:1999;139-148.
68. Derman M. P., Chen J. Y., Spokes K. C., Songyang Z., Cantley L. G. An 11-amino acid sequence from c-met initiates epithelial chemotaxis via phosphatidylinositol 3-kinase and phospholipase C. J. Biol. Chem. 271:1996;4251-4255.
69. Wells A., Gupta K., Chang P., Swindle S., Glading A., Shiraha H. Epidermal growth factor receptor-mediated motility in fibroblasts. Microsc. Res. Technol. 43:1998;395-411.
70. Clyman R. I., Peters K. G., Chen Y. Q., Escobedo J., Williams L. T., Ives H. E., Wilson E. Phospholipase Cγ activation, phosphatidylinositol hydrolysis, and calcium mobilization are not required for FGF receptor-mediated chemotaxis. Cell Adhes. Commun. 1:1994;333-342.
71. Landgren E., Klint P., Yokote K., Claesson-Welsh L. Fibroblast growth factor receptor-1 mediates chemotaxis independently of direct SH2-domain protein binding. Oncogene. 17:1998;283-291.
72. Yokote K., Mori S., Siegbahn A., Rönnstrand L., Wernstedt C., Heldin C.-H., Claesson-Welsh L. Structural determinants in the platelet-derived growth factor α-receptor implicated in modulation of chemotaxis. J. Biol. Chem. 271:1996;5101-5111.
73. Williams E. Y., Farness J., Walsh Y. S., Doherty P. Characterisation of the second messenger pathway underlying neurite outgrowth stimulated by FGF. Development. 120:1994;1685-1693.
74. Stephens R. M., Loeb D. M., Copeland T. D., Pawson T., Greene L. A., Kaplan D. R. Trk receptors use redundant signal transduction pathways involving SHC and PLC-γ1 to mediate NGF responses. Neuron. 12:1994;691-705.
75. Obermeier A., Bradshaw R. A., Seedorf K., Choidas A., Schlessinger J., Ulrich A. Neuronal differentiation signals are controlled by nerve growth factor receptor/Trk binding sites for SHC and PLC-γ EMBO J. 13:1994;1585-1590.
76. Hall H., Williams E. Y., Moore S. E., Walsh Y. S., Prochiantz A., Doherty P. Inhibition of FGF-stimulated phosphatidylinositol hydrolysis and neurite outgrowth by a cell-membrane permeable phosphopeptide. Curr. Biol. 6:1996;580-587.
77. Saffrell J. L., Williams E. Y., Mason I. J., Walsh Y. S., Doherty P. Expression of a dominant negative FGF receptor inhibits axonal growth and FGF receptor phosphorylation stimulated by CAMs. Neuron. 18:1997;231-242.
78. Bae S. K., Lee Y. H., Chang J.-S., Galadari S. H., Kim Y. S., Ryu S. H., SH P.-G. Src homology domains of phospholipase C γ1 inhibit nerve growth factor-induced differentiation of PC12 cells. J. Cell. Neurochem. 71:1998;178-185.
79. Rao A., Luo C., Hogan P. G. Transcription factors of the NFAT family: Regulation and function. Annu. Rev. Immunol. 15:1997;707-747.
80. van Leeuwen J. E. M., Samelson L. E. T cell antigen-receptor signal transduction. Curr. Opin. Immunol. 11:1999;242-248.
81. Williams B. L, Irvin B. J., Sutor S. L., Chini C. C. S., Yacyshyn E., Wardenburg J. B., Dalton M., Chan A. C., Abraham R. T. Phosphorylation of Tyr319 in ZAP-70 is required for T-cell antigen receptor-dependent phospholipase C-γ1 and Ras activation. EMBO J. 18:1999;1832-1844.
82. Liu K. B., Bunnell S. C., Gurniak C. G., Berg L. J. T cell receptor-initiated calcium release is uncoupled from capacitative calcium entry in itk-deficient T cells. J. Exp. Med. 187:1998;1721-1727.
83. Schaeffer E. M., Debnath J., Yap G., McVicar D., Liao X. C., Littman D. R., Sher A., Varmus H. E., Lenardo M. J., Schwartzberg P. L. Requirement for Tec kinases Rlk and Itk in T cell receptor signaling and immunity. Science. 284:1999;638-641.
84. Rudd C. E. Adaptors and molecular scaffolds in immune cell signaling. Cell. 96:1999;5-8.
85. Clement J. L., Boerth N. J., Lee J. R., Koretzky G. A. Integration of T cell receptor-dependent signaling pathways by adapter proteins. Annu. Rev. Immunol. 17:1999;89-108.
86. Zhang W., Sloan-Lancaster J., Kitchen J., Trible R. P., Samelson L. E. LAT: The ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation. Cell. 92:1998;83-92.
87. Finco T. S., Kadlecek T., Zhang W., Samelson L. E., Weiss A. LAT is required for TCR-mediated activation of PLCγ1 and the Ras pathway. Immunity. 9:1998;617-626.
88. Zhang W., Irvin B. J., Trible R. P., Abraham R. T., Samelson L. E. Functional analysis of LAT in TCR-mediated signaling pathways using a LAT-deficient Jurkat cell line. Int. Immunol. 11:1999;943-950.
89. Zhang W., Trible R. P., Samelson L. E. LAT palmitoylation: Its essential role in membrane microdomain targeting and tyrosine phosphorylation during T cell activation. Immunity. 9:1998;239-246.
90. Brdicǩa T., Černy J., Hořejší V. T cell receptor signalling results in rapid tyrosine phosphorylation of the linker protein LAT present in detergent-resistant membrane microdomains. Biochem. Biophys. Res. Commun. 248:1998;356-360.
91. Xavier R., Seed B. Membrane compartmentation and the response to antigen. Curr. Opin. Immunol. 11:1999;265-269.
92. Xavier R., Brennan T., Li Q., McCormack C., Seed B. Membrane compartmentation is required for efficient T cell activation. Immunity. 8:1998;723-732.
93. Stauffer T. P., Meyer T. Compartmentalized IgE receptor-mediated signal transduction in living cells. J. Cell. Biol. 139:1997;1447-1454.
94. Hope H. R., Pike L. J. Phosphoinositides and phosphoinositide-utilizing enzymes in detergent-insoluble lipid domains. Mol. Biol. Cell. 7:1996;843-851.
95. Pike L., Casey L. Localization and turnover of phosphatidylinositol 4,5-bisphosphate in caveolin-enriched membrane domains. J. Biol. Chem. 271:1996;26453-26456.
96. Jackman J. K., Motto D. G., Sun Q., Tanemoto M., Turck C. W., Peltz G. A., Koretzky G. A., Findell P. R. Molecular cloning of SLP-76, a 76-kDa tyrosine phosphoprotein associated with Grb2 in T cells. J. Biol. Chem. 270:1995;7029-7032.
97. Wardenburg J. B., Fu C., Jackman J. K., Flotow H., Wilkinson S. E., Williams D. H., Johnson R., Kong G., Chan A. C., Findell P. R. Phosphorylation of SLP-76 by the ZAP-70 protein-tyrosine kinase is required for T-cell receptor function. J. Biol. Chem. 271:1996;19641-19644.
98. Yablonski D., Kuhne M. R., Kadlecek T., Weiss A. Uncoupling of nonreceptor tyrosine kinases from PLC-γ1 in a SLP-76-deficient T cell. Science. 281:1998;413-415.
99. Kurosaki T. Molecular mechanisms in B cell antigen receptor signaling. Curr. Opin. Immunol. 9:1997;309-318.
100. Tamir I., Cambier J. C. Antigen receptor signaling: integration of protein tyrosine kinase functions. Oncogene. 17:1998;1353-1364.
101. Campbell K. S. Signal transduction from the B cell antigen-receptor. Curr. Opin. Immunol. 11:1999;256-264.
102. 2+ mobilization through distinct pathways. EMBO J. 13:1994;1341-1349.
103. Kurosaki T., Johnson Sara A., Pao L., Sada K., Yamamura H., Cambier J. C. Role of the Syk autophosphorylation site and SH2 domains in B cell antigen receptor signaling. J. Exp. Med. 182:1995;1815-1823.
104. Law C.-L., Chandran K. A., Sidorenko S. P., Clark E. A. Phospholipase C-γ1 interact with conserved phosphotyrosyl residues in the linker region of Syk and is a substrate for Syk. Mol. Cell. Biol. 16:1996;1305-1315.
105. Takata M., Kurosaki T. A role for Bruton's tyrosine kinase in B cell antigen receptor-mediated activation of phospholipase C-γ2. J. Exp. Med. 184:1996;31-40.
106. 2+ following B-cell receptor activation. EMBO J. 17:1998;1973-1985.
107. 3)/Tec kinase-dependent calcium signaling pathway: a target for SHIP-mediated inhibitory signals. EMBO J. 17:1998;1961-1972.
108. Scharenberg A. M., Kinet J.-P. PtdIns-3-4-5-P3: A regulatory nexus between tyrosine kinases and sustained calcium signals. Cell. 94:1998;5-8.
109. Barker S. A., Caldwell K. K., Pfeiffer J. R., Wilson B. S. Wortmannin-sensitive phosphorylation, translocation, and activation of PLCγ1, but not PLCγ2, in antigen-stimulated RBL-2H3 mast cells. Mol. Biol. Cell. 9:1998;483-496.
110. 2+ mobilization in antigen-stimulated mast cells. J. Leukocyte Biol. 65:1999;321-329.
111. Gratacap M.-P., Payrastre B., Viala C., Mauco G., Plantavid M., Chap H. Phosphatidylinositol 3,4,5-trisphosphate-dependent stimulation of phospholipase C-γ2 is an early key event in FcγRIIA-mediated activation of human platelets. J. Biol. Chem. 273:1998;24314-24321.
112. Fu C., Chan A. C. Identification of two tyrosine phosphoproteins, pp70 and pp68, which interact with phospholipase Cγ, Grb2, and Vav after B cell antigen receptor activation. J. Biol. Chem. 272:1997;27362-27368.
113. Fu C., Turck C. W., Kurosaki T., Chan A. C. BLNK: A central linker protein in B cell activation. Immunity. 9:1998;93-103.
114. Ishial M., Kurosaki M., Pappu R., Okawa K., Ronko I., Fu C., Shibata M., Iwamatau A., Chan A. C., Kurosaki T. BLNK required for coupling Syk to PLCγ2 and Rac1-JNK in B cells. Immunity. 10:1999;117-125.
115. Ishiai M., Sugawara H., Kurosaki M., Kurosaki T. Cutting edge: Association of phospholipase C-γ2 Src homology 2 domains with BLNK is critical for B cell antigen receptor signaling. J. Immunol. 163:1999;1746-1749.
116. 2+ spiking. Biochem J. 316:1996;583-591.
117. De Nadai C., Cailliau K., Epel D., Ciapa B. Detection of phospholipase Cγ in sea urchin eggs. Dev. Growth Differ. 40:1998;669-676.
118. Shilling F. M., Carroll D. J., Muslin A. J., Escobedo J. A., Williams L. T., Jaffe L. A. Evidence for both tyrosine kinase and G-protein-coupled pathways leading to starfish egg activation. Dev. Biol. 162:1994;590-599.
119. Sette C., Bevilacqua A., Geremia R., Rossi P. Involvement of phospholipase Cγ1 in mouse egg activation induced by a truncated form of the c-kit tyrosine kinase present in spermatozoa. J. Cell Biol. 142:1998;1063-1074.
120. Carroll D. J., Ramarao C. S., Mehlmann L. M., Roche S., Terasaki M., Jaffe L. A. Calcium release at fertilization in starfish eggs is mediated by phospholipase Cγ J. Cell Biol. 138:1997;1303-1311.
121. Carroll D. J., Albay D. T., Terasaki M., Jaffe L. A., Foltz K. R. Identification of PLCγ-dependent and -independent events during fertilization of sea urchin eggs. Dev. Biol. 206:1999;232-247.
122. Shearer J., De Nadai C., Emily-Fenouil F., Gache C., Whitaker M., Ciapa B. Role of phospholipase Cγ at fertilization and during mitosis in sea urchin eggs and embryos. Development. 126:1999;2273-2284.
123. Giusti A. F., Carroll D. J., Abassi Y. A., Foltz K. R. Evidence that a starfish egg Src family tyrosine kinase activates with PLC-γ1 SH2 domains at fertilization. Dev. Biol. 208:1999;189-199.