The role of B7 costimulation in CD4/CD8 T cell homeostasis

Journal of Immunology

Volumn 164, Issue 7, 2000, Pages 3543-3553

  Yu, Xiang ^a   Fournier, Sylvie ^b   Allison, James P ^b   Sharpe, Arlene H ^c   Hodes, Richard J ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

B7 ANTIGEN; CD28 ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; CD86 ANTIGEN;

ANIMAL CELL; ANTIGEN EXPRESSION; ARTICLE; HELPER CELL; LYMPHOID HYPERPLASIA; MOUSE; NONHUMAN; PRIORITY JOURNAL; SUPPRESSOR CELL; T LYMPHOCYTE; THYMOCYTE; TRANSGENIC MOUSE;

EID: 0034176939     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.164.7.3543     Document Type: Article

References (36)

1. + T cells. Immunol. Rev. 165:231.
2. Greenfield, E. A., K. A. Nguyen, and V. K. Kuchroo. 1998. CD28/B7 costimulation: a review. Crit. Rev. Immunol. 18:389.
3. Hathcock, K. S., G. Laszlo, H. B. Dickler, J. Bradshaw, P. Linsley, and R. J. Nodes. 1993. Identification of an alternative CTLA-4 ligand costimulatory for T cell activation. Science 262:905.
4. Linsley, P. S., and J. A. Ledbetter. 1993. The role of the CD28 receptor during T cell responses to antigen. Annu. Rev. Immunol. 11:191.
5. Guinan, E. C., J. G. Gribben, V. A. Boussiotis, G .J. Freeman, and L. M. Nadler. 1994. Pivotal role of the B7:CD28 pathway in transplantation tolerance and tumor immunity. Blood 84:3261.
6. June, C. H., J. A. Bluestone, L. M. Nadler, and C. B. Thompson. 1994. The B7 and CD28 receptor families. Immunol. Today 15:321.
7. Harlan, D. M., H. Hengartner, M. L. Huang, Y. H. Kang, R. Abe, R. W. Moreadith, H. Pircher, G. S. Gray, P.S. Ohashi, and G .J. Freeman. 1994. Mice expressing both B7-1 and viral glycoprotein on pancreatic β cells along with glycoprotein-specific Tg T cells develop diabetes due to a breakdown of T-lymphocyte unresponsiveness. Proc. Natl. Acad. Sci. USA 91:3117.
8. Shahinian, A., K. Pfeffer, K. P. Lee, T .M. Kundig, K. Kishihara, A. Wakeham, K. Kawai, P. S. Ohashi, C. B. Thompson, and T. W. Mak. 1993. Differential T cell costimulatory requirements in CD28-delicient mice. Science 261:609.
9. Waterhouse, P., J. M. Penninger, E. Timms, A. Wakeham, A. Shahinian, K. P. Lee, C. B. Thompson, H. Griesser, and T. W. Mak. 1995. Lymphoprolifcrative disorders with early lethality in mice deficient in CTLA-4. Science 270: 985.
10. Tivol, E. A., F. Borriello, A. N. Schweitzer, W. P. Lynch, J. A. Bluestone, and A. H. Sharpe. 1995. Loss of CTLA-4 leads to massive lymphoproliferalion and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4. Immunity 3:541.
11. Borriello, F., M. P. Sethna, S. D. Boyd, A. N. Schweitzer, E. A. Tivol, D. Jacoby, T. B. Strom, E. M. Simpson, G. J. Freeman, and A. H. Sharpe. 1997. B7-1 and B7-2 have overlapping, critical roles in immunoglobulin class switching and germinal center formation. Immunity 6:303.
12. van Parijs, L., M. P. Sethna, A. N. Schweitzer, F. Borriello, A. H. Sharpe, and A. K. Abbas. 1997. Functional consequences of dysregulated B7-1 (CD80) and B7-2 (CD86) expression in B or T lymphocytes of transgenic mice. J. Immunol. 159:5336.
13. Fournier, S., J. C. Rathmell, C. C. Goodnow, and J. P. Allison. 1997. T cell-mediated elimination of B7.2 transgenic B cells. Immunity 6:327.
14. Sethna, M. P., L. van Parijs, A. H. Sharpe, A. K. Abbas, and G. J. Freeman. 1994. A negative regulatory function of B7 revealed in B7-1 transgenic mice. Immunity 1:415.
15. + thymocytes by two distinct mechanisms differing in their requirement for CD28 costimulation: implications for negative selection in the thymus. J. Exp. Med. 186:1911.
16. + thymocytes by T cell receptor-induced apoptosis requires a costimulatory signal that can be provided by CD28. J. Exp. Med. 179:709.
17. Noel, P. J., M. L. Alegre, S. L. Reiner, and C. B. Thompson. 1998. Impaired negative selection in CD28-deficient mice. Cell. Immunol. 187:131.
18. Cilio, C. M., M. R. Daws, A. Malashicheva, C. L. Sentman, and D. Holmberg. 1998. Cytotoxic T lymphocyte antigen 4 is induced in the thymus upon in vivo activation and its blockade prevents anti-CD3-mediated depletion of thymocytes. J. Exp. Med. 188:1239.
19. Jones, L. A., D. J. Izon, J. D. Nieland, P. S. Linsley, and A. M. Kruisbeek. 1993. CD28-B7 interactions are not required for intrathymic clonal deletion. Int. Immunol. 5:503.
20. Walunas, T. L., A. I. Sperling, R. Khattri, C. B. Thompson, and J. A. Bluestone. 1996. CD28 expression is not essential for positive and negative selection of thymocytes or peripheral T cell tolerance. J. Immunol. 156:1006.
21. lo thymocytes in vivo. Science 250: 1720.
22. Hathcock, K. S., G. Laszlo, C. Pucillo, P. Linsley, and R. J. Hodes. 1994. Comparative analysis of B7-1 and B7-2 costimulatory ligands: expression and function. J. Exp. Med. 180:631.
23. Singer, A., K. S. Hathcock, and R. J. Hodes. 1979. Cellular and genetic control of antibody responses. V. Helper T-cell recognition of H-2 determinants on accessory cells but not B cells. J. Exp. Med. 149:1208.
24. Lucas, P. J., I. Negishi, K. Nakayama, L. E. Fields, and D. Y. Loh. 1995. Naive CD28-deficient T cells can initiate but not sustain an in vitro antigen-specific immune response. J. Immunol. 154:5757.
25. Sentman, C. L., J. R. Shutter, D. Hockenbery, O. Kanagawa, and S. J. Korsmeyer. 1991. bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes. Cell 67:879.
26. + stage during positive selection and promotes thymocyte differentiation at several control points. Immunity 1:197.
27. Robey, E., D. Chang, A. Itano, D. Cado, H. Alexander, D. Lans, G. Weinmaster, and P. Salmon. 1996. An activated form of Notch influences the choice between CD4 and CD8 T cell lineages. Cell 87:483.
28. Strasser, A., A. W. Harris, and S. Cory. 1991. bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship. Cell 67:889.
29. Siegel, R. M., M. Katsumata, T. Miyashita, D. C. Louie, M. I. Greene, and J. C. Reed. 1992. Inhibition of thymocyte apoptosis and negative antigenic selection in bcl-2 (ransgenic mice. Proc. Natl. Acad. Sci. USA 89:7003.
30. Deftos, M. L., Y. W. He, E. W. Ojala, and M. J. Bevan. 1998. Correlating notch signaling with thymocyte maturation. Immunity 9:777.
31. Itano, A., D. Cado, F. K. Chan, and E. Robey. 1994. A role for the cytoplasmic tail of the β chain of CD8 in thymic selection. Immunity 1:287.
32. Matechak, E. O., N. Killeen, S. M. Hedrick, and B. J. Fowlkes. 1996. MHC class II-specific T cells can develop in the CD8 lineage when CD4 is absent. Immunity 4:337.
33. L can inhibit apoptosis in cells that have undergone Fas-induced protease activation. Proc. Natl. Acad. Sci. USA 94: 3759.
34. Veis, D. J., C. L. Sentman, E. A. Bach, and S. J. Korsmeyer. 1993. Expression of the Bcl-2 protein in murine and human thymocytes and in peripheral T lymphocytes. J. Immunol. 151:2546.
35. Chambers, C. A., D. Cado, T. Truong, and J. P. Allison. 1997. Thymocyte development is normal in CTLA-4-deficient mice. Proc. Natl. Acad Sci. USA 94: 9296.
36. Mandelbrot, D. A., A. J. McAdam, and A. H. Sharpe. 1999. B7-1 or B7-2 is required to produce the lymphoproliferative phenotype in mice lacking cytotoxic T lymphocyte-associated antigen 4 (CTLA-4). J. Exp. Med. 189:435.