Differential regulation of the IL-12 p40 promoter and of p40 secretion by CpG DNA and lipopolysaccharide

Journal of Immunology

Volumn 162, Issue 11, 1999, Pages 6770-6775

  Cowdery, John S ^a,b   Boerth, Nancy J ^b   Norian, Lyse A ^b   Myung, Peggy S ^b   Koretzky, Gary A ^b  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b UNIVERSITY OF IOWA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 12; LIPOPOLYSACCHARIDE; PROTEIN P40;

ANIMAL CELL; ARTICLE; CYTOKINE RELEASE; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN SECRETION; REGULATORY MECHANISM; TATA BOX;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; BINDING SITES; CELL LINE; CPG ISLANDS; DNA; GENE EXPRESSION REGULATION; INTERFERON TYPE II; INTERLEUKIN-12; LIPOPOLYSACCHARIDES; MICE; MICE, INBRED BALB C; NF-KAPPA B; OLIGONUCLEOTIDES; PROMOTER REGIONS (GENETICS); RESPONSE ELEMENTS; TRANSCRIPTION FACTORS;

EID: 0033151919     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (34)

1. Trinchieri, G. 1995. Interbukin-12: a proinflammalory cytokine with immuno-regulatory functions that bridge innate resistance and antigen-specific adaptive immunity. Annu. Rev. Immunol. 13:251.
2. Gately, M. K., L. M. Renzetti, J. Magram, A. S. Stern, L. Adorini, U. Gubler, and D. H. Presky. 1998. The interleukin-12/interleukin-12-receptor system: role in normal and pathologic immune responses. Ann. Rev. Immunol. 16:495.
3. Afonso, L. C., T. M. Scharton, L. Q. Vieira, M. Wysocka, G. Trinchieri, and P. Scott. 1994. The adjuvant effect of interleukin-12 in a vaccine against Leishmania major. Science 263:235.
4. Flynn, J. L., M. M. Goldstein, K. J. Triebold, J. Sypek, S. Wolf, and B. R. Bloom. 1995. IL-12 increases resistance of BALB/c mice to Mycobacterium tuberculosis infection. J. Immunol 155:2515.
5. Zhou, P., M. C. Sieve, J. Bennett, K. J. Kwon-Chung, R. P. Tewari, R. T. Gazzinelli, A. Sher, and R. A. Seder. 1995. IL-12 prevents mortality in mice infected with Histoplasma capsulation through induction of IFN-γ. J. Immunol. 155:785.
6. Trembleau, S., G. Penna, E. Bosi, A. Mortara, M. K. Gately, and L. Adorini. 1995. Interleukin 12 administration induces T helper type 1 cells and accelerates autoimmune diabetes in NOD mice. J. Exp. Med. 181:817.
7. Windhagen, A., J. Newcombe, F. Dangond, C. Strand, M. N. Woodroofe, M. L. Cuzner, and D. A. Hafler. 1995. Expression of costimulatory molecules B7-1 (CD80), B7-2 (CD86), and interleukin 12 cytokine in multiple sclerosis lesions. J. Exp. Med. 182:1985.
8. Ma, X., J. M. Chow, G. Gri, G. Carra, F. Gerosa, S. F. Wolf, R. Dzialo, and G. Trinchieri. 1996. The interleukin 12 p40 gene promoter is primed by interferon γ in monocytic cells. J. Exp. Med. 183:147.
9. Ma, X., M. Neurath, G. Gri, and G. Trinchieri. 1997. Identification and characterization of a novel Ets-2-related nuclear complex implicated in the activation of the human interleukin-12 p40 gene promoter. J. Biol. Chem. 272:10389.
10. Wysocka, M., M. Kubin, L. Q. Vieira, L. Ozmen, G. Garotta, P. Scott, and G. Trinchieri. 1995. Interleukin-12 is required for interferon-γ production and lethality in lipopolysaccharide-induced shock in mice. Eur. J. Immunol. 25:671.
11. Koch, F., U. Stanzl, P. Jennewein, K. Janke, C. Heufter, E. Kampgen, N. Romani, and G. Schuler. 1996. High level IL-12 production by murine dendritic cells: upregulation via MHC class II and CD40 molecules and downregulation by IL-4 and IL-10. J. Exp. Med. 184:741.
12. Cella, M., D. Scheidegger, K. Paltner-Lehmann, P. Lane, A. Lanzavecchia, and G. Alber. 1996. Ugation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation. J. Exp. Med. 184:747.
13. Murphy, T. L., M. G. Cleveland, P. Kulesza, J. Magram, and K. M. Murphy. 1995. Regulation of interleukin 12 p40 expression through an NF-KB half-site. Mol. Cell. Biol. 15:5258.
14. Scharton-Kersten, T., C. Contursi, A. Maaumi, A. Sher, and K. Ozato. 1997. Interferon consensus sequence binding protein-deficient mice display impaired resistance to intracellular infection due to a primary defect in interleukin 12 p40 induction. J. Exp. Med. 186:1523.
15. Giese, N. A., L. Gabriele, T. M. Doherty, D. M. Klinman, L. Tadesse-Heath, C. Contursi, S. L. Epstein, and H. C. Morse III. 1997. Interferon (IFN) consensus sequence-binding protein, a transcription factor of the IFN regulatory factor family, regulates immune responses in vivo through control of interleukin 12 expression. J. Exp. Med. 186:1535.
16. Pisetsky, D. 1996. Immune activation by bacterial DNA: a new genetic code. Immunity 5:303.
17. Krieg, A. M. 1996. An innate immune defense mechanism based on the recognition of CpG motifs in microbial DNA. J. Clin. Lab. Med. 128:128.
18. Krieg, A. M., A-K. Yi, S. Matson, T. J. Waldschmidt, G. A. Bishop, R. Teasdale, G. A. Koretzky, and D. M. Klinman. 1995. CpG motifs in bacterial DNA trigger direct B-cell activation. Nature 374:546.
19. Halpern, M. D., R. J. Kurlander, and D. S. Pisetsky. 1996. Bacterial DNA induces murine IFN-γ production by stimulation of IL-12 and tumor necrosis factor-α. Cell. Immunol. 167:72.
20. Chace, J. H., N. A. Hooker, K. L. Mildenstein, A. M. Krieg, and J. S. Cowdery. 1997. Bacterial DNA-induced NK cell IFN-γ production is dependent on macrophage secretion of IL-12. Clin. Immunol. Immunopathol. 84:185.
21. Stacey, K. J., M. J. Sweet, and D. A. Hume. 1996. Macrophages ingest and are activated by bacterial DNA. J. Immunol. 157:2116.
22. Anitescu, M., J. H. Chace, R. Tuetken, A-K. Yi, D. J. Berg, A. M. Krieg, and J. S. Cowdery. 1997. Interleukin-10 functions in vitro and in vivo to inhibit bacterial DNA-induced secretion of interleukin-12. J. Interferon Cytokine Res. 17:781.
23. Yi, A-K., R. Tuetken, T. W. Redford, M. Waldschmidt, J. Kirsch, and A. M. Krieg. 1998. CpG motifs in bacterial DNA activate leukocytes through the pH-dependent generation of reactive oxygen species. J. Immunol. 160:4755.
24. Yi, A-K., and A. M. Krieg. 1998. CpG DNA rescue from anti-IgM-induced WEHI-231B lymphoma apoptosis via modulation of I 75 Bα and I 75 Bβ and sustained activation of nuclear factor-75 B/C-rel. J. Immunol. 160:1240.
25. Crowley, M. T., P. S. Costello, C. J. Fitzer-Attas, M. Turner, F. Meng, C. Lowell, V. L. J. Tybulewicz, and A. L. DeFranco. 1997. A critical role for syk in signal transduction and phagocytosis mediated by Fcγ receptors on macrophages. J. Exp. Med. 186:1027.
26. Berberich, I., G. L. Shu, and E. A. Clark. 1994. Cross-linking CD40 on B cells rapidly activates nuclear factor-75 B. J. Immunol. 153:4357.
27. Latinis, K. M., L. L. Carr, E. J. Peterson, L. A. Norian, S. L. Eliason, and G. A. Koretzky. 1997. Regulation of CD95 (Fas) ligand expression by TCR-mediated signaling events. J. Immunol. 158:4602.
28. Thompson, C. B., C. Y. Wang, J. C. Ho, R. P. Bohjanen, B. Petyrniak, C. H. June, S. Miesfeldt, L. Zhang, G. J. Nabel, B. Karpinski, and J. N. Leiden. 1992. cis-Acting sequences required for inducible interleukin-2 enhancer function bind a novel Ets-related protein Elf-1. Mol. Cell. Biol. 12:1043.
29. Latinis, K. M., L. A. Norian, S. L. Eliason, and G. A. Koretzky. 1997. Two NFAT transcription factor binding sites participate in the regulation of CD95 (Fas) ligand expression in activated human T cells. J. Biol. Cnem. 272:31427.
30. Aste-Amezaga, M., X. Ma, A. Sartori, and G. Trinchieri. 1998. Molecular Mechanisms of the induction of IL-12 and its inhibition by 1L-10. J. Immunol. 160: 5936.
31. Yamamoto, S., T. Yamamolo, T. Katoka, E. Kuramoto, O. Yano, and T. Tokunaga. 1992. Unique palindromic sequences in synthetic oligonucleotides are required to induce IFN and augment IFN-mediated natural killer activity. J. Immunol. 148:4072.
32. Cowdery, J. S., J. H. Chace, A-K. Yi, and A. M. Krieg. 1996. Bacterial DNA induces NK cells to produce IFN-γ in vivo and increases the toxicity of lipopolysaccharides, J. Immunol. 156:4570.
33. Gillessen, S , D. Carvajal, P. Ling, F. J. Podlaski, D. L. Stremlo, P. C. Familletti, U. Gubler, D. H. Presky, A. S. Stern, and M. K. Gately. 1995. Mouse interleukin-12 (IL-12) p40 homodimer: a potent IL-12 antagonist. Eur. J. Immunol. 25: 200.
34. Krieg, A. M., L. Love-Homan, A-K. Yi, and J. T. Harty. 1998. CpG DNA induces sustained IL-12 expression in vivo and resistance to Listeria monocytogenes challenge. J. Immunol. 161:2428.