A Btk transgene restores the antiviral TI-2 antibody responses of xid mice in a dose-dependent fashion

European Journal of Immunology

Volumn 29, Issue 9, 1999, Pages 2981-2987

  Pinschewer, Daniel D ^a   Ochsenbein, Adrian F ^b   Satterthwaite, Anne B ^b   Witte, Owen N ^a   Hengartner, Hans ^b   Zinkernagel, Rolf M ^a  

^a INSTITUTE OF EXPERIMENTAL IMMUNOLOGY   (Switzerland)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Btk; TI 2; Transgene; Virus; Xid

Indexed keywords

COMPLEMENTARY DNA; IMMUNOGLOBULIN HEAVY CHAIN; PROTEIN TYROSINE KINASE; T LYMPHOCYTE ANTIBODY;

ANIMAL EXPERIMENT; ANTIBODY RESPONSE; ANTIBODY TITER; ARTICLE; CONTROLLED STUDY; ENHANCER REGION; GENE EXPRESSION; GENE MUTATION; IMMUNE DEFICIENCY; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; MOUSE; NONHUMAN; POLIOMYELITIS VIRUS; PRIORITY JOURNAL; PROMOTER REGION; TH1 CELL; TH2 CELL; TRANSGENE; VACCINIA VIRUS; VESICULAR STOMATITIS VIRUS; X CHROMOSOME LINKAGE; X LINKED AGAMMAGLOBULINEMIA;

EID: 0033370171     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1521-4141(199909)29:09<2981::AID-IMMU2981>3.0.CO;2-Y     Document Type: Article

References (38)

1. Mohamed, A. J., Nore, B. F., Christensson, B. and Smith, C. I., Signalling of Bruton's tyrosine kinase, Btk. Scand. J. Immunol. 1999. 49:113-118.
2. Desiderio, S., Role of Btk in B cell development and signaling. Curr. Opin. Immunol. 1997. 9: 534-540.
3. Hardy, R. R., Hayakawa, K., Haaijman, J. and Herzenberg, L. A., B-cell subpopulations identified by twocolour fluorescence analysis. Nature 1982. 297: 589-591.
4. Satterthwaite, A. B., Cheroutre, H., Khan, W. N., Sideras, P. and Witte, O. N., Btk dosage determines sensitivity to B cell antigen receptor cross-linking. Proc. Natl. Acad. Sei. USA 1997. 94: 13152-13157.
5. Scher, l., CBA/N immune defective mice; evidence for the failure of a B cell subpopulation to be expressed. Immunol. Rev. 1982. 64:117-136.
6. Bachmann, M. F., Hengartner, H. and Zinkernagel, R. M., T helper cell-independent neutralizing B cell response against vesicular stomatitis virus: role of antigen patterns in B cell induction? Eur. J. Immunol. 1995. 25:3445-3451.
7. Amsbaugh, D. F., Hansen, C. T., Prescott, B., Stashak, P. W., Asofsky, R. and Baker, P. J., Genetic control of the antibody response to type 3 pneumococcal polysaccharide in mice. II. Relationship between IgM immunoglobulin levels and the ability to give an IgM antibody response. J. Exp. Med. 1974.139:1499-1512.
8. Scher, I., Frantz, M. M. and Steinberg, A. D., The genetics of the immune response to a synthetic doublestranded RNA in a mutant CBA mouse strain. J. Immunol. 1973.110:1396-1401.
9. Rawlings, D. J., Saffran, D. C., Tsukada, S., Largaespada, D. A., Grimaldi, J. C., Cohen, L., Mohr, R. N., Bazan, J. F., Howard, M. and Copeland, N. G., Mutation of unique region of Bruton's tyrosine kinase in immunodeficient XID mice. Science 1993. 261: 358-361.
10. Thomas, J. D., Sidéras, P., Smith, C. I., Vorechovsky, I., Chapman, V. and Paul, W. E., Colocalization of X-linked agammaglobulinemia and X-linked immunodeficiency genes. Science 1993. 261: 355-358.
11. Conley, M. E., B cells in patients with X-linked agammaglobulinemia. J. Immunol. 1985.134: 3070-3074.
12. Conley, M. E., Brown, P., Pickard, A. R., Buckley, R. H., Miller, D. S., Raskind, W. H., Singer, J. W. and Fialkow, P. J., Expression of the gene defect in X-linked agammaglobulinemia. N. Engl. J. Med. 1986. 315: 564-567.
13. Dosch, H. M., Percy, M. E. and Gelfand, E. W., Functional differentiation of B lymphocytes in congenital agammaglobulinemia. I. Generation of hemolytic plaque-forming cells. J. Immunol. 1977. 119: 1959-1964.
14. Khan, W. N., Alt, F. W., Gerstein, R. M. et al., Defective B cell development and function in Btk-deficient mice. Immunity 1995. 3: 283-299.
15. Conley, M. E., Parolini, O., Rohrer, J. and Campana, D., X-linked agammaglobulinemia: new approaches to old questions based on the identification of the defective gene. Immunol. Rev. 1994.138: 5-21.
16. deWeers, M., Mensink, R. G., Kraakman, M. E., Schuurman, R. K. and Hendriks, R. W., Mutation analysis of the Bruton's tyrosine kinase gene in X-linked agammaglobulinemia: identification of a mutation which affects the same codon as is altered in immunodeficient xid mice. Hum. Mol. Genet. 1994/3:-} 61 -166.
17. Kerner, J. D., Appleby, M. W., Mohr, R. N., Chien, S., Rawlings, D. J., Maliszewski, C. R., Witte, O. N. and Perlmutter, R. M., Impaired expansion of mouse B cell progenitors lacking Btk. Immunity 1995. 3: 301-312.
18. Hendriks, R. W., de Bruijn, M. F., Maas, A., Dingjan, G. M., Karis, A. and Grosveld, F., Inactivation of Btk by insertion of lacZ reveals defects in B cell development only past the pre-B cell stage. EMBO J. 1996. 15: 4862-4872.
19. Bona, C., Mond, J. J. and Paul, W. E., Synergistic genetic defect in B-lymphocyte function. I. Defective responses to B-cell stimulants and their genetic basis. J. Exp. Med. 1980.151: 224-234.
20. Bykowsky, M. J., Haire, R. N., Ohta, Y., Tang, H., Sung, S. S., Veksler, E. S., Greene, J. M., Fu, S. M., Litman, G. W. and Sullivan, K. E., Discordant phenotype in siblings with X-linked agammaglobulinemia. Am. J. Hum. Genet. 1996. 58: 477-483.
21. Ochs, H. D. and Smith, C. I., X-linked agammaglobulinemia. A clinical and molecular analysis. Medicine (Baltimore) 1996. 75: 287-299.
22. Amsbaugh, D. F., Hansen, C. T., Prescott, B., Stashak, P. W., Barthold, D. R. and Baker, P. J., Genetic contol of the antibody response to type 3 pneumococcal polysaccharide in mice. I. Evidence that an X-linked gene plays a decisive role in determining responsiveness. J. Exp. Med. 1972.136:931-949.
23. Kimura, S., Kiyono, H., Beagley, K. W., Torii, M., Eldridge, J. H., Hamada, S., Michalek, S. M., Koop-man, W. J. and McGhee, J. R., Streptococcal serotype carbohydrate represents a novel class of type 2 antigen which is "["-independent. J. Immunol. 1987. 138: 4387-4394.
24. Burns, W., Billups, L. C. and Notkins, A. L., Thymus dependence of viral antigens. Nature 1975. 256: 654-656.
25. Bachmann, M. F. and Zinkernagel, R. M., The influence of virus structure on antibody responses and virus seratype formation. Immunol. Today 1996.12: 553-558.
26. Feldmann, M. and Easten, A., The relationship between antigenic structure and the requirement for thymusderived cells in the immune response. J. Exp. A/fed. 1971. 134:103-119.
27. Bachmann, M. F., Rohrer, U. H., Kündig, T. M., Bürki, K., Hengartner, H. and Zinkernagel, R. M., The influence of antigen organization on B cell responsiveness. Science 1993. 262:1448-1451.
28. Fehr, T., Skrastina, D., Pumpens, P. and Zinkernagel, R. M., T cell-independent type I antibody response against B cell epitopes expressed repetitively on recombinant virus particles. Proc. Natl. Acad. Sei. USA 1998. 95: 9477-9481.
29. Drabek, D., Raguz, S., De Wit, T. P., Dingjan, G. M., Savelkoul, H. F., Grosveld, F. and Hendriks, R. W., Correction of the X-linked immunodeficiency phenotype by transgenic expression of human Bruton tyrosine kinase under the control of the class II major histocompatibility complex Ea locus control region. Proc. Natl. Acad. Sei. USA 1997. 94:610-615.
30. Dingjan, G. M., Maas, A., Nawijn, M. C., Smit, L., Voerman, J. S., Grosveld, F. and Hendriks, R. W., Severe B cell deficiency and disrupted splenic architecture in transgenic mice expressing the E41K mutated form of Bruton's tyrosine kinase. EMBOJ. 1998.17:5309-5320.
31. Sidéras, P. and Smith, C. I., Molecular and cellular aspects of X-linked agammaglobulinemia. Adv. Immunol. 1995.59:135-223.
32. de Weers, M., Verschuren, M. C., Kraakman, M. E., Mensink, R. G., Schuurman, R. K., van Dongen, J. J. and Hendriks, R. W., The Bruton's tyrosine kinase gene is expressed throughout B cell differentiation, from early precursor B cell stages preceding immunoglobulin gene rearrangement up to mature B cell stages. Eur. J. Immunol. 1993.23:3109-3114.
33. Ridderstad, A. and Tarlinton, D. M., B cell memory in xid mice is long-lived despite reduced memory B cell frequency. Scand. J. Immunol. 1997. 45: 655-659.
34. Bachmann, M. F., Hengartner, H. and Zinkernagel, R. M., Immunization with recombinant protein: conditions for cytotoxic T cell and/or antibody induction. Med. Microbiol. Immunol. (Berl.) 1994.183: 315-324.
35. Bachmann, M. F., Odermatt, B., Hengartner, H. and Zinkernagel, R. M., Induction of long-lived germinal centers associated with persisting antigen after viral infection. J. Exp. Med. 1996.183: 2259-2269.
36. Fehr, T., Nairn, H. Y., Bachmann, M. F., Ochsenbein, A. F., Spielhofer, P., Bucher, E., Hengartner, H., Billeter, M. A. and Zinkernagel, R. M., T-cell independent IgM and enduring protective IgG antibodies induced by chimeric measles viruses. Nat. Med. 1998. 4: 945-948.
37. Battegay, M., Moskophidis, D., Waldner, H., Brundler, M. A., Fung-Leung, W.-R, Mak, T. W., Hengartner, H. and Zinkernagel, R. M., Impairment and delay of neutralizing antiviral antibody responses by virus-specific cytotoxic T cells. J. Immunol. 1993.151: 5408-5415.
38. Fehr, T., Rickert, R. C., Odermatt, B., Roes, J., Rajewsky, K., Hengartner, H. and Zinkernagel, R. M., Antiviral protection and germinal center formation, but impaired B cell memory in the absence of CD19. J. Exp. Med. 1998.188:145-155.