The pathology of familial breast cancer. How do the functions of BRCA1 and BRCA2 relate to breast tumour pathology?

Breast Cancer Research

Volumn 1, Issue 1, 1999, Pages 41-47

  Bertwistle, D ^a   Ashworth, A ^a  

^a INSTITUTE OF CANCER RESEARCH   (United Kingdom)

Author keywords

BRCA1; BRCA2; Breast cancer; Cell cycle checkpoints; DNA repair; Gene expression

Indexed keywords

BRCA1 PROTEIN; BRCA2 PROTEIN; DNA; PROTEIN BAX; PROTEIN MDM2; PROTEIN P21; PROTEIN TYROSINE PHOSPHATASE;

ANEUPLOIDY; ANIMAL EXPERIMENT; ANIMAL MODEL; BREAST CANCER; BREAST CARCINOGENESIS; CANCER GRADING; CANCER INHIBITION; CELL PROLIFERATION; CENTROSOME; CHROMOSOME ABERRATION; CONTROLLED STUDY; DNA REPAIR; FAMILIAL CANCER; FEMALE; GENE FUNCTION; GENE LOSS; GENE TARGETING; GENETIC CODE; HUMAN; MITOSIS; MOUSE; NONHUMAN; PROTEIN INTERACTION; PROTEIN STRUCTURE; REVIEW; TRANSCRIPTION REGULATION; TUMOR CELL;

BRCA1 PROTEIN; BRCA2 PROTEIN; BREAST NEOPLASMS; CELL CYCLE; DNA REPAIR; DNA REPLICATION; FEMALE; GENES, BRCA1; HUMANS; NEOPLASM PROTEINS; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

EID: 0033281717     PISSN: 14655411     EISSN: None     Source Type: Journal    
DOI: 10.1186/bcr12     Document Type: Review

References (65)

1. The genetics of breast cancer susceptibility
2. Functions of the BRCA1 and BRCA2 genes
3. Breast cancer genes: What are the real risks?
4. A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1
5. Identification of the breast cancer susceptibility gene BRCA2
6. Internal repeats in the BRCA2 protein sequence
7. The BRC repeats are conserved in mammalian BRCA2 proteins
8. The BRC repeats in BRCA2 are critical for RAD51 binding and resistance to methyl methanesulfonate treatment
9. RAD51 interacts with the evolutionarily conserved BRC motifs in the human breast cancer susceptibility gene BRC
10. Pathology of familial breast cancer: Differences between breast cancers in carriers of BRCA1 or BRCA2 mutations and sporadic cases
11. Transcriptional activation by BRCA1
12. Evidence for a transcriptional activation function of BRCA1 C-terminal region
13. Activation of transcription in vitro by the BRCA1 carboxyl-terminal domain
14. BRCA1 is a component of the RNA polymerase II holoenzyme
15. BRCA1 protein is linked to the RNA polymerase II holoenzyme complex via RNA helicase A
16. Factors associated with the mammalian RNA polymerase II holoenzyme
17. A human RNA polymerase II complex associated with SRB and DNA-repair proteins
18. Effects of p21 (Cip1/Waf1) at both the G1/S and the G2/M cell cycle transitions: pRb is a critical determinant in blocking DNA replication and in preventing endoreduplication
19. WAF1
20. BRCA1 physically associates with p53 and stimulates its transcriptional activity
21. BRCA1 regulates p53-dependent gene expression
22. The second BRCT domain of BRCA1 proteins interacts with p53 and stimulates transcription from the p21WAF1/CIP1 promoter
23. Induction of GADD45 and JNK/SAPK-dependent apoptosis following inducible expression of BRCA1
24. BRCA1 binds c-Myc and inhibits its transcriptional and transforming activity in cells
25. BRCA1 inhibition of estrogen receptor signaling in transfected cells
26. The C-terminal (BRCT) domains of BRCA1 interact in vivo with CtIP, a protein implicated in the CtBP pathway of transcriptional repression
27. Binding of CtIP to the BRCT repeats of BRCA1 involved in the transcription regulation of p21 is disrupted upon DNA damage
28. BRCA1 interacts with components of the histone deacetylase complex
29. The tumor suppressor gene Brca1 is required for embryonic cellular proliferation in the mouse
30. Transcriptional activation functions in BRCA2
31. The BRCA2 is a histo-acetyltransferase
32. BRCA2 associates with acetyltransferase activity when bound to P/CAF
33. BRCA-associated breast cancer: Absence of a characteristic immunophenotype
34. Hormone status in-situ cancer in BRCA1 and BRCA2 mutation carriers
35. Embryonic lethality an radiation hypersensitivity mediated by Rad51 in mice lacking Brca2
36. A targeted disruption of the murine Brca1 gene causes gamma-irradiation hypersensitivity and genetic instability
37. Tumorigenesis and a DNA repair defect in mice with a truncating Brca2 mutation
38. Involvement of Brca2 in DNA repair
39. Homologous recombination and non-homologous end-joining pathways of DNA double-strand break repair have overlapping roles in the maintenance of chromosomal integrity in vertebrate cells
40. BRCA1 is a 220-kDa nuclear phosphoprotein that is expressed and phosphorylated in a cell cycle-dependent manner
41. Nuclear location and cell cycle regulation of the BRCA2 protein
42. Homology-directed repair is a major double-strand break repair pathway in mammalian cells
43. Role of the human Rad51 protein in homologous recombination and double-strand break repair
44. Association of BRCA1 with Rad51 in mitotic and meiotic cells
45. Association of BRCA1 with the hRad50-hMre11-p95 complex and the DNA damage response
46. BRCA1 required for transcription-coupled repair of oxidative DNA damage
47. Rad51-deficient vertebrate cells accumulate chromosomal breaks prior to cell death
48. DNA double-strand breaks caused by replication arrest
49. Holliday junctions accumulate in replication mutants via a RecA homolog-independent mechanism
50. A mutation in mouse Rad51 results in an early embryonic lethal that is suppressed by a mutation in p53
51. Mitotic checkpoint inactivation fosters transformation in cells lacking the breast cancer susceptibility gene, Brca2
52. Targeted mutations of breast cancer susceptibility gene homologs in mice: Lethal phenotypes of Brca1, Brca2, Brca1/Brca2, Brca1/p53 and Brca2/p53 nullizygous embryos
53. P53 mutations in BRCA1-associated familial breast cancer
54. P53 mutation with frequent novel condons but not a mutator phenotype in BRCA1- and BRCA2-associated breast tumours
55. Centrosome amplification and a defective G2-M cell cycle checkpoint induce genetic instability in BRCA1 exon 11 isoform-deficient cells
56. A BRCA1 mutant alters G2-M cell cycle control in human mammary epithelial cells
57. The spindle checkpoint
58. Amorphous no longer: The centrosome comes into focus
59. Absence of BRCA2 causes genome instability by chromosome breakage and loss associated with centrosome amplification
60. The check-point control for anaphase onset does not monitor excess numbers of spindle poles or bipolar spindle symmetry
61. The centrosome: A tiny organelle with big potential
62. BRCA1 is associated with the centrosome during mitosis
63. Requirement of Cdk2-cyclin E activity for repeated centrosome reproduction in Xenopus egg extracts
64. Distinct somatic genetic changes associated with tumor progression in carriers of BRCA1 and BRCA2 germ-line mutations
65. Breast cancer genes: Therapeutic strategies