IL-12 enhances antibody responses to T-independent polysaccharide vaccines in the absence of T and NK cells

Journal of Immunology

Volumn 161, Issue 10, 1998, Pages 5525-5533

  Buchanan, Renee M ^a   Arulanandam, Bernard P ^a   Metzger, Dennis W ^a  

^a MEDICAL COLLEGE OF OHIO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,4 DINITROPHENOL; ALUMINUM POTASSIUM SULFATE; FICOLL; FREUND ADJUVANT; GAMMA INTERFERON; IMMUNOGLOBULIN G2A; IMMUNOLOGICAL ADJUVANT; MENINGOCOCCUS VACCINE; OVALBUMIN; PNEUMOCOCCUS VACCINE; POLYSACCHARIDE VACCINE; RECOMBINANT INTERLEUKIN 12;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIBODY RESPONSE; ARTICLE; CELLULAR IMMUNODEFICIENCY; COMPLEMENT FIXATION; CONTROLLED STUDY; IMMUNOSTIMULATION; INTRAPERITONEAL DRUG ADMINISTRATION; KNOCKOUT MOUSE; NATURAL KILLER CELL; NEISSERIA MENINGITIDIS; NONHUMAN; OPSONIZATION; PRIORITY JOURNAL; STREPTOCOCCUS PNEUMONIAE; T LYMPHOCYTE;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; ANTIBODIES, BACTERIAL; ANTIBODY FORMATION; ANTIGENS, T-INDEPENDENT; BACTERIAL VACCINES; DINITROPHENOLS; FICOLL; HAPTENS; IMMUNOGLOBULIN G; INTERFERON TYPE II; INTERFERON-ALPHA; INTERLEUKIN-12; KILLER CELLS, NATURAL; LYMPHOPENIA; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, INBRED CBA; MICE, KNOCKOUT; MICE, TRANSGENIC; NEISSERIA MENINGITIDIS; OVALBUMIN; PNEUMOCOCCAL VACCINES; POLYSACCHARIDES, BACTERIAL; STREPTOCOCCUS PNEUMONIAE; T-LYMPHOCYTES;

EID: 0032533813     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (33)

1. Bondada, S., and M. Garg. 1994. Thymus-independent antigens. In Handbook of B and T Lymphocytes. E. C. Snow, ed. Academic Press, San Diego, p. 343.
2. Laman, J. D., and E. Claassen. 1996. T-cell-independent and T-cell-dependent humoral immunity. In Cytokine Regulation of Humoral Immunity: Basic and Clinical Aspects. C. M. Snapper, ed. John Wiley & Sons, New York, p. 23.
3. Peeters, C. C., A. M. Tenbergen-Meekes, J. T. Poolman, M. Beurret, B. J. Zegers, and G. T. Rijkers. 1991. Effect of carrier priming on immunogenicity of saccharide-protein conjugate vaccines. Infect. Immun. 59:3504.
4. Seppala, I., J. Pelkonen, and O. Makela. 1985. Isotypes of antibodies induced by plain dextran or a dextran-protein conjugate. Eur. J. Immunol. 15:827.
5. Trinchieri, G. 1995. Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. Annu. Rev. Immunol. 13:251.
6. McKnight, A. J., G. J. Zimmer, I. Fogelman, S. F. Wolf, and A. K. Abbas. 1994. Effects of IL-12 on helper T cell-dependent immune responses in vivo. J. Immunol. 152:2172.
7. Morris, S. C., K. B. Madden, J. J. Adamovicz, W. C. Gause, B. R. Hubbard, M. K. Gately, and F. D. Finkelman. 1994. Effects of IL-12 on in vivo cytokine gene expression and Ig isotype selection. J. Immunol. 152:1047.
8. Germann, T., M. Bongartz, H. Dlugonska, H. Hess, E. Schmitt, L. Kolbe, E. Kolsch, F. J. Podlaski, M. K. Gately, and E. Rude. 1995. Interleukin-12 profoundly up-regulates the synthesis of antigen-specific complement-fixing IgG2a, IgG2b and IgG3 antibody subclasses in vivo. Eur. J. Immunol. 25:823.
9. Buchanan, J. M., L. A. Vogel, V. H. Van Cleave, and D. W. Metzger. 1995. Interleukin 12 alters the isotype-restricted antibody response of mice to hen egg-white lysozyme. Int. Immunol. 7:1519.
10. Wynn, T. A., A. Reynolds, S. James, A. W. Cheever, P. Caspar, S. Hieny, D. Jankovic, M. Strand, and A. Sher. 1996. IL-12 enhances vaccine-induced immunity to schistosomes by augmenting both humoral and cell-mediated immune responses against the parasite. J. Immunol. 157:4068.
11. Bliss, J., V. Van Cleave, K. Murray, A. Wiencis, M. Ketchum, R. Maylor, T. Haire, C. Resmini, A. K. Abbas, and S. F. Wolf. 1996. IL-12, as an adjuvant, promotes a T helper 1 cell, but does not suppress a T helper 2 cell recall response. J. Immunol. 156:887.
12. Snapper, C. M., T. M. McIntyre, R. Mandler, L. M. T. Pecanha, F. D. Finkelman, A. Lees, and J. J. Mond. 1992. Induction of IgG3 secretion by interferon γ a model for T cell-independent class switching in response to T cell-independent type 2 antigens. J. Exp. Med. 175:1367.
13. Metzger. D. W., R. M. McNutt, J. T. Collins, J. M. Buchanan, V. H. Van Cleave, and W. A. Dunnick. 1997. Interleukin-12 acts as an adjuvant for humoral immunity through interferon-γ-dependent and -independent mechanisms. Eur. J. Immunol. 27:1958.
14. Snapper, C. M., and W. E. Paul. 1987. Interferon-γ and B cell stimulatory factor-1 reciprocally regulate Ig isotype production. Science 236:944.
15. Collins, J. T., and W. A. Dunnick. 1993. Germline transcripts of the murine immunoglobulin γ2a gene: structure and induction by IFN-γ. Int. Immunol. 5:885.
16. Vogel, L. A., L. C. Showe, T. L. Lester, R. M. McNutt, V. H. Van Cleave, and D. W. Metzger. 1996. Direct binding of IL-12 to human and murine B lymphocytes. Int. Immunol. 8:1955.
17. Snapper, C. M., H. Yamaguchi, M. A. Moorman, and J. J. Mond. 1994. An in vitro model for T cell-independent induction of humoral immunity: a requirement for NK cells. J. Immunol. 152:4884.
18. Snapper, C. M., and J. J. Mond. 1996. A model for induction of T cell-independent humoral immunity in response to polysaccharide antigens. J. Immunol. 157: 2229.
19. Wilder, J. A., C. Y. Koh, and D. Yuan. 1996. The role of NK cells during in vivo antigen-specific antibody responses. J. Immunol. 156:146.
20. Buchanan, J. M., G. B. Humphrey, and D. W. Metzger. 1996. Biological properties and potential clinical applications of interleukin 12. Int. J. Pediatr. Hematol./Oncol. 3:123.
21. Trinchieri, G. 1994. Interleukin-12: a cytokine produced by antigen-presenting cells with immunoregulatory functions in the generation of T-helper cells type 1 and cytotoxic lymphocytes. Blood 84:4008.
22. Koh, C. Y., and D. Yuan. 1997. The effect of NK cell activation by tumor cells on antigen-specific antibody responses. J. Immunol. 159:4745.
23. Wang, B., C. Biron, J. She, K. Higgins, M. Sunshine, E. Lacy, N. Lonberg, and C. Terhorst. 1994. A block in both early T lymphocyte and natural killer cell development in transgenic mice with high-copy numbers in the human CD3E gene Proc. Natl. Acad. Sci. USA 91:9402.
24. Finkelman, F. D., A. Svetic, I. Gresser, C. Snapper, J. Holmes, P. P. Trotta, I. M. Katona, and W. C. Gause. 1991. Regulation by interferon-α of immunoglobulin isotype selection and lymphokine production in mice. J. Exp. Med. 174: 1179.
25. Westerink, M. A., D. W. Metzger, W. A. Hutchins, A. R. Adkins, P. F. Holder, L. B. Pais, L. L. Gheesling, and G. M. Carlone. 1997. Primary human immune response to Neisseria meningitidis serogroup C in interleukin-12-treated severe combined immunodencient mice engrafted with human peripheral blood lymphocytes. J. Infect. Dis. 175:84.
26. - B cells with anti-Ig, but not LPS, induces surface CD5: two B-cell activation pathways. Int. Immunol., 3:467.
27. Riggs, J. E., R. S. Stowers, and D. E. Mosier. 1990. The immunoglobulin allotype contributed by peritoneal cavity B cells dominates in SCID mice reconstituted with allotype-disparate mixtures of splenic and peritoneal cavity B cells. J. Exp. Med. 172:475.
28. Vogel, L. A., T. L. Lester, V. H. Van Cleave, and D. W. Metzger. 1996. Inhibition of murine B1 lymphocytes by interleukin-12. Eur. J. Immunol. 26:219.
29. Velupillai, P., J. Sypek, and D. A. Harn. 1996. Interleukin-12 and -10 and gamma interferon regulate polyclonal and ligand-specific expansion of murine B-1 cells. Infect. Immun. 64:4557.
30. Pang, Y., Y. Norihisa, D. Benjamin, R. R. Kantor, and H. A. Young. 1992. Interferon-γ gene expression in human B-cell lines: induction by interleukm-2, protein kinase C activators, and possible effect of hypomethylation on gene regulation. Blood 80:724.
31. Yoshimoto, T., H. Okamura, Y. I. Tagawa, Y. Iwakura, and K. Nakanishi. 1997. Interleukin 18 together with interleukin 12 inhibits IgE production by induction of interferon-γ production from activated B cells. Proc. Natl. Acad. Sci. USA 94:3948.
32. Robbins, J. B., R. Schneerson, and S. C. Szu. 1995. Perspective: hypothesis: serum IgG antibody is sufficient to confer protection against infectious diseases by inactivating the inoculum. J. Infect. Dis. 171:1387.
33. Robbins, J. B., R. Schneerson, and S. C. Szu. 1996. Hypothesis: how licensed vaccines confer protective immunity. Adv. Exp. Med. Biol. 397:169.