Natural killer cell receptors

Current Opinion in Immunology

Volumn 10, Issue 3, 1998, Pages 298-305

  Yokoyama, Wayne M ^a  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL RECEPTOR; IMMUNOGLOBULIN RECEPTOR; LECTIN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1;

NATURAL KILLER CELL; REVIEW;

EID: 0031860633     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0952-7915(98)80168-4     Document Type: Article

References (83)

1. Yokoyama WM. Recognition structures on natural killer cells. Curr Opin Immunol. 5:1993;67-73.
2. Kärre K. Role of target histocompatibility antigens in regulation of natural killer activity: a re-evaluation and a hypothesis. Herberman RB, Callewaert DM. Mechanisms of Cytotoxicity by NK Cells. 1985;81-103 Academic Press, Orlando.
3. Yokoyama WM. The mother-child union: the case of missing-self and protection of the fetus. of special interest Proc Natl Acad Sci USA. 94:1997;5998-6000 A review of HLA-G and natural killer cells, and how they may be involved in maternal tolerance for the fetus.
4. Reyburn HT, Mandelboim O, Vales-Gomez M, Davis DM, Pazmany L, Strominger JL. The class I MHC homologue of human cytomegalovirus inhibits attack by natural killer cells. of outstanding interest Nature. 386:1997;514-517 Together with Farrell et al., 1997 [5] and Cosman et al., 1997 [6], this paper demonstrates that natural killer (NK) cells can specifically recognize an open reading frame in cytomegalovirus that encodes an MHC-class-I-like heavy chain. Viruses also suppress host class I expression. The viral MHC class I homolog can inhibit NK cell activity and allow the virus to evade the host immune response, indicating that subversion of NK cells is an important viral evasion strategy and highlighting the role of NK cells in anti-pathogen defense.
5. Farrell HE, Vally H, Lynch DM, Fleming P, Shellam GR, Scalzo AA, Davis-Poynter NJ. Inhibition of natural killer cells by a cytomegalovirus MHC class I homologue in vivo. of outstanding interest Nature. 386:1997;510-514 Together with Reyburn et al., 1997 [4] and Cosman et al., 1997 [6], this paper demonstrates that natural killer (NK) cells can specifically recognize an open reading frame in cytomegalovirus that encodes an MHC-class-I-like heavy chain. Viruses also suppress host class I expression. The viral MHC class I homolog can inhibit NK cell activity and allow the virus to evade the host immune response, indicating that subversion of NK cells is an important viral evasion strategy and highlighting the role of NK cells in anti-pathogen defense.
6. Cosman D, Fanger N, Borges L, Kubin M, Chin W, Peterson L, Hsu M-L. A novel immunoglobulin superfamily receptor for cellular and viral MHC class I molecules. of outstanding interest Immunity. 7:1997;273-282 Together with Reyburn et al., 1997 [4] and Farrell et al., 1997 [5], this paper demonstrates that natural killer (NK) cells can specifically recognize an open reading frame in cytomegalovirus that encodes an MHC-class-I-like heavy chain. Viruses also suppress host class I expression. The viral MHC class I homolog can inhibit NK cell activity and allow the virus to evade the host immune response, indicating that subversion of NK cells is an important viral evasion strategy and highlighting the role of NK cells in anti-pathogen defense.
7. Zhang BN, Yamamura T, Kondo T, Fujiwara M, Tabira T. Regulation of experimental autoimmune encephalomyelitis by natural killer (NK) cells. of outstanding interest J Exp Med. 186:1997;1677-1687 This demonstrates that NK cells are important in autoimmunity.
8. of special interest Parham P. NK cells, MHC class I antigens, and missing self. Immunol Rev. 155:1997;1-221 This is an entire issue devoted to natural killer (NK) cells and their receptors. See also the annotation to Yokoyama, 1997 [12].
9. Leibson PJ. Signal transduction during natural killer cell activation: inside the mind of a killer. of special interest Immunity. 6:1997;655-661 This paper and those in Parham, 1997 [8] and by Lanier, 1997 [10], Moretta, 1997 [11] and Yokoyama, 1997 [12] represent current reviews of natural killer (NK) cells that provide a comprehensive overview of this rapidly moving field.
10. Lanier LL. Natural killer cells: from no receptors to too many. of special interest Immunity. 6:1997;371-378 This paper and those in Parham, 1997 [8] and by Leibson, 1997 [9], Moretta, 1997 [11] and Yokoyama, 1997 [12] represent current reviews of natural killer (NK) cells that provide a comprehensive overview of this rapidly moving field.
11. Moretta A. Molecular mechanisms in cell-mediated cytotoxicity. of special interest Cell. 90:1997;13-18 This paper and those in Parham, 1997 [8] and by Leibson, 1997 [9], Lanier, 1997 [10] and Yokoyama, 1997 [12] represent current reviews of natural killer (NK) cells that provide a comprehensive overview of this rapidly moving field.
12. Yokoyama WM. What goes up must come down: The emerging spectrum of inhibitory receptors. of special interest J Exp Med. 186:1997;1803-1808 This paper and those in Parham, 1997 [8], Leibson, 1997 [9], Lanier, 1997 [10] and Moretta, 1997 [11] represent current reviews of natural killer (NK) cells that provide a comprehensive overview of this rapidly moving field.
13. Brown MG, Scalzo AA, Matsumoto K, Yokoyama WM. The natural killer gene complex - a genetic basis for understanding natural killer cell function and innate immunity. Immunol Rev. 155:1997;53-65.
14. Brown MG, Fulmek S, Matsumoto K, Cho R, Lyons PA, Levy ER, Scalzo AA, Yokoyama WM. A 2-Mb YAC contig and physical map of the natural killer gene complex on mouse chromosome 6. of outstanding interest Genomics. 42:1997;16-25 This describes the assembly of a YAC contig and physical mapping of the mouse natural killer gene complex, encompassing over 2 million base pairs.
15. Held W, Cado D, Raulet DH. Transgenic expression of the Ly49A natural killer cell receptor confers class I major histocompatibility complex (MHC)-specific inhibition and prevents bone marrow allograft rejection. of outstanding interest J Exp Med. 184:1996;2037-2041 This reports that transgenic expression of Ly49A confers MHC class I specificity and inhibitory function to NK cells, a formal proof of its function and specificity in vivo and in vitro.
16. Nakamura MC, Niemi EC, Fisher MJ, Shultz LD, Seaman WE, Ryan JC. Mouse Ly-49A interrupts early signaling events in natural killer cell cytotoxicity and functionally associates with the Shp-1 tyrosine phosphatase. of outstanding interest J Exp Med. 185:1997;673-684 The authors show that transfection of Ly49A confers MHC class I specificity and inhibitory function to a cloned NK cell line, a formal proof of its function and specificity in vitro.
17. Smith HRC, Karlhofer FM, Yokoyama WM. Ly-49 multigene family expressed by IL-2-activated NK cells. J Immunol. 153:1994;1068-1079.
18. Stoneman ER, Bennett M, An J, Chesnut KA, Wakeland EK, Scheerer JB, Siciliano MJ, Kumar V, Mathew PA. Cloning and characterization of 5E6(Ly-49C), a receptor molecule expressed on a subset of murine natural killer cells. J Exp Med. 182:1995;305-313.
19. Mason LH, Ortaldo JR, Young HA, Kumar V, Bennett M, Anderson SK. Cloning and functional characteristics of murine large granular lymphocyte-1: a member of the Ly-49 gene family (Ly-49G2). J Exp Med. 182:1995;293-303.
20. Brennan J, Lemieux S, Freeman JD, Mager DL, Takei F. Heterogeneity among Ly-49C natural killer (NK) cells - characterization of highly related receptors with differing functions and expression patterns. J Exp Med. 184:1996;2085-2090.
21. of special interest Salcedo M, Diehl AD, Olsson-Alheim MY, Sundback J, Van Kaer L, Karre K, Ljunggren HG. Altered expression of Ly49 inhibitory receptors on natural killer cells from MHC class I-deficient mice. of oustanding interest J Immunol. 158:1997;3174-3180 Important papers in the past year by Salcedo et al., 1997, Held and Raulet, 1997 [23], Fahlen et al., 1997 [24], and Johansson et al., 1997 [25] have evaluated the issue of natural killer (NK) cell education by MHC class I with regard to NK cell receptor expression and function.
22. Mason LH, Anderson SK, Yokoyama WM, Smith HRC, Winklerpickett R, Ortaldo JR. The Ly-49D receptor activates murine natural killer cells. of special interest J Exp Med. 184:1996;2119-2128 This reports that Ly-49 receptors also activate NK cells, despite previous descriptions of inhibitory forms.
23. of outstanding interest Held W, Raulet DH. Ly49A transgenic mice provide evidence for a major histocompatibility complex-dependent education process in natural killer cell development. of special interest J Exp Med. 185:1997;2079-2088 Important papers in the past year by Held and Raulet, 1997, Salcedo et al., 1997 [21], Fahlen et al., 1997 [24] and Johansson et al., 1997 [25] have evaluated the issue of natural killer (NK) cell education by MHC class I with regard to NK cell receptor expression and function.
24. of outstanding interest Fahlen L, Khoo NK, Daws MR, Sentman CL. Location-specific regulation of transgenic Ly49A receptors by major histocompatibility complex class I molecules. of special interest Eur J Immunol. 27:1997;2057-2065 Important papers in the past year by Fahlen et al., 1997, Salcedo et al., 1997 [21], Held and Raulet, 1997 [23] and Johansson et al., 1997 [25] have evaluated the issue of natural killer (NK) cell education by MHC class I with regard to NK cell receptor expression and function.
25. of outstanding interest Johansson MH, Bieberich C, Jay G, Karre K, Hoglund P. Natural killer cell tolerance in mice with mosaic expression of major histocompatibility complex class I transgene. of special interest J Exp Med. 186:1997;353-364 Important papers in the past year by Johansson et al., 1997, Salcedo et al., 1997 [21], Held and Raulet, 1997 [23] and Fahlen et al., 1997 [24] have evaluated the issue of natural killer (NK) cell education by MHC class I with regard to NK cell receptor expression and function.
26. Held W, Roland J, Raulet DH. Allelic exclusion of Ly49-family genes encoding class I MHC-specific receptors on NK cells. Nature. 376:1995;355-358.
27. Held W, Raulet DH. Expression of the Ly49A gene in murine natural killer cell clones is predominantly but not exclusively mono-allelic. of special interest Eur J Immunol. 27:1997;2876-2884 An important follow-up to Held et al., 1995 [26] demonstrating that 'allelic exclusion' of Ly49 receptor expression is apparently due to a stochastic process.
28. Lazetic S, Chang C, Houchins JP, Lanier LL, Phillips JH. Human natural killer cell receptors involved in MHC class I recognition are disulfide-linked heterodimers of CD94 and NKG2 subunits. J Immunol. 157:1996;4741-4745.
29. Plougastel B, Trowsdale J. Cloning of NKG2-F, a new member of the NKG2 family of human natural killer cell receptor genes. Eur J Immunol. 27:1997;2835-2839.
30. Houchins JP, Lanier LL, Niemi EC, Phillips JH, Ryan JC. Natural killer cell cytolytic activity is inhibited by NKG2-A and activated by NKG2-C. of special interest J Immunol. 158:1997;3603-3609 This is a demonstration that the cytoplasmic domains of NKG2-A or -C, respectively, mediate inhibition or activation of NK cell activity, implying that whichever chain partners CD94 is responsible for functional activity.
31. Moretta A, Vitale M, Sivori S, Bottino C, Morelli L, Augugliaro R, Barbaresi M, Pende D, Ciccone E, Lopez-Botet M, et al. Human natural killer cell receptors for HLA-class I molecules. Evidence that the Kp43 (CD94) molecule functions as receptor for HLA-B alleles. J Exp Med. 180:1994;545-555.
32. Sivori S, Vitale M, Bottino C, Marcenaro E, Sanseverino L, Parolini S, Moretta L, Moretta A. CD94 functions as a natural killer cell inhibitory receptor for different HLA class I alleles - identification of the inhibitory form of CD94 by the use of novel monoclonal antibodies. Eur J Immunol. 26:1996;2487-2492.
33. Phillips JH, Chang CW, Mattson J, Gumperz JE, Parham P, Lanier LL. CD94 and a novel associated protein (94ap) form a NK cell receptor involved in the recognition of HLA-A, HLA-B, and HLA-C allotypes. Immunity. 5:1996;163-172.
34. of special interest Braud VM, Allan DSJ, Wilson D, McMichael AJ. Tap- and tapasin-dependent HLA-E surface expression correlates with the binding of an MHC class I leader peptide. of outstanding interest Curr Biol. 8:1998;1-10 The reports of Braud et al., 1998 and of Lee et al., 1998 [35] demonstrate that HLA-E binds peptides derived from leader sequences of other HLA class I molecules, providing the basis for papers by Lee et al., 1998 [36], Borrego et al., 1998 [37] and Braud et al., 1998 [38].
35. of special interest Lee N, Goodlett DR, Ishitani A, Marquardt H, Geraghty DE. HLA-E surface expression depends on binding of TAP-dependent peptides derived from certain HLA class I sequences. of outstanding interest J Immunol. 1998; The reports of Lee et al., 1998, and Braud et al., 1998 [34] demonstrate that HLA-E binds peptides derived from leader sequences of other HLA class I molecules, providing the basis for papers by Lee et al. [36], Borrego et al., 1998 [37] and Braud et al., 1998 [38].
36. Lee N, Llano M, Carretero M, Ishitani A, Navarro F, López-Botet M, Geraghty DE. HLA-E is a major ligand for the NK inhibitory receptor CD94/NKG2A. of outstanding interest Proc Natl Acad Sci USA. 1998; This paper by Lee et al., 1998, and those of Borrego et al., 1998 [37], Braud et al., 1998 [38] and Carretero et al., 1998 [39] are very important and provocative studies demonstrating that CD94/NKG2A is specific for HLA-E, and binds HLA-E, resulting in inhibitory signaling. Since HLA-E requires the leader sequence of another MHC class I molecule in order to be expressed on the cell surface, the findings imply that CD94/NKG2A could simultaneously detect the contribution of two MHC class I molecules.
37. Borrego F, Ulbrecht M, Weiss EH, Coligan JE, Brooks AG. Recognition of human histocompatibility leukocyte antigen (HLA)-E complexed with HLA class I signal sequence-derived peptides by CD94/NKG2 confers protection from natural killer cell-mediated lysis. of outstanding interest J Exp Med. 187:1998;813-818 Papers by Borrego et al., 1998, Lee et al., 1998 [36], Braud et al., 1998 [38] and Carretero et al., 1998 [39] are very important and provocative studies demonstrating that CD94/NKG2A is specific for HLA-E, and binds HLA-E, resulting in inhibitory signaling. Since HLA-E requires the leader sequence of another MHC class I molecule in order to be expressed on the cell surface, the findings imply that CD94/NKG2A could simultaneously detect the contribution of two MHC class I molecules.
38. Braud VM, Allen DSJ, O'Callaghan CA, Söderström K, D'Andrea A, Ogg GS, Lazetic S, Young NT, Bell JI, Phillips JH, McMichael AJ. HLA-E binds to natural-killer-cell receptors CD94/NKG2A, B and C. of outstanding interest Nature. 391:1998;795-799 Papers by Braud et al., 1998, Lee et al., 1998 [36], Borrego et al., 1998 [37] and Carretero et al., 1998 [39] are very important and provocative studies demonstrating that CD94/NKG2A is specific for HLA-E, and binds HLA-E, resulting in inhibitory signaling. Since HLA-E requires the leader sequence of another MHC class I molecule in order to be expressed on the cell surface, the findings imply that CD94/NKG2A could simultaneously detect the contribution of two MHC class I molecules.
39. Carretero M, Palmieri G, Llano M, Tullio V, Santoni A, Geraghty DE, López-Botet M. Specific engagement of the CD94/NKG2-A killer inhibitory receptor by the HLA-E class lb molecule induces SHP-1 phosphatase recruitment to tyrosine-phosphorylated NKG2-A: evidence for receptor function in heterologous transfectants. of outstanding interest Eur J Immunol. 28:1998;1280-1291 Papers by Carretero et al., 1998, Lee et al., 1998 [36], Borrego et al., 1998 [37] and Braud et al., 1998 [38] are very important and provocative studies demonstrating that CD94/NKG2A is specific for HLA-E, and binds HLA-E, resulting in inhibitory signaling. Since HLA-E requires the leader sequence of another MHC class I molecule in order to be expressed on the cell surface, the findings imply that CD94/NKG2A could simultaneously detect the contribution of two MHC class I molecules.
40. Dissen E, Berg SF, Westgaard IH, Fossum S. Molecular characterization of a gene in the rat homologous to human CD94. of special interest Eur J Immunol. 27:1997;2080-2086 Papers by Dissen et al., 1997 and by Berg et al., 1998 [41], Vance et al., 1997 [42] and Ho et al., 1998 [43] demonstrate that rodents, already known to express and utilize Ly-49 receptors, also express the CD94 and NKG2 family of molecules. This increases the repertoire of lectin-like natural killer (NK) cell receptors in rodents.
41. Berg SF, Dissen E, Westgaard IH, Fossum S. Two genes in the rat homologous to human NKg2. of special interest Eur J Immunol. 28:1998;444-450 Papers by Berg et al., 1998 and by Dissen et al., 1997 [40], Vance et al., 1997 [42] and Ho et al., 1998 [43] demonstrate that rodents, already known to express and utilize Ly-49 receptors, also express the CD94 and NKG2 family of molecules. This increases the repertoire of lectin-like natural killer (NK) cell receptors in rodents.
42. Vance RE, Tanamachi DM, Hanke T, Raulet DH. Cloning of a mouse homolog Of CD94 extends the family of C-type lectins on murine natural killer cells. of special interest Eur J Immunol. 27:1997;3236-3241 Papers by Vance et al., 1997 and by Dissen et al., 1997 [40], Berg et al., 1998 [41] and Ho et al., 1998 [43] demonstrate that rodents, already known to express and utilize Ly-49 receptors, also express the CD94 and NKG2 family of molecules. This increases the repertoire of lectin-like natural killer (NK) cell receptors in rodents.
43. Ho E, Heusel JW, Brown MG, Matsumoto K, Yokoyama WM. Murine NKG2-D and CD94 are clustered within the natural killer complex and are expressed independently in NK cells. of special interest Proc Natl Acad Sci USA. 1998; Papers by Ho et al., 1998, and by Dissen et al., 1997 [40], Berg et al., 1998, [41] and Vance et al., 1997 [42] demonstrate that rodents, already known to express and utilize Ly-49 receptors, also express the CD94 and NKG2 family of molecules. This increases the repertoire of lectin-like natural killer (NK) cell receptors in rodents.
44. Houchins JP, Yabe T, McSherry C, Bach FH. DNA sequence analysis of NKG2, a family of related cDNA clones encoding type II integral membrane proteins on human natural killer cells. J Exp Med. 173:1991;1017-1020.
45. d, has a functional carbohydrate recognition domain. Immunity. 1:1994;785-792.
46. d. Chimeric MHC class I molecules were also analyzed with results demonstrating an apparent recognition of residues in the α1 and α2 domains of MHC class I.
47. d restricts the allelic specificity of the murine NK cell inhibitory receptor Ly-49A. of special interest J Immunol. 1998; This describes the analysis of Ly-49A recognition of exon-shuffled MHC class I molecules, suggesting binding to the α2 domain of the MHC.
48. Correa I, Raulet DH. Binding of diverse peptides to MHC class I molecules inhibits target cell lysis by activated natural killer cells. Immunity. 2:1995;61-71.
49. Orihuela M, Margulies DH, Yokoyama WM. The natural killer cell receptor Ly-49A recognizes a peptide-induced conformational determinant on its major histocompatibility complex class I ligand. Proc Natl Acad Sci USA. 93:1996;11792-11797.
50. Uhrberg M, Valiante NM, Shum BP, Shilling HG, Lienertweidenbach K, Corliss B, Tyan D, Lanier LL, Parham P. Human diversity in killer cell inhibitory receptor genes. of special interest Immunity. 7:1997;753-763 The authors show that KIR genes are polygenic and display allelic polymorphism.
51. Arm JP, Gurish MF, Reynolds DS, Scott HC, Gartner CS, Austen KF, Katz HR. Molecular cloning of gp49, a cell-surface antigen that is preferentially expressed by mouse mast cell progenitors and is a new member of the immunoglobulin superfamily. J Biol Chem. 266:1991;15966-15973.
52. Samaridis J, Colonna M. Cloning of novel immunoglobulin superfamily receptors expressed on human myeloid and lymphoid cells: structural evidence for new stimulatory and inhibitory pathways. of special interest Eur J Immunol. 27:1997;660-665 Papers by Samaridis and Colonna, 1997 and by Cella et al., 1997 [53], Meyaard et al., 1997 [54], Kubagawa et al., 1997 [55], Hayami et al., 1997 [56], Wagtmann et al., 1997 [57], Colonna et al., 1997 [58] and Kharitonenkov et al., 1997 [59] describe new molecules that are widely distributed and are probably inhibitory in the cases where it is not already demonstrated. Although the relationship between all of the molecules is under investigation, several are members of a gene complex that resemble the killer inhibitory receptor molecules.
53. Cella M, Dohring C, Samaridis J, Dessing M, Brockhaus M, Lanzavecchia A, Colonna M. A novel inhibitory receptor (ILT3) expressed on monocytes, macrophages, and dendritic cells involved in antigen processing. of special interest J Exp Med. 185:1997;1743-1751 Papers by Cella et al., 1997 and by Samaridis and Colonna, 1997 [52], Meyaard et al., 1997 [54], Kubagawa et al., 1997 [55], Hayami et al., 1997 [56], Wagtmann et al., 1997 [57], Colonna et al., 1997 [58] and Kharitonenkov et al., 1997 [59] describe new molecules that are widely distributed and are probably inhibitory in the cases where it is not already demonstrated. Although the relationship between all of the molecules is under investigation, several are members of a gene complex that resemble the killer inhibitory receptor molecules.
54. Meyaard L, Adema GJ, Chang C, Woollatt E, Sutherland GR, Lanier LL, Phillips JH. LAIR-1, a novel inhibitory receptor expressed on human mononuclear leukocytes. of special interest Immunity. 7:1997;283-290 Papers by Meyaard et al., 1997 and by Samaridis and Colonna, 1997 [52], Cella et al., 1997 [53], Kubagawa et al., 1997 [55], Hayami et al., 1997 [56], Wagtmann et al., 1997 [57], Colonna et al., 1997 [58] and Kharitonenkov et al., 1997 [59] describe new molecules that are widely distributed and are probably inhibitory in the cases where it is not already demonstrated. Although the relationship between all of the molecules is under investigation, several are members of a gene complex that resemble the killer inhibitory receptor molecules.
55. Kubagawa H, Burrows PD, Cooper MD. A novel pair of immunoglobulin-like receptors expressed by B cells and myeloid cells. of special interest Proc Natl Acad Sci USA. 94:1997;5261-5266 Papers by Kubagawa et al., 1997 and by Samaridis and Colonna, 1997 [52], Cella et al., 1997 [53], Meyaard et al., 1997 [54], Hayami et al., 1997 [56], Wagtmann et al., 1997 [57], Colonna et al., 1997 [58] and Kharitonenkov et al., 1997 [59] describe new molecules that are widely distributed and are probably inhibitory in the cases where it is not already demonstrated. Although the relationship between all of the molecules is under investigation, several are members of a gene complex that resemble the killer inhibitory receptor molecules.
56. Hayami K, Fukuta D, Nishikawa Y, Yamashita Y, Inui M, Ohyama Y, Hikida M, Ohmori H, Takai T. Molecular cloning of a novel murine cell-surface glycoprotein homologous to killer cell inhibitory receptors. of special interest J Biol Chem. 272:1997;7320-7327 Papers by Hayami et al., 1997 and by Samaridis and Colonna, 1997 [52], Cella et al., 1997 [53], Meyaard et al., 1997 [54], Kubagawa et al., 1997 [55], Wagtmann et al., 1997 [57], Colonna et al., 1997 [58] and Kharitonenkov et al., 1997 [59] describe new molecules that are widely distributed and are probably inhibitory in the cases where it is not already demonstrated. Although the relationship between all of the molecules is under investigation, several are members of a gene complex that resemble the killer inhibitory receptor molecules.
57. Wagtmann N, Rojo S, Eichler E, Mohrenweiser H, Long EO. A new human gene complex encoding the killer cell inhibitory receptors and related monocyte/macrophage receptors. of special interest Curr Biol. 7:1997;615-618 Papers by Wagtmann et al., 1997 and by Samaridis and Colonna, 1997 [52], Cella et al., 1997 [53], Meyaard et al., 1997 [54], Kubagawa et al., 1997 [55], Hayami et al., 1997 [56], Colonna et al., 1997 [58] and Kharitonenkov et al., 1997 [59] describe new molecules that are widely distributed and are probably inhibitory in the cases where it is not already demonstrated. Although the relationship between all of the molecules is under investigation, several are members of a gene complex that resemble the killer cell inhibitory receptor molecules.
58. Colonna M, Navarro F, Bellon T, Llano M, Garcia P, Samaridis J, Angman L, Cella M, Lopez-Botet M. A common inhibitory receptor for MHC class I molecules on human lymphoid and myelomonocytic cells. of special interest J Exp Med. 186:1997;1809-1818 Papers by Colonna et al., 1997 and by Samaridis and Colonna, 1997 [52], Cella et al., 1997 [53], Meyaard et al., 1997 [54], Kubagawa et al., 1997 [55], Hayami et al., 1997 [56], Wagtmann et al., 1997 [57] and Kharitonenkov et al., 1997 [59] describe new molecules that are widely distributed and are probably inhibitory in the cases where it is not already demonstrated. Although the relationship between all of the molecules is under investigation, several are members of a gene complex that resemble the killer inhibitory receptor molecules.
59. Kharitonenkov A, Chen Z, Sures I, Wang H, Schilling J, Ullrich A. A family of proteins that inhibit signalling through tyrosine kinase receptors. of special interest Nature. 386:1997;181-186 Papers by Karitonenkov et al., 1997 and by Samaridis and Colonna, 1997 [52], Cella et al., 1997 [53], Meyaard et al., 1997 [54], Kubagawa et al., 1997 [55], Hayami et al., 1997 [56], Wagtmann et al., 1997 [57] and Colonna et al., 1997 [58] describe new molecules that are widely distributed and are probably inhibitory in the cases where it is not already demonstrated. Although the relationship between all of the molecules is under investigation, several are members of a gene complex that resemble the killer inhibitory receptor molecules.
60. Valiante NM, Uhrberg M, Shilling HG, Lienertweidenbach K, Arnett KL, Dandrea A, Phillips JH, Lanier LL, Parham P. Functionally and structurally distinct NK cell receptor repertoires in the peripheral blood of two human donors. of special interest Immunity. 7:1997;739-751 Here, the MHC class I, killer inhibitory receptor and CD94/NKG2 molecules from two donors were molecularly characterized. Natural killer (NK) cell clones were derived and tested for expression of these receptors and for their capacity to be inhibited by MHC class I molecules. Nearly all clones could be inhibited by autologous MHC class I molecules. There were differences with regard to the predominant MHC class I receptor utilized. The data are consistent with the 'missing-self' hypothesis (see text).
61. Fan QR, Mosyak L, Winter CC, Wagtmann N, Long EO, Wiley DC. Structure of the inhibitory receptor for human natural killer cells resembles haematopoietic receptors. of outstanding interest Nature. 389:1997;96-100 This demonstrates that the crystal structure of a killer inhibitory receptor resembles that of cytokine receptors.
62. Winter CC, Long EO. A single amino acid in the p58 killer cell inhibitory receptor controls the ability of natural killer cells to discriminate between the two groups of HLA-C allotypes. of special interest J Immunol. 158:1997;4026-4028 This is a mutagenesis study that corroborates the crystal structure described by Fan et al., 1997 [61].
63. Mandelboim O, Reyburn HT, Sheu EG, Vales-Gomez M, Davis DM, Pazmany L, Strominger JL. The binding site of NK receptors on HLA-C molecules. of outstanding interest Immunity. 6:1997;341-350 This demonstrates that the binding site of a killer inhibitory receptor is much larger than initially predicted from earlier work.
64. Mandelboim O, Wilson SB, Vales-Gomez M, Reyburn HT, Strominger JL. Self and viral peptides can initiate lysis by autologous natural killer cells. of special interest Proc Natl Acad Sci USA. 94:1997;4604-4609 Together with papers by Rajagopalan and Long, 1997 [65], Zappacosta et al., 1997 [66], Peruzzi et al., 1996 [67] and Mandelboim et al., 1996 [68], this study indicates that killer cell inhibitory receptors can apparently recognize MHC class I-bound peptides and apparently 'empty' MHC class I molecules.
65. Rajagopalan S, Long EO. The direct binding of a p58 killer cell inhibitory receptor to human histocompatibility leukocyte antigen (HLA)-Cw4 exhibits peptide selectivity. of special interest J Exp Med. 185:1997;1523-1528 Together with papers by Mandelboim et al., 1997 [64], Zappacosta et al., 1997 [66], Peruzzi et al., 1996 [67] and Mandelboim et al., 1996 [68], this study indicates that killer cell inhibitory receptors can apparently recognize MHC class I-bound peptides and apparently 'empty' MHC class I molecules.
66. Zappacosta F, Borrego F, Brooks AG, Parker KC, Coligan JE. Peptides isolated from HLA-Cw*0304 confer different degrees of protection from natural killer cell-mediated lysis. of special interest Proc Natl Acad Sci USA. 94:1997;6313-6318 Together with papers by Mandelboim et al., 1997 [64], Rajagolopalan and Long, 1997 [65], Peruzzi et al., 1996 [67] and Mandelboim et al., 1996 [68], this study indicates that killer cell inhibitory receptors can apparently recognize MHC class I-bound peptides and apparently 'empty' MHC class I molecules.
67. Peruzzi M, Wagtmann N, Long EO. A p70 killer cell inhibitory receptor specific for several HLA-B allotypes discriminates among peptides bound to HLA-B-asterisk-2705. of special interest J Exp Med. 184:1996;1585-1590 Together with papers by Mandelboim et al., 1997 [64], Rajagopalan and Long, 1997 [65], Zappacosta et al., 1997 [66] and Mandelboim et al., 1996 [68], this study indicates that killer cell inhibitory receptors can apparently recognize MHC class I-bound peptides and apparently 'empty' MHC class I molecules.
68. Mandelboim O, Reyburn HT, Valesgomez M, Pazmany L, Colonna M, Borsellino G, Strominger JL. Protection from lysis by natural killer cells of group 1 and 2 specificity is mediated by residue 80 in human histocompatibility leukocyte antigen C alleles and also occurs with empty major histocompatibility complex molecules. of special interest J Exp Med. 184:1996;913-922 Together with papers by Mandelboim et al., 1997 [64], Rajagopalan and Long, 1997 [65], Zappacosta et al., 1997 [66] and Peruzzi et al., 1996 [67], this study indicates that killer cell inhibitory receptors can apparently recognize MHC class I-bound peptides and apparently 'empty' MHC class I molecules.
69. Binstadt BA, Brumbaugh KM, Dick CJ, Scharenberg AM, Williams BL, Colonna M, Lanier LL, Kinet JP, Abraham RT, Leibson PJ. Sequential involvement of LCK and SHP-1 with MHC-recognizing receptors on NK cells inhibits FcR-initiated tyrosine kinase activation. of special interest Immunity. 5:1996;629-638 This demonstrates that Lck may be the enzyme responsible for phosphorylating the immunoreceptor tyrosine-based inhibitory motif when the inhibitory receptor is engaged.
70. Ono M, Bolland S, Tempst P, Ravetch JV. Role of the inositol phosphatase SHIP in negative regulation of the immune system by the receptor Fc(gamma)RIIB. Nature. 383:1996;263-266.
71. Gupta N, Scharenberg AM, Burshtyn DN, Wagtmann N, Lioubin MN, Rohrschneider LR, Kinet JP, Long EO. Negative signaling pathways of the killer cell inhibitory receptor and Fc-gamma-RIIb1 require distinct phosphatases. of outstanding interest J Exp Med. 186:1997;473-478 This paper, together with Ono et al., 1997 [72] demonstrates differences in phosphatase recruitment by different immunoreceptor tyrosine-based inhibitory motifs.
72. Ono M, Okada H, Bolland S, Yanagi S, Kurosaki T, Ravetch JV. Deletion of SHIP or SHP-1 reveals two distinct pathways for inhibitory signaling. of outstanding interest Cell. 90:1997;293-301 This paper, together with Gupta et al., 1997 [71] demonstrates differences in phosphatase recruitment by different immunoreceptor tyrosine-based inhibitory motifs.
73. Moretta A, Sivori S, Vitale M, Pende D, Morelli L, Augugliaro R, Bottino C, Moretta L. Existence of both inhibitory (p58) and activatory (p50) receptors for HLA-C molecules in human natural killer cells. J Exp Med. 182:1995;875-884.
74. Mandelboim O, Davis DM, Reyburn HT, Valesgomez M, Sheu EG, Pazmany L, Strominger JL. Enhancement of class II-restricted T cell responses by costimulatory NK receptors for class I MHC proteins. Science. 274:1996;2097-2100.
75. Ryan JC, Niemi EC, Nakamura MC, Seaman WE. NKR-P1A is a target-specific receptor that activates natural killer cell cytotoxicity. J Exp Med. 181:1995;1911-1915.
76. lck may be important in NKR-P1 signaling.
77. of special interest Olcese L, Cambiaggi A, Semenzato G, Bottino C, Moretta A, Vivier E. Human killer cell activatory receptors for MHC class I molecules are included in a multimeric complex expressed by natural killer cells. of outstanding interest J Immunol. 158:1997;5083-5086 This paper, together with Lanier et al., 1998 [78], describes a new chain that contains an immunoreceptor tyrosine-based activation motif that is associated with activating isoforms of killer inhibitory receptor molecules. This finding strongly suggests that, like antigen receptors on B and T cells, the natural killer cell activation receptor is also in a multichain complex.
78. of outstanding interest Lanier LL, Cortiss BC, Wu J, Leong C, Phillips JH. Immunoreceptor DAP12 bearing a tyrosine-based activation motif is involved in activating NK cells. of special interest Nature. 391:1998;703-707 This paper, together with Olcese et al., 1997 [77], describes a new chain that contains an immunoreceptor tyrosine-based activation motif that is associated with activating isoforms of killer inhibitory receptor molecules. This finding strongly suggests that, like antigen receptors on B and T cells, the natural killer cell activation receptor is also in a multichain complex.
79. Brumbaugh KM, Binstadt BA, Billadeau DD, Schoon RA, Dick CJ, Ten RM, Leibson PJ. Functional role for syk tyrosine kinase in natural killer cell-mediated natural cytotoxicity. of outstanding interest J Exp Med. 186:1997;1965-1974 This reports that Syk may play a critical role in NK cell activation.
80. + T cells. of outstanding interest J Exp Med. 186:1997;1957-1963 The authors show that activation receptors on NK cells may utilize strategies similar to that which have been described for signaling receptors on other cells.
81. Valiante NM, Phillips JH, Lanier LL, Parham P. Killer cell inhibitory receptor recognition of HLA class I blocks formation of a PP36/PLC-γ signaling complex in human NK cells. of special interest J Exp Med. 184:1996;2243-2250 This shows inhibition of natural killer (NK) cells is proximal to pp36 phosphorylation.
82. Zhang WG, Sloanlancaster J, Kitchen J, Trible RP, Samelson LE. LAT - the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation. of outstanding interest Cell. 92:1998;83-92 This report, together with that of Weber et al., 1998 [83] describes the molecular cloning of the long sought-after pp36 molecule and its function as an adaptor molecule.
83. Weber JR, rstavik S, Torgersen KM, Danbolt NC, Berg SF, Ryan JC, Tasken K, Imboden JB, Vaaget JT. Molecular cloning of the cDNA encoding pp36, a tyrosine-phosphorylated adaptor protein selectively expressed by T cells and natural killer cells. of outstanding interest J Exp Med. 187:1998;1157-1161 This report, together with that of Zhang et al., 1998 [82] describes the molecular cloning of the long sought-after pp36 molecule and its function as an adaptor molecule.