Brain administration of OB protein (leptin) inhibits neuropeptide-Y-induced feeding in ob/ob mice

Regulatory Peptides

Volumn 75-76, Issue , 1998, Pages 433-439

  Smith, Françoise J ^a   Campfield, L Arthur ^a   Moschera, John A ^b   Bailon, Pascal S ^b   Burn, Paul ^a  

^a Hoffman La Roche Department of Metabolic Diseases   (United States)

^b HOFFMANN LA ROCHE INC   (United States)

Author keywords

CRH; Food intake; Neuropeptides; NPY; Obesity; POMC

Indexed keywords

LEPTIN; NEUROPEPTIDE Y;

ANIMAL MODEL; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; DOSE RESPONSE; FOOD INTAKE; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL;

ANIMALS; BRAIN; CORTICOTROPIN-RELEASING HORMONE; DRUG INTERACTIONS; EATING; FEMALE; HUMANS; INJECTIONS, INTRAVENTRICULAR; LEPTIN; MALE; MICE; MICE, INBRED C57BL; MICE, OBESE; NEUROPEPTIDE Y; OBESITY; PRO-OPIOMELANOCORTIN; PROTEINS; RECOMBINANT PROTEINS;

EID: 0032566830     PISSN: 01670115     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0167-0115(98)00099-8     Document Type: Article

References (49)

1. Tatemoto K, Caarlquist M, Mutt V Neuropeptide Y - a novel brain peptide with structural similarities to peptide YY and pancreatic polypeptide. Nature. 296:1982;659-660.
2. Clark JT, Kalra PS, Crowley WR, Kalra SP Neuropeptide Y and human pancreatic polypeptide stimulate feeding behavior in rats. Endocrinology. 115:1984;427-429.
3. Stanley BG, Kyrkouli SE, Lampert S, Leibowitz SF Neuropeptide Y chronically injected into the hypothalamus: a powerful neurochemical inducer of hyperphagia and obesity. Peptides. 7:1986;189-192.
4. Kalra SP, Dube MG, Sahu A, Phelps CP, Kalra PS Neuropeptide Y increases in the paraventricular nucleus in association with increased appetite for food. Proc Natl Acad Sci USA. 88:1992;10931-10935.
5. Zarjevski N, Cusin I, Vettor R, Rohner-Jeanrenaud F, Jeanrenaud B Chronic intercerebroventricular neuropeptide Y administration to normal rats mimics hormonal and metabolic changes to obesity. Endocrinology. 133:1993;1753-1758.
6. Leibowitz SF, Alexander JT Analysis of neuropeptide Y-induced feeding: dissociation of Y1 and Y2 receptor effects on natural meal patterns. Peptides. 12:1991;1252-1260.
7. Schwartz MW, Figlewicz DP, Baskin DG, Woods SC, Porte D Jr. Insulin and the central regulation of energy balance: update 1994. Endocr Rev. 2:1994;109-113.
8. Kaiyala KJ, Woods SC, Schwartz MW New model for the regulation of energy balance and adiposity by the central nervous system. Am J Clin Nutr. 62:1995;1123s-1134s.
9. Frankish HM, Dryden S, Hopkins D, Wang Q, Williams G Neuropeptide Y, the hypothalamus, and diabetes: insights into the central control of metabolism. Peptides. 16:1995;757-771.
10. Corp ES, Melville LD, Greenberg D, Gibbs J, Smith GP Effect of fourth ventricular neuropeptide Y and peptide YY on ingestive and other behaviors. Am J Physiol. 259:1990;R317-R323.
11. Campfield LA, Smith FJ, Guisez Y, Devos R, Burn P Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks. Science. 269:1995;546-549.
12. Campfield LA, Smith FJ, Guisez Y, Devos R, Burn P OB protein: a peripheral signal linking adiposity and central neural networks. Appetite. 26:1996;302.
13. Campfield LA, Smith FJ, Burn P The OB protein (leptin) pathway - a link between adipose tissue mass and central neural networks. Horm Metab Res. 28:1996;619-632.
14. Campfield LA, Smith FJ, Burn P OB protein: a hormonal controller of central neural networks mediating behavioral, metabolic and neuroendocrine responses. Endocrinol Metab. 4:1997;81-102.
15. Seeley RJ, van Dijk G, Campfield LA, Smith FJ, Burn P, Nelligan JA, Bell MS, Baskin DG, Woods SC, Schwartz MW Intraventricular leptin reduces food intake and body weight of lean rats but not obese Zucker rats. Horm Metab Res. 28:1996;664-668.
16. Stephens TW, Basinski M, Bristow PK, Bue-Valleskey JM, Burgett SG, Craft L, Hale J, Hoffmann J, Hsiung HM, Kriauciunas A, MacKeller W, Rosteck PR Jr., Schoner B, Smith D, Tinsley FC, Zhang X-Y, Heiman M The role of neuropeptide Y in the antiobesity action of the obese gene product. Nature. 377:1995;530-532.
17. Schwartz MW, Baskin DG, Bukowski TR, Kuijper JL, Foster D, Lasser G, Prunkard DE, Porte D Jr., Woods SC, Seeley RJ, Weigle DS Specificity of leptin action on elevated blood glucose levels and hypothalamic neuropeptide Y gene expression in ob/ob mice. Diabetes. 45:1996;531-535.
18. Schwartz MW, Seeley RJ, Campfield LA, Burn P, Baskin DG Identification of targets of leptin action in rat hypothalamus. J Clin Invest. 98:1996;1101-1106.
19. Ezzell C Fat times for obesity research: tons of new information, but how does it all fit together. J NIH Res. 7:1995;39-45.
20. Rohner-Jeanrenaud F, Jeanrenaud B Obesity, leptin, and the brain. N Engl J Med. 334:1996;324-325.
21. Rohner-Jeanrenaud F, Cusin I, Sainsbury A, Zakrzewska K, Jeanrenaud B Neuropeptide Y and leptin in lean and genetically obese fa/fa rats. Horm Metab Res. 28:1996;642-648.
22. Guisez Y., Fache I., Campfield L.A., Smith F.J., Farid A., Platinck G., Van der Heyden J., Tavernier J., Fiers W., Burn P., Devos R. Efficient secretion of biologically active recombinant OB protein (leptin) in Escherichia coli, purification from the periplasm and characterization. Protein Express Purif. 12:1998;249-258.
23. Snedecor GW, Cochran WG. Statistical methods. Ames, IA: Iowa University Press, 1989:503 pp.
24. Considine RV, Sinha MK, Heiman ML, Kriauciunas A, Stephens TW, Nyce MR, Ohannesian JP, Marco CC, McKee LJ, Baur TL, Caro JF Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N Engl J Med. 334:1996;292-295.
25. Maffei M, Halaas J, Ravussin E, Pratley RE, Lee GH, Zhang Y, Fei H, Kim S, Lallone R, Ranganathan S, Kern PA, Friedman JM Leptin levels in human and rodent: measurement of plasma leptin and ob mRNA in obese and weight-reduced subjects. Nature Med. 1:1995;1155-1161.
26. Tempel DL, Leibowitz SF Diurnal variations in the feeding responses to norepinephrine, neuropeptide Y and galanin in the PVN. Brain Res Bull. 25:1990;821-825.
27. Steinman JL, Gunion MW, Morley JE Forebrain and hindbrain involvement of neuropeptide Y in ingestive behaviors of rats. Pharmacol Biochem Behav. 47:1994;207-214.
28. Xu B, Dube MG, Kalra PS, Farmerie WG, Kaibara A, Moldawer LL, Martin D, Kalra SP Anorectic effects of the cytokine, ciliary neurotrophic factor, are mediated by hypothalamic neuropeptide Y: comparison with leptin. Endocrinology. 139:1998;466-473.
29. Smith FJ, Campfield LA, Moschera JA, Bailon P, Burn P Feeding inhibition by neuropeptide Y. Nature. 382:1996;307.
30. Stricker-Krongrad A, Chiesi M, Cumin F, Spanka C, Whitesbread S, Rentsch J, Lollman B, Hofbauer KG, Levens N Interactions between leptin and neuropeptide Y in the control of food intake in the rat. Obesity Res. 4(1):1996;37s.
31. Yokosuka M, Xu B, Pu S, Karla SP The magnocellular part of the paraventricular hypothalamic nucleus (PVN): a selective site for inhibition of NPY-induced food intake by leptin. Soc Neurosci Abstr. 23:1997;852.
32. Erickson JC, Clegg KE, Palmiter RD Sensitivity to leptin and susceptibility to seizures of mice lacking neuropeptide Y. Nature. 381:1996;415-418.
33. Schwartz MW, Seeley RJ, Woods SC, Weigle DS, Campfield LA, Burn P, Baskin DG Leptin increases hypothalamic pro-opiomelanocortin mRNA expression in the rostral arcuate nucleus. Diabetes. 46:1997;2119-2123.
34. Tartaglia LA, Dembski M, Weng X, Deng N, Culpepper J, Devos R, Richards JG, Campfield LA, Clark FT, Deeds J, Muir C, Sanker S, Moriarty A, Moore KJ, Smutko JS, Mays GG, Woolf EA, Monroe CA, Tepper RI Identification and expression cloning of a leptin receptor (OB-R). Cell. 83:1995;1263-1271.
35. Chen H, Charlat O, Tartaglia LA, Woolf EA, Weng X, Ellis SJ, Lakey ND, Culpepper J, Moore KJ, Breitbart RF, Duyk GM, Tepper RI, Morgenstern JP Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice. Cell. 84:1996;491-495.
36. Lee G, Proenca R, Montez JM, Carrol KM, Darvishzadeh JG, Lee JI, Friedman JM Abnormal splicing of the leptin receptor in diabetic mice. Nature. 379:1996;632-635.
37. Devos R, Richards JG, Campfield LA, Tartaglia LA, Guisez Y, Van der Heyden J, Travernier J, Plaetinck G, Burn P OB protein binds specifically to the choroid plexus of mice and rats. Proc Natl Acad Sci USA. 93:1996;5668-5673.
38. Hulsey MG, Martin RJ. Feeding response to sequential, ICV-administered adipocyte satiety factor (ASF) and neuropeptide Y (NPY). Proc. SSIB/NAASO Joint Meeting, 1994 (abstract).
39. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM Positional cloning of the mouse obese gene and its human homologue. Nature. 372:1994;425-431.
40. Halaas JL, Gajiwala KS, Maffei M, Cohen SL, Chait BT, Rabinowitz D, Lallone RL, Burley SK, Friedman JM Weight-reducing effects of the plasma protein encoded by the obese gene. Science. 269:1995;543-546.
41. Pelleymounter M, Cullen M, Baker M, Hecht R, Winters D, Bone T, Collins F Effects of the obese gene product on body weight regulation in ob/ob mice. Science. 269:1995;540-543.
42. Rentsch J, Levens N, Chiesi M Recombinant ob-gene product reduces food intake in fasted mice. Biochem Biophys Res Commun. 214:1995;131-136.
43. Levin N, Nelson C, Gurney A, Vandlen R, DeSauvage F Decreased food intake does not completely account for adiposity reduction after OB protein infusion. Proc Natl Acad Sci USA. 93:1996;1726-1730.
44. Sonti G, Ilyin SE, Plata-Salaman CR Neuropeptide Y blocks and reverses interleukin-1 beta-induced anorexia in rats. Peptides. 17:1997;517-520.
45. Campfield LA, Smith FJ. Systemic factors in the control of food intake: evidence for patterns as signals. In: Stricker EM, editor. Handbook of behavioral neurobiology, vol. 10, neurobiology of food and fluid intake. Plenum Press: New York, 1990:183-206.
46. Campfield LA, Smith FJ Transient declines in blood glucose signal meal initiation. Int J Obesity. 14:1990;15-33.
47. Le Magnen J. Neurobiology of feeding and nutrition. San Diego, CA: Academic Press, 1992:385 p.
48. Stricker EM. Handbook of behavioral neurobiology, vol. 10, neurobiology of food and fluid intake. New York: Plenum Press, 1990:553 p.
49. Huszar D, Lynch CA, Fairchild-Huntress V, Dunmore JH, Fang Q, Berkemeier LR, Gu W, Kesterson RA, Boston BA, Cone RD, Smith FJ, Campfield LA, Burn P, Lee F Targeted disruption of the melanocortin-4 receptor results in obesity in mice. Cell. 88:1997;131-141.