B-cell activation by T-cell-independent type 2 antigens as an integral part of the humoral immune response to pathogenic microorganisms

Immunological Reviews

Volumn 176, Issue , 2000, Pages 154-170

  Vos, Q ^a   Lees, A ^a   Wu, Z Q ^a   Snapper, C M ^a   Mond, J J ^a  

^a UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

B LYMPHOCYTE RECEPTOR; BACTERIUM LIPOPOLYSACCHARIDE; COMPLEMENT COMPONENT C3D RECEPTOR; CYTOKINE; IMMUNOGLOBULIN M ANTIBODY; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; PROTEIN TYROSINE KINASE; T LYMPHOCYTE ANTIGEN; T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; ANTIGEN EXPRESSION; B LYMPHOCYTE; DENDRITIC CELL; ENZYME ACTIVATION; HUMORAL IMMUNITY; IMMUNE RESPONSE; MACROPHAGE; MAJOR HISTOCOMPATIBILITY COMPLEX RESTRICTION; MOUSE; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION; T LYMPHOCYTE;

EID: 0033822039     PISSN: 01052896     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1600-065X.2000.00607.x     Document Type: Review

References (271)

1. The protective or curative element in type b H. influenzae rabbit serum
2. Polysaccharide vaccines as probes of antibody repertoires in man
3. Clinical efficacy of meningococcus group A capsular polysaccharide vaccine in children three months to five years of age
4. Tetravalent (A, C, W, 135) meningocococcal vaccine in children: Immunogenicity and safety
5. Reexamination of the protective role of the capsular polysaccharide (Vi antigen) of Salmonella typhi
6. Protective activity of Vi capsular polysaccharide vaccine against typhoid fever
7. Immunogenicity and immunochemistry of Streptococcus pneumoniae capsular polysaccharide
8. Anti-polysaccharide immunoglobulin isotype levels and opsonic activity of antisera: Relationship with protection against Streptococcus pneumoniae infection in mice
9. The relationship between antigenic structure and the requirement for thymus-derived cells in the immune reponse
10. Studies on the immunogenicity and tolerogenicity of T-independent antigens
11. The ontogeny of thymic independent antibody responses in vitro in normal mice and in mice with an X-linked B cell defect
12. Genetic control of the antibody response to type 3 pneumococcal polysaccharide in mice. I. Evidence that an X-linked gene plays a decisive role in determining responsiveness
13. Colocalization of X-linked agammaglobulinemia and X-linked immunodeficiency genes
14. Mutation of unique region of Bruton's tyrosine kinase in immunodeficient XID mice
15. Correction of the X-linked immunodeficiency phenotype by transgenic expression of human Bruton tyrosine kinase under the control of the class II major histocompatibility complex Ea locus control region
16. A Btk transgene restores the antiviral TI-2 antibody response of xid mice in a dose-dependent fashion
17. Defective B cell development and function in Btk-deficient mice
18. Impaired expansion of mouse B cell progenitors lacking Btk
19. T-independent responses in B cell defective CBA/N mice to Brucella abortus and to trinitrophenyl (TNP) conjugates of Brucella abortus
20. Thymus-independent antigens: Complexity or B-lymphocyte activation revealed
21. T cell-independent antigens type 2
22. T cell independent antigens
23. A model for the induction of T cell-independent humoral immunity to polysaccharide antigen
24. The influence of antigen organization on B cell responsiveness
25. T helper cell-independent neutralizing B cell response against vesicular stomatitis virus: Role of antigen patterns in B cell induction?
26. T-independent activation of B cells by vesicular stomatitis virus: No evidence for the need of a second signal
27. Neutralizing antiviral B cell responses
28. Thymus-independence of slowly metabolized immunogens
29. Role of epitope density in the induction of immunity and tolerance with thymus-independent antigens. I. Studies with 2,4-dinitrophenyl conjugates in vitro
30. Role of epitope density in the induction of immunity and tolerance with thymus-independent antigens. II. Studies with 2,4-dinitrophenyl conjugates in vivo
31. Analysis of B cell activation with TNP-conjugated polyacrylamide beads
32. T-cell-independent immunoglobulin G responses in vivo are elicited by live-virus infection but not by immunization with viral proteins or virus-like particles
33. Picogram quantities of anti-Ig antibodies coupled to dextran induce B cell proliferation
34. Molecular determinants of immungenicity: The immunon model of immune response
35. Model for the binding of multivalent antigen to cells
36. Photobleaching recovery studies of antigen-specific mouse lymphocyte stimulation by DNP-conjugated polymerized flagellin
37. Specific cellular stimulation in the primary immune response: Experimental test of a quantized model
38. Paradoxes in B-cell stimulation by polymeric antigen and the immunon concept
39. Equilibrium binding of multivalent antigen to cells: Effects of cell and receptor density
40. Immunons revisited: Binding of multivalent antigen to B cells
41. The magnitude of signal amplification by ligand-induced receptor clustering
42. Membrane IgM-mediated signaling of human B cells. Effect of increased ligand binding site valency on the affinity and concentration requirements for inducing diverse stages of activation
43. Antigens varying in affinity for the B cell receptor induce differential B lymphocyte responses
44. Configurations of polymeric antigen adsorbed to a B-cell membrane
45. Genetic analysis of B cell antigen receptor signaling
46. Signal transduction from the B cell antigen-receptor
47. T cell-dependent B cell activation
48. A role for lipid rafts in B cell antigen receptor signaling and antigen targeting
49. Distinct p53/56(lyn) and p59(fyn) domains associate with nonphosphorylated and phosphorylated Ig-α
50. Signal transduction by lymphocyte antigen receptors
51. Protein tyrosine kinases in the intitiation of antigen receptor signaling
52. Temporal differences in the activation of three classes of non-transmembrane protein tyrosine kinases following B-cell antigen receptor surface engagement
53. Activation of Btk by a phosphorylation mechanism initiated by Src family kinases
54. Transphosphorylation of Bruton's tyrosine kinase on tyrosine 551 is critical for B cell antigen receptor function
55. Comparison of tyrosine kinase activation by mitogenic and nonmitogenic anti-IgD antibodies
56. Phosphatidylinositol 3-kinase-γ activates Bruton's tyrosine kinase in concert with Src family kinases
57. Activation of phosphatidylinositol-3' kinase by Src-family kinase SH3 binding to the p85 subunit
58. Phosphorylation of CD19 Y484 and Y515, and linked activation of phosphatidylinositol 3-kinase, are required for B cell antigen receptor-mediated activation of Bruton's tyrosine kinase
59. 2+ mobilization
60. In situ detection of activated Bruton's tyrosine kinase in the Ig signaling complex by phosphopeptide-specific monoclonal antibodies
61. Redistribution of Bruton's tyrosine kinase by activation of phosphatidylinositol 3-kinase and rho-family GTPases
62. Distinct specificity in the recognition of phosphoinositides by the pleckstrin homology domains of dynamin and Bruton's tyrosine kinase
63. Surface immunoglobuiln-mediated B-cell activation in the absence of detectable elevations in intracellular ionized calcium: A model for T-cell-independent B-cell activation
64. Absence of demonstrable phospholipid turnover in B cells stimulated by low mitogenic concentrations of dextran-anti-immunoglobulin conjugates
65. Increased phosphatidylinositol metabolism is an important but not an obligatory event in B lymphocyte activation
66. Btk function in B cell development and response
67. A role for Bruton's tyrosine kinase in B cell antigen receptor-mediated activation of phospholipase C-γ2
68. 2+ following B-cell receptor activation
69. Bruton's tyrosine kinase controls a sustained calcium signal essential for B lineage development and function
70. Regulation of B cell survival in xid mice by the proto-oncogene bcI-2
71. Role of the inositol phosphatase SHIP in negative regulation of the immune system by the receptor Fc-γ-RIIB
72. Hematopoietic cell phosphatase is recruited to CD22 following B cell antigen receptor ligation
73. Polygenic autoimmune traits: Lyn, CD22, and SHP-1 are limiting elements of a biochemical pathway regulating BCR signaling and selection
74. Deletion of SHIP or SHP-1 reveals two distinct pathways for inhibitory signaling
75. 2+ mobilzation is integrated by CD19 dephosphorylation
76. SHIP modulates immune receptor responses by regulating membrane association of Btk
77. Co-receptors on B lymphocytes
78. Persistent calcium elevation correlates with the induction of surface immunoglobulin-mediated B cell DNA synthesis
79. 2+ response amplitude and duration
80. Calcium oscillations increase the efficiency and specificity of gene expression
81. Dextran-conjugated anti-Ig antibodies as a model for T cell-independent type 2 antigen-mediated stimulation of Ig secretion in vitro. I. Lymphokine dependence
82. The liquid scintillation counter as an analogy for the distinction between 'self' and 'not-self' in immunological systems
83. Minimal model for the mechanism of antibody induction and paralysis by antigen
84. The wisdom of hindsight
85. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity
86. Approaching the asymptote? Evolution and revolution in immunology
87. Innate immunity: The virtues of a nonclonal system of recognition
88. Drosophila host defense: Differential induction of antimicrobial peptide genes after infection by various classes of microorganisms
89. The 18-wheeler mutation reveals complex antibacterial gene regulation in Drosophila host defense
90. Cloning and characterization of two Toll/interleukin-1 receptor-like genes TIL3 and TIL4: Evidence for a multigene receptor family in humans
91. A family of human receptors structurally related to Drosophila Toll
92. TLR6: A novel member of an expanding toll-like receptor family
93. The role of complement and complement receptors in induction and regulation of immunity
94. B lymphocyte differentiaition induced by lipopolysaccharide. I. Generation of cells synthesizing four major immunoglobulin classes
95. Cyclic development of immunological memory to bacterial lipopolysaccharide
96. B cell memory to thymus-independent antigens type 1 and type 2: The role of lipopolysaccharide in B memory induction
97. CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein
98. Receptor-dependent mechanisms of cell stimulation by bacterial endotoxin
99. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: Mutations in Tlr4 gene
100. Endotoxin-tolerant mice have mutations in Toll-like receptor 4 (Tlr4)
101. Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: Evidence for TLR4 as the Lps gene product
102. Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components
103. Toll-like receptor-4 mediates lipopolysaccharide-induced signal transduction
104. Human toll-like receptor 2 confers responsiveness to bacterial lipopolysaccharide
105. Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signaling
106. Signaling events induced by lipopolysaccharide-activated toll-like receptor 2
107. Host defense mechanisms triggered by microbial lipoproteins through Toll-like receptors
108. Cell activation and apoptosis by bacterial lipoproteins through Toll-like receptor-2
109. MyD88: An adapter that recruits IRAK to the IL-1 receptor complex
110. MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways
111. TRAF6 is a signal transducer for interleukin-1
112. The human toll signaling pathway: Divergence of nuclear factor κB and JNK/SAPK activation upstream of tumor necrosis factor receptor-associated factor 6 (TRAF6)
113. MAP3K-related kinase involved in NF-κB induction by TNF, CD95 and IL-1
114. Differential regulation of IκB kinase α and β by two upstream kinases, NF-κB-inducing kinase and mitogen-activated protein kinase/ERK kinase kinase-1
115. B lymphocyte differentiation induced by lipopolysaccharide. II1. Suppression of B cell maturation by anti-mouse immunoglobulin antibodies
116. B cell differentiation induced by lipopolysaccharide. V. Suppression of plasma cell maturation by anti-μ: Mode of action and characteristics of suppressed cells
117. Neisserial porins may provide critical second signals to polysaccharide-activated murine B cells for induction of immunoglobulin secretion
118. Inflammatory signaling by Borrelia burgdorferi lipoproteins is mediated by Toll-like receptor 2
119. Bacterial lipoproteins may substitute for cytokines in the humoral immune response to T cell-independent type II antigens
120. Major outer membrane protein of Neisseria gonorrhoeae forms channels in lipid bilayer membranes
121. Polyclonal activation of routine B lymphocytes in vitro by Salmonella typhimurium porins
122. Neisserial porins induce B lymphocytes to express costimulatory B7-2 molecules and to proliferate
123. Immune activation by bacterial DNA: A new genetic code
124. CpG motifs in bacterial DNA trigger direct B-cell activation
125. Bacterial CpG DNA activates immune cells to signal infectious danger
126. Multivalent cross-linking of membrane Ig sensitizes murine B cells to a broader spectrum of CpG-containing oligodeoxynudeotide motifs, including their methylated counterparts, for stimulation of proliferation and Ig secretion
127. Molecular organization and function of the complement system
128. Immunobiology of CR2, the B lymphocyte receptor for Epstein-Barr virus and the C3d complement fragment
129. Complement receptor 2 in the regulation of the immune response
130. Cells in the marginal zone of the spleen
131. Human marginal-zone B cells
132. Human marginal zone B cells are not an activated B cell subset: Strong expression of CD21 as a putative mediator for rapid B cell activation
133. IgM(high)CD21(high) lymphocytes enriched in the splenic marginal zone generate effector cells more rapidly than the bulk of follicular B cells
134. Cells of the marginal zone of the spleen are lymphocytes derived from recirculating precursors
135. The origin of marginal zone B cells in the rat
136. Marginal zones: The major B cell compartment of rat spleen
137. In vitro complement-dependent binding and in vivo kinetics of pneumocococcal polysacchazide TI-2 antigens in the rat spleen marginal zone and follicle
138. Human immune response to pneumococcal polysaccharides: Complement-mediated localization preferentially on CD21-positive splenic marginal zone B cells and follicular dendritic cells
139. Analysis of thymus-independent type 2 antigen uptake by marginal zone macrophages in thin slices of viable lymphoid tissue in vitro
140. The generation of memory cells. I. The role of C3 in the generation of B memory cells
141. Role of C3 in immunity. Defective antibody production in C3-deficient dogs
142. Inhibition of immunological memory and T-independent humoral responses by monoclonal antibodies specific for murine complement receptors
143. Pneumococcal polysaccharides complexed with C3d bind to human B lymphocytes via complement receptor 2
144. Complement-mediated follicular localization of T-independent type-2 antigens: The role of marginal zone macrophages revisited
145. T-independent type 2 antigens induce B cell proliferation in multiple splenic sites, but exponential growth is confined to extrafollicular foci
146. Comparative in vitro analysis of proliferation, Ig secretion, and Ig class switching by murine marginal zone and follicular B cells
147. Marginal zone B cells exhibit unique activation, proliferative and immunoglobulin secretory responses
148. Intersection between the complement and immune sytems: A signal transduction complex of the B lymphocyte containing complement receptor type 2 and CD19
149. The CD19/CD21 signal transducing complex of human B lymphocytes includes the target of antiproliferative antibody-1 and Leu-13 molecules
150. Regulation of B lymphocyte development and activation by the CD19/CD21/CD81/Leu 13 complex requires the cytoplasmic domain of CD19
151. The CD19-CD21 complex regulates signal transduction thresholds governing humoral immunity and autoimmunity
152. Normal lymphocyte development but delayed humoral immune response in CD81-null mice
153. Normal development but differentially altered proliferative responses of lymphocytes in mice lacking CD81
154. Impaired CD19 expression and signaling, enhanced antibody response to type II T independent antigen and reduction of B-1 cells in CD81-deficient mice
155. CD81 on B cells promotes interleukin 4 secretion and antibody production during T helper type 2 immune responses
156. Synergistic interaction between complement receptor type 2 and membrane IgM on B lymphocytes
157. Signal transduction in human B cells by crosslinking of complement receptor 2 (CR2) and simultaneous crosslinking of CR2 and surface IgM (sIgM)
158. CD19: Lowering the threshold for antigen receptor stimulation of B lymphocytes
159. The affinity threshold for human B cell acivation via the antigen receptor complex is reduced upon co-ligation of the antigen receptor with CD21 (CR2)
160. CD19 as a membrane-anchored adaptor protein of B lymphocytes: Costimulation of lipid and protein kinases by recruitment of Vav
161. CD19 amplifies B lymphocyte signal transduction by regulating Src-family protein tyrosine activation
162. C3d of complement as a molecular adjuvant: Bridging innate and acquired immunity
163. Enhanced and sustained activation of human B cells by anti-immunoglobulin conjugated to the EBV glycoprotein gp350
164. Abnormal B lymphocyte development activation and differentiation in mice that lack or overexpress the CD19 signal transduction molecule
165. Impairment of T-cell-dependent B-cell responses and B-1 cell development in CD19-deficient mice
166. The CD19 signal transduction molecule is a response regulator of B-lymphocyte diffrentiation
167. Antiviral protection and germinal center formation, but impaired B cell memory in the absence of CD19
168. Disruption of the Cr2 locus results in a reduction in B-1a cells and in an impaired B cell response to T-dependent antigen
169. Evidence for an important interaction between a complement-derived CD21 ligand on follicular dendritic cells and CD21 on B cells in the initiation of IgG responses
170. Protective T cell-independent antiviral antibody responses are dependent on complement
171. CD22 a B lymphocyte-specific adhesion molecule that regulates antigen receptor signaling
172. CD22 is both a positive and negative regulator of B lymphocyte antigen receptor signal transduction: Altered signaling in CD22-deficient mice
173. CD19 and CD22 expression reciprocally regulates tyrosine phosphorylation of Vav protein during B lymphocyte signaling
174. Counterregulation by the coreceptors CD19 and CD22 of MAP kinase activation by membrane immunoglobulin
175. Modulation of B lymphocyte antigen receptor signal transduction by a CD19/CD22 regulatory loop
176. Role of T lymphocytes in reponse to TNP-AECM-Ficoll
177. B lymphocyte responses to trinitrophenyl-conjugated Ficoll: Requirement for T lymphocyte and Ia bearing adherent cells
178. T cell control of the antibody response to the T independent antigen DAGG-Ficoll
179. Characterization of helper T cells induced by the type 2 antigen polyvinylpyrrolidone (PVP)
180. In vitro activation of specific helper and suppressor T cells by the type 2 antigen polivinylpyrrolidone (PVP)
181. Lymphokine control of type 2 antigen response: IL-10 inhibits IL-5- but not IL-2-induced Ig secretion by T cell-independent antigens
182. Induction of IgG3 secretion by interferon γ: A model for T cell-independent class switching in response to T cell-independent type 2 antigens
183. IL-3 and granulocyte-macrophage colony-stimulating factor strongly induce Ig secretion by sort-purified murine B cells activated through the membrane Ig, but not the CD40, signaling pathway
184. IL-10 selectively regulates routine isotype switching
185. IFN-γ is a potent inducer of Ig secretion by sort-purified murine B cells activated through the mIg, but not the CD40, signaling pathway
186. The immune response in CD40-deficient mice: Impaired immunoglobulin class switching and germinal center formation
187. Mice deficient for the CD40 ligand
188. Multivalent, but not divalent, antigen receptor cross-linkers synergize with CD40 ligand for induction of Ig synthesis and class switching in normal murine B cells. A redefinition of the TI-2 versus T cell-dependent antigen dichotomy
189. Enhancement of T cell-independent immune responses in vivo by CD40 antibodies
190. Anti-CD40 antibody enhances responses to polysaccharide without mimicking T cell help
191. In vivo polysaccharide-specific IgG isotype responses to intact Streptococcus pneumoniae are T cell dependent and require CD40- and B7-ligand interactions
192. Requirement for B cell-derived immunoglobulin for T(H) activation by the type 2 antigen polyvinylpyrrolidone
193. Towards a network theory of the immune system
194. Processing and presentation of idiotypes to MHC-restricted T cells
195. Establishment of idiotypic helper T-cell repertoires early in life
196. Mice whose B cells cannot produce the T15 idiotype also lack an antigen-specific helper T cell required for T15 expression
197. The antibody response to specific immune complexes is under genetic control and correlates with the expression of a recurrent idiotype
198. 4+ T cells in vivo
199. Antigen valence determines the binding of nominal antigen to cytolytic T cell clones
200. The interaction of nominal antigen with T cell antigen receptors. I. Specific binding of multivalent nominal antigen to cytolytic T cell clones
201. Direct evidence for the existence of nominal antigen binding sites on T cell surface Ti α-β heterodimers of MHC-restricted T cell clones
202. Major histocompatibility complex independent T cell receptor-antigen interaction: Functional analysis using fluorescein derivatives
203. Inhibition or activation of human T cell receptor transfectants is controlled by defined, soluble antigen arrays
204. Site of specific B cell activation in primary and secondary responses to T cell-dependent and T cell independent antigens
205. Viral superantigen drives extrafollicular and follicular B cell differentiation leading to virus-specific antibody production
206. T helper 1 (Th1) and Th2 characteristics start to develop during T cell priming and are associated with an immediate ability to induce Ig class switching
207. Recognition by γ/δ T cells
208. Phosphate is essential for stimulation of Vγ9Vδ2 T lymphocytes by mycobacterial low molecular weight ligand
209. Stimulation of human γδ T cells by nonpeptidic mycobacterial ligands
210. Interferon γ-producing γδ T cell-dependent antibody isotype switching in the absence of germinal center formation during virus infection
211. Mouse CD1-specific NK1 T cells: Development, specificity, and function
212. Natural ligand of mouse CD1d1: Cellular glycosylphosphatidylinositol
213. CD1d-mediated recognition of an α-galactosylceramide by natural killer T cells is highly conserved through mammalian evolution
214. CD1d-restricted recognition of synthetic glycolipid antigens by human natural killer T cells
215. CD1-mediated immune responses to glycolipids
216. CD1d-restricted immunoglobulin G formation to GPI-anchored antigens mediated by NKT cells
217. Activation of NKT cells by Cd1d and α-galatosylceramide directs conventional T cells to the acquisition of a Th2 phenotype
218. CD4(pos), NK1.1(pos) T cells promptly produce interleukin 4 in response to in vivo challenge with anti-CD3
219. Th1 versus Th2 cytokine profile determines the modulation of in vitro T cell independent type 2 responses by IL-4
220. IL4 is not required for proliferative responses in B cells stimulated with anti-IgD-dextran conjugates even under limiting conditions of cell-cell interaction
221. Natural killer cells in antiviral defense: Function and regulation by innate cytokines
222. A T cell-independent mechanism of macrophage activation by interferon-γ
223. Regulation of gamma interferon production by natural killer cells in scid mice: Roles of tumor necrosis factor and bacterial stimuli
224. Human large granular lymphocytes induce immunoglobulin synthesis after bone marrow transplantation
225. The role of NK cells during in vivo antigen-specific antibody responses
226. NK cell receptors
227. Natural killer cell receptors
228. + NK cells with H-2D(d) target cells leads to Dap-12 phosphorylation and IFN-γ secretion
229. Oligodeoxynucleotides containing palindrome sequences with internal 5'-CpG-3' act directly on human NK and activated T cells to induce IFN-γ production in vitro
230. Comparison of the effects of interleulkin-1α, interleukin-1β, and interferon-γ-inducing factor on the production of interferon-γ by natural killer cells
231. Natural killer (NK) cells as a responder to interleukin 2 (IL-2). II. IL-2 induced interferon γ production
232. Induction of interferon γ production by natural killer cell stimulatory factor: Characterization of the responder cells and synergy with other inducers
233. Endogenous production of interleukin 15 by activated human monocytes is critical for optimal production of interferon-γ by natural killer cells in vitro
234. Purification of a factor which provides a costimulatory signal for γ interferon production
235. Regulation of B lymphocytes by natural killer cells. Role of IFN-γ
236. Productive interactions between B and natural killer cells
237. Interactions between B lymphocytes and NK cells
238. Regulation of IFN-γ mRNA production in murine natural killer cells
239. IL-12 enhances antibody responses to T-independent polysaccharide vaccines in the absence of T and NK cells
240. The effect of NK cell activation by tumor cells on antigen-specific antibody-responses
241. Human natural killer cell clones enhance in vitro antibody production by tumour necrosis factor α and γ interferon
242. Activation of B lymphocytes by NK cells
243. Activated human NK cells can stimulate resting B cells to secrete immunoglobulin
244. Natural killer cells induce activated murine B cells to secrete Ig
245. An in vitro model for T-cell-independent induction of humoral immunity. A requirement for NK cells
246. Phenotypic and functional characterization of a panel of cytotoxic murine NK clones that are heterogeneous in their enhancement of Ig secretion in vitro
247. Heterogeneity in the ability of cytotoxic murine NK cell clones to enhance Ig secretion in vitro
248. Bacteria and bacterial cell wail constituents induce the production of regulatory cytokines in dendritic cell clones
249. In vivo microbial stimulation induces rapid CD40 ligand-independent production of interleukin 12 by dendritic cells and their redistribution to T cell areas
250. Dendritic cell activation induced by various stimuli, e.g. exposure to microorganisms, their products, cytokines, and simple chemicals as well as adhesion to extracellular matrix
251. Bacterial DNA and immunostimulatory CpG oligonucleotides trigger maturation and activation of murine dendritic cells
252. Oligodeoxynucleotides containing CpG motifs induce IL-12, IL-18 and IFN-γ production in cells from allergic individuals and inhibit IgE secretion in vitro
253. CpG DNA: A potent signal for growth, activation, and maturation of human dendritic cells
254. Presence of bacterial flora-derived antigen in synovial tissue macrophages and dendritic cells
255. Follicular dendritic cell-dependent adhesion and proliferation of B cells in vitro
256. 2
257. Involvement of mannose receptor in cytokine interleukin-1β (IL-1 β), IL-6, and granulocyte-macrophage colony-stimulating factor responses, but not in chemokine macrophage inflammatory protein 1β (MIP-1β), MIP-2, and KC responses, caused by attachment of Candida albicans to macrophages
258. Streptococcal histone induces murine macrophages to produce interleukin-1 and tumor necrosis facto α
259. Preferentially the r-stereoisomer of the mycosomal lipopeptide macrophage-activating lipopeptide-2 activates immune cells through a Toll-like receptor 2- and MyD88-dependent signaling pathway
260. Macrophages ingest and are activated by bacterial DNA
261. IFN-γ primes macrophage responses to bacterial DNA
262. The actions of bacterial DNA on murine macrophages
263. Differential regulation of the IL-12 p40 promoter and of p40 secretion by CpG DNA and lipopolysaccharide
264. Cell type-specific activation of mitogen-activated protein kinases by CpG-DNA controls interleukin-12 release from antigen-presenting cells
265. IL-6 production by rat peritoneal mast cells is not necessarily preceded by histamine release and can be induced by bacterial lipopolysaccharide
266. Mast cells in infection and immunity
267. Mast cells as sentinels of innate immunity
268. Rat peritoneal mast cells produce IFN-γ following IL-12 treatment but not in response to IgE-mediated activation
269. + cells at the site of antigen deposition predicts the development of a T helper 2 cell response to Schistosoma mansoni eggs
270. Schistosoma mansoni egg-induced early IL-4 production is dependent upon IL-5 and eosinophils
271. Human basophils release interleukin-4 after stimulation with Schistosoma mansoni egg antigen