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Volumn 910, Issue , 2000, Pages 207-222

Inhibition of CDKs as a therapeutic modality

Author keywords

[No Author keywords available]

Indexed keywords

6 N,N DIMETHYLADENINE; 7 HYDROXYSTAUROSPORINE; 9 NITROPAULLONE; ALSTERPAULLONE; ANTINEOPLASTIC AGENT; CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE INHIBITOR; FLAVOPIRIDOL; LACTONE DERIVATIVE; NSC 705701; OLOMOUCINE; PAULLONE DERIVATIVE; PURINE DERIVATIVE; PURVALANOL; ROSCOVITINE; STAUROSPORINE DERIVATIVE; UNCLASSIFIED DRUG;

EID: 0033913696     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2000.tb06710.x     Document Type: Conference Paper
Times cited : (94)

References (63)
  • 1
    • 0029000579 scopus 로고
    • Cyclins and cyclin dependent kinase: A biochemical view
    • 1. PINES, J. 1995. Cyclins and cyclin dependent kinase: a biochemical view. Biochem. J. 308: 697-711.
    • (1995) Biochem. J. , vol.308 , pp. 697-711
    • Pines, J.1
  • 2
    • 0031466305 scopus 로고    scopus 로고
    • Cyclin dependent kinases: Engines, clocks and microprocessors
    • 2. MORGAN, D.O. 1997. Cyclin dependent kinases: engines, clocks and microprocessors. Ann. Rev. Cell Dev. Biol. 13: 261-291.
    • (1997) Ann. Rev. Cell Dev. Biol. , vol.13 , pp. 261-291
    • Morgan, D.O.1
  • 3
    • 0029849620 scopus 로고    scopus 로고
    • Cancer cell cycles
    • 3. SHERR, C.J. 1996. Cancer cell cycles. Science 274: 1672-1677.
    • (1996) Science , vol.274 , pp. 1672-1677
    • Sherr, C.J.1
  • 4
    • 0024390591 scopus 로고
    • Reversible tyrosine phosphorylation of cdc2: Dephosphorylation accompanies activation during entry into mitosis
    • 4. MARLA, A.O., G. DRAETTA, D. BEACH et al. 1989. Reversible tyrosine phosphorylation of cdc2: dephosphorylation accompanies activation during entry into mitosis. Cell 58: 193-203.
    • (1989) Cell , vol.58 , pp. 193-203
    • Marla, A.O.1    Draetta, G.2    Beach, D.3
  • 5
    • 0026027660 scopus 로고
    • Differential phosphorylation of vertebrate p34cdc2 kinase of the G2/S and G2/M transitions of the cell cycle: Identification of major phosphorylation sites
    • 5. KREK, W. & E.A. NIGG. 1991. Differential phosphorylation of vertebrate p34cdc2 kinase of the G2/S and G2/M transitions of the cell cycle: identification of major phosphorylation sites. EMBO J. 10: 305-316.
    • (1991) EMBO J. , vol.10 , pp. 305-316
    • Krek, W.1    Nigg, E.A.2
  • 6
    • 0027359827 scopus 로고
    • WAF1, a potential mediator of p53 tumor suppression
    • 6. EL-DËIRY, W.S., T. TOKINO, V. VELCULESCU et al. 1993. WAF1, a potential mediator of p53 tumor suppression. Cell 75: 817-825.
    • (1993) Cell , vol.75 , pp. 817-825
    • El-Dëiry, W.S.1    Tokino, T.2    Velculescu, V.3
  • 7
    • 0027496935 scopus 로고
    • The p21 CDK-interacting protein cip1 is a potent inhibitor of G1 cyclin-dependent kinases
    • 7. HARPER, J.W., G.R. ADAMI, N. WEI et al. 1993. The p21 CDK-interacting protein cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell 75: 805-816.
    • (1993) Cell , vol.75 , pp. 805-816
    • Harper, J.W.1    Adami, G.R.2    Wei, N.3
  • 8
    • 0028363519 scopus 로고
    • p27, A novel inhibitor of G1 cyclin-cdk protein kinase activity, is related to p21
    • 8. TOYOSHIMA, H. & T. HUNTER. 1994. p27, a novel inhibitor of G1 cyclin-cdk protein kinase activity, is related to p21. Cell 78: 67-74.
    • (1994) Cell , vol.78 , pp. 67-74
    • Toyoshima, H.1    Hunter, T.2
  • 9
    • 0030044817 scopus 로고    scopus 로고
    • CDK inhibitors in development and cancer
    • 9. HARPER, J. & S. ELLEDGE. 1996. CDK inhibitors in development and cancer. Curr. Opin. Genet. Dev. 6: 56-65.
    • (1996) Curr. Opin. Genet. Dev. , vol.6 , pp. 56-65
    • Harper, J.1    Elledge, S.2
  • 10
    • 0032548918 scopus 로고    scopus 로고
    • A novel CDK9-associated C-type cyclin interacts directly with HIV tat and mediates its high-affinity loop-specific binding to TAR RNA
    • 10. WEI, P., M. GARBER & S.M. FANG. 1998. A novel CDK9-associated C-type cyclin interacts directly with HIV tat and mediates its high-affinity loop-specific binding to TAR RNA. Cell 92: 451-462.
    • (1998) Cell , vol.92 , pp. 451-462
    • Wei, P.1    Garber, M.2    Fang, S.M.3
  • 11
    • 0029921317 scopus 로고    scopus 로고
    • Genetic alterations of cyclins, cyclin dependent kinases, and cdk inhibitors in human cancer
    • 11. HALL, M. & G. PETERS. 1996. Genetic alterations of cyclins, cyclin dependent kinases, and cdk inhibitors in human cancer. Adv. Cancer Res. 68: 67-108.
    • (1996) Adv. Cancer Res. , vol.68 , pp. 67-108
    • Hall, M.1    Peters, G.2
  • 12
    • 0031048236 scopus 로고    scopus 로고
    • Increased proteosome-dependent degradation of the cyclin dependent kinase inhibitor p27 in aggressive colorectal carcinomas
    • 12. LODA, M., B. CUKOR, S.W. TAM et al. 1997. Increased proteosome-dependent degradation of the cyclin dependent kinase inhibitor p27 in aggressive colorectal carcinomas. Nature Med. 3: 231-234.
    • (1997) Nature Med. , vol.3 , pp. 231-234
    • Loda, M.1    Cukor, B.2    Tam, S.W.3
  • 14
    • 0028294605 scopus 로고
    • CIP1 is induced in p53-mediated G1 arrest apoptosis
    • 14. EL-DËIRY, W.S., J.W. HARPER, P.M. O'CONNOR et al. 1994. CIP1 is induced in p53-mediated G1 arrest apoptosis. Cancer Res. 54: 1169-1174.
    • (1994) Cancer Res. , vol.54 , pp. 1169-1174
    • El-Dëiry, W.S.1    Harper, J.W.2    O'Connor, P.M.3
  • 15
    • 0030665150 scopus 로고    scopus 로고
    • The role of the cdc2 feedback control loop control in the DNA damage checkpoint in mammalian cells
    • 15. POON, R.Y.C., M.S. CHAW, K. YAMASHITA et al. 1997. The role of the cdc2 feedback control loop control in the DNA damage checkpoint in mammalian cells. Cancer Res. 57: 5168-5178.
    • (1997) Cancer Res. , vol.57 , pp. 5168-5178
    • Poon, R.Y.C.1    Chaw, M.S.2    Yamashita, K.3
  • 16
    • 0030612166 scopus 로고    scopus 로고
    • Mammalian G1 and G2 phase checkpoints
    • 16. O'CONNOR, P.M. 1997. Mammalian G1 and G2 phase checkpoints. Cancer Surv. 29: 151-182.
    • (1997) Cancer Surv. , vol.29 , pp. 151-182
    • O'Connor, P.M.1
  • 17
    • 0029417882 scopus 로고
    • Chemical inhibitors of cyclin-dependent kinases
    • L. Meijer, S. Guidet & H.Y. LimTung, Eds. Plenum Press. New York
    • 17. MEIJER, L. 1995. Chemical inhibitors of cyclin-dependent kinases. In Progress in Cell Cycle Research, Vol. 1. L. Meijer, S. Guidet & H.Y. LimTung, Eds.: 351-363. Plenum Press. New York.
    • (1995) Progress in Cell Cycle Research , vol.1 , pp. 351-363
    • Meijer, L.1
  • 18
    • 0028076240 scopus 로고
    • Increased expression of cyclin B1 mRNA coincides with diminished G2 arrest in irradiated HeLa cells treated with staurosporine or caffeine
    • 18. BERNHARD, E.J., A. MAITY, R.J. MUSCHEL et al. 1994. Increased expression of cyclin B1 mRNA coincides with diminished G2 arrest in irradiated HeLa cells treated with staurosporine or caffeine. Radiation Res. 140: 393-400.
    • (1994) Radiation Res. , vol.140 , pp. 393-400
    • Bernhard, E.J.1    Maity, A.2    Muschel, R.J.3
  • 19
    • 0028901034 scopus 로고
    • Disruption of p53 function sensitizes breast cancer MCF-7 cells to cisplatin and pentoxifylline
    • 19. FAN, S., M.L. SMITH, D.J. RIVET II et al. 1995. Disruption of p53 function sensitizes breast cancer MCF-7 cells to cisplatin and pentoxifylline. Cancer Res. 55: 1649-1654.
    • (1995) Cancer Res. , vol.55 , pp. 1649-1654
    • Fan, S.1    Smith, M.L.2    Rivet D.J. II3
  • 20
    • 0025854476 scopus 로고
    • Morphometric and colorimelric analyses of human tumor cell line growth and drug sensitivity in soft agar culture
    • 20. ALLEY, M.C., C.M. PACULA-COX, M. HURSEY et al. 1991. Morphometric and colorimelric analyses of human tumor cell line growth and drug sensitivity in soft agar culture. Cancer Res. 51: 1247-1252.
    • (1991) Cancer Res. , vol.51 , pp. 1247-1252
    • Alley, M.C.1    Pacula-Cox, C.M.2    Hursey, M.3
  • 21
    • 0008538380 scopus 로고
    • Utility of a PVDF filter plate assay to facilitate selection of tumor cell liver for in vivo drug testing
    • 21. ALLEY, M.C., C.M. PACULA-COX, M.G. HOLLINGSHEAD et al. 1995. Utility of a PVDF filter plate assay to facilitate selection of tumor cell liver for in vivo drug testing. Proc. Am. Assoc. Cancer Res. 36: 305.
    • (1995) Proc. Am. Assoc. Cancer Res. , vol.36 , pp. 305
    • Alley, M.C.1    Pacula-Cox, C.M.2    Hollingshead, M.G.3
  • 22
    • 0029807115 scopus 로고    scopus 로고
    • Flavopiridol (L86-8297, NSC 649890), a new kinase inhibitor for tumor therapy
    • 22. SEDLACEK, H.H., J. CZECH, R. NAIK et al. 1996. Flavopiridol (L86-8297, NSC 649890), a new kinase inhibitor for tumor therapy. Int. J. Oncol. 9: 1143-1168.
    • (1996) Int. J. Oncol. , vol.9 , pp. 1143-1168
    • Sedlacek, H.H.1    Czech, J.2    Naik, R.3
  • 23
    • 0026452974 scopus 로고
    • Growth inhibition with reversible cell cycle arrest of carcinoma cells by flavone L86-8275
    • 23. KAUR, G., M. STETLER-STEVENSON, S. SEBERS et al. 1992. Growth inhibition with reversible cell cycle arrest of carcinoma cells by flavone L86-8275. J. Natl. Cancer Inst. 84: 1736-1740.
    • (1992) J. Natl. Cancer Inst. , vol.84 , pp. 1736-1740
    • Kaur, G.1    Stetler-Stevenson, M.2    Sebers, S.3
  • 24
    • 0028176485 scopus 로고
    • Potent inhibition of cdc2 kinase activity by the flavonoid L86-8275
    • 24. LOSIEWICZ, M.D., B.A. CARLSON, G. KAUR et al. 1994. Potent inhibition of cdc2 kinase activity by the flavonoid L86-8275. Biochem. Biophys. Res. Commun. 201: 589-595.
    • (1994) Biochem. Biophys. Res. Commun. , vol.201 , pp. 589-595
    • Losiewicz, M.D.1    Carlson, B.A.2    Kaur, G.3
  • 26
    • 0029665778 scopus 로고    scopus 로고
    • Flavopiridol induces G1 arrest with inhibition of cyclin-dependent kinase (CDK)2 and (CDK)4 in human breast carcinoma cells
    • 26. CARLSON, B.A., M.M. DUBAY, E.A. SAUSVILLE et al. 1996. Flavopiridol induces G1 arrest with inhibition of cyclin-dependent kinase (CDK)2 and (CDK)4 in human breast carcinoma cells. Cancer Res. 56: 2973-2978.
    • (1996) Cancer Res. , vol.56 , pp. 2973-2978
    • Carlson, B.A.1    Dubay, M.M.2    Sausville, E.A.3
  • 27
    • 0027433237 scopus 로고
    • Alteration of the phosphorylation state of p34 cdc2 kinase by the flavone L86-8275 in breast carcinoma cells
    • 27. WORLAND, P.H., G. KAUER, M. STETLER-STEVENSON et al. 1993. Alteration of the phosphorylation state of p34 cdc2 kinase by the flavone L86-8275 in breast carcinoma cells. Biochem. Pharmacol. 46: 1831-1840.
    • (1993) Biochem. Pharmacol. , vol.46 , pp. 1831-1840
    • Worland, P.H.1    Kauer, G.2    Stetler-Stevenson, M.3
  • 28
    • 0033568521 scopus 로고    scopus 로고
    • Downregulation of cyclin D1 by transcriptional repression in MCF-7 human breast carcinoma cells induced by flavopiridol
    • 28. CARLSON, B., T. LAHUSEN, S. SINGH et al. 1999. Downregulation of cyclin D1 by transcriptional repression in MCF-7 human breast carcinoma cells induced by flavopiridol. Cancer Res. 59: 4634-4641.
    • (1999) Cancer Res. , vol.59 , pp. 4634-4641
    • Carlson, B.1    Lahusen, T.2    Singh, S.3
  • 29
    • 0031963058 scopus 로고    scopus 로고
    • Early induction of apoptosis in hematopoietic cell lines after exposure to flavopiridol
    • 29. PARKER, B.G., G. KAUR, W. NIEVES-NEIRA et al. 1998. Early induction of apoptosis in hematopoietic cell lines after exposure to flavopiridol. Blood 91: 458-465.
    • (1998) Blood , vol.91 , pp. 458-465
    • Parker, B.G.1    Kaur, G.2    Nieves-Neira, W.3
  • 30
    • 0040932434 scopus 로고    scopus 로고
    • The novel cyclin-dependent kinase inhibitor flavopiridol downregulates bc12 and induces growth arrest and apoptosis in chronic B-cell leukemia lines
    • 30. KONIG, A., G.K. SCHWARTZ, R.M. MOHAMMAD et al. 1997. The novel cyclin-dependent kinase inhibitor flavopiridol downregulates bc12 and induces growth arrest and apoptosis in chronic B-cell leukemia lines. Blood 90: 4307-4312.
    • (1997) Blood , vol.90 , pp. 4307-4312
    • Konig, A.1    Schwartz, G.K.2    Mohammad, R.M.3
  • 31
    • 0032533599 scopus 로고    scopus 로고
    • Flavopiridol induces apoptosis in chronic lymphocytic leukemia cells via activation of caspase 3 without evidence of bcl2 modulation or dependence on functional p53
    • 31. BYRD, J.C., C. SHINN, J.K. WASELENKO et al. 1998. Flavopiridol induces apoptosis in chronic lymphocytic leukemia cells via activation of caspase 3 without evidence of bcl2 modulation or dependence on functional p53. Blood 92: 3804-3816.
    • (1998) Blood , vol.92 , pp. 3804-3816
    • Byrd, J.C.1    Shinn, C.2    Waselenko, J.K.3
  • 32
    • 0029904810 scopus 로고    scopus 로고
    • Flavopiridol: A cytotoxic flavone that induces cell death in non-cycling A549 lung carcinoma cells
    • 32. BIBLE, K.C. & S.M. KAUFMANN. 1996. Flavopiridol: a cytotoxic flavone that induces cell death in non-cycling A549 lung carcinoma cells. Cancer Res. 56: 4856-4861.
    • (1996) Cancer Res. , vol.56 , pp. 4856-4861
    • Bible, K.C.1    Kaufmann, S.M.2
  • 33
    • 0031019034 scopus 로고    scopus 로고
    • Flavopiridol (L86-8275): Selective antitumor activity in vitro and activity in vivo for prostate carcinoma cells
    • 33. DREES, M., W.A. DENGLER, T. ROTH et al. 1997. Flavopiridol (L86-8275): selective antitumor activity in vitro and activity in vivo for prostate carcinoma cells. Clin. Cancer Res. 3: 273-279.
    • (1997) Clin. Cancer Res. , vol.3 , pp. 273-279
    • Drees, M.1    Dengler, W.A.2    Roth, T.3
  • 34
    • 0032212885 scopus 로고    scopus 로고
    • Flavopiridol, a novel cyclin-dependent kinase inhibitor, suppresses the growth of head and neck squamous cell carcinomas by inducing apoptosis
    • 34. PATEL, V., A.M. SENDEROWICZ, P. DECIO et al. 1998. Flavopiridol, a novel cyclin-dependent kinase inhibitor, suppresses the growth of head and neck squamous cell carcinomas by inducing apoptosis. J. Clin. Invest. 102: 1674-1681.
    • (1998) J. Clin. Invest. , vol.102 , pp. 1674-1681
    • Patel, V.1    Senderowicz, A.M.2    Decio, P.3
  • 35
    • 0032055497 scopus 로고    scopus 로고
    • Flavopiridol induces apoptosis of normal lymphoid cells, causes immunosuppression, and has potent antitumor activity in vivo against human leukemia and lymphoma xenografts
    • 35. ARGUELLO, F., M. ALEXANDER, J. STERRY et al. 1998. Flavopiridol induces apoptosis of normal lymphoid cells, causes immunosuppression, and has potent antitumor activity in vivo against human leukemia and lymphoma xenografts. Blood 91: 2482-2490.
    • (1998) Blood , vol.91 , pp. 2482-2490
    • Arguello, F.1    Alexander, M.2    Sterry, J.3
  • 36
    • 0033231301 scopus 로고    scopus 로고
    • Flavopiridol, a protein kinase inhibitor, down-regulates hypoxic induction of vascular endothelial growth factor (VEGF) expression in human monocytes
    • 36. MELILLO, G., E.A. SAUSVILLE, K. CLOUD et al. 1999. Flavopiridol, a protein kinase inhibitor, down-regulates hypoxic induction of vascular endothelial growth factor (VEGF) expression in human monocytes. Cancer Res. 1: 5433-5437.
    • (1999) Cancer Res. , vol.1 , pp. 5433-5437
    • Melillo, G.1    Sausville, E.A.2    Cloud, K.3
  • 37
    • 0031670668 scopus 로고    scopus 로고
    • Phase i trial of continuous infusion flavopiridol, a novel cyclin-dependent kinase inhibitor in patients with refractory neoplasms
    • 37. SENDEROWICZ, A.M., D. HEADLEE, S.F. STINSON et al. 1998. Phase I trial of continuous infusion flavopiridol, a novel cyclin-dependent kinase inhibitor in patients with refractory neoplasms. J. Clin. Oncol. 16: 2986-2999.
    • (1998) J. Clin. Oncol. , vol.16 , pp. 2986-2999
    • Senderowicz, A.M.1    Headlee, D.2    Stinson, S.F.3
  • 38
    • 0032503010 scopus 로고    scopus 로고
    • Metabolism of the anticancer drug flavopiridol, a new inhibitor of cyclin-dependent kinases, in rat liver
    • 38. JAGER, W., B. ZEMBSCH, P. WAFSCHANN et al. 1998. Metabolism of the anticancer drug flavopiridol, a new inhibitor of cyclin-dependent kinases, in rat liver. Life Sci. 62: 1861-1873.
    • (1998) Life Sci. , vol.62 , pp. 1861-1873
    • Jager, W.1    Zembsch, B.2    Wafschann, P.3
  • 39
    • 0001114216 scopus 로고    scopus 로고
    • Phase I clinical and pharmacokinetic trial of flavopiridol
    • 39. THOMAS, J., J. CLEARY, K. TUTSCH et al. 1997. Phase I clinical and pharmacokinetic trial of flavopiridol. Proc. Am. Assoc. Cancer Res. 38: 222.
    • (1997) Proc. Am. Assoc. Cancer Res. , vol.38 , pp. 222
    • Thomas, J.1    Cleary, J.2    Tutsch, K.3
  • 40
    • 0026723057 scopus 로고
    • Multiple kinase arrest points in the G1 phase of non-transmitted mammalian cells are absent in transformed cells
    • 40. GADBOIS, D.M., H.A. CRISSMAN, R.A. TOBEY et al. 1992. Multiple kinase arrest points in the G1 phase of non-transmitted mammalian cells are absent in transformed cells. Proc. Natl. Acad. Sci. USA: 8620-8630.
    • (1992) Proc. Natl. Acad. Sci. USA , pp. 8620-8630
    • Gadbois, D.M.1    Crissman, H.A.2    Tobey, R.A.3
  • 41
    • 0028990479 scopus 로고
    • Apoptosis in 7-hydroxy staurosporine-treated T lymphoblasts correlates with activation of cyclin dependent kinases 1 and 2
    • 41. WANG, Q., P.J. WORLAND, J.L. CLARK et al. 1995. Apoptosis in 7-hydroxy staurosporine-treated T lymphoblasts correlates with activation of cyclin dependent kinases 1 and 2. Cell Growth Differ. 6: 927-936.
    • (1995) Cell Growth Differ. , vol.6 , pp. 927-936
    • Wang, Q.1    Worland, P.J.2    Clark, J.L.3
  • 42
    • 0030615323 scopus 로고    scopus 로고
    • G1 phase accumulation induced by UCN-01 is associated with dephosphorylation of Rb and CDK2 proteins as well as induction of CDK inhibitor p21/Cip1/WAF1/sdi1 in p53 mutated human epidermoid carcinoma A431 cells
    • 42. AKIUYAMA T., T. YOSHIDA, T. TSUJITA et al. 1997. G1 phase accumulation induced by UCN-01 is associated with dephosphorylation of Rb and CDK2 proteins as well as induction of CDK inhibitor p21/Cip1/WAF1/sdi1 in p53 mutated human epidermoid carcinoma A431 cells. Cancer Res. 57: 1495-1501.
    • (1997) Cancer Res. , vol.57 , pp. 1495-1501
    • Akiuyama, T.1    Yoshida, T.2    Tsujita, T.3
  • 43
    • 0027157590 scopus 로고
    • Cell cycle arrest and growth inhibition by the protein kinase antagonist UCN-01 in human breast carcinoma cells
    • 43. SEYNAEVE, C., M. STETLER-STEVENSON, S. SEBERS et al. 1993. Cell cycle arrest and growth inhibition by the protein kinase antagonist UCN-01 in human breast carcinoma cells. Cancer Res. 53: 2087-2091.
    • (1993) Cancer Res. , vol.53 , pp. 2087-2091
    • Seynaeve, C.1    Stetler-Stevenson, M.2    Sebers, S.3
  • 44
    • 0029895439 scopus 로고    scopus 로고
    • UCN-01: A potent abrogator of G2 checkpoint function in cancer cells with disrupted p53
    • 44. WANG, O., S. FAN, A. EASTMAN et al. 1996. UCN-01: a potent abrogator of G2 checkpoint function in cancer cells with disrupted p53. J. Natl. Cancer Inst. 88: 956-965.
    • (1996) J. Natl. Cancer Inst. , vol.88 , pp. 956-965
    • Wang, O.1    Fan, S.2    Eastman, A.3
  • 45
    • 0029992520 scopus 로고    scopus 로고
    • Enhancement of cisplatin-induced cytotoxicity by 7-hydroxy staurosporine (UCN-01) a new G2 checkpoint inhibitor
    • 45. BUNCH, R.T. & A. EASTMAN. 1996. Enhancement of cisplatin-induced cytotoxicity by 7-hydroxy staurosporine (UCN-01) a new G2 checkpoint inhibitor. Clin. Cancer Res. 2: 791-797.
    • (1996) Clin. Cancer Res. , vol.2 , pp. 791-797
    • Bunch, R.T.1    Eastman, A.2
  • 46
    • 0032509403 scopus 로고    scopus 로고
    • UCN-01 abrogates G2 arrest through a cdc2-dependent pathway that is associated with in activation of the Wee1Hu kinase and activation of the cdc25c phosphatase
    • 46. YU, L., L. ORLANDI, P. WANG et al. 1998. UCN-01 abrogates G2 arrest through a cdc2-dependent pathway that is associated with in activation of the Wee1Hu kinase and activation of the cdc25c phosphatase. J. Biol. Chem. 273: 33455-33464.
    • (1998) J. Biol. Chem. , vol.273 , pp. 33455-33464
    • Yu, L.1    Orlandi, L.2    Wang, P.3
  • 47
    • 0000398216 scopus 로고    scopus 로고
    • The checkpoint kinase Chk1 is a target for the anticancer drug, UCN-01
    • 47. YU, L., P. GRAVES, Z. TEMPCYZK et al. 1999. The checkpoint kinase Chk1 is a target for the anticancer drug, UCN-01. Proc. Am. Assoc. Cancer Res. 40: 304.
    • (1999) Proc. Am. Assoc. Cancer Res. , vol.40 , pp. 304
    • Yu, L.1    Graves, P.2    Tempcyzk, Z.3
  • 48
    • 0031672099 scopus 로고    scopus 로고
    • Clinical pharmacology of UCN-01: Initial observations and comparison to preclinical models
    • 48. SAUSVILLE, E.A., R.D. LUSH, D. HEADLEE et al. 1998. Clinical pharmacology of UCN-01: initial observations and comparison to preclinical models. Cancer Chemother. Pharmacol. 42(Suppl.): S54-S59.
    • (1998) Cancer Chemother. Pharmacol. , vol.42 , Issue.SUPPL.
    • Sausville, E.A.1    Lush, R.D.2    Headlee, D.3
  • 49
    • 0032145499 scopus 로고    scopus 로고
    • Unpredicted clinical pharmacology of UCN-01 caused by specific binding to human α1-acid glycoprotein
    • 49. FUSE, E., H. TANII, N. KURATA et al. 1998. Unpredicted clinical pharmacology of UCN-01 caused by specific binding to human α1-acid glycoprotein. Cancer Res. 58: 3248-3253.
    • (1998) Cancer Res. , vol.58 , pp. 3248-3253
    • Fuse, E.1    Tanii, H.2    Kurata, N.3
  • 50
    • 0012090767 scopus 로고    scopus 로고
    • Phase I trial of infusional UCN-01, a novel protein kinase inhibitor, in patients with refractory neoplasms
    • Atlanta, GA, May 15-18
    • 50. SENDEROWICZ, A.M., D. HEADLEE, R. LUSH et al. Phase I trial of infusional UCN-01, a novel protein kinase inhibitor, in patients with refractory neoplasms. Presented at the American Society of Clinical Oncology, Atlanta, GA, May 15-18, 1999.
    • (1999) American Society of Clinical Oncology
    • Senderowicz, A.M.1    Headlee, D.2    Lush, R.3
  • 51
    • 0028093182 scopus 로고
    • Inhibition of cyclin-dependent kinases by purine analogs
    • 51. VESELY, J., L. HAVLICEK, M. STRAD et al. 1994. Inhibition of cyclin-dependent kinases by purine analogs. Eur. J. Biochem. 224: 771-786.
    • (1994) Eur. J. Biochem. , vol.224 , pp. 771-786
    • Vesely, J.1    Havlicek, L.2    Strad, M.3
  • 52
    • 0031037714 scopus 로고    scopus 로고
    • Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin dependent kinases cdc2, cdk2, and cdk5
    • 52. MEIJER, L., A. BORGNE, O. MULNER et al. 1997. Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin dependent kinases cdc2, cdk2, and cdk5. Eur. J. Biochem. 243: 527-536.
    • (1997) Eur. J. Biochem. , vol.243 , pp. 527-536
    • Meijer, L.1    Borgne, A.2    Mulner, O.3
  • 53
    • 0029090514 scopus 로고
    • Multiple modes of ligand recognition: Crystal structures of cyclin dependent kinase 2 in complex with ATP and two inhibitors, olomoucine and isopentenyladenine
    • 53. SCHULZE-GAHMEN, U., J. BRANDSEN, H.D. JONES et al. 1995. Multiple modes of ligand recognition: crystal structures of cyclin dependent kinase 2 in complex with ATP and two inhibitors, olomoucine and isopentenyladenine. Proteins Struct. Funct. Genet. 22: 378-391.
    • (1995) Proteins Struct. Funct. Genet. , vol.22 , pp. 378-391
    • Schulze-Gahmen, U.1    Brandsen, J.2    Jones, H.D.3
  • 54
    • 15444355744 scopus 로고    scopus 로고
    • CVT 313, a specific and potent inhibitor of CDK2 that prevents neointimal proliferation
    • 54. BROOKS, E.E., N.S. GRAY, A. JOLY et al. 1997. CVT 313, a specific and potent inhibitor of CDK2 that prevents neointimal proliferation. J. Biol. Chem. 272: 29207-29211.
    • (1997) J. Biol. Chem. , vol.272 , pp. 29207-29211
    • Brooks, E.E.1    Gray, N.S.2    Joly, A.3
  • 55
    • 0032563315 scopus 로고    scopus 로고
    • Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors
    • 55. GRAY, N.S., L. WODICKA, A.M. THUNNISEN et al. 1998. Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors. Science 281: 533-538.
    • (1998) Science , vol.281 , pp. 533-538
    • Gray, N.S.1    Wodicka, L.2    Thunnisen, A.M.3
  • 56
    • 0030798355 scopus 로고    scopus 로고
    • Effects of olomoucine, a selective inhibitor of cyclin-dependent kinases, on cell cycle progression in human cancer cell liver
    • 56. BUQUET-FAGOT, C., F. LALLEMARD, M.N. MONTAGNE et al. 1997. Effects of olomoucine, a selective inhibitor of cyclin-dependent kinases, on cell cycle progression in human cancer cell liver. Anti-Cancer Drug 8: 623-638.
    • (1997) Anti-Cancer Drug , vol.8 , pp. 623-638
    • Buquet-Fagot, C.1    Lallemard, F.2    Montagne, M.N.3
  • 57
    • 0008572014 scopus 로고    scopus 로고
    • Comparative inhibition of CDK1 and CDK2 by 6-substituted purines and 4-substituted pyrimidines
    • 57. ARRIS, C.E., F.T. BOYLE, A.M. CALVERT et al. 1999. Comparative inhibition of CDK1 and CDK2 by 6-substituted purines and 4-substituted pyrimidines. Proc. Am. Assoc. Cancer Res. 40: 305.
    • (1999) Proc. Am. Assoc. Cancer Res. , vol.40 , pp. 305
    • Arris, C.E.1    Boyle, F.T.2    Calvert, A.M.3
  • 58
    • 0033152122 scopus 로고    scopus 로고
    • Discovery and initial characterization of the paullones, a novel class of small-molecule inhibitors of cyclin-dependent kinases
    • 58. ZAHAREVITZ, D.W., R. GUSSIO, M. LEOST et al. 1999. Discovery and initial characterization of the paullones, a novel class of small-molecule inhibitors of cyclin-dependent kinases. Cancer Res. 59: 2566-2569.
    • (1999) Cancer Res. , vol.59 , pp. 2566-2569
    • Zaharevitz, D.W.1    Gussio, R.2    Leost, M.3
  • 59
    • 0033614949 scopus 로고    scopus 로고
    • The paullones, a series of cyclin-dependent kinase inhibitors synthesis. Evaluation of CDK1/cyclin B inhibition and in vitro antitumor activity
    • 59. SCHULTZ, C., A. LINK, M. LEOST et al. 1999. The paullones, a series of cyclin-dependent kinase inhibitors synthesis. Evaluation of CDK1/cyclin B inhibition and in vitro antitumor activity. J. Med. Chem. 42: 2909-2919.
    • (1999) J. Med. Chem. , vol.42 , pp. 2909-2919
    • Schultz, C.1    Link, A.2    Leost, M.3
  • 60
    • 0032485025 scopus 로고    scopus 로고
    • Characterization of the cyclin dependent kinase inhibition domain of the INK4 family as a model for a synthetic tumor suppressor molecule
    • 60. FAHREUS, R., S. LAIN, K.L. BALL et al. 1998. Characterization of the cyclin dependent kinase inhibition domain of the INK4 family as a model for a synthetic tumor suppressor molecule. Oncogene 16: 587-596.
    • (1998) Oncogene , vol.16 , pp. 587-596
    • Fahreus, R.1    Lain, S.2    Ball, K.L.3
  • 61
    • 0030615324 scopus 로고    scopus 로고
    • p21 WAF1-derived peptides linked to an internalization peptide inhibit human cancer cell growth
    • 61. BONFANTI, M., S. TAVERNA, M. SALMONA et al. 1997. p21 WAF1-derived peptides linked to an internalization peptide inhibit human cancer cell growth. Cancer Res. 57: 1442-1446.
    • (1997) Cancer Res. , vol.57 , pp. 1442-1446
    • Bonfanti, M.1    Taverna, S.2    Salmona, M.3
  • 63
    • 0031933739 scopus 로고    scopus 로고
    • In vitro growth suppression by adenoviral transduction of p21 and p16 in squamous cell carcinoma of the head and neck: A research model for combination gene therapy
    • 63. MOBLEY, S.R., T.J. LIU, J.M. HUDSON et al. 1998. In vitro growth suppression by adenoviral transduction of p21 and p16 in squamous cell carcinoma of the head and neck: a research model for combination gene therapy. Arch. Otolaryngol. Head Neck Surg. 124: 88-92.
    • (1998) Arch. Otolaryngol. Head Neck Surg. , vol.124 , pp. 88-92
    • Mobley, S.R.1    Liu, T.J.2    Hudson, J.M.3


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