Linker for activation of T cells (LAT), a novel immunohistochemical marker for T cells, NK cells, mast cells, and megakaryocytes. Evaluation in normal and pathological conditions

American Journal of Pathology

Volumn 154, Issue 4, 1999, Pages 1037-1046

  Facchetti, Fabio ^a,b   Chan, John K C ^c   Zhang, Weiguo ^e   Tironi, Andrea ^a   Chilosi, Marco ^d   Parolini, Silvia ^a   Notarangelo, Luigi D ^b   Samelson, Lawrence E ^e  

^a Department of Pathology ^*  (Italy)

^b UNIVERSITY OF BRESCIA   (Italy)

^c QUEEN ELIZABETH HOSPITAL   (Hong Kong)

^d UNIVERSITY OF VERONA   (Italy)

^e NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD3 ANTIGEN; LINK PROTEIN; POLYCLONAL ANTIBODY; PROTEIN TYROSINE KINASE; T LYMPHOCYTE RECEPTOR;

ARTICLE; B LYMPHOCYTE; CONTROLLED STUDY; DIAGNOSTIC VALUE; ENZYME ACTIVATION; FLOW CYTOMETRY; HODGKIN DISEASE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LARGE CELL LYMPHOMA; LYMPHOCYTE DIFFERENTIATION; MAST CELL; MASTOCYTOSIS; MEGAKARYOCYTE; NATURAL KILLER CELL; PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; T CELL LYMPHOMA; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; THROMBOCYTE;

EID: 0032921873     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)65356-4     Document Type: Article

References (42)

1. Chan AC, Dalton M, Johnson R, Kong GH, Wang T, Thoma R, Kurosaki T: Activation of ZAP-70 kinase activity by phosphorylation of tyrosine 493 is required for lymphocyte antigen receptor function. EMBO J 1995, 14:2499-2508
2. Wange RL, Guitian R, Isakov N. Watts JD, Aebersold R, Samelson LE: Activating and inhibitory mutations in adjacent tyrosines in the kinase domain of ZAP-70. J Biol Chem 1995, 270:18730-18733
3. Pawson T: Protein modules and signaling networks. Nature 1995, 373:573-580
4. Zhang W, Sloan-Lancaster J, Kitchen J, Trible RP, Samelson LE: LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation. Cell 1998, 92:83-92
5. Finco TS, Kadlecek T, Zhang W, Samelson LE, Weiss A: LAT is required for TCR-mediated activation of PLCγ1 and the Ras pathway. Immunity 1998, 9:617-626
6. June CH, Fletcher MC, Ledbetter JA, Samelson LE: Increases in tyrosine phosphorylation are detectable before phospnolipase C activation after T cell receptor stimulation. J Immunol 1990, 144:1591-1599
7. Gilliland LK, Schieven GL, Norris NA, Kanner SB, Aruffo A, Ledbetter JA: Lymphocyte lineage-restricted tyrosine-phosphorylated proteins that bind PLCγ1 SH2 domains. J Biol Chem 1992, 267:13610-13616
8. Buday L, Egan SE, Rodriguez Viciana P, Cantrell DA, Downward J: A complex of Grb2 adaptor protein, Sos exchange factor, and a 36-kd membrane-bound tyrosine phosphoprotein is implicated in ras activation in T cells. J Biol Chem 1994, 269:9019-9023
9. Sieh M, Batzer A, Schlessinger J, Weiss A: GRB2 and phospholipase C-γ 1 associate with a 36- to 38-kilodalton phosphotyrosine protein after T-cell receptor stimulation. Mol Cell Biol 1998, 14:4435-4442
10. Fukazawa T, Reedquist KA, Panchamoorthy G, Soltoff S, Trub T, Druker B, Cantley L, Shoelson SE, Band H: T cell activation-dependent association between the p85 subunit of the phosphatidylinositol 3-kinase and Grb2/phospholipase C-γ 1-binding phosphotyrosyl protein pp36/38. J Biol Chem 1998, 270:20177-20182
11. Harris NL, Jaffe ES, Stein H, Banks PM, Chan JKC, Cleary ML, Delsol G, De Wolf Peeters C, Falini B, Gatter KC, Grogan TM, Isaacson PG, Knowles DM, Mason DY, Muller Hermelink H, K, Pileri SA, Piris MA, Ralfkiaer E, Warnke RA: A revised European-American classification of lymphoid neoplasms: a proposal from the International Lymphoma Study Group. Blood 1994, 84:1361-1392
12. Pulford K, Lamant L, Morris SW, Butler LH, Wood KM, Stroud D, Delsol G, Mason DY: Detection of anaplastic lymphoma kinase (ALK) and nucleolar protein nucleophosmin (NPM)-ALK proteins in normal and neoplastic cells with the monoclonal antibody ALK1. Blood 1997, 89:1394-1404
13. Moretta A, Tambussi G, Bottino C, Tripodi G, Merli A, Ciocone E, Pantaleo G, Moretta L: A novel surface antigen expressed by a subset of human CD3-CD16+ natural killer cells: role in cell activation and regulation of cytolytic function. J Exp Med 1990, 171:695-714
14. Deibel MR, Jr., Riley LK, Coleman MS, Cibull ML, Fuller SA, Todd E: Expression of terminal deoxynucleotidyl transferase in human thymus during ontogeny and development. J Immunol 1983, 131:195-200
15. Bodger MP, Janossy G, Bollum FJ, Burford GD, Hoffbrand AV: The ontogeny of terminal deoxynucleotidyl transferase positive cells in the human fetus. Blood 1983, 61:1125-1131
16. Vroom TM, Scholte G, Ossendorp F, Borst J: Tissue distribution of human γ delta T cells: no evidence for general epithelial tropism. J Clin Pathol 1991, 44:1012-1017
17. Russell GJ, Winter HS, Fox VL, Bhan AK: Lymphocytes bearing the γ delta T-cell receptor in normal human intestine and celiac disease. Hum Pathol 1991, 22:690-694
18. Anderson P, Caligiuri M, Ritz J, Schlossman SF: CD3-negative natural killer cells express zeta TCR as part of a novel molecular complex. Nature 1989, 341:159-162
19. Ting AT, Dick CJ, Schoon RA, Karnitz LM, Abraham RT, Leibson PJ: Interaction between lck and syk family tyrosine kinases in Fc γ receptor-initiated activation of natural killer cells. J Biol Chem 1995, 270:16415-16421
20. Viver E, da Silva AJ, Ackerly M, Levine H, Rudd CE, Anderson P: Association of a 70-kd tyrosine phosphoprotein with the CD16ζγ complex expressed in human natural killer cells. Eur J Immunol 1993, 23:1872-1876
21. Nel AE, Gupta S, Lee L, Ledbetter JA, Kanner SB: Ligation of the T-cell antigen receptor (TCR) induces association of hSos1, ZAP-70, phospholipase C-γ 1, and other phosphoproteins with GRb2 and the ζ-chain of the TCR. J Biol Chem 1995, 270:18428-18436
22. Jin YJ, Friedman J, Burakoff SJ: Regulation of tyrosine phosphorylation in isolated T cell membrane by inhibition of protein tyrosine phosphatases. J Immunol 1998, 161:1743-1750
23. Beaven MA, Baumgartner RA: Downstream signals initiated in mast cells by Fc∈ RI and other receptors. Curr Opin Immunol 1996, 8:766-772
24. Yablonski D, Kuhne MR, Kadlecek T, Weiss A: Uncoupling of nonreceptor tyrosine kinases from PLCγ1 in an SLP-76-deficient T cell. Science 1998, 281:413-416
25. Zhang W, Trible RP, Samelson LE: LAT palmitoylation: its essential role in membrane microdomain targeting and tyrosine phosphorylation during T cell activation. Immunity 1998, 9:239-246
26. Pivniouk V, Tsitsikiv E, Swinton P, Rathbun G, Alt FW, Geha RS: Impaired viability and profound block in thymocyte development in mice lacking the adapter protein SLP-76. Cell 1998, 94:229-238
27. Turner M, Mee PJ, Costello PS, Williams O, Price AA, Duddy LP, Furlong MT, Geahlen RL, Tybulewicz VL: Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk. Nature 1995, 378:298-302
28. Cheng AM, Rowley B, Pao W, Mayday A, Bolen JB, Pawson T: Syk tyrosine kinase required for mouse viability and B-cell development. Nature 1995, 378:303-306
29. Wood KM, Pallesen G, Ralfkiaer E, Warnke R, Gatter KC, Mason DY: Heterogeneity of CD3 antigen expression in T-cell lymphoma. Histopathology 1993, 22:311-317
30. Cabecadas JM, Isaacson PG: Phenotyping of T-cell lymphomas in paraffin sections-which antibodies? Histopathology 1991, 19:419-424
31. Davey FR, Elghetany MT, Kurec AS: Immunophenotyping of hematologic neoplasms in paraffin-embedded tissue sections. Am J Clin Pathol 1990, 93:317-26
32. Linder J, Ye YL, Harrington DS, Armitage JO, Weisenburger DD: Monoclonal antibodies marking T lymphocytes in paraffin-embedded tissue. Am J Pathol 1987, 127:1-8
33. Chadburn A, Knowles DM: Paraffin-resistant antigens detectable by antibodies L26 and polyclonal CD3 predict the B- or T-cell lineage of 95% of diffuse aggressive non-Hodgkin's lymphomas. Am J Clin Pathol 1994, 102:284-291
34. Pilozzi E, Pulford K, Jones M: Coexpression of CD79a (JCB117) and CD3 by lymphoblastic lymphoma. J Pathol 1998, 186:140-143
35. Picker LJ, Brenner MB, Weiss LM, Smith SD, Warnke RA: Discordant expression of CD3 and T-cell receptor β-chain antigens in T-lineage lymphomas. Am J Pathol 1987, 129:434-440
36. Picker LJ, Weiss LM, Medeiros LJ, Wood GS, Warnke RA: Immunophenotypic criteria for the diagnosis of non-Hodgkin's lymphoma. Am J Pathol 1987, 128:181-201
37. Weiss LM, Crabtree GS, Rouse RV, Warnke RA: Morphologic and immunologic characterization of 50 peripheral T-cell lymphomas. Am J Pathol 1985, 118:316-324
38. Benharroch D, Meguerian-Bedoyan Z, Lamant L, Amin C, Brugieres L, Terrier-Lacombe MJ, Haralambieva E, Pulford K, Pileri S, Morris SW, Mason DY, Delsol G: ALK-positive lymphoma: a single disease with a broad spectrum of morphology. Blood 1998, 91:2076-2084
39. Beljaards RC, Kaudewitz P, Berti E, Gianotti R, Neumann C, Rosso R, Paulli M, Meijer CJ, Willemze R: Primary cutaneous CD30-positive large cell lymphoma: definition of a new type of cutaneous lymphoma with a favorable prognosis. A European Multicenter Study of 47 patients. Cancer 1993, 71:2097-2104
40. Shiota M, Nakamura S, Ichinohasama R, Abe M, Akagi T, Takeshita M, Mori N, Fujimoto J, Miyauchi J, Mikata A, Nanba K, Takami T, Yamabe H, Takano Y, Izumo T, Nagatani T, Mohri N, Nasu K, Satoh H, Katano H, Yamamoto T, Mori S: Anaplastic large cell lymphomas expressing the novel chimeric protein p80NPM/ALK: a distinct clinicopathologic entity. Blood 1995, 86:1954-1960
41. Bitter MA, Franklin WA, Larson RA, McKeithan TW, Rubin CM, Le Beau MM, Stephens JK, Vardiman JW: Morphology in KM(CD30)-positive non-Hodgkin's lymphoma is correlated with clinical features and the presence of a unique chromosomal abnormality, t(2;5)(p23; q35). Am J Surg Pathol 1990, 14:305-316
42. Mason DY, Krissansen GW, Davey FR, Crumpton MJ, Gatter KC: Antisera against epitopes resistant to denaturation on T3 (CD3) antigen can detect reactive and neoplastic T cells in paraffin embedded tissue biopsy specimens. J Clin Pathol 1988, 41:121-127