Association of Nck with tyrosine-phosphorylated SLP-76 in activated T lymphocytes

European Journal of Immunology

Volumn 29, Issue 4, 1999, Pages 1068-1075

  Wunderlich, Livius ^a   Faragó, Anna ^a   Downward, Julian ^b   Buday, László ^a  

^a SEMMELWEIS UNIVERSITY OF MEDICINE   (Hungary)

^b IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

Author keywords

Cbl; Nck; SH2; SH3 domain; Slp 76; T lymphocyte

Indexed keywords

PHOSPHOPEPTIDE; PHOSPHOPROTEIN; POLYCLONAL ANTIBODY; TYROSINE;

ARTICLE; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; T LYMPHOCYTE;

EID: 0032910208     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/(sici)1521-4141(199904)29:04<1068::aid-immu1068>3.0.co;2-p     Document Type: Article

References (40)

1. Lehmann, J. M., Riethmüller, G. and Johnson, J. P., Nck, a melanoma cDNA encoding a cytoplasmic protein consisting of the src homology units SH2 and SH3. Nucleic Acids Res. 1990. 18: 1048.
2. Park, D. and Rhee, S. G., Phosphorylation of Nck in response to a variety of receptors, phorbol myristate acetate, and cyclic AMP. Mol. Cell. Biol. 1992. 12: 5816-5823.
3. Chou, M. M., Fajardo, J. E. and Hanafusa, H., The SH2- and SH3-containing Nek protein transforms mammalian fibroblasts in the absence of elevated phosphotyrosine levels. Mol. Cell. Biol. 1992. 12: 5834-5842.
4. Li, W., Hu, P., Skolnik, E. Y., Ullrich, A. and Schlessinger, J., The SH2 and SH3 domain-containing Nek protein is oncogenic and a common target for phosphorylation by different surface receptors. Mol. Cell. Biol. 1992. 12: 5824-5833.
5. Meisenhelder, J. and Hunter, T., The SH2/SH3 domain-containing protein Nck is recognized by certain anti-phospholipase C-gamma 1 monoclonal antibodies, and its phosphorylation on tyrosine is stimulated by platelet-derived growth factor and epidermal growth factor treatment. Mol. Cell. Biol. 1992. 12: 5843-5856.
6. Hu, Q., Milfay, D. and Williams, L. T., Binding of Nck to Sos and activation of ras-dependent gene expression. Mol. Cell. Biol. 1995. 15: 1169-1174.
7. Okada, S. and Pessin, J. E., Interactions between src homology (SH) 2/SH3 adapter proteins and the guanylnucleotide exchange factor Sos are differentially regulated by insulin and epidermal growth factor. J. Biol. Chem. 1996. 271: 25533-25538.
8. Rivero-Lezcano, O. M., Sameshima, J. H., Marcilla, A. and Robbins, K. C., Physical association between src homology 3 elements and the protein product of the c-cbl proto-oncogene. J. Biol. Chem. 1994. 269: 17363-17366.
9. Bokoch, G. M., Wang, Y., Bohl, B. P., Sells, M. A., Quilliam, L. A. and Knaus, U. G., Interaction of the Nck adapter protein with p21-activated kinase (PAK1). J. Biol. Chem. 1996. 271: 25746-25749.
10. Galisteo, M. L., Chernoff, J., Su, Y., Skolnik, E. Y. and Schlessinger, J., The adaptor protein Nck links receptor tyrosine kinases with the serine-threonine kinase PAK1. J. Biol. Chem. 1996. 271: 20997-21000.
11. Quilliam, L. A., Lambert, Q. T., Mickelson-Young, L. A., Westwick, J. K., Sparks, A. B., Kay, B. K., Jenkins, N. A., Gilbert, D. J., Copeland, N. G. and Der, C. J., Isolation of a Nck-associated kinase. PRK2, and SH3-binding protein and potential effector of Rho protein signaling. J. Biol. Chem. 1996. 271: 28772-28776.
12. Rivero-Lezcano, O. M., Marcilla, A., Sameshima, J. H. and Robbins, K. C., Wiskott-Aldrich syndrome protein physically associates with Nck through src homology 3 domains. Mol. Cell. Biol. 1995. 15: 5725-5731.
13. Chou, M. M. and Hanafusa, H., A novel ligand for SH3 domains. J. Biol. Chem. 1995. 270: 7359-7364.
14. Klausner, R. D. and Samelson, L. E., T cell antigen receptor activation pathways: the tyrosine kinase connection. Cell 1991. 64: 875-878.
15. Weiss, A., T cell antigen receptor signal transduction: A tale of tails and cytoplasmic protein-tyrosine kinases. Cell 1993. 73: 209-223.
16. Buday, L., Egan, S. E., Viciana, P. R., Cantrell, D. A. and Downward, J., A complex of Grb2 adaptor protein, Sos exchange factor, and a 36 kDa membrane-bound tyrosine phosphoprotein is implicated in Ras activation in T cells. J. Biol. Chem. 1994. 269: 9019-9023.
17. Sieh, M., Batzer, A., Schlessinger, J. and Weiss, A., Grb2 and phospholipase C-γ1 associate with a 36 to 38 kDa phosphotyrosine protein after T cell receptor stimulation. Mol. Cell. Biol. 1994. 14: 4435-4442.
18. Reif, K., Buday, L., Downward, J. and Cantrell, D. A., SH3 domains of the adapter molecule Grb2 complex with two proteins in T cells: the guanine nucleotide exchange protein Sos and a 75 kDa protein that is a substrate for the T antigen receptor-activated tyrosine kinases. J. Biol. Chem. 1994. 269: 14081-14087.
19. Motto, D. G., Ross, S. E., Jackman, J. N., Sun, Q., Olson, A. L., Findell, P. R. and Koretzky, G. A., In vivo association of Grb2 with p116, a substrate of the T cell antigen receptor activated protein tyrosine kinase. J. Biol. Chem. 1994. 269: 21608-21613.
20. Buday, L., Khwaja, A., Sipeki, S., Faragó, A. and Downward, J., Interaction of Cbl with two adaptor proteins, Grb2 and Crk, upon T cell activation. J. Biol. Chem. 1996. 271: 6159-6163.
21. Zhang, W., Sloan-Lancaster, J., Kitchen, J., Trible, R. P. and Samelson, L. S., LAT: The ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation. Cell 1998. 92: 83-92.
22. Weber, J. R., Orstavik, S., Torgersen, K. M., Danbolt, N. C., Berg, S. F., Ryan, J. C., Tasken, K., Imboden, J. B. and Vaage, J. T., Molecular cloning of the cDNA encoding pp36, a tyrosine-phosphorylated adaptor protein selectively expressed by T cells and natural killer cells. J. Exp. Med. 1998. 187: 1157-1161.
23. Ravichandran, K. S., Lee, K. K., Songyang, Z., Cantley, L. C., Burn, P. and Burakoff, S. J., Interaction of Shc with the ζ chain of the T cell receptor upon T cell activation. Science 1993. 262: 902-905.
24. Jackman, J. K., Motto, D. G., Sun, Q., Masayuki, T., Turck, C. W., Peltz, G. A., Koretzky, G. A. and Findell, P. R., Molecular cloning of SLP-76, a 76 kDa tyrosine phosphoprotein associated with Grb2 in T cells. J. Biol. Chem. 1995. 270: 7029-7032.
25. Wardenburg, J. B., Fu, C., Jackman, J. K., Flotow, H., Wilkinson, S. E., Williams, D. H., Johnson, R., Kong, G., Chan, A. C. and Findell, P. R., Phosphorylation of SLP-76 by the ZAP-70 protein-tyrosine kinase is required for T-cell receptor function. J. Biol. Chem. 1996. 271: 19641-19644.
26. Wu, J., Motto, D. G., Koretzky, G. A. and Weiss, A., Vav and SLP-76 interact and functionally cooperate in IL-2 gene activation. Immunity 1996. 4: 593-602.
27. vav associates with tyrosine-phosphorylated SLP-76 in antigen-stimulated T cells. J. Exp. Med. 1996. 184: 1161-1166.
28. Raab, M., da Silva, A. J., Findell, P. R. and Rudd, C. E., Regulation of Vav-SLP-76 binding by ZAP-70 and its relevance to TCRζ/CD3 induction of interleukin-2. Immunity 1997. 6: 155-164.
29. Motto, D. G., Ross, S. E., Wu, J., Hendricks-Taylor, L. R. and Koretzky, G. A., Implication of the Grb2-associated phosphoprotein SLP-76 in the T cell receptor-mediated interleukin-2 production. J. Exp. Med. 1996. 183: 1937-1943.
30. Donovan, J. A., Wange, R. L., Langdon, W. Y. and Samelson, L. E., The protein product of the c-cbl protooncogene is the 120 KDa tyrosine-phosphorylated protein in Jurkat cells activated via the T cell antigen receptor. J. Biol. Chem. 1994. 269: 22921-22924.
31. Fukazawa, T., Reedquist, K. A., Trub, T., Soltoff, S., Panchamoorthy, G., Druker, B., Cantley, L., Shoelson, S. E. and Band, H., The SH3 domain-binding T cell tyrosyl phosphoprotein p120. J. Biol. Chem. 1995. 270: 19141-19150.
32. Meisner, H., Conway, B. R., Hartley, D. and Czech, M. P., Interactions of Cbl with Grb2 and phosphatidylinositol 3′-kinase in activated Jurkat cells. Mol. Cell. Biol. 1995. 15: 3571-3578.
33. Fang, N., Motto, D. G., Ross, S. E. and Koretzky, G. A., Tyrosine 113, 128, and 145 of SLP-76 are required for optimal augmentation of NFAT promoter activity. J. Immunol. 1996. 157: 3769-3773.
34. Koretzky, G. A., The role of Grb2-associated proteins in T-cell activation. Immunol. Today 1997. 18: 401-408.
35. Boguski, M. S. and McCormick, F., Proteins regulating Ras and its relatives. Nature 1993. 366: 643-654.
36. Reif, K. and Cantrell, D. A., Networking Rho family GTPases in lymphocytes. Immunity 1998. 8: 395-401.
37. Yablonski, D., Kane, L. P., Qian, D. and Weiss, A., A Nck-Pak1 signaling module is required for T-cell receptor-mediated activation of NFAT, but not of JNK. EMBO J. 1998. 17: 5647-5657.
38. cbl with Grb2 in Jurkat cells. J. Biol. Chem. 1996. 271: 26369-26374.
39. Rellahan, B. L., Graham, L. J., Stoica, B., DeBell, K. E. and Bonvini, E., Cbl-mediated regulation of T cell receptor-induced AP1 activation. J. Biol. Chem. 1997. 272: 30806-30811.
40. Wunderlich, L., Gohér, A., Faragó, A., Downward, J. and Buday, L., Requirement of multiple SH3 domains of Nck for ligand binding. Cell. Signal. 1999, in press.