메뉴 건너뛰기




Volumn 274, Issue 5 43-5, 1998, Pages

A potent neuropeptide Y antagonist, 1229U91, suppressed spontaneous food intake in Zucker fatty rats

Author keywords

Feeding behavior; Galanin; Obesity

Indexed keywords

GALANIN; GR 231118; LEPTIN RECEPTOR; NEUROPEPTIDE Y RECEPTOR ANTAGONIST; UNCLASSIFIED DRUG;

EID: 0031858896     PISSN: 03636119     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpregu.1998.274.5.r1500     Document Type: Article
Times cited : (64)

References (32)
  • 1
    • 0025339808 scopus 로고
    • Hyperphagia in obesity is associated with a central peptidergic dysregulation in rats
    • Beck, B., A. Burlet, J. P. Nicolas, and C. Burlet. Hyperphagia in obesity is associated with a central peptidergic dysregulation in rats. J. Nutr. 120: 806-811, 1990.
    • (1990) J. Nutr. , vol.120 , pp. 806-811
    • Beck, B.1    Burlet, A.2    Nicolas, J.P.3    Burlet, C.4
  • 2
    • 0027197580 scopus 로고
    • Galanin in the hypothalamus of fed and fasted lean and obese Zucker rats
    • Beck, B., A. Burlet, J. P. Nicolas, and C. Burlet. Galanin in the hypothalamus of fed and fasted lean and obese Zucker rats. Brain Res. 623: 124-130, 1993.
    • (1993) Brain Res. , vol.623 , pp. 124-130
    • Beck, B.1    Burlet, A.2    Nicolas, J.P.3    Burlet, C.4
  • 3
    • 0025046607 scopus 로고
    • Rapid and localized alterations of neuropeptide Y in discrete hypothalamic nuclei with feeding status
    • Beck, B., M. Jhanwar-Uniyal, A. Burlet, M. Chapleur-Chateau, S. F. Leibowitz, and C. Burlet. Rapid and localized alterations of neuropeptide Y in discrete hypothalamic nuclei with feeding status. Brain Res. 528: 245-249, 1990.
    • (1990) Brain Res. , vol.528 , pp. 245-249
    • Beck, B.1    Jhanwar-Uniyal, M.2    Burlet, A.3    Chapleur-Chateau, M.4    Leibowitz, S.F.5    Burlet, C.6
  • 4
    • 0027967938 scopus 로고
    • Putative neuropeptide Y antagonist failed to decrease overeating in obese Zucker rats
    • Beck, B., A. Stricker-Krongrad, N. Musse, J.-P. Nicolas, and C. Burlet. Putative neuropeptide Y antagonist failed to decrease overeating in obese Zucker rats. Neurosci. Lett. 181: 126-128, 1994.
    • (1994) Neurosci. Lett. , vol.181 , pp. 126-128
    • Beck, B.1    Stricker-Krongrad, A.2    Musse, N.3    Nicolas, J.-P.4    Burlet, C.5
  • 5
    • 0031566869 scopus 로고    scopus 로고
    • 1 receptor antagonist, inhibits the vasoconstrictor effect of neuropeptide Y in the hamster microcirculation
    • 1 receptor antagonist, inhibits the vasoconstrictor effect of neuropeptide Y in the hamster microcirculation. Eur. J. Pharmacol. 319: 43-47, 1997.
    • (1997) Eur. J. Pharmacol. , vol.319 , pp. 43-47
    • Bitran, M.1    Daniels, A.J.2    Boric, M.P.3
  • 6
    • 0017347635 scopus 로고
    • The Zucker-fatty rat: A review
    • Bray, G. A. The Zucker-fatty rat: a review. Federation Proc. 36: 148-153, 1977.
    • (1977) Federation Proc. , vol.36 , pp. 148-153
    • Bray, G.A.1
  • 7
    • 0030028959 scopus 로고    scopus 로고
    • Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (Leptin) receptor
    • Chua, S. C., W. K. Chung, X. S. Wu-Peng, Y. Zhang, S. Liu, L. Tartaglia, and R. L. Leibel. Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (Leptin) receptor. Science 271: 994-996, 1996.
    • (1996) Science , vol.271 , pp. 994-996
    • Chua, S.C.1    Chung, W.K.2    Wu-Peng, X.S.3    Zhang, Y.4    Liu, S.5    Tartaglia, L.6    Leibel, R.L.7
  • 9
    • 0024156571 scopus 로고
    • Neuropeptide Y (NPY), and endogenous presynaptic modulator of adrenergic neurotransmission in the rat vas deferens: Structural and functional studies
    • Donoso, V., M. Silva, S. St-Pierre, and J. P. HuidobroToro. Neuropeptide Y (NPY), and endogenous presynaptic modulator of adrenergic neurotransmission in the rat vas deferens: structural and functional studies. Peptides 9: 545-553, 1988.
    • (1988) Peptides , vol.9 , pp. 545-553
    • Donoso, V.1    Silva, M.2    St-Pierre, S.3    Huidobrotoro, J.P.4
  • 10
    • 0029122302 scopus 로고
    • Increased neuropeptide Y secretion in the hypothalamic paraventricular nucleus of obese (fa/fa) Zucker rats
    • Dryden, S., L. Pickavance, H. M. Frankish, and G. Williams. Increased neuropeptide Y secretion in the hypothalamic paraventricular nucleus of obese (fa/fa) Zucker rats. Brain Res. 690: 185-188, 1995.
    • (1995) Brain Res. , vol.690 , pp. 185-188
    • Dryden, S.1    Pickavance, L.2    Frankish, H.M.3    Williams, G.4
  • 11
    • 0028335412 scopus 로고
    • Evidence that neuropeptide Y is a physiological signal for normal food intake
    • Dube, M. G., B. Xu, W. R. Crowley, P. S. Kalra, and S. P. Kalra. Evidence that neuropeptide Y is a physiological signal for normal food intake. Brain Res. 646: 341-344, 1994.
    • (1994) Brain Res. , vol.646 , pp. 341-344
    • Dube, M.G.1    Xu, B.2    Crowley, W.R.3    Kalra, P.S.4    Kalra, S.P.5
  • 14
    • 0025859668 scopus 로고
    • Structure-function analysis of stimulation of food intake by neuropeptide Y: Effects of receptor agonists
    • Kalra, S. P., M. G. Dube, A, Fournier, and P. S. Kalra. Structure-function analysis of stimulation of food intake by neuropeptide Y: effects of receptor agonists. Physiol. Behav. 50: 5-9, 1991.
    • (1991) Physiol. Behav. , vol.50 , pp. 5-9
    • Kalra, S.P.1    Dube, M.G.2    Fournier, A.3    Kalra, P.S.4
  • 16
    • 0026325302 scopus 로고
    • 2 receptor effects on natural meal patterns
    • 2 receptor effects on natural meal patterns. Peptides 12: 1251-1260, 1991.
    • (1991) Peptides , vol.12 , pp. 1251-1260
    • Leibowitz, S.F.1    Alexander, J.T.2
  • 17
    • 0026438824 scopus 로고
    • Blockade of natural and neuropeptide Y-induced carbohydrate feeding by a receptor antagonist PYX-2
    • Leibowitz, S. F., M. Xuereb, and T. Kim. Blockade of natural and neuropeptide Y-induced carbohydrate feeding by a receptor antagonist PYX-2. Neuroreport 3: 1023-1026, 1992.
    • (1992) Neuroreport , vol.3 , pp. 1023-1026
    • Leibowitz, S.F.1    Xuereb, M.2    Kim, T.3
  • 18
    • 0025988223 scopus 로고
    • Hypothalamic neuropeptide Y receptor characteristics and NPY-induced feeding responses in lean and obese Zucker rats
    • McCarthy, H. D., P. E. McKibbin, B. Holloway, R. Mayers, and G. Williams. Hypothalamic neuropeptide Y receptor characteristics and NPY-induced feeding responses in lean and obese Zucker rats. Life Sci. 49: 1491-1497, 1991.
    • (1991) Life Sci. , vol.49 , pp. 1491-1497
    • McCarthy, H.D.1    McKibbin, P.E.2    Holloway, B.3    Mayers, R.4    Williams, G.5
  • 19
    • 0026094772 scopus 로고
    • Altered neuropeptide Y concentrations in specific hypothalamic regions of obese (fa/fa) Zucker rats: Possible relationship to obesity and neuroendocrine disturbances
    • McKibbin, P. E., S. J. Cotton, S. McMillan, B. Holloway, R. Mayers, H. D. McCarthy, and G. Williams. Altered neuropeptide Y concentrations in specific hypothalamic regions of obese (fa/fa) Zucker rats: possible relationship to obesity and neuroendocrine disturbances. Diabetes 40: 1423-1429, 1991.
    • (1991) Diabetes , vol.40 , pp. 1423-1429
    • McKibbin, P.E.1    Cotton, S.J.2    McMillan, S.3    Holloway, B.4    Mayers, R.5    McCarthy, H.D.6    Williams, G.7
  • 20
    • 0024467343 scopus 로고
    • Lateral cerebroventricular injection of neuropeptide Y stimulates feeding in sheep
    • Regulatory Integrative Comp. Physiol. 26
    • Miner, J. L., M. A. Della-Fera, J. A. Paterson, and C. A. Baile. Lateral cerebroventricular injection of neuropeptide Y stimulates feeding in sheep. Am. J. Physiol. 257 (Regulatory Integrative Comp. Physiol. 26): R383-R387, 1989.
    • (1989) Am. J. Physiol. , vol.257
    • Miner, J.L.1    Della-Fera, M.A.2    Paterson, J.A.3    Baile, C.A.4
  • 21
    • 0023569324 scopus 로고
    • Neuropeptide Y increases food intake in mice
    • Regulatory Integrative Comp. Physiol. 22
    • Morley, J. E., E. N. Hernandez, and J. F. Flood. Neuropeptide Y increases food intake in mice. Am. J. Physiol. 253 (Regulatory Integrative Comp. Physiol. 22): R516-R522, 1987.
    • (1987) Am. J. Physiol. , vol.253
    • Morley, J.E.1    Hernandez, E.N.2    Flood, J.F.3
  • 22
    • 0022650258 scopus 로고
    • Stimulation of feeding in the satiated pig by intracerebroventricluar injection of neuropeptide Y
    • Parrott, R. F., R. P. Heavens, and B. A. Baldwin. Stimulation of feeding in the satiated pig by intracerebroventricluar injection of neuropeptide Y. Physiol. Behav. 36: 523-525, 1986.
    • (1986) Physiol. Behav. , vol.36 , pp. 523-525
    • Parrott, R.F.1    Heavens, R.P.2    Baldwin, B.A.3
  • 24
    • 0026737862 scopus 로고
    • Hypothalamic neuropeptide Y gene expression in rats on scheduled feeding regimen
    • Sahu, A., J. D. White, P. S. Kalra, and S. P. Kalra. Hypothalamic neuropeptide Y gene expression in rats on scheduled feeding regimen. Mol. Brain Res. 15: 15-18, 1992.
    • (1992) Mol. Brain Res. , vol.15 , pp. 15-18
    • Sahu, A.1    White, J.D.2    Kalra, P.S.3    Kalra, S.P.4
  • 25
    • 0025072899 scopus 로고
    • Increased hypothalamic content of preproneuropeptide Y messenger ribonucleic acid in genetically obese Zucker rats and its regulation by food deprivation
    • Sanacora, G., M. Kershaw, J. A. Finkelstein, and J. D. White. Increased hypothalamic content of preproneuropeptide Y messenger ribonucleic acid in genetically obese Zucker rats and its regulation by food deprivation. Endocrinology 127: 730-737, 1990.
    • (1990) Endocrinology , vol.127 , pp. 730-737
    • Sanacora, G.1    Kershaw, M.2    Finkelstein, J.A.3    White, J.D.4
  • 26
    • 0002372785 scopus 로고
    • Neuropeptide Y in multiple hypothalamic sites controls eating behavior, endocrine, and autonomic systems for body energy balance
    • edited by W. F. Colmers and C. Wahlestedt. Totowa, NJ: Humana
    • Stanley, B. G. Neuropeptide Y in multiple hypothalamic sites controls eating behavior, endocrine, and autonomic systems for body energy balance. In: The Biology of Neuropeptide Y and Related Peptides, edited by W. F. Colmers and C. Wahlestedt. Totowa, NJ: Humana, 1993, p. 457-509.
    • (1993) The Biology of Neuropeptide Y and Related Peptides , pp. 457-509
    • Stanley, B.G.1
  • 27
    • 0000555383 scopus 로고
    • Neuropeptide Y injected in the paraventricular hypothalamus: A powerful stimulant of feeding behavior
    • Stanley, B. G., and S. F. Leibowitz. Neuropeptide Y injected in the paraventricular hypothalamus: a powerful stimulant of feeding behavior. Proc. Natl. Acad. Sci. USA 82: 3940-3943, 1985.
    • (1985) Proc. Natl. Acad. Sci. USA , vol.82 , pp. 3940-3943
    • Stanley, B.G.1    Leibowitz, S.F.2
  • 28
    • 0022873040 scopus 로고
    • Neuropeptide Y chronically injected into the hypothalamus: A powerful neurochemical inducer of hyperphagia and obesity
    • Stanley, B. G., S. E. Kyrkouli, S. Lampert, and S. F. Leibowitz. Neuropeptide Y chronically injected into the hypothalamus: a powerful neurochemical inducer of hyperphagia and obesity. Peptides 7: 1189-1192, 1986.
    • (1986) Peptides , vol.7 , pp. 1189-1192
    • Stanley, B.G.1    Kyrkouli, S.E.2    Lampert, S.3    Leibowitz, S.F.4
  • 30
    • 0028083279 scopus 로고
    • Increased threshold concentrations of neuropeptide Y for a stimulatory effect on food intake in obese Zucker rats: Changes in the microstructure of the feeding behavior
    • Stricker-Krongrad, A., J. P. Max, N. Musse, J. P. Nicolas, C. Burlet, and B. Beck. Increased threshold concentrations of neuropeptide Y for a stimulatory effect on food intake in obese Zucker rats: changes in the microstructure of the feeding behavior. Brain Res. 660: 162-166, 1994.
    • (1994) Brain Res. , vol.660 , pp. 162-166
    • Stricker-Krongrad, A.1    Max, J.P.2    Musse, N.3    Nicolas, J.P.4    Burlet, C.5    Beck, B.6
  • 31
    • 0026557170 scopus 로고
    • Synthesis of receptor antagonists of neuropeptide Y
    • Tatemoto, K., M. J. Mann, and M. Shimizu. Synthesis of receptor antagonists of neuropeptide Y. Proc. Natl. Acad. Sci. USA 89: 1174-1178, 1992.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 1174-1178
    • Tatemoto, K.1    Mann, M.J.2    Shimizu, M.3
  • 32
    • 0012664686 scopus 로고
    • Chemical determination of polypeptide hormones
    • Tatemoto, K., and V. Mutt. Chemical determination of polypeptide hormones. Proc. Natl. Acad. Sci. USA 75: 4115-4119, 1978.
    • (1978) Proc. Natl. Acad. Sci. USA , vol.75 , pp. 4115-4119
    • Tatemoto, K.1    Mutt, V.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.