LAT is required for tyrosine phosphorylation of phospholipase Cγ2 and platelet activation by the receptor GPVI

Molecular and Cellular Biology

Volumn 19, Issue 12, 1999, Pages 8326-8334

  Pasquet, Jean Max ^a   Gross, Barbara ^a   Quek, Lynn ^a   Asazuma, Naoki ^a   Zhang, Weiguo ^b   Sommers, Connie L ^c   Schweighoffer, Edina ^d   Tybulewicz, Victor ^d   Judd, Barbara ^e   Lee, Jong Ran ^e   Koretzky, Gary ^e   Love, Paul E ^c   Samelson, Lawrence E ^b   Watson, Steve P ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

^c EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

^d NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

^e UNIVERSITY OF IOWA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

C REACTIVE PROTEIN; COLLAGEN; GLYCOPROTEIN; INTEGRIN; PADGEM PROTEIN; PHOSPHATIDIC ACID; PHOSPHOLIPASE C; PLECKSTRIN; RECEPTOR; THROMBIN;

ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME REGULATION; HUMAN; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN CROSS LINKING; PROTEIN INTERACTION; PROTEIN PHOSPHORYLATION; PROTEIN SECRETION; THROMBOCYTE ACTIVATION;

EID: 0033500154     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/mcb.19.12.8326     Document Type: Article

References (44)

1. Achison, M., C. Joel, P. G. Hargreaves, S. O. Sage, M. J. Barnes, and R. W. Farndale. 1996. Signals elicited from human platelets by synthetic, triple helical, collagen-like peptides. Blood Coagul. Fibrinolysis 7:149-152.
2. Asazuma, N., and S. P. Watson. Unpublished data.
3. 1. Blood 89:1235-1242.
4. August, A., A. Sadra, B. Dupont, and H. Hanafusa. 1997. Src-induced activation of inducible T cell kinase (ITK) requires phosphatidylinositol 3-kinase activity and the pleckstrin homology domain of inducible T cell kinase. Proc. Natl. Acad. Sci. USA 94:11227-11232.
5. Bauer, M., M. Retzer, J. I. Wilde, P. Maschberger, M. Essler, M. Aepfelbacher, S. Watson, and W. Siess. Dichotomous regulation of myosin phosphorylation and shape change by Rho-kinase and calcium in intact platelets. Blood, in press.
6. Blake, R. A., J. Asselin, T. Walker, and S. Watson. 1994. Fcγ receptor II stimulated formation of inositol phosphates in human platelets is blocked by tyrosine kinase inhibitors and associated with tyrosine phosphorylation of the receptor. FEBS Lett. 342:15-18.
7. Blake, R. A., G. L. Schieven, and S. P. Watson. 1994. Collagen stimulates tyrosine phosphorylation of phospholipase C-γ2 but not phospholipase C-γ1 in human platelets. FEBS Lett. 353:212-216.
8. Brass, L. F., J. A. Hoxie, T. Kieber-Emmons, D. Manning, M. Poncz, and M. Woolkalis. 1993. Agonist receptors and G proteins as mediators of platelet activation. Adv. Exp. Med. Biol. 344:17-37.
9. lyn in signalling via the collagen receptor in human platelets. Biochem. J. 337:203-209.
10. Bruyns, E., A. Marie-Cardine, H. Kirchgessner, K. Sagolla, A. Shevchenko, M. Mann, F. Autschbach, A. Bensussan, S. Mener, and B. Schraven. 1998. T cell receptor (TCR) interacting molecule (TRIM), a novel disulfide-linked dimer associated with the TCR-CD3-ζ complex, recruits intracellular signaling proteins to the plasma membrane. J. Exp. Med. 188:561-575.
11. Cantrell, D. 1998. The real LAT steps forward. Trends Cell Biol 8:180-182.
12. Cardine, A.-M., H. Kirchgessner, E. Bruyns, A. Shevchenko, M. Mann, F. Autschbach, S. Ratnofsky, S. Meuer, and B. Schraven. 1999. SHP2-interacting transmembrane adapor protein (SIT), a novel disulfide-linked dimer regulating human T cell activation. J. Exp. Med. 189:1181-1194.
13. Clements, J. L., J. R. Lee, B. Gross, B. Yang, J. D. Olson, A. Sandra, S. P. Watson, S. R. Lentz, and G. A. Koretzky. 1999. Fetal hemorrhage and platelet dysfunction in SLP-76-deficient mice. J. Clin. Investig. 103:19-25.
14. Ezumi, Y., K. Shindoh, M. Tsuji, and H. Takayama. 1998. Physical and functional association of the Src family kinases Fyn and Lyn with the collagen receptor glycoprotein VI-Fc receptor γ chain complex on human platelets. J. Exp. Med. 188:267-276.
15. Falasca, M., S. K. Logan, V. P. Lehto, G. Baccante, M. A. Lemmon, and J. Schlessinger. 1998. Activation of phospholipase Cγ by PI 3-kinase-induced PH domain-mediated membrane targeting. EMBO J. 17:414-422.
16. Finco, T. S., T. Kadlecek, W. Zhang, L. E. Samelson, and A. Weiss. 1998. LAT is required for TCR-mediated activation of PLCγ1 and the Ras pathway. Immunity 9:617-626.
17. Gibbins, J., J. Asselin, R. Farndale, M. Barnes, C.-L. Law, and S. P. Watson. 1996. Tyrosine phosphorylation of the Fc receptor γ-chain in collagen-stimulated platelets. J. Biol. Chem. 271:18095-18099.
18. Gibbins, J. M., S. Briddon, A. Shutes, M. J. van Vugt, J. G. J. van de Winkel, T. Saito, and S. P. Watson. 1998. The p85 subunit of phosphatidylinositol 3-kinase associates with the Fc receptor γ-chain and LAT in platelets stimulated by collagen and convulxin. J. Biol. Chem. 273:34437-34443.
19. Gratacap, M.-P., B. Payrastre, C. Viala, G. Mauco, M. Plantavid, and H. phospholipase C-γ2 is an early key event in FcγRIIA-mediated activation of human platelets. J. Biol. Chem. 273:24314-24321.
20. Gross, B., J. R. Lee, J. L. Clements, M. Turner, V. L. J. Tybulewicz, P. R. Findell, G. A. Koretzky, and S. P. Watson. 1999. Tyrosine phosphorylation of SLP-76 is downstream of Syk following stimulation of the collagen receptor GPVI in platelets. J. Biol. Chem. 274:5963-5971.
21. Gross, B. S., S. K. Melford, and S. P. Watson. 1999. Evidence that PLC-γ2 interacts with SLP-76, Syk, Lat, Lyn and the FcR γ-chain following stimulation of the collagen receptor in human platelets. Eur. J. Biochem. 263: 1-13.
22. Kiefer, F., J. Brumell, N. Al-Alawi, S. Latour. A. Cheng, A. Veillette, S. Grinstein, and T. Pawson. 1998. The Syk protein tyrosine kinase is essential for Fcγ receptor signaling macrophages and neutrophils. Mol. Cell. Biol. 18: 4209-4220.
23. Kovacsovics, T. J., C. Bachelot, A. Toker, C. J. Vlahos, B. Duckworth, L. C. Cantley, and J. H. Hartwig. 1995. Phosphoinositide 3-kinase inhibition spares actin assembly in activating platelets but reverses platelet aggregation. J. Biol. Chem. 270:11358-11366.
24. Law, C.-L., K. A. Chandran, S. P. Sidorenko, and E. A. Clark. 1996. Phospholipase C-γ1 interacts with conserved phosphotyrosyl residues in the linker region of syk and is a substrate for syk. Mol. Cell. Biol. 16:1305-1315.
25. Lee, S. B., A. K. Rao, K. H. Lee, X. Yang, Y. S. Bae, and S. G. Rhee. 1996. Decreased expression of phospholipase C-β2 isozyme in human platelets with impaired function. Blood 88:1684-1691.
26. Morton, L. F., P. G. Hargreaves, R. W. Farndale, R. D. Young, and M. J. Barnes. 1995. Integral alpha 2 beta 1-independent activation of platelets by simple collagen-like peptides: collagen tertiary (triple-helical) and quaternary (polymeric) structures are sufficient alone for alpha 2 beta 1-independent platelet reactivity. Biochem. J. 306:337-344.
27. Motto, D. G., S. E. Ross, J. Wu, L. R. Hendricks-Taylor, and G. A. Koretsky. 1996. Implication of the GRB2-associated phosphoprotein SLP-76 in cell receptor-mediated interleukin 2 production. J. Exp. Med. 183:1937-1943.
28. Pasqnet, J.-M., R. Bobe, B. Gross, M.-P. Gratacap, M. Tomlinson, B. Payrastre, and S. P. Watson. 1999. A collagen related peptide regulates phospholipase Cγ2 via phosphatidylinositol 3-kinase in human platelets. Biochem. J. 342:171-177.
29. Poole, A., J. M. Gibbins, M. Turner, M. van Vugt, J. van de Winkel, T. Saito, V. L. J. Tybulewicz, and S. P. Watson. 1997. The Fc receptor γ-chain and the tyrosine kinase Syk are essential for activation of mouse platelets by collagen. EMBO J. 16:2333-2341.
30. Quek, L. S., J. Bolen, and S. P. Watson. 1998. Regulation of Bruton's tyrosine kinase and phospholipase Cγ2 in collagen-stimulated platelets. Curr. Biol. 8:1137-1140.
31. Rhee, S. G., and K. D. Choi. 1992. Regulation of inositol phospholipid-specific phospholipase C isozymes. J. Biol. Chem. 267:12393-12396.
32. Robinson, A., J. Gibbins, B. Rodriguez-Linares, P. Finan, L. Wilson, S. Kellie, P. Findall, and S. Watson. 1996. Characterisation of Grb2-binding proteins in human platelets activated by FcγRIIA cross-linking. Blood 88: 522-530.
33. Sarkar, S. 1998. Tyrosine phospholylation and translocation of LAT in platelets. FEBS Lett. 441:357-360.
34. Schaeffer, E. M., J. Debnath, G. Yap, D. McVicar, X. C. Liao, D. R. Littman. A. Sher, H. E. Varmus, M. J. Lenardo, and P. L. Schwartzberg. 1999 Requirement for Tec kinases Rlk and Itk in T cell receptor signaling and immunity. Science 284:638-641.
35. Scharenberg, A. M., O. El-Hillal, D. A. Fruman, L. O. Beitz, Z. Li, S. Lin, I. Gout, L. C. Cantley, D. J. Rawlings, and J.-P. Kinet. 1998. Phosphatidylinositol-3,4,5-trisphosphate (PtdIns-3,4,5-P3)/Tec kinase dependent calcium signaling pathway: a target for SHIP-mediated inhibitory signals. EMBO J. 17:1961-1972.
36. Siess, W. 1989. Molecular mechanism of platelet activation. Physiol. Rev. 69: 158-178.
37. Turner, M., P. J. Mee, P. S. Costello, O. Williams, A. A. Price, L. P. Duddy, M. T. Furlong, R. L. Geahlen, and V. L. J. Tybulewicz. 1995. Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk. Nature 378:298-302.
38. 2+ and protein kinase C is the major factor in determining the level of secretion from human platelets. Biochem. J. 289:277-282.
39. Watson, S. P., and J. Gibbins. 1998. Collagen receptor signalling in platelets: extending the role of the ITAM. Immunol. Today 19:260-265.
40. Yablonski, D., M. R. Kuhne, T. Kadlecek, and A. Weiss. 1998. Uncoupling of nonreceptor tyrosine kinases form PLC-γI in an SLP-76-deflcient T cell. Science 281:413-416.
41. Zhang, J., J. Zhang, S. J. Shattil, M. C. Cunningham, and S. E. Rittenhouse. 1996. Phosphonositide 3-kinase gamma and p85/phosphoinositide 3-kinase in platelets. Relative activation by thrombin receptor or beta-phorbol myristate acetate and roles in promoting the ligand-binding function of alphaII-beta3 integrin. J. Biol. Chem. 271:6265-6272.
42. Zhang, W., J. Sloan-Lancaster, J. Kitchen, R. P. Trible, and L. E. Samelson. 1998. LAT: the zap-70 tyrosine kinase substrate that links T cell receptor to cellular activation. Cell 92:83-92.
43. Zhang, W., C. L. Sommers, D. N. Burshtyn, C. C. Stebbins, J. B. DeJarnette, R. P. Trible, A. Grinberg, H. C. Tsay, H. M. Jacobs, C. M. Kessler, E. O. Long, P. E. Love, and L. E. Samelson. 1999. Essential role of LAT in T cell development. Immunity 10:323-332.
44. Zhang, W., R. P. Trible, and L. E. Samelson. 1998. LAT palmitoylation: its essential role in membrane microdomain targeting and tyrosine phosphorylation during T cell activation. Immunity 9:239-246.