Two important systems in energy homeostasis: Melanocortins and melanin- concentrating hormone

Neuropeptides

Volumn 33, Issue 5, 1999, Pages 339-349

  Tritos, N A ^a   Maratos Flier, E ^a  

^a JOSLIN DIABETES CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGOUTI PROTEIN; ALPHA INTERMEDIN; BOMBESIN; CHOLECYSTOKININ; CORTICOTROPIN RELEASING FACTOR; GLUCAGON LIKE PEPTIDE; INTERMEDIN INHIBITING FACTOR; MAHOGANY PROTEIN; MELANIN CONCENTRATING HORMONE; MELANOCORTIN; MELANOCORTIN RECEPTOR; NEUROTENSIN; PEPTIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; APPETITE; BODY FAT; ENERGY BALANCE; ENERGY EXPENDITURE; FOOD INTAKE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REVIEW;

AGOUTI; ANIMALIA; SWIETENIA;

EID: 0032754997     PISSN: 01434179     EISSN: None     Source Type: Journal    
DOI: 10.1054/npep.1999.0055     Document Type: Article

References (98)

1. Flier J. S., Maratos-Flier E. Obesity and the hypothalamus: novel peptides for new pathways [see comments]. Cell. 92:1998;437-440.
2. Anand B. K., Brobeck J. R. Localization of a "feeding center" in the hypothalamus of the rat. Proc Soc Exper Biol Med. 77:1951;323-324;
3. Sahakian B. J., Trayhurn P., Wallace M. Increased weight gain and reduced activity in brown adipose tissue produced by depletion of hypothalamic noradrenaline. Neurosci Lett. 39:1983;321-326.
4. Breisch S. T., Zemlan F. P., Hoebel B. G. Hyperphagia and obesity following serotonin depletion by intraventricular p-chlorophenylalanine. Science. 192:1976;382-385.
5. Leibowitz S. F. Brain monoamines and peptides: role in the control of eating behavior. Fed Proc. 45:1986;1396-1403.
6. Leibowitz S. F. Hypothalamic neurochemical systems mediate drug effects on food intake. Clin Neuropharmacol. 15 (suppl. 1, Pt A):1992;701A-702A.
7. Leibowitz S. F., Alexander J. T. Hypothalamic serotonin in control of eating behavior, meal size, and body weight. Biol Psychiatry. 44:1998;851-864.
8. Gibbs J., Smith G. P. Gut peptides and food in the gut produce similar satiety effects. Peptides. 3:1982;553-557;
9. Clark J. T., Sahu A., Kalra P. S., Balasubramaniam A., Kalra S. P. Neuropeptide Y (NPY)-induced feeding behavior in female rats: comparison with human NPY ([Met17]NPY), NPY analog ([norLeu4]NPY) and peptide Y Y. Regul Peptides. 17:1987;31-39.
10. Morley J. E., Levine A. S., Yim G. K., Lowy M. T. Opioid modulation of appetite. Neurosci Biobehav Rev. 7:1983;281-305.
11. Levine A. S., Billington C. J. Opioids.Are they regulators of feeding? Ann N Y Acad Sci. 575:1989;209-219; discussion 219-220.
12. Tsujii S., Bray G. A. Acetylation alters the feeding response to MSH and beta-endorphin. Brain Res Bull. 23:1989;165-169.
13. Poggioli R., Vergoni A. V., Bertolini A. ACTH-(1-24) and alpha-MSH antagonize feeding behavior stimulated by kappa opiate agonists. Peptides. 7:1986;843-848.
14. y) mutation in mouse aggregation chimeras. Development. 109:1990;683-690.
15. Bultman S. J., Michaud E. J., Woychik R. P. Molecular characterization of the mouse agouti locus. Cell. 71:1992;1195-1204.
16. Miller M. W., Duhl D. M., Vrieling H. Cloning of the mouse agouti gene predicts a secreted protein ubiquitously expressed in mice carrying the lethal yellow mutation. Genes Dev. 7:1993;454-467.
17. y) mutation. Proc Natl Acad Sci USA. 91:1994;2562-2656.
18. Mountjoy K. G., Wong J. Obesity, diabetes and functions for proopiomelanocortin-derived peptides. Mol Cell Endocrinol. 128:1997;171-177.
19. Cone R. D., Lu D., Koppula S. The melanocortin receptors: agonists, antagonists, and the hormonal control of pigmentation. Recent Prog Horm Res. 51:1996;287-317; discussion 318.
20. Lu D., Willard D., Patel I. R. Agouti protein is an antagonist of the melanocyte-stimulating-hormone receptor. Nature. 371:1994;799-802.
21. Huszar D., Lynch C. A., Fairchild-Huntress V. Targeted disruption of the melanocortin-4 receptor results in obesity in mice. Cell. 88:1997;131-141.
22. Ollmann M. M., Wilson B. D., Yang Y. K. Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein [published erratum appears in Science 1998 Sep 11; 281(5383): 1615]. Science. 278:1997;135-138.
23. Shutter J. R., Graham M., Kinsey A. C., Scully S., Luthy R., Stark K. L. Hypothalamic expression of ART, a novel gene related to agouti, is up-regulated in obese and diabetic mutant mice. Genes Dev. 11:1997;593-602.
24. Vaughan J. M., Fischer W. H., Hoeger C., Rivier J., Vale W. Characterization of melanin-concentrating hormone from rat hypothalamus. Endocrinology. 125:1989;1660-1665.
25. Qu D., Ludwig D. S., Gammeltoft S. A role for melanin-concentrating hormone in the central regulation of feeding behaviour. Nature. 380:1996;243-247.
26. Zhang Y., Proenca R., Maffei M., Barone M., Leopold L., Friedman J. M. Positional cloning of the mouse obese gene and its human homologue [published erratum appears in Nature 1995 Mar 30; 374(6521): 479] [see comments]. Nature. 372:1994;425-432.
27. Stephens T. W., Basinski M., Bristow P. K. The role of neuropeptide Y in the antiobesity action of the obese gene product. Nature. 377:1995;530-532.
28. Halaas J. L., Gajiwala K. S., Maffei M. Weight-reducing effects of the plasma protein encoded by the obese gene [see comments]. Science. 269:1995;543-546.
29. Campfield L. A., Smith F. J., Guisez Y., Devos R., Burn P. Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks [see comments]. Science. 269:1995;546-549.
30. Friedman J. M., Halaas J. L. Leptin and the regulation of body weight in mammals. Nature. 395:1998;763-770.
31. Gunn T. M., Miller K. A., He L. The mouse mahogany locus encodes a transmembrane form of human attractin. Nature. 398:1999;152-156.
32. Nagle D. L., McGrail S. H., Vitale J. The mahogany protein is a receptor involved in suppression of obesity. Nature. 398:1999;148-152.
33. Watson S. J., Akil H. The presence of two alpha-MSH positive cell groups in rat hypothalamus. Eur J Pharmacol. 58:1979;101-103.
34. Elias C. F., Saper C. B., Maratos-Flier E. Chemically defined projections linking the mediobasal hypothalamus and the lateral hypothalamic area. J Comp Neurol. 402:1998;442-459.
35. Elmquist J. K., Elias C. F., Saper C. B. From lesions to leptin: hypothalamic control of food intake and body weight. Neuron. 22:1999;221-232.
36. Sakurai T., Amemiya A., Ishii M. Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior [see comments]. Cell. 92:1998;573-585.
37. Kristensen P., Judge M. E., Thim L. Hypothalamic CART is a new anorectic peptide regulated by leptin. Nature. 393:1998;72-76.
38. Elias C. F., Lee C., Kelly J. Leptin activates hypothalamic CART neurons projecting to the spinal cord. Neuron. 21:1998;1375-1385.
39. Fan W., Boston B. A., Kesterson R. A., Hruby V. J., Cone R. D. Role of melanocortinergic neurons in feeding and the agouti obesity syndrome [see comments]. Nature. 385:1997;165-168.
40. Tritos N. A., Vicent D., Gillette J., Ludwig D. S., Flier E. S., Maratos-Flier E. Functional interactions between melanin-concentrating hormone, neuropeptide Y, and anorectic neuropeptides in the rat hypothalamus. Diabetes. 47:1998;1687-1692.
41. Huang Q. H., Entwistle M. L., Alvaro J. D., Duman R. S., Hruby V. J., Tatro J. B. Antipyretic role of endogenous melanocortins mediated by central melanocortin receptors during endotoxin-induced fever. J Neurosci. 17:1997;3343-3351.
42. Krude H., Biebermann H., Luck W., Horn R., Brabant G., Gruters A. Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans. Nat Genet. 19:1998;155-157.
43. O'Rahilly S., Gray H., Humphreys P. J. Brief report: impaired processing of prohormones associated with abnormalities of glucose homeostasis and adrenal function. N Engl J Med. 333:1995;1386-1390.
44. Jackson R. S., Creemers J. W., Ohagi S. Obesity and impaired prohormone processing associated with mutations in the human prohormone convertase 1 gene [see comments]. Nat Genet. 16:1997;303-306.
45. Cheung C. C., Clifton D. K., Steiner R. A. Proopiomelanocortin neurons are direct targets for leptin in the hypothalamus. Endocrinology. 138:1997;4489-4492.
46. Mizuno T. M., Kleopoulos S. P., Bergen H. T., Roberts J. L., Priest C. A., Mobbs C. V. Hypothalamic pro-opiomelanocortin mRNA is reduced by fasting and [corrected] in ob / ob anddb / db mice, but is stimulated by leptin [published erratum appears in Diabetes 1998 Apr; 47(4): 696]. Diabetes. 47:1998;294-297.
47. Schwartz M. W., Seeley R. J., Woods S. C. Leptin increases hypothalamic pro-opiomelanocortin mRNA expression in the rostral arcuate nucleus. Diabetes. 46:1997;2119-2123.
48. Thornton J. E., Cheung C. C., Clifton D. K., Steiner R. A. Regulation of hypothalamic proopiomelanocortin mRNA by leptin in ob / ob mice. Endocrinology. 138:1997;5063-5066.
49. Shimada M., Tritos N. A., Lowell B. B., Flier J. S., Maratos-Flier E. Mice lacking melanin-concentrating hormone are hypophagic and lean. Nature. 396:1998;670-674.
50. Tritos N. A., Elmquist J. K., Mastaitis J. W., Flier J. S., Maratos-Flier E. Characterization of expression of hypothalamic appetite-regulating peptides in obese hyperleptinemic brown adipose tissue-deficient (uncoupling protein-promoter-driven diphtheria toxin A) mice. Endocrinology. 139:1998;4634-4641.
51. Seeley R. J., Yagaloff K. A., Fisher S. L. Melanocortin receptors in leptin effects [letter]. Nature. 390:1997;349.
52. Bergen H. T., Mizuno T. M., Taylor J., Mobbs C. V. Hyperphagia and weight gain after gold-thioglucose: relation to hypothalamic neuropeptide Y and proopiomelanocortin. Endocrinology. 139:1998;4483-4488.
53. Cone R. D., Mountjoy K. G., Robbins L. S. Cloning and functional characterization of a family of receptors for the melanotropic peptides. Ann N Y Acad Sci. 680:1993;342-363.
54. Mountjoy K. G., Robbins L. S., Mortrud M. T., Cone R. D. The cloning of a family of genes that encode the melanocortin receptors. Science. 257:1992;1248-1251.
55. Mountjoy K. G., Mortrud M. T., Low M. J., Simerly R. B., Cone R. D. Localization of the melanocortin-4 receptor (MC4-R) in neuroendocrine and autonomic control circuits in the brain. Mol Endocrinol. 8:1994;1298-1308.
56. Yeo G. S., Farooqi I. S., Aminian S., Halsall D. J., Stanhope R. G., O'Rahilly S. A frameshift mutation in MC4R associated with dominantly inherited human obesity [letter]. Nat Genet. 20:1998;111-112.
57. Vaisse C., Clement K., Guy-Grand B., Froguel P. A frameshift mutation in human MC4R is associated with a dominant form of obesity [letter]. Nat Genet. 20:1998;113-114.
58. Chagnon Y. C., Chen W. J., Perusse L. Linkage and association studies between the melanocortin receptors 4 and 5 genes and obesity-related phenotypes in the Quebec Family Study. Mol Med. 3:1997;663-673.
59. Norman R. A., Permana P., Tanizawa Y., Ravussin E. Absence of genetic variation in some obesity candidate genes (GLP1R, ASI P, MC4R, MC5R) among Pima indians [In Process Citation]. Int J Obes Relat Metab Disord. 23:1999;163-165.
60. Chen W., Kelly M. A., Opitz-Araya X., Thomas R. E., Low M. J., Cone R. D. Exocrine gland dysfunction in MC5-R-deficient mice: evidence for coordinated regulation of exocrine gland function by melanocortin peptides. Cell. 91:1997;789-798.
61. Zemel M. B. Agouti/melanocortin interactions with leptin pathways in obesity. Nutr Rev. 56:1998;271-274.
62. iapy) is correlated with methylation state and is influenced by parental lineage. Genes Dev. 8:1994;1463-1472.
63. y) mutation explained by deletion of a maternally expressed gene and the simultaneous production of agouti fusion RNAs. Development. 120:1994;1695-1708.
64. hvy) mutation at the agouti locus. Genetics. 142:1996;557-567.
65. Klebig M. L., Wilkinson J. E., Geisler J. G., Woychik R. P. Ectopic expression of the agouti gene in transgenic mice causes obesity, features of type II diabetes, and yellow fur [see comments]. Proc Natl Acad Sci U S A. 92:1995;4728-4732.
66. Blanchard S. G., Harris C. O., Ittoop O. R. Agouti antagonism of melanocortin binding and action in the B16F10 murine melanoma cell line. Biochemistry. 34:1995;10,406-10,411.
67. Perry W. L., Hustad C. M., Swing D. A., Jenkins N. A., Copeland N. G. A transgenic mouse assay for agouti protein activity. Genetics. 140:1995;267-274.
68. Ollmann M. M., Lamoreux M. L., Wilson B. D., Barsh G. S. Interaction of agouti protein with the melanocortin 1 receptor in vitro and in vivo. Genes Dev. 12:1998;316-330.
69. Kim J. H., Kiefer L. L., Woychik R. P. Agouti regulation of intracellular calcium: role of melanocortin receptors. Am J Physiol. 272:1997;E379-E384.
70. Jones B. H., Kim J. H., Zemel M. B. Upregulation of adipocyte metabolism by agouti protein: possible paracrine actions in yellow mouse obesity. Am J Physiol. 270:1996;E192-E196.
71. Zemel M. B., Kim J. H., Woychik R. P. Agouti regulation of intracellular calcium: role in the insulin resistance of viable yellow mice [see comments]. Proc Natl Acad Sci USA. 92:1995;4733-4737.
72. Wilson B. D., Ollmann M. M., Kang L., Stoffel M., Bell G. I., Barsh G. S. Structure and function of ASP, the human homolog of the mouse agouti gene. Hum Mol Genet. 4:1995;223-230.
73. Boston B. A., Blaydon K. M., Varnerin J., Cone R. D. Independent and additive effects of central POMC and leptin pathways on murine obesity. Science. 278:1997;1641-1644.
74. Broberger C., De Lecea L., Sutcliffe J. G., Hokfelt T. Hypocretin/orexin- and melanin-concentrating hormone-expressing cells form distinct populations in the rodent lateral hypothalamus: relationship to the neuropeptide Y and agouti gene-related protein systems. J Comp Neurol. 402:1998;460-474.
75. Hahn T. M., Breininger J. F., Baskin D. G., Schwartz M. W. Coexpression of Agrp and NPY in fasting-activated hypothalamic neurons [letter] [In Process Citation]. Nat Neurosci. 1:1998;271-272.
76. Mercer J. G., Hoggard N., Williams L. M. Coexpression of leptin receptor and preproneuropeptide Y mRNA in arcuate nucleus of mouse hypothalamus. J Neuroendocrinol. 8:1996;733-735.
77. Mercer J. G., Hoggard N., Williams L. M., Lawrence C. B., Hannah L. T., Trayhurn P. Localization of leptin receptor mRNA and the long form splice variant (Ob-Rb) in mouse hypothalamus and adjacent brain regions by in situ hybridization. FEBS Lett. 387:1996;113-116.
78. Bjorbaek C., Elmquist J. K., Frantz J. D., Shoelson S. E., Flier J. S. Identification of SOCS-3 as a potential mediator of central leptin resistance. Mol Cell. 1:1998;619-625.
79. Mizuno T. M., Mobbs C. V. Hypothalamic agouti-related protein messenger ribonucleic acid is inhibited by leptin and stimulated by fasting. Endocrinology. 140:1999;814-817.
80. Tota M. R., Smith T. S., Mao C. Molecular interaction of agouti protein and agouti-related protein with human melanocortin receptors. Biochemistry. 38:1999;897-904.
81. Yang Y. K., Thompson D. A., Dickinson C. J. Characterization of agouti-related protein binding to melanocortin receptors. Mol Endocrinol. 13:1999;148-155.
82. Rosenfeld R. D., Zeni L., Welcher A. A. Biochemical, biophysical, and pharmacological characterization of bacterially expressed human agouti-related protein. Biochemistry. 37:1998;16,041-16,052.
83. Rossi M., Kim M. S., Morgan D. G. A C-terminal fragment of agouti-related protein increases feeding and antagonizes the effect of alpha-melanocyte stimulating hormone in vivo. Endocrinology. 139:1998;4428-4431.
84. Graham M., Shutter J. R., Sarmiento U., Sarosi I., Stark K. L. Overexpression of Agrt leads to obesity in transgenic mice [letter]. Nat Genet. 17:1997;273-274.
85. Miller K. A., Gunn T. M., Carrasquillo M. M., Lamoreux M. L., Galbraith D. B., Barsh G. S. Genetic studies of the mouse mutations mahogany and mahoganoid. Genetics. 146:1997;1407-1415.
86. Dinulescu D. M., Fan W., Boston B. A. Mahogany (mg) stimulates feeding and increases basal metabolic rate independent of its suppression of agouti. Proc Natl Acad Sci USA. 95:1998;12,707-12,712.
87. Kawauchi H., Kawazoe I., Tsubokawa M., Kishida M., Baker B. I. Characterization of melanin-concentrating hormone in chum salmon pituitaries. Nature. 305:1983;321-323.
88. Miller C. L., Hruby V. J., Matsunaga T. O., Bickford P. C. Alpha-Msh and Mch are functional antagonists in a central nervous system auditory gating paradigm. Ann N Y Acad Sci. 680:1993;571-574.
89. Miller C. L., Hruby V. J., Matsunaga T. O., Bickford P. C. Alpha-MSH and MCH are functional antagonists in a CNS auditory gating paradigm. Peptides. 14:1993;431-440.
90. Ludwig D. S., Mountjoy K. G., Tatro J. B. Melanin-concentrating hormone: a functional melanocortin antagonist in the hypothalamus. Am J Physiol. 274:1998;E627-E633.
91. Bittencourt J. C., Presse F., Arias C. The melanin-concentrating hormone system of the rat brain: an immuno- and hybridization histochemical characterization. J Comp Neurol. 319:1992;218-245.
92. Harrell L. E., Decastro J. M., Balagura S. A critical evaluation of body weight loss following lateral hypothalamic lesions. Physiol Behav. 15:1975;133-136.
93. Rossi M., Choi S. J., O'Shea D., Miyoshi T., Ghatei M. A., Bloom S. R. Melanin-concentrating hormone acutely stimulates feeding, but chronic administration has no effect on body weight. Endocrinology. 138:1997;351-355.
94. Sanchez M., Baker B. I., Celis M. Melanin-concentrating hormone (MCH) antagonizes the effects of alpha-MSH and neuropeptide E-I on grooming and locomotor activities in the rat. Peptides. 18:1997;393-396.
95. Saito Y., Nothacker H-P., Wang Z., Lin S. H. S., Leslie F., Civelli O. Molecular characterization of the melanin-concentrating hormone receptor. Nature. 400:1999;265-269.
96. Chambers J., Ames R. S., Bergsma D. Melanin-concentrating hormone is the cognate ligand for the orphan G-protein-coupled receptor SLC-1. Nature. 400:1999;261-265.
97. Lakaye B., Minet A., Zorzi W., Grisar T. Cloning of the rat brain cDNA encoding for the SLC-1 G protein-coupled receptor reveals the presence of an intron in the gene. Biochim Biophys Acta. 1401:1998;216-220.
98. Kolakowski L. F. Jr, Jung B. P., Nguyen T. Characterization of a human gene related to genes encoding somatostatin receptors. FEBS Lett. 398:1996;253-258.