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Volumn 29, Issue , 1997, Pages 151-182

Mammalian G1, and G2 Phase Checkpoints

Author keywords

[No Author keywords available]

Indexed keywords

AMSACRINE; ANTINEOPLASTIC AGENT; CAMPTOTHECIN; CARBOPLATIN; CHLORAMBUCIL; CHLORMETHINE; CISPLATIN; DNA; DOXORUBICIN; ETOPOSIDE; IRINOTECAN; MELPHALAN; MITOMYCIN C; RETINOBLASTOMA PROTEIN; TOPOTECAN; CELL CYCLE PROTEIN; CYCLIN DEPENDENT KINASE;

EID: 0030612166     PISSN: 02612429     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (194)

References (169)
  • 2
    • 0026610360 scopus 로고
    • Regulation of p34Cdc28 tyrosine phosphorylation is not required for entry into mitosis in S. cerevisiae
    • Amon A, Surana U, Muroff I and Nasmyth K (1992) Regulation of p34Cdc28 tyrosine phosphorylation is not required for entry into mitosis in S. cerevisiae. Nature 355 368-371
    • (1992) Nature , vol.355 , pp. 368-371
    • Amon, A.1    Surana, U.2    Muroff, I.3    Nasmyth, K.4
  • 3
    • 0029147732 scopus 로고
    • Both p16 and p21 families of cyclin-dependent kinase (CDK) inhibitors block the phosphorylation of cyclin-dependent kinases by the CDK-activating kinase
    • Aprelikova O, Xiong Y and Liu ET (1995) Both p16 and p21 families of cyclin-dependent kinase (CDK) inhibitors block the phosphorylation of cyclin-dependent kinases by the CDK-activating kinase. Journal of Biological Chemistry 270 18195-18197
    • (1995) Journal of Biological Chemistry , vol.270 , pp. 18195-18197
    • Aprelikova, O.1    Xiong, Y.2    Liu, E.T.3
  • 4
    • 0028978117 scopus 로고
    • Relationships between G1 arrest and stability of the p53 and p21Cip1/Waf1 proteins following γ-irradiation of human lymphoma cells
    • Bae I, Fan S, Bhatia K, Kohn KW, Fornace AJ Jr and O'Connor PM (1995) Relationships between G1 arrest and stability of the p53 and p21Cip1/Waf1 proteins following γ-irradiation of human lymphoma cells. Cancer Research 55 2387-2393
    • (1995) Cancer Research , vol.55 , pp. 2387-2393
    • Bae, I.1    Fan, S.2    Bhatia, K.3    Kohn, K.W.4    Fornace A.J., Jr.5    O'Connor, P.M.6
  • 5
    • 15844426692 scopus 로고    scopus 로고
    • Atm-deficient mice: A paradigm of ataxia telangiectasia
    • Barlow C, Hirotsune S, Paylor R et al(1996) Atm-deficient mice: a paradigm of ataxia telangiectasia. Cell 86 159-171
    • (1996) Cell , vol.86 , pp. 159-171
    • Barlow, C.1    Hirotsune, S.2    Paylor, R.3
  • 6
    • 0024450727 scopus 로고
    • Comparison of gamma-radiation induced accumulation of ataxia telangiectasia and control cells in G2 phase
    • Bates PR and Lavin MF (1989) Comparison of gamma-radiation induced accumulation of ataxia telangiectasia and control cells in G2 phase. Mutation Research 218 165-170
    • (1989) Mutation Research , vol.218 , pp. 165-170
    • Bates, P.R.1    Lavin, M.F.2
  • 7
    • 0028928540 scopus 로고
    • A mutant p21 cyclin-dependent kinase inhibitor isolated from a Burkitt's lymphoma
    • Bhatia K, Fan S, Spangler G et al(1995) A mutant p21 cyclin-dependent kinase inhibitor isolated from a Burkitt's lymphoma. Cancer Research 55 1431-1435
    • (1995) Cancer Research , vol.55 , pp. 1431-1435
    • Bhatia, K.1    Fan, S.2    Spangler, G.3
  • 8
    • 0027282044 scopus 로고
    • Bcl-x, a bcl2 related gene that functions as a dominant regulator of apoptotic death
    • Boise LH, Gonzalez-Garcia M, Postema CE et al(1993) bcl-x, a bcl2 related gene that functions as a dominant regulator of apoptotic death. Cell 74 597-608
    • (1993) Cell , vol.74 , pp. 597-608
    • Boise, L.H.1    Gonzalez-Garcia, M.2    Postema, C.E.3
  • 10
    • 0027369120 scopus 로고
    • Increased accumulation of p53 protein in cisplatin-resistant ovarian cell lines
    • Brown R, Clugston C, Burns P et al(1993) Increased accumulation of p53 protein in cisplatin-resistant ovarian cell lines. International Journal of Cancer 55 678-684
    • (1993) International Journal of Cancer , vol.55 , pp. 678-684
    • Brown, R.1    Clugston, C.2    Burns, P.3
  • 12
    • 0028070989 scopus 로고
    • P53-dependent apoptosis is not mediated by transcriptional activation of p53-target genes
    • Caelles G, Helmberg A and Karin M (1994) p53-dependent apoptosis is not mediated by transcriptional activation of p53-target genes. Nature 370 220-223
    • (1994) Nature , vol.370 , pp. 220-223
    • Caelles, G.1    Helmberg, A.2    Karin, M.3
  • 13
  • 15
    • 11944257840 scopus 로고
    • Direct interaction of Gadd45 with PCNA and evidence for competitive interaction of Gadd45 and p21Waf1/Cip1 with PCNA
    • Chen IT, Smith ML, O'Connor PM and Fornace AJ Jr (1995) Direct interaction of Gadd45 with PCNA and evidence for competitive interaction of Gadd45 and p21Waf1/Cip1 with PCNA. Oncogene 11 1931-1937
    • (1995) Oncogene , vol.11 , pp. 1931-1937
    • Chen, I.T.1    Smith, M.L.2    O'Connor, P.M.3    Fornace A.J., Jr.4
  • 16
    • 0029670606 scopus 로고    scopus 로고
    • Characterization of p21Cip1/Waf1 peptide domains required for cyclin E/Cdk2 and PCNA interaction
    • Chen IT, Akamatsu M, Smith ML et al(1996) Characterization of p21Cip1/Waf1 peptide domains required for cyclin E/Cdk2 and PCNA interaction. Oncogene 12 595-607
    • (1996) Oncogene , vol.12 , pp. 595-607
    • Chen, I.T.1    Akamatsu, M.2    Smith, M.L.3
  • 17
    • 0028899480 scopus 로고
    • Separate domains of p21 involved in the inhibition of Cdk kinase and PCNA
    • Chen J, Jackson PK, Kirschner MW and Dutta A (1995) Separate domains of p21 involved in the inhibition of Cdk kinase and PCNA. Nature 374 386-388
    • (1995) Nature , vol.374 , pp. 386-388
    • Chen, J.1    Jackson, P.K.2    Kirschner, M.W.3    Dutta, A.4
  • 18
    • 0029033333 scopus 로고
    • P53, through p21 (WAF1/GIP1), induces cyclin D1 synthesis
    • Chen X, Bargonetti J and Prives C (1995) p53, through p21 (WAF1/GIP1), induces cyclin D1 synthesis. Cancer Research 55 4257-4263
    • (1995) Cancer Research , vol.55 , pp. 4257-4263
    • Chen, X.1    Bargonetti, J.2    Prives, C.3
  • 19
    • 0027983669 scopus 로고
    • Crystal structure of a p53 tumor suppressor-DNA complex: Understanding tumorigenic mutations
    • Cho Y, Gorina S, Jeffrey PD and Pavletich NP (1994) Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations. Science 265 346-356
    • (1994) Science , vol.265 , pp. 346-356
    • Cho, Y.1    Gorina, S.2    Jeffrey, P.D.3    Pavletich, N.P.4
  • 20
    • 0027258466 scopus 로고
    • Thymocyte apoptosis induced by p53-dependent and independent pathways
    • Clarke AR, Purdie CA, Harrison DJ et al(1993) Thymocyte apoptosis induced by p53-dependent and independent pathways. Nature 362 849-852
    • (1993) Nature , vol.362 , pp. 849-852
    • Clarke, A.R.1    Purdie, C.A.2    Harrison, D.J.3
  • 21
    • 0028978183 scopus 로고
    • Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control
    • Deng C, Zhang P, Harper JW, Elledge SJ and Leder P (1995) Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control. Cell 82 675-684
    • (1995) Cell , vol.82 , pp. 675-684
    • Deng, C.1    Zhang, P.2    Harper, J.W.3    Elledge, S.J.4    Leder, P.5
  • 22
    • 0025047276 scopus 로고
    • Phase I trial of escalating pentoxifylline dose with constant thiotepa
    • Dezube BJ, Eder JP and Pardee AB (1990) Phase I trial of escalating pentoxifylline dose with constant thiotepa. Cancer Research 50 6806-6810
    • (1990) Cancer Research , vol.50 , pp. 6806-6810
    • Dezube, B.J.1    Eder, J.P.2    Pardee, A.B.3
  • 23
    • 0027970713 scopus 로고
    • DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts
    • Di Leonardo A, Linke SP, Clarkin K and Wahl GM (1994) DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts. Genes and Development 8 2540-2551
    • (1994) Genes and Development , vol.8 , pp. 2540-2551
    • Di Leonardo, A.1    Linke, S.P.2    Clarkin, K.3    Wahl, G.M.4
  • 24
    • 0028220204 scopus 로고
    • P53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest
    • Dulic V, Kaufmann WK, Wilson SJ et al(1994) p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest. Cell 76 1013-23
    • (1994) Cell , vol.76 , pp. 1013-1023
    • Dulic, V.1    Kaufmann, W.K.2    Wilson, S.J.3
  • 26
    • 0027359827 scopus 로고
    • WAF1, a potential mediator of p53 tumor suppression
    • El-Deiry WS, Tokino T, Velculescu VE et al(1993) WAF1, a potential mediator of p53 tumor suppression. Cell 75 817-825
    • (1993) Cell , vol.75 , pp. 817-825
    • El-Deiry, W.S.1    Tokino, T.2    Velculescu, V.E.3
  • 27
    • 0028294605 scopus 로고
    • WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis
    • El-Deiry WS, Harper JW, O'Connor PM et al(1994) WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis. Cancer Research 54 1169-1174
    • (1994) Cancer Research , vol.54 , pp. 1169-1174
    • El-Deiry, W.S.1    Harper, J.W.2    O'Connor, P.M.3
  • 28
    • 0025021753 scopus 로고
    • Mutation of fission yeast cell cycle control genes abolishes dependence of mitosis on DNA replication
    • Enoch T and Nurse P (1990) Mutation of fission yeast cell cycle control genes abolishes dependence of mitosis on DNA replication. Cell 60 665-673
    • (1990) Cell , vol.60 , pp. 665-673
    • Enoch, T.1    Nurse, P.2
  • 29
    • 0028171454 scopus 로고
    • P53 gene mutations are associated with decreased sensitivity of human lymphoma cells to DNA damaging agents
    • Fan S, El-Deiry WS, Bae I et al(1994) p53 gene mutations are associated with decreased sensitivity of human lymphoma cells to DNA damaging agents. Cancer Research 54 5824-5830
    • (1994) Cancer Research , vol.54 , pp. 5824-5830
    • Fan, S.1    El-Deiry, W.S.2    Bae, I.3
  • 30
    • 0028901034 scopus 로고
    • Disruption of p53 function sensitizes breast cancer MCF-7 cells to cisplatin and pentoxifylline
    • Fan S, Smith ML, Rivet DJ II et al(1995) Disruption of p53 function sensitizes breast cancer MCF-7 cells to cisplatin and pentoxifylline. Cancer Research 55 1649-54
    • (1995) Cancer Research , vol.55 , pp. 1649-1654
    • Fan, S.1    Smith, M.L.2    Rivet D.J. II3
  • 31
    • 85046166394 scopus 로고    scopus 로고
    • O'Connor PM Cells lacking CIP1/WAF1 genes exhibit preferential sensitivity to cisplatin and nitrogen mustard
    • in press
    • Fan S, Chang JK, Smith ML, Duba D, Fornace AJ Jr and O'Connor PM Cells lacking CIP1/WAF1 genes exhibit preferential sensitivity to cisplatin and nitrogen mustard. Oncogene (in press)
    • Oncogene
    • Fan, S.1    Chang, J.K.2    Smith, M.L.3    Duba, D.4    Fornace A.J., Jr.5
  • 32
    • 0022590755 scopus 로고
    • Cytotoxic, cell cycle and chromosomal effects of methylxanthines in human tumor cells treated with alkylating agents
    • Fingert HJ, Chang JD and Pardee AB (1986) Cytotoxic, cell cycle and chromosomal effects of methylxanthines in human tumor cells treated with alkylating agents. Cancer Research 46 2463-2467
    • (1986) Cancer Research , vol.46 , pp. 2463-2467
    • Fingert, H.J.1    Chang, J.D.2    Pardee, A.B.3
  • 33
    • 0027981476 scopus 로고
    • Cdk-interacting protein-1 (Cip1, Waf1) directly binds to proliferating cell nuclear antigen and inhibits DNA replication catalyzed by the DNA polymerase δ holoenzyme
    • Flores-Rozas H, Keiman Z, Dean FB et al(1994) Cdk-interacting protein-1 (Cip1, Waf1) directly binds to proliferating cell nuclear antigen and inhibits DNA replication catalyzed by the DNA polymerase δ holoenzyme. Proceedings of the National Academy of Sciences of the USA 91 8655-8659
    • (1994) Proceedings of the National Academy of Sciences of the USA , vol.91 , pp. 8655-8659
    • Flores-Rozas, H.1    Keiman, Z.2    Dean, F.B.3
  • 34
    • 0029029741 scopus 로고
    • Li-Fraumeni syndrome fibroblasts homozygous for p53 mutations are deficient in global DNA repair but exhibit normal transcription-coupled repair and enhanced UV resistance
    • Ford JM and Hanawalt PC (1995) Li-Fraumeni syndrome fibroblasts homozygous for p53 mutations are deficient in global DNA repair but exhibit normal transcription-coupled repair and enhanced UV resistance. Proceedings of the National Academy of Sciences of the USA 92 8876-8880
    • (1995) Proceedings of the National Academy of Sciences of the USA , vol.92 , pp. 8876-8880
    • Ford, J.M.1    Hanawalt, P.C.2
  • 36
    • 0029948612 scopus 로고    scopus 로고
    • P21 contains independent binding sites for cyclin and cdk2: Both sites are required to inhibit cdk2 kinase activity
    • Fotedar R, Fitzgerald P, Rousselle T et al(1996) p21 contains independent binding sites for cyclin and cdk2: both sites are required to inhibit cdk2 kinase activity. Oncogene 12 2155-2164
    • (1996) Oncogene , vol.12 , pp. 2155-2164
    • Fotedar, R.1    Fitzgerald, P.2    Rousselle, T.3
  • 37
    • 0028137084 scopus 로고
    • P53: A glimpse at the puppet behind the shadow play
    • Friend S (1994) p53: a glimpse at the puppet behind the shadow play. Science 265 334-335
    • (1994) Science , vol.265 , pp. 334-335
    • Friend, S.1
  • 39
    • 0029021714 scopus 로고
    • Identification of binding domains on the p21Cip1 cyclin-dependent kinase inhibitor
    • Goubin F and Ducommun B (1995) Identification of binding domains on the p21Cip1 cyclin-dependent kinase inhibitor. Oncogene 10 2281-2287
    • (1995) Oncogene , vol.10 , pp. 2281-2287
    • Goubin, F.1    Ducommun, B.2
  • 40
    • 0028071555 scopus 로고
    • Mutations in the p53 tumor suppressor gene: Clues to cancer etiology and molecular pathogenesis
    • Greenblatt MS, Bennett WP, Hollstein M and Harris CC (1994) Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis. Cancer Research 54 4855-4878
    • (1994) Cancer Research , vol.54 , pp. 4855-4878
    • Greenblatt, M.S.1    Bennett, W.P.2    Hollstein, M.3    Harris, C.C.4
  • 42
    • 0027496935 scopus 로고
    • The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases
    • Harper JW, Adami GR, Wei N, Keyomarsi K and Elledge SJ (1993) The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell 75 805-816
    • (1993) Cell , vol.75 , pp. 805-816
    • Harper, J.W.1    Adami, G.R.2    Wei, N.3    Keyomarsi, K.4    Elledge, S.J.5
  • 44
    • 0026452949 scopus 로고
    • Defects in a cell cycle checkpoint may be responsible for the genomic instability of cancer cells
    • Hartwell L (1992) Defects in a cell cycle checkpoint may be responsible for the genomic instability of cancer cells. Cell 71 543-546
    • (1992) Cell , vol.71 , pp. 543-546
    • Hartwell, L.1
  • 45
    • 0024425887 scopus 로고
    • Checkpoints: Controls that ensure the order of cell cycle events
    • Hartwell L and Weinert T (1989) Checkpoints: controls that ensure the order of cell cycle events. Science 246 629-634
    • (1989) Science , vol.246 , pp. 629-634
    • Hartwell, L.1    Weinert, T.2
  • 46
    • 0028568315 scopus 로고
    • Cell cycle control and cancer
    • Hartwell LH and Kastan MB (1994) Cell cycle control and cancer. Science 266 1821-1828
    • (1994) Science , vol.266 , pp. 1821-1828
    • Hartwell, L.H.1    Kastan, M.B.2
  • 47
    • 0027244234 scopus 로고
    • Human Weel maintains mitotic timing by protecting the nucleus from cytoplasmically activated Cdc2 kinase
    • Heald R, McLoughlin M and Mckeon F (1993) Human Weel maintains mitotic timing by protecting the nucleus from cytoplasmically activated Cdc2 kinase. Cell 74 463-474
    • (1993) Cell , vol.74 , pp. 463-474
    • Heald, R.1    McLoughlin, M.2    Mckeon, F.3
  • 48
    • 0027382336 scopus 로고
    • Inhibition of E2F1 transactivation by direct binding of the retinoblastoma protein
    • Helin K, Harlow E and Fattaey A (1993) Inhibition of E2F1 transactivation by direct binding of the retinoblastoma protein. Molecular and Cellular Biology 13 6501-6508
    • (1993) Molecular and Cellular Biology , vol.13 , pp. 6501-6508
    • Helin, K.1    Harlow, E.2    Fattaey, A.3
  • 49
    • 0027509501 scopus 로고
    • Phosphorylation and activation of human Cdc25C by Cdc2-cyclin B and its involvement in the self-amplification of MPF at mitosis
    • Hoffmann I, Clarke PC, Marcote MJ, Karsenti E and Draetta G (1993) Phosphorylation and activation of human Cdc25C by Cdc2-cyclin B and its involvement in the self-amplification of MPF at mitosis. EMBO Journal 12 53-63
    • (1993) EMBO Journal , vol.12 , pp. 53-63
    • Hoffmann, I.1    Clarke, P.C.2    Marcote, M.J.3    Karsenti, E.4    Draetta, G.5
  • 51
    • 0028171847 scopus 로고
    • G2/M phase arrest and release in ataxia telangiectasia and normal cells after exposure to ionizing radiation
    • Hong J-H, Gatti RA, Huo YK, Chiang CS and McBride WH (1994) G2/M phase arrest and release in ataxia telangiectasia and normal cells after exposure to ionizing radiation. Radiation Research 140 17-23
    • (1994) Radiation Research , vol.140 , pp. 17-23
    • Hong, J.-H.1    Gatti, R.A.2    Huo, Y.K.3    Chiang, C.S.4    McBride, W.H.5
  • 52
    • 0019166395 scopus 로고
    • Effect of ionizing radiation on DNA synthesis in ataxia telangiectasia cells
    • Houldsworth J and Lavin MF (1980) Effect of ionizing radiation on DNA synthesis in ataxia telangiectasia cells. Nucleic Acids Research 8 3709-3720
    • (1980) Nucleic Acids Research , vol.8 , pp. 3709-3720
    • Houldsworth, J.1    Lavin, M.F.2
  • 54
    • 0028845158 scopus 로고
    • Small peptides activate the latent sequence-specific DNA binding function of p53
    • Hupp TR, Sparks A and Lane DP (1995) Small peptides activate the latent sequence-specific DNA binding function of p53. Cell 83 237-245
    • (1995) Cell , vol.83 , pp. 237-245
    • Hupp, T.R.1    Sparks, A.2    Lane, D.P.3
  • 55
    • 0029055808 scopus 로고
    • Activation of p53 sequence-specific DNA binding by short single strands of DNA requires the p53 C-terminus
    • Jayaraman L and Prives C (1995) Activation of p53 sequence-specific DNA binding by short single strands of DNA requires the p53 C-terminus. Cell 81 1021-1029
    • (1995) Cell , vol.81 , pp. 1021-1029
    • Jayaraman, L.1    Prives, C.2
  • 56
    • 0031059869 scopus 로고    scopus 로고
    • Cyclin B1 availability is a rate-limiting component of the radiation-induced delay in HeLa cell
    • in press
    • Kao GD, McKenna WG, Maity A, Blank K and Muschel RJ Cyclin B1 availability is a rate-limiting component of the radiation-induced delay in HeLa cell. Cancer Research (in press)
    • Cancer Research
    • Kao, G.D.1    McKenna, W.G.2    Maity, A.3    Blank, K.4    Muschel, R.J.5
  • 58
    • 0026496885 scopus 로고
    • A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia
    • Kastan MB, Zhan Q, El-Deiry WS et al(1992) A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia. Cell 71 587-597
    • (1992) Cell , vol.71 , pp. 587-597
    • Kastan, M.B.1    Zhan, Q.2    El-Deiry, W.S.3
  • 59
    • 0027288908 scopus 로고
    • Direct binding of cyclin D to the retinoblastoma gene product (pRb) and pRb phosphorylation by the cyclin D- Dependent kinase CDK4
    • Kato J, Matsushime H, Hiebert SW, Ewen ME and Sherr CJ (1993) Direct binding of cyclin D to the retinoblastoma gene product (pRb) and pRb phosphorylation by the cyclin D- dependent kinase CDK4. Genes and Development 7 331-342
    • (1993) Genes and Development , vol.7 , pp. 331-342
    • Kato, J.1    Matsushime, H.2    Hiebert, S.W.3    Ewen, M.E.4    Sherr, C.J.5
  • 61
    • 0028876192 scopus 로고
    • Does p53 up-regulated Gadd45 protein have a role in excision repair?
    • Kazantev A and Sancar A (1995) Does p53 up-regulated Gadd45 protein have a role in excision repair? Science 10 1003-1004
    • (1995) Science , vol.10 , pp. 1003-1004
    • Kazantev, A.1    Sancar, A.2
  • 62
    • 0029641626 scopus 로고
    • Does the p53-up-regulated Gadd45 protein have a role in excision repair?
    • Kearsey JM, Shivji MK, Hall PA and Wood RD (1995) Does the p53-up-regulated Gadd45 protein have a role in excision repair? Science 10 1004-1005
    • (1995) Science , vol.10 , pp. 1004-1005
    • Kearsey, J.M.1    Shivji, M.K.2    Hall, P.A.3    Wood, R.D.4
  • 63
    • 0025815451 scopus 로고
    • Identification of p53 as a sequence-specific DNA- Binding protein
    • Kern SE, Kinzler KW, Bruskin A et al(1991) Identification of p53 as a sequence-specific DNA- binding protein. Science 252 1708-1711
    • (1991) Science , vol.252 , pp. 1708-1711
    • Kern, S.E.1    Kinzler, K.W.2    Bruskin, A.3
  • 65
    • 0026006392 scopus 로고
    • Mutations in p34Cdc2 phosphorylation sites induce premature mitotic events in HeLa cells: Evidence for a double block to p34Cdc2 kinase activation in vertebrates
    • Krek W and Nigg EA (1991) Mutations in p34Cdc2 phosphorylation sites induce premature mitotic events in HeLa cells: evidence for a double block to p34Cdc2 kinase activation in vertebrates. EMBO Journal 10 3331-3341
    • (1991) EMBO Journal , vol.10 , pp. 3331-3341
    • Krek, W.1    Nigg, E.A.2
  • 67
    • 0028210429 scopus 로고
    • Endogenous p53 protein generated from wild-type alternatively spliced p53 RNA in mouse epidermal cells
    • Kulesz-Martin MF, Lisafeld B, Huang H, Kisiel ND and Lee L (1994) Endogenous p53 protein generated from wild-type alternatively spliced p53 RNA in mouse epidermal cells. Molecular and Cellular Biology 14 1698-1708
    • (1994) Molecular and Cellular Biology , vol.14 , pp. 1698-1708
    • Kulesz-Martin, M.F.1    Lisafeld, B.2    Huang, H.3    Kisiel, N.D.4    Lee, L.5
  • 68
    • 0027109075 scopus 로고
    • P53, guardian of the genome
    • Lane DP (1992) p53, guardian of the genome. Nature 358 15-16
    • (1992) Nature , vol.358 , pp. 15-16
    • Lane, D.P.1
  • 69
    • 0029941446 scopus 로고    scopus 로고
    • Inhibition of p53-mediated growth arrest by overexpression of cyclin-dependent kinases
    • Latham KM, Eastman SW, Wong A and Hinds PW (1996) Inhibition of p53-mediated growth arrest by overexpression of cyclin-dependent kinases. Molecular and Cellular Biology 16 4445-4455
    • (1996) Molecular and Cellular Biology , vol.16 , pp. 4445-4455
    • Latham, K.M.1    Eastman, S.W.2    Wong, A.3    Hinds, P.W.4
  • 72
    • 0028988158 scopus 로고
    • Cloning of p57Kip2, a cyclin-dependent kinase inhibitor with unique domain structure and tissue distribution
    • Lee M-H, Reynisdottir I and Massague J (1995) Cloning of p57Kip2, a cyclin-dependent kinase inhibitor with unique domain structure and tissue distribution. Genes and Development 9 539-649
    • (1995) Genes and Development , vol.9 , pp. 539-649
    • Lee, M.-H.1    Reynisdottir, I.2    Massague, J.3
  • 73
    • 0029013273 scopus 로고
    • P53 and its 14 kDa C-terminal domain recognize primary DNA damage in the form of insertion/deletion mismatches
    • Lee S, Elenbaas B, Levine A and Griffith J (1995) p53 and its 14 kDa C-terminal domain recognize primary DNA damage in the form of insertion/deletion mismatches. Cell 81 1013- 1020
    • (1995) Cell , vol.81 , pp. 1013-1020
    • Lee, S.1    Elenbaas, B.2    Levine, A.3    Griffith, J.4
  • 74
    • 0025876591 scopus 로고
    • The p53 tumor suppressor gene
    • Levine A, Momand J and Finlay CA (1991) The p53 tumor suppressor gene. Nature 351 453- 456
    • (1991) Nature , vol.351 , pp. 453-456
    • Levine, A.1    Momand, J.2    Finlay, C.A.3
  • 77
    • 0026801062 scopus 로고
    • Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53
    • Livingstone LR, Whitem A, Sprousem J, Livanosm E, Jacks T and Tlsty TD (1992) Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53. Cell 70 923- 935
    • (1992) Cell , vol.70 , pp. 923-935
    • Livingstone, L.R.1    Whitem, A.2    Sprousem, J.3    Livanosm, E.4    Jacks, T.5    Tlsty, T.D.6
  • 78
    • 0026611089 scopus 로고
    • Inhibition of p34cdc2 kinase activation, p34cdc2 tyrosine dephosphorylation and mitotic progression in Chinese hamster ovary cells exposed to etoposide
    • Lock RB (1992) Inhibition of p34cdc2 kinase activation, p34cdc2 tyrosine dephosphorylation and mitotic progression in Chinese hamster ovary cells exposed to etoposide. Cancer Research 52 1817-1822
    • (1992) Cancer Research , vol.52 , pp. 1817-1822
    • Lock, R.B.1
  • 79
    • 0025196215 scopus 로고
    • Inhibition of p34Cdc2 kinase induced by etoposide or irradiation as a mechanism of G2 arrest in Chinese hamster ovary cells
    • Lock RB and Ross WE (1990a) Inhibition of p34Cdc2 kinase induced by etoposide or irradiation as a mechanism of G2 arrest in Chinese hamster ovary cells. Cancer Research 50 3761-376
    • (1990) Cancer Research , vol.50 , pp. 3761-4376
    • Lock, R.B.1    Ross, W.E.2
  • 80
    • 0025196216 scopus 로고
    • Possible role for p34Cdc2 kinase in etoposide-induced cell death of Chinese hamster ovary cells
    • Lock RB and Ross WE (1990b) Possible role for p34Cdc2 kinase in etoposide-induced cell death of Chinese hamster ovary cells. Cancer Research 50 3767-3771
    • (1990) Cancer Research , vol.50 , pp. 3767-3771
    • Lock, R.B.1    Ross, W.E.2
  • 81
    • 0027524676 scopus 로고
    • Responses of HeLa and Chinese hamster ovary p34Cdc2/cyclin B-kinase in relation to cell cycle perturbations induced by etoposide
    • Lock RB and Keeling PK (1993) Responses of HeLa and Chinese hamster ovary p34Cdc2/cyclin B-kinase in relation to cell cycle perturbations induced by etoposide. International Journal of Oncology 3 33-42
    • (1993) International Journal of Oncology , vol.3 , pp. 33-42
    • Lock, R.B.1    Keeling, P.K.2
  • 82
    • 0027451668 scopus 로고
    • P53-dependent apoptosis modulates the cytotoxicity of anticancer agents
    • Lowe SW, Ruley HE, Jacks T and Houseman DE (1993a) p53-dependent apoptosis modulates the cytotoxicity of anticancer agents. Cell 74 957-967
    • (1993) Cell , vol.74 , pp. 957-967
    • Lowe, S.W.1    Ruley, H.E.2    Jacks, T.3    Houseman, D.E.4
  • 83
    • 0027319521 scopus 로고
    • P53 is required for radiation-induced apoptosis in mouse thymocytes
    • Lowe SW, Schmitt EM, Smith SW, Osborne BA and Jacks T (1993b) p53 is required for radiation-induced apoptosis in mouse thymocytes. Nature 362 847-849
    • (1993) Nature , vol.362 , pp. 847-849
    • Lowe, S.W.1    Schmitt, E.M.2    Smith, S.W.3    Osborne, B.A.4    Jacks, T.5
  • 84
    • 0029063745 scopus 로고
    • Cell cycle inhibition by independent Cdk and PCNA binding domains in p21Cip1
    • Luo Y, Hurwitz J and Massague J (1995) Cell cycle inhibition by independent Cdk and PCNA binding domains in p21Cip1. Nature 375 159-161
    • (1995) Nature , vol.375 , pp. 159-161
    • Luo, Y.1    Hurwitz, J.2    Massague, J.3
  • 85
    • 0028882869 scopus 로고
    • Yeast checkpoint genes in DNA damage processing: Implications for repair and arrest
    • Lydall D and Weinert T (1995) Yeast checkpoint genes in DNA damage processing: implications for repair and arrest. Science 270 1488-1491
    • (1995) Science , vol.270 , pp. 1488-1491
    • Lydall, D.1    Weinert, T.2
  • 87
    • 0027318117 scopus 로고
    • Specific repression of TATA-mediated but not initiator-mediated transcription by wild-type p53
    • Mack DH, Vartikar J, Pipas JM and Laimins LA (1993) Specific repression of TATA-mediated but not initiator-mediated transcription by wild-type p53. Nature 363 281-283
    • (1993) Nature , vol.363 , pp. 281-283
    • Mack, D.H.1    Vartikar, J.2    Pipas, J.M.3    Laimins, L.A.4
  • 88
    • 0026129706 scopus 로고
    • Increased G2 delay in radiation-resistant cells obtained by transformation of primary rat embryo cells with the on- Cogenes H-ras and V-myc
    • McKenna WG, Iliakis G, Weiss MC, Bernhard EJ and Muschel RJ (1991) Increased G2 delay in radiation-resistant cells obtained by transformation of primary rat embryo cells with the on- cogenes H-ras and V-myc. Radiation Research 125 283-287
    • (1991) Radiation Research , vol.125 , pp. 283-287
    • McKenna, W.G.1    Iliakis, G.2    Weiss, M.C.3    Bernhard, E.J.4    Muschel, R.J.5
  • 89
    • 0025081901 scopus 로고
    • The pathogenesis of Burkitt's lymphoma
    • Magrath I (1990) The pathogenesis of Burkitt's lymphoma. Advances in Cancer Research 5 133-270
    • (1990) Advances in Cancer Research , vol.5 , pp. 133-270
    • Magrath, I.1
  • 90
    • 0028896811 scopus 로고
    • Evidence for post-transcriptional regulation of cyclin B1 mRNA in the cell cycle and following irradiation in HeLa cell
    • Maity A, McKenna WG and Muschel RJ (1995) Evidence for post-transcriptional regulation of cyclin B1 mRNA in the cell cycle and following irradiation in HeLa cell. EMBO Journal 14 603-609
    • (1995) EMBO Journal , vol.14 , pp. 603-609
    • Maity, A.1    McKenna, W.G.2    Muschel, R.J.3
  • 91
    • 0021616838 scopus 로고
    • UV irradiation stimulates levels of p53 cellular antigen in non transformed mouse cells
    • Maltzman W and Czyzyk L (1984) UV irradiation stimulates levels of p53 cellular antigen in non transformed mouse cells. Molecular and Cellular Biology 4 1689-1694
    • (1984) Molecular and Cellular Biology , vol.4 , pp. 1689-1694
    • Maltzman, W.1    Czyzyk, L.2
  • 92
    • 0026093164 scopus 로고
    • Cellular localization and cell cycle regulation by a temperature mutant p53 protein
    • Martinez J, Georgoff I, Martinez J and Levine AJ (1991) Cellular localization and cell cycle regulation by a temperature mutant p53 protein. Genes and Development 5 151-159
    • (1991) Genes and Development , vol.5 , pp. 151-159
    • Martinez, J.1    Georgoff, I.2    Martinez, J.3    Levine, A.J.4
  • 93
    • 0028988159 scopus 로고
    • P57Kip2, a structurally related distinct member of the p21Cip1 Cdk inhibitor family, is a candidate tumor suppressor
    • Matsuoka S, Edwards M, Bai C et al(1995) p57Kip2, a structurally related distinct member of the p21Cip1 Cdk inhibitor family, is a candidate tumor suppressor. Genes and Development 9 650-662
    • (1995) Genes and Development , vol.9 , pp. 650-662
    • Matsuoka, S.1    Edwards, M.2    Bai, C.3
  • 94
    • 0029147449 scopus 로고
    • Transient failure to dephosphorylate the Cdc2-cyclin B1 complex accompanies radiation-induced G2 phase arrest in HeLa cells
    • Metting NF and Little JB (1995) Transient failure to dephosphorylate the Cdc2-cyclin B1 complex accompanies radiation-induced G2 phase arrest in HeLa cells. Radiation Research 143 286-292
    • (1995) Radiation Research , vol.143 , pp. 286-292
    • Metting, N.F.1    Little, J.B.2
  • 95
    • 0025111068 scopus 로고
    • Conditional inhibition of transformation and of cell proliferation by a temperature sensitive mutant p53
    • Michalovitz D, Halevy O and Oren M (1990) Conditional inhibition of transformation and of cell proliferation by a temperature sensitive mutant p53. Cell 62 671-680
    • (1990) Cell , vol.62 , pp. 671-680
    • Michalovitz, D.1    Halevy, O.2    Oren, M.3
  • 97
    • 0028883179 scopus 로고
    • Tumor suppressor p53 is a direct transcriptional activator of the human bax gene
    • Miyashita T and Reed JC (1995) Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Cell 80 293-299
    • (1995) Cell , vol.80 , pp. 293-299
    • Miyashita, T.1    Reed, J.C.2
  • 98
    • 0028335717 scopus 로고
    • Tumor suppressor p53 is a regulator of bcl2 and bax gene expression in vitro and in vivo
    • Miyashita T, Krajewski S, Krajewski M et al(1994) Tumor suppressor p53 is a regulator of bcl2 and bax gene expression in vitro and in vivo. Oncogene 9 1799-1805
    • (1994) Oncogene , vol.9 , pp. 1799-1805
    • Miyashita, T.1    Krajewski, S.2    Krajewski, M.3
  • 99
    • 0028931265 scopus 로고
    • Principles of CDK regulation
    • Morgan DO (1995) Principles of CDK regulation. Nature 374 131-134
    • (1995) Nature , vol.374 , pp. 131-134
    • Morgan, D.O.1
  • 103
    • 0026703325 scopus 로고
    • Creative blocks: Cell-cycle checkpoints and feedback controls
    • Murray AW (1992) Creative blocks: cell-cycle checkpoints and feedback controls. Nature 359 599-604
    • (1992) Nature , vol.359 , pp. 599-604
    • Murray, A.W.1
  • 104
    • 0026069862 scopus 로고
    • Cyclin B expression in HeLa cells during the G2 block induced by ionizing radiation
    • Muschel RJ, Zhang HB, Iliakis G and McKenna WG (1991) Cyclin B expression in HeLa cells during the G2 block induced by ionizing radiation. Cancer Research 51 5113-5117
    • (1991) Cancer Research , vol.51 , pp. 5113-5117
    • Muschel, R.J.1    Zhang, H.B.2    Iliakis, G.3    McKenna, W.G.4
  • 105
    • 0027537380 scopus 로고
    • Differential effect of ionizing radiation on the expression of cyclin A and cyclin B in HeLa cells
    • Muschel RJ, Zhang HB and McKenna WG (1993) Differential effect of ionizing radiation on the expression of cyclin A and cyclin B in HeLa cells. Cancer Research 53 1128-1135
    • (1993) Cancer Research , vol.53 , pp. 1128-1135
    • Muschel, R.J.1    Zhang, H.B.2    McKenna, W.G.3
  • 106
    • 0028895385 scopus 로고
    • Identification of the active region of the DNA synthesis inhibitor gene p21(sdi1/cip1/WAF1)
    • Nakanishi M, Robetorge RS, Adami GR, Pereira-Smith OM and Smith JR (1995) Identification of the active region of the DNA synthesis inhibitor gene p21(sdi1/cip1/WAF1). EMBO Journal 14 555-563
    • (1995) EMBO Journal , vol.14 , pp. 555-563
    • Nakanishi, M.1    Robetorge, R.S.2    Adami, G.R.3    Pereira-Smith, O.M.4    Smith, J.R.5
  • 107
    • 0028204160 scopus 로고
    • DNA strand breaks: The DNA template alterations that trigger p53-dependent DNA damage response pathways
    • Nelson WG and Kastan MB (1994) DNA strand breaks: the DNA template alterations that trigger p53-dependent DNA damage response pathways. Molecular and Cellular Biology 14 1815-1823
    • (1994) Molecular and Cellular Biology , vol.14 , pp. 1815-1823
    • Nelson, W.G.1    Kastan, M.B.2
  • 108
    • 0026526437 scopus 로고
    • E2F: A link between the Rb tumor suppressor protein and viral oncogenes
    • Nevins JR (1992) E2F: a link between the Rb tumor suppressor protein and viral oncogenes. Science 258 424-429
    • (1992) Science , vol.258 , pp. 424-429
    • Nevins, J.R.1
  • 110
    • 0025246110 scopus 로고
    • Universal control mechanism regulating onset of M-phase
    • Nurse P (1990) Universal control mechanism regulating onset of M-phase. Nature 344 503-508
    • (1990) Nature , vol.344 , pp. 503-508
    • Nurse, P.1
  • 111
    • 0027284915 scopus 로고
    • P53-catalyzed annealing of complementary single-stranded nucleic acids
    • Oberosler P, Hloch P, Ramsperger U and Stahl H (1993) p53-catalyzed annealing of complementary single-stranded nucleic acids. EMBO Journal 12 2389-2396
    • (1993) EMBO Journal , vol.12 , pp. 2389-2396
    • Oberosler, P.1    Hloch, P.2    Ramsperger, U.3    Stahl, H.4
  • 112
    • 8244249529 scopus 로고    scopus 로고
    • DNA damage checkpoints: Implications for cancer therapy
    • Meijer L, Guidet S and Vogel L (eds), Plenum Press, New York (in press)
    • O'Connor PM and Fan S DNA damage checkpoints: implications for cancer therapy. In: Meijer L, Guidet S and Vogel L (eds). Progress in Cell Cycle Research, Plenum Press, New York (in press)
    • Progress in Cell Cycle Research
    • O'Connor, P.M.1    Fan, S.2
  • 113
    • 0026444481 scopus 로고
    • Relationships between cdc2 kinase, DNA crosslinking, and cell cycle perturbations induced by nitrogen mustard
    • O'Connor PM, Ferris DK, White GA et al(1992) Relationships between cdc2 kinase, DNA crosslinking, and cell cycle perturbations induced by nitrogen mustard. Cell Growth and Differentiation 3 43-52
    • (1992) Cell Growth and Differentiation , vol.3 , pp. 43-52
    • O'Connor, P.M.1    Ferris, D.K.2    White, G.A.3
  • 114
    • 0027340012 scopus 로고
    • G2 delay induced by nitrogen mustard in human cells affects cyclin A/cdk2 and cyclin B1/cdc2-kinase complexes differently
    • O'Connor PM, Ferris DK, Pagano M et al(1993a) G2 delay induced by nitrogen mustard in human cells affects cyclin A/cdk2 and cyclin B1/cdc2-kinase complexes differently. Journal of Biological Chemistry 268 8298-8308
    • (1993) Journal of Biological Chemistry , vol.268 , pp. 8298-8308
    • O'Connor, P.M.1    Ferris, D.K.2    Pagano, M.3
  • 115
    • 0027421045 scopus 로고
    • Role of the p53 tumor suppressor gene in cell cycle arrest and radiosensitivity of Burkitt's lymphoma cell lines
    • O'Connor PM, Jackman J, Jondle D, Bhatia K, Magrath I and Kohn KW (1993b) Role of the p53 tumor suppressor gene in cell cycle arrest and radiosensitivity of Burkitt's lymphoma cell lines. Cancer Research 53 4776-80
    • (1993) Cancer Research , vol.53 , pp. 4776-4780
    • O'Connor, P.M.1    Jackman, J.2    Jondle, D.3    Bhatia, K.4    Magrath, I.5    Kohn, K.W.6
  • 117
    • 0026740449 scopus 로고
    • Amplification of a gene encoding a p53-associated protein in human sarcomas
    • Oliner JD, Kinzler KW, Meltzer PS, George DL and Vogelstein B (1992) Amplification of a gene encoding a p53-associated protein in human sarcomas. Nature 358 80-83
    • (1992) Nature , vol.358 , pp. 80-83
    • Oliner, J.D.1    Kinzler, K.W.2    Meltzer, P.S.3    George, D.L.4    Vogelstein, B.5
  • 118
    • 0027166048 scopus 로고
    • Bcl2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death
    • Oltvai ZN, Millman CL and Korsmeyer SJ (1993) Bcl2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell 74 609-619
    • (1993) Cell , vol.74 , pp. 609-619
    • Oltvai, Z.N.1    Millman, C.L.2    Korsmeyer, S.J.3
  • 120
    • 0028129498 scopus 로고
    • Cyclin D1-mediated inhibition of repair and replicative DNA synthesis in human fibroblasts
    • Pagano M, Theodoras AM, Tam SW and Draetta GF (1994) Cyclin D1-mediated inhibition of repair and replicative DNA synthesis in human fibroblasts. Genes and Development 8 1627-1639
    • (1994) Genes and Development , vol.8 , pp. 1627-1639
    • Pagano, M.1    Theodoras, A.M.2    Tam, S.W.3    Draetta, G.F.4
  • 124
    • 0024427288 scopus 로고
    • Isolation of a human cyclin cDNA: Evidence for cyclin mRNA and protein regulation in the cell cycle and for interaction with p34Gdc2
    • Pines J and Hunter T (1989) Isolation of a human cyclin cDNA: Evidence for cyclin mRNA and protein regulation in the cell cycle and for interaction with p34Gdc2. Cell 58 833-846
    • (1989) Cell , vol.58 , pp. 833-846
    • Pines, J.1    Hunter, T.2
  • 125
    • 0028176483 scopus 로고
    • Cloning of p27Kip1, a cyclindependent kinase inhibitor and potential mediator of extracellular antimitogenic signals
    • Polyak K, Lee M-H, Erdjument-Bromage H et al(1994) Cloning of p27Kip1, a cyclindependent kinase inhibitor and potential mediator of extracellular antimitogenic signals Cell 78 59-66
    • (1994) Cell , vol.78 , pp. 59-66
    • Polyak, K.1    Lee, M.-H.2    Erdjument-Bromage, H.3
  • 126
    • 0028936626 scopus 로고
    • Differential sensitivity of p53(-) and p53(+) cells to caffeine-induced radiosensitization and override of G2 delay
    • Powell SN, DeFrank JS, Connell P et al(1995) Differential sensitivity of p53(-) and p53(+) cells to caffeine-induced radiosensitization and override of G2 delay. Cancer Research 55 1643- 1648
    • (1995) Cancer Research , vol.55 , pp. 1643-1648
    • Powell, S.N.1    Defrank, J.S.2    Connell, P.3
  • 127
    • 0023128784 scopus 로고
    • Functional identity of proliferating cell nuclear antigen and a DNA polymerase delta auxiliary protein
    • Prelich G, Kostura M, Marshak DR, Mathews MB and Stillman B (1987) Functional identity of proliferating cell nuclear antigen and a DNA polymerase delta auxiliary protein. Nature 326 471-475
    • (1987) Nature , vol.326 , pp. 471-475
    • Prelich, G.1    Kostura, M.2    Marshak, D.R.3    Mathews, M.B.4    Stillman, B.5
  • 129
    • 0028985932 scopus 로고
    • Abrogation of the G2 checkpoint results in differential radiosensitization of G1 checkpoint-deficient and competent cells
    • Russell KJ, Wiens LW, Galloway DA and Groudine M (1995) Abrogation of the G2 checkpoint results in differential radiosensitization of G1 checkpoint-deficient and competent cells. Cancer Research 55 1639-1642
    • (1995) Cancer Research , vol.55 , pp. 1639-1642
    • Russell, K.J.1    Wiens, L.W.2    Galloway, D.A.3    Groudine, M.4
  • 130
    • 0029665852 scopus 로고    scopus 로고
    • Crystal structure of the p27Kip1 cyclin-dependent kinase inhibitor bound to the cyclin A-CDK2 complex
    • Russo AA, Jeffrey PD, Patten A, Massague J and Pavletich NP (1996) Crystal structure of the p27Kip1 cyclin-dependent kinase inhibitor bound to the cyclin A-CDK2 complex. Nature 382 325-331
    • (1996) Nature , vol.382 , pp. 325-331
    • Russo, A.A.1    Jeffrey, P.D.2    Patten, A.3    Massague, J.4    Pavletich, N.P.5
  • 131
    • 0029057336 scopus 로고
    • A single ataxia telangiectasia gene with a product similar to PI-3 kinase
    • Savitsky K, Bar-Shira A, Gilad S et al(1995) A single ataxia telangiectasia gene with a product similar to PI-3 kinase. Science 268 1749-1753
    • (1995) Science , vol.268 , pp. 1749-1753
    • Savitsky, K.1    Bar-Shira, A.2    Gilad, S.3
  • 132
    • 0020411735 scopus 로고
    • Cell cycle dependence of mitotic delay in X-irradiated normal and ataxia-telangiectasia fibroblasts
    • Scott D and Zampetti-Bosseler F (1982) Cell cycle dependence of mitotic delay in X-irradiated normal and ataxia-telangiectasia fibroblasts. International Journal of Radiation Biology 42 679-683
    • (1982) International Journal of Radiation Biology , vol.42 , pp. 679-683
    • Scott, D.1    Zampetti-Bosseler, F.2
  • 133
    • 0027058705 scopus 로고
    • Chromosome condensation caused by loss of RCC1 function requires the cdc25C protein that is located in the cytoplasm
    • Seki T, Yamashita K, Nishitani H, Takagi T, Russel P and Nishimoto T (1992) Chromosome condensation caused by loss of RCC1 function requires the cdc25C protein that is located in the cytoplasm. Molecular Biology of the Cell 3 1373-1388
    • (1992) Molecular Biology of the Cell , vol.3 , pp. 1373-1388
    • Seki, T.1    Yamashita, K.2    Nishitani, H.3    Takagi, T.4    Russel, P.5    Nishimoto, T.6
  • 134
    • 0028238213 scopus 로고
    • Immediate early up-regulation of bax expression by p53 but not TGFβl: A paradigm for distinct apoptotic pathways
    • Selvakumaran M, Lin HK, Miyashita T et al(1994) Immediate early up-regulation of bax expression by p53 but not TGFβl: a paradigm for distinct apoptotic pathways. Oncogene 9 1791-1798
    • (1994) Oncogene , vol.9 , pp. 1791-1798
    • Selvakumaran, M.1    Lin, H.K.2    Miyashita, T.3
  • 135
    • 0028171292 scopus 로고
    • G1 phase progression: Cycling on cue
    • Sherr CJ (1994) G1 phase progression: cycling on cue. Cell 79 551-555
    • (1994) Cell , vol.79 , pp. 551-555
    • Sherr, C.J.1
  • 136
    • 0028868432 scopus 로고
    • Wild-type human p53 transactivates the human proliferating cell nuclear antigen promoter
    • Shivakumar CV, Brown DR, Deb S and Deb SP (1995) Wild-type human p53 transactivates the human proliferating cell nuclear antigen promoter. Molecular and Cellular Biology 15 6785-6793
    • (1995) Molecular and Cellular Biology , vol.15 , pp. 6785-6793
    • Shivakumar, C.V.1    Brown, D.R.2    Deb, S.3    Deb, S.P.4
  • 137
    • 0026546407 scopus 로고
    • Proliferating cell nuclear antigen is required for nucleotide excision repair
    • Shivji MK, Kenny MK and Wood RD (1992) Proliferating cell nuclear antigen is required for nucleotide excision repair. Cell 69 367-374
    • (1992) Cell , vol.69 , pp. 367-374
    • Shivji, M.K.1    Kenny, M.K.2    Wood, R.D.3
  • 138
    • 0028177401 scopus 로고
    • P53-dependent G1 arrest involves pRb-related proteins and is disrupted by the human papillomavirus 16 E7 oncoprotein
    • Slebos RJC, Lee MH, Plunkett B et al(1994) p53-dependent G1 arrest involves pRb-related proteins and is disrupted by the human papillomavirus 16 E7 oncoprotein. Proceedings of the National Academy of Sciences of the USA 91 5320-5324
    • (1994) Proceedings of the National Academy of Sciences of the USA , vol.91 , pp. 5320-5324
    • Slebos, R.J.C.1    Lee, M.H.2    Plunkett, B.3
  • 139
    • 0027893001 scopus 로고
    • Loss of a p53-associated G1 checkpoint does not decrease cell survival following DNA damage
    • Slichenmyer WJ, Nelson WG, Slebos RJ and Kastan MB (1993) Loss of a p53-associated G1 checkpoint does not decrease cell survival following DNA damage. Cancer Research 53 4164-4168
    • (1993) Cancer Research , vol.53 , pp. 4164-4168
    • Slichenmyer, W.J.1    Nelson, W.G.2    Slebos, R.J.3    Kastan, M.B.4
  • 140
    • 0028569767 scopus 로고
    • Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen
    • Smith ML, Chen IT, Zhan Q, et al(1994) Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen. Science 266 1376-1380
    • (1994) Science , vol.266 , pp. 1376-1380
    • Smith, M.L.1    Chen, I.T.2    Zhan, Q.3
  • 141
    • 0028919069 scopus 로고
    • Involvement of the p53 tumor suppressor in repair of u.v.-type DNA damage
    • Smith ML, Chen IT, Zhan Q, O'Connor PM and Fornace AJ Jr (1995) Involvement of the p53 tumor suppressor in repair of u.v.-type DNA damage. Oncogene 10 1053-1059
    • (1995) Oncogene , vol.10 , pp. 1053-1059
    • Smith, M.L.1    Chen, I.T.2    Zhan, Q.3    O'Connor, P.M.4    Fornace A.J., Jr.5
  • 142
    • 0029818965 scopus 로고    scopus 로고
    • Antisense GADD45 expression results in decreased DNA repair and sensitizes cells to UV-irradiation or cisplatin
    • Smith ML, Kotny HU, Zhan Q, Sreenath A, O'Connor PM and Fornace AJ Jr (1996) Antisense GADD45 expression results in decreased DNA repair and sensitizes cells to UV-irradiation or cisplatin. Oncogene 13 2255-2263
    • (1996) Oncogene , vol.13 , pp. 2255-2263
    • Smith, M.L.1    Kotny, H.U.2    Zhan, Q.3    Sreenath, A.4    O'Connor, P.M.5    Fornace A.J., Jr.6
  • 143
    • 0026567896 scopus 로고
    • S-phase feedback control in budding yeast independent of tyrosine phosphorylation of p34Cdc28
    • Sorger PK and Murray AW (1992) S-phase feedback control in budding yeast independent of tyrosine phosphorylation of p34Cdc28. Nature 355 365-367
    • (1992) Nature , vol.355 , pp. 365-367
    • Sorger, P.K.1    Murray, A.W.2
  • 144
    • 0028813528 scopus 로고
    • Evidence for a second cell cycle block at G2/M by p53
    • Stewart N, Hicks GG, Paraskeas F and Mowat M (1995) Evidence for a second cell cycle block at G2/M by p53. Oncogene 10 109-115
    • (1995) Oncogene , vol.10 , pp. 109-115
    • Stewart, N.1    Hicks, G.G.2    Paraskeas, F.3    Mowat, M.4
  • 145
    • 0028128954 scopus 로고
    • Differential expression and regulation of cyclin D1 protein in normal and tumor human cells: Association with Cdk4 is required for cyclin D1 function in G1 progression
    • Tam S W, Theodoras AM, Shay JW, Draetta GF and Pagano M (1994) Differential expression and regulation of cyclin D1 protein in normal and tumor human cells: association with Cdk4 is required for cyclin D1 function in G1 progression. Oncogene 9 2663-2674
    • (1994) Oncogene , vol.9 , pp. 2663-2674
    • Tam, S.W.1    Theodoras, A.M.2    Shay, J.W.3    Draetta, G.F.4    Pagano, M.5
  • 146
    • 0029014496 scopus 로고
    • Requirement for tyrosine phosphorylation of Cdk4 in G1 arrest induced by ultraviolet light
    • Terada Y, Tatsuka M, Jinno S and Okayama H (1995) Requirement for tyrosine phosphorylation of Cdk4 in G1 arrest induced by ultraviolet light. Nature 376 358-362
    • (1995) Nature , vol.376 , pp. 358-362
    • Terada, Y.1    Tatsuka, M.2    Jinno, S.3    Okayama, H.4
  • 147
    • 0028363519 scopus 로고
    • P27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21
    • Toyoshima H and Hunter T (1994) p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21. Cell 78 67-74
    • (1994) Cell , vol.78 , pp. 67-74
    • Toyoshima, H.1    Hunter, T.2
  • 148
    • 0028352434 scopus 로고
    • The p21 inhibitor of cyclin-depndent kinases controls DNA replication by interacting with PCNA
    • Waga S, Hannon GJ, Beach D and Stillman B (1994) The p21 inhibitor of cyclin-depndent kinases controls DNA replication by interacting with PCNA. Nature 369 574-578
    • (1994) Nature , vol.369 , pp. 574-578
    • Waga, S.1    Hannon, G.J.2    Beach, D.3    Stillman, B.4
  • 149
    • 0028034199 scopus 로고
    • Myc-mediated apoptosis requires wild-type p53 in a manner independent of cell cycle arrest and the ability of p53 to induce p21Waf1/Cip1
    • Wagner AJ, Kokontis J M and Hay N (1994) Myc-mediated apoptosis requires wild-type p53 in a manner independent of cell cycle arrest and the ability of p53 to induce p21Waf1/Cip1. Genes and Development 8 2817-2830
    • (1994) Genes and Development , vol.8 , pp. 2817-2830
    • Wagner, A.J.1    Kokontis, J.M.2    Hay, N.3
  • 150
    • 0028849274 scopus 로고
    • P21 is necessary for the p53-mediated G1 arrest in human cancer cells
    • Waldman T, Kinzler KW and Vogelstein B (1995) p21 is necessary for the p53-mediated G1 arrest in human cancer cells. Cancer Research 55 5187-5190
    • (1995) Cancer Research , vol.55 , pp. 5187-5190
    • Waldman, T.1    Kinzler, K.W.2    Vogelstein, B.3
  • 154
    • 0028989236 scopus 로고
    • P53 modulation of TFIIH associated nucleotide excision repair activity
    • Wang XW, Yeh H, Schaeffer L et al( 1995) p53 modulation of TFIIH associated nucleotide excision repair activity. Nature Genetics 10 188-195
    • (1995) Nature Genetics , vol.10 , pp. 188-195
    • Wang, X.W.1    Yeh, H.2    Schaeffer, L.3
  • 155
    • 0029033861 scopus 로고
    • The retinoblastoma protein and cell cycle control
    • Weinberg RA (1995) The retinoblastoma protein and cell cycle control. Cell 81 323-330
    • (1995) Cell , vol.81 , pp. 323-330
    • Weinberg, R.A.1
  • 156
    • 0023712476 scopus 로고
    • The RAD9 gene controls the cell cycle response to DNA damage in Saccharomyces cerevisiae
    • Weinert TA and Hartwell LH (1988) The RAD9 gene controls the cell cycle response to DNA damage in Saccharomyces cerevisiae. Science 241 317-322
    • (1988) Science , vol.241 , pp. 317-322
    • Weinert, T.A.1    Hartwell, L.H.2
  • 159
    • 0026459047 scopus 로고
    • D type cyclins associate with multiple protein kinases and the DNA replication and repair factor PCNA
    • Xiong Y, Zhang H and Beach D (1992) D type cyclins associate with multiple protein kinases and the DNA replication and repair factor PCNA. Cell 71 505-514
    • (1992) Cell , vol.71 , pp. 505-514
    • Xiong, Y.1    Zhang, H.2    Beach, D.3
  • 160
    • 0030008450 scopus 로고    scopus 로고
    • Two S phase checkpoint systems, one involving the function of both BIME and Tyr15 phosphorylation of p34Cdc2, inhibit NIMA and prevent premature mitosis
    • Ye XS, Fincher RR, Tang A, O'Donnell KO and Osmani SA (1996) Two S phase checkpoint systems, one involving the function of both BIME and Tyr15 phosphorylation of p34Cdc2, inhibit NIMA and prevent premature mitosis. EMBO Journal 15 3599-3610
    • (1996) EMBO Journal , vol.15 , pp. 3599-3610
    • Ye, X.S.1    Fincher, R.R.2    Tang, A.3    O'Donnell, K.O.4    Osmani, S.A.5
  • 161
    • 0026801977 scopus 로고
    • Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles
    • Yin Y, Tainsky MA, Bischoff FZ, Strong LC and Wahl GM (1992) Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles. Cell 70 937-948
    • (1992) Cell , vol.70 , pp. 937-948
    • Yin, Y.1    Tainsky, M.A.2    Bischoff, F.Z.3    Strong, L.C.4    Wahl, G.M.5
  • 162
    • 0025784539 scopus 로고
    • Wild-type p53 induces apoptosis of myeloid leukemic cells that is inhibited by interleukin-6
    • Yonish-Rouach E, Resnitzky D, Lotem J, Sachs L, Kimchi A and Oren M (1991) Wild-type p53 induces apoptosis of myeloid leukemic cells that is inhibited by interleukin-6. Nature 352 345-347
    • (1991) Nature , vol.352 , pp. 345-347
    • Yonish-Rouach, E.1    Resnitzky, D.2    Lotem, J.3    Sachs, L.4    Kimchi, A.5    Oren, M.6
  • 163
    • 0029973738 scopus 로고    scopus 로고
    • Role for c-Abl tyrosine kinase in growth arrest response to DNA damage
    • Yuan Z-M, Huang Y, Whang Y et al(1996) Role for c-Abl tyrosine kinase in growth arrest response to DNA damage. Nature 382 272-274
    • (1996) Nature , vol.382 , pp. 272-274
    • Yuan, Z.-M.1    Huang, Y.2    Whang, Y.3
  • 164
    • 0029127643 scopus 로고
    • ATM-related genes: What do they tell us about functions of the human gene?
    • Zakian RV (1995) ATM-related genes: what do they tell us about functions of the human gene? Cell 82 685-687
    • (1995) Cell , vol.82 , pp. 685-687
    • Zakian, R.V.1
  • 165
    • 0027234492 scopus 로고
    • A comparison of the biological activities of wild-type and mutant p53
    • Zambetti GP and Levine AJ (1993) A comparison of the biological activities of wild-type and mutant p53. FASEB Journal 7 855-65
    • (1993) FASEB Journal , vol.7 , pp. 855-865
    • Zambetti, G.P.1    Levine, A.J.2
  • 166
    • 0019506288 scopus 로고
    • Cell death, chromosome damage and mitotic delay in normal human, ataxia telangiectasia and retinoblastoma fibroblasts after X-irradiation
    • Zampetti-Bosseler F and Scott D (1981) Cell death, chromosome damage and mitotic delay in normal human, ataxia telangiectasia and retinoblastoma fibroblasts after X-irradiation. International Journal of Radiation Biology 39 547-558
    • (1981) International Journal of Radiation Biology , vol.39 , pp. 547-558
    • Zampetti-Bosseler, F.1    Scott, D.2
  • 167
    • 0027944228 scopus 로고
    • Induction of bax by genotoxic stress in human cells correlates with normal p53 status and apoptosis
    • Zhan Q, Fan S, Bae I et al(1994) Induction of bax by genotoxic stress in human cells correlates with normal p53 status and apoptosis. Oncogene 9 3743-51
    • (1994) Oncogene , vol.9 , pp. 3743-3751
    • Zhan, Q.1    Fan, S.2    Bae, I.3
  • 168
    • 0029801085 scopus 로고    scopus 로고
    • The apoptosis-associated γ-ray response of BCL-XL depends on normal p53 function
    • Zhan Q, Alamo I, Yu K et al(1996) The apoptosis-associated γ-ray response of BCL-XL depends on normal p53 function. Oncogene 13 2287-2293
    • (1996) Oncogene , vol.13 , pp. 2287-2293
    • Zhan, Q.1    Alamo, I.2    Yu, K.3
  • 169
    • 0028169236 scopus 로고
    • P21-containing complexes exist both in active and inactive states
    • Zhang H, Hannon GJ and Beach D (1994) p21-containing complexes exist both in active and inactive states. Genes and Development 8 1750-1758
    • (1994) Genes and Development , vol.8 , pp. 1750-1758
    • Zhang, H.1    Hannon, G.J.2    Beach, D.3


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