Telomeres, telomerase, and cancer: Life on the edge of genomic stability

Current Opinion in Oncology

Volumn 12, Issue 1, 2000, Pages 74-81

  Oulton, Rena ^a   Harrington, Lea ^a  

^a UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

RNA DIRECTED DNA POLYMERASE; TELOMERASE;

CANCER; CANCER THERAPY; CELL IMMORTALIZATION; CELL PROLIFERATION; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME INHIBITION; GENETIC STABILITY; HUMAN; IN VITRO STUDY; MALIGNANT TRANSFORMATION; MAMMAL CELL; MOLECULAR CLONING; NONHUMAN; PRIORITY JOURNAL; REVIEW; TELOMERE;

ANIMALS; APOPTOSIS; CELL SURVIVAL; CELL TRANSFORMATION, NEOPLASTIC; DNA DAMAGE; HUMANS; MICE; NEOPLASMS; TELOMERASE; TELOMERE;

EID: 0034521108     PISSN: 10408746     EISSN: None     Source Type: Journal    
DOI: 10.1097/00001622-200001000-00013     Document Type: Review

References (78)

1. Telomere length regulation
2. A highly conserved repetitive DNA sequence, (TTAGGG)n, present at the telomeres of human chromosomes
3. Human telomeres contain at least three types of G-rich repeat distributed non-randomly
4. The terminal DNA structure of mammalian chromosomes
5. Normal human chromosomes have long G-rich telomeric overhangs at one end
6. Mammalian telomeres end in a large duplex loop
7. Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2
8. A human telomeric protein
9. Control of telomere length by the human telomeric protein TRF1
10. TRF2 protects human telomeres from end-to-end fusions
11. Principle of marginotomy in template synthesis of polynucleotides
12. A theory of marginotomy. The incomplete copying of template margin in enzymic synthesis of polynucleotides and biological significance of the phenomenon
13. Origin of concatemeric T7 DNA
14. Identification of a specific telomere terminal transferase activity in Tetrahymena extracts
15. Specific association of human telomerase activity with immortal cells and cancer
16. A survey of telomerase activity in human cancer
17. Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity
18. Telomere dynamics and instability in human cancer
19. Telomerase activity in human ovarian carcinoma
20. Immortalized cells with no detectable telomerase activity. A review
21. Telomere elongation in immortal human cells without detectable telomerase activity
22. An alternative pathway for yeast telomere maintenance rescues est1-senescence
23. Telomerase and cancer: Revisiting the telomere hypothesis
24. The telomerase reverse transcriptase: Components and regulation
25. The RNA component of human telomerase
26. Human telomerase contains evolutionarily conserved catalytic and structural subunits
27. Telomerase catalytic subunit homologs from fission yeast and human
28. Telomerase activation by hTRT in human normal fibroblasts and hepatocellular carcinomas
29. Isolation of a candidate human telomerase catalytic subunit gene, which reveals complex splicing patterns in different cell types
30. hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization
31. Reconstitution of human telomerase activity in vitro
32. Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRT
33. Constitutive and regulated expression of telomerase reverse transcriptase (hTERT) in human lymphocytes
34. The limited in vitro lifetime of human diploid cell strains
35. Reversible cellular senescence: Implications for immortalization of normal human diploid fibroblasts
36. The frequency of immortalization of human fibroblasts and mammary epithelial cells transfected with SV40 large T-antigen
37. Telomeres and aging
38. Telomere loss: Mitotic clock or genetic time bomb?
39. Extension of life-span by introduction of telomerase into normal human cells
40. Reconstitution of telomerase activity in normal human cells leads to elongation of telomeres and extended replicative life span
41. Telomerase extends the lifespan of virus-transformed human cells without net telomere lengthening
42. Human endothelial cell life extension by telomerase expression
43. Telomerase expression in human somatic cells does not induce changes associated with a transformed phenotype
44. Absence of cancer-associated changes in human fibroblasts immortalized with telomerase
45. Analysis of genomic integrity and p53-dependent G1 checkpoint in telomerase-induced extended-life-span human fibroblasts
46. Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells
47. Dissociation among in vitro telomerase activity, telomere maintenance, and cellular immortalization
48. Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes
49. Creation of human tumour cells with defined genetic elements
50. Quantitative studies of the growth of mouse embryo cells in culture and their development into established lines
51. Telomere shortening and tumor formation by mouse cells lacking telomerase RNA
52. Essential role of mouse telomerase in highly proliferative organs
53. Disease states associated with telomerase deficiency appear earlier in mice with short telomeres
54. Longevity, stress response, and cancer in aging telomerase-deficient mice
55. Telomere shortening in mTR-/- embryos is associated with failure to close the neural tube
56. Telomere length dynamics and chromosomal instability in cells derived from telomerase null mice
57. The INK4a/ARF tumor suppressor: One gene-two products-two pathways
58. Short dysfunctional telomeres impair tumorigenesis in the INK4a(delta2/3) cancer-prone mouse
59. p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis
60. p53, the cellular gatekeeper for growth and division
61. From telomere loss to p53 induction and activation of a DNA-damage pathway at senescence: The telomere loss/DNA damage model of cell aging
62. Does telomere shortening drive selection for p53 mutation in human cancer?
63. The effects of nucleoside analogs on telomerase and telomeres in Tetrahymena
64. Inhibition of telomerase by G-quartet DNA structures
65. Human telomerase inhibition by 7-deaza-2′-deoxypurine nucleoside triphosphates
66. Identification of determinants for inhibitor binding within the RNA active site of human telomerase using PNA scanning
67. Cellular delivery of peptide nucleic acids and inhibition of human telomerase
68. Targeted therapy of human malignant glioma in a mouse model by 2-5A antisense directed against telomerase RNA
69. Antisense telomerase treatment: Induction of two distinct pathways, apoptosis and differentiation
70. Inhibition of human telomerase activity by peptide nucleic acids
71. Inhibition of human telomerase by 2′-O-methyl-RNA
72. Inhibition of human telomerase by a G-quadruplex-interactive compound
73. Telomere shortening and apoptosis in telomerase-inhibited human tumor cells
74. Inhibition of telomerase limits the growth of human cancer cells
75. p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2
76. Rebuilding the road to cancer
77. Telomeres: Has cancer's Achilles' heel been exposed?
78. Myc activates telomerase