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Volumn 42, Issue , 1998, Pages

Clinical pharmacology of UCN-01: Initial observations and comparison to preclinical models

Author keywords

Protein kinase antagonist; Staurosporine, 7 hydroxy; 1 Acidic glycoprotein

Indexed keywords

7 HYDROXYSTAUROSPORINE;

EID: 0031672099     PISSN: 09439404     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002800051080     Document Type: Conference Paper
Times cited : (83)

References (13)
  • 1
    • 0026425587 scopus 로고
    • Antitumor activity of UCN-01, a selective inhibitor of protein kinase C, in murine and tumor models
    • Akinaga S, Gomi K, Morimoto M, Tamaoki T, Okabe M (1991) Antitumor activity of UCN-01, a selective inhibitor of protein kinase C, in murine and tumor models. Cancer Res 51:4888
    • (1991) Cancer Res , vol.51 , pp. 4888
    • Akinaga, S.1    Gomi, K.2    Morimoto, M.3    Tamaoki, T.4    Okabe, M.5
  • 2
    • 0030615323 scopus 로고    scopus 로고
    • Gi phase accumulation induced by UCN-01 is associated with dephosphorylation of Rb and CDK2 proteins as well as induction of CDK inhibitor p21/Cip1/WAF1/ Sdi1 in p53-mutated human epidermoid carcinoma A431 cells
    • Akiyama T, Yoshida T, Tetsuya T, Shimizu M, Mizukami T, Okabe M, Akinaga S (1997) Gi phase accumulation induced by UCN-01 is associated with dephosphorylation of Rb and CDK2 proteins as well as induction of CDK inhibitor p21/Cip1/WAF1/ Sdi1 in p53-mutated human epidermoid carcinoma A431 cells. Cancer Res 57:1495
    • (1997) Cancer Res , vol.57 , pp. 1495
    • Akiyama, T.1    Yoshida, T.2    Tetsuya, T.3    Shimizu, M.4    Mizukami, T.5    Okabe, M.6    Akinaga, S.7
  • 3
    • 0029992520 scopus 로고    scopus 로고
    • Enhancement of cisplatin-induced cytotoxicity by 7-hydroxystaurosporine (UCN-01), a new 62-checkpoint inhibitor
    • Bunch RT, Eastman A (1996) Enhancement of cisplatin-induced cytotoxicity by 7-hydroxystaurosporine (UCN-01), a new 62-checkpoint inhibitor. Clin Cancer Res 2:791
    • (1996) Clin Cancer Res , vol.2 , pp. 791
    • Bunch, R.T.1    Eastman, A.2
  • 4
    • 0030811613 scopus 로고    scopus 로고
    • 7-hydroxystaurosporine (UCN-01) causes redistribution of proliferating cell nuclear antigen and abrogates cisplatin-induced S-phase arrest in Chinese hamster ovary cells
    • Bunch RT, Eastman A (1997) 7-hydroxystaurosporine (UCN-01) causes redistribution of proliferating cell nuclear antigen and abrogates cisplatin-induced S-phase arrest in Chinese hamster ovary cells. Cell Growth Differ 7:779
    • (1997) Cell Growth Differ , vol.7 , pp. 779
    • Bunch, R.T.1    Eastman, A.2
  • 5
    • 0027970385 scopus 로고
    • Disposition in mice of 7-hydroxystaurosporine, a protein kinase inhibitor with antitumor activity
    • Hill DL, Tillery KF, Rose LM, Posey CF (1994) Disposition in mice of 7-hydroxystaurosporine, a protein kinase inhibitor with antitumor activity. Cancer Chemother Pharmacol 35:89
    • (1994) Cancer Chemother Pharmacol , vol.35 , pp. 89
    • Hill, D.L.1    Tillery, K.F.2    Rose, L.M.3    Posey, C.F.4
  • 6
    • 0023690101 scopus 로고
    • Drug binding to human alpha-1-acid glycoprotein in health and disease
    • Kremer JMH, Wilting J, Janssen LHM (1988) Drug binding to human alpha-1-acid glycoprotein in health and disease. Pharmacol Rev 40:1
    • (1988) Pharmacol Rev , vol.40 , pp. 1
    • Kremer, J.M.H.1    Wilting, J.2    Janssen, L.H.M.3
  • 8
    • 0027157590 scopus 로고
    • Cell cycle arrest and growth inhibition by the protein kinase antagonist UCN-01 in human breast carcinoma cells
    • Seynaeve CM, Stetler-Stevenson M, Sebers S, Kaur G, Sausville EA, Worland PJ (1993) Cell cycle arrest and growth inhibition by the protein kinase antagonist UCN-01 in human breast carcinoma cells. Cancer Res 53:2081
    • (1993) Cancer Res , vol.53 , pp. 2081
    • Seynaeve, C.M.1    Stetler-Stevenson, M.2    Sebers, S.3    Kaur, G.4    Sausville, E.A.5    Worland, P.J.6
  • 11
    • 0000288599 scopus 로고    scopus 로고
    • Safety testing of antitumor agents
    • Sipes IG, Gandolf AJ, McQueen CA (eds) Pergamon, New York
    • Tomaszewski JE, Smith AC (1997) Safety testing of antitumor agents. In Sipes IG, Gandolf AJ, McQueen CA (eds) Comprehensive toxicology, vol 2. Pergamon, New York, p 299
    • (1997) Comprehensive Toxicology , vol.2 , pp. 299
    • Tomaszewski, J.E.1    Smith, A.C.2
  • 12
    • 0028990479 scopus 로고
    • Apoptosis in 7-hydroxy-staurosporine-treated T lymphoblasts correlates with activation of cyclin-dependent kinases 1 and 2
    • Wang Q, Worland PJ, Clark JL, Carlson, BA, Sausville EA (1995) Apoptosis in 7-hydroxy-staurosporine-treated T lymphoblasts correlates with activation of cyclin-dependent kinases 1 and 2. Cell Growth Differ 6:927
    • (1995) Cell Growth Differ , vol.6 , pp. 927
    • Wang, Q.1    Worland, P.J.2    Clark, J.L.3    Carlson, B.A.4    Sausville, E.A.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.