-
1
-
-
0033590513
-
Drug therapy: Treatment of asthma with drugs modifying the leukotriene pathway
-
Drazen JM, Israel E, O'Byrne PM: Drug therapy: Treatment of asthma with drugs modifying the leukotriene pathway. New Engl J Med 1999, 340:197-206.
-
(1999)
New Engl J Med
, vol.340
, pp. 197-206
-
-
Drazen, J.M.1
Israel, E.2
O'Byrne, P.M.3
-
3
-
-
0031755494
-
Biological insights from clinical trials with anti-TNF therapy
-
Feldmann M, Charles P, Taylor P, Maini RN: Biological insights from clinical trials with anti-TNF therapy. Springer Semin Immunopathol 1998, 20:211-228.
-
(1998)
Springer Semin Immunopathol
, vol.20
, pp. 211-228
-
-
Feldmann, M.1
Charles, P.2
Taylor, P.3
Maini, R.N.4
-
4
-
-
0033611515
-
Anticytokine therapy - A new era in the treatment of rheumatoid arthritis
-
O'Dell JR: Anticytokine therapy - A new era in the treatment of rheumatoid arthritis. New Engl J Med 1999, 340:310-312.
-
(1999)
New Engl J Med
, vol.340
, pp. 310-312
-
-
O'Dell, J.R.1
-
5
-
-
0031686456
-
The future role of anti-tumor necrosis factor-alpha products in the treatment of Crohn's disease
-
Van Hogezand RA, Verspaget HW: The future role of anti-tumor necrosis factor-alpha products in the treatment of Crohn's disease. Drugs 1998, 56:299-305.
-
(1998)
Drugs
, vol.56
, pp. 299-305
-
-
Van Hogezand, R.A.1
Verspaget, H.W.2
-
6
-
-
0030996312
-
Anti-tumor necrosis factor-alpha therapy of rheumatoid arthritis
-
Feldmann M, Elliott MH, Woody JN, Maini RN: Anti-tumor necrosis factor-alpha therapy of rheumatoid arthritis. Adv Immunol 1997, 64:283-350.
-
(1997)
Adv Immunol
, vol.64
, pp. 283-350
-
-
Feldmann, M.1
Elliott, M.H.2
Woody, J.N.3
Maini, R.N.4
-
7
-
-
0013511183
-
c fusion protein
-
c fusion protein. New Engl J Med 1997, 337:141-147.
-
(1997)
New Engl J Med
, vol.337
, pp. 141-147
-
-
Moreland, L.W.1
Baumgartner, S.W.2
Schiff, M.H.3
Tindall, E.A.4
Fleischmann, R.M.5
Weaver, A.L.6
Ettlinger, R.E.7
Cohen, S.8
Koopman, W.J.9
Mohler, K.10
-
10
-
-
0032516626
-
Feedback inhibition of macrophage tumor necrosis factor-α production by tristetraprolin
-
Carballo E, Lai WS, Blackshear PJ: Feedback inhibition of macrophage tumor necrosis factor-α production by tristetraprolin. Science 1998, 281:1001-1005.
-
(1998)
Science
, vol.281
, pp. 1001-1005
-
-
Carballo, E.1
Lai, W.S.2
Blackshear, P.J.3
-
11
-
-
0028810316
-
Effects of murine recombinant interleukin 1 but not tumor necrosis factor in early cartilage damage in immune complex arthritis in mice
-
Van de Loo AAJ, van den Berg WB: Effects of murine recombinant interleukin 1 but not tumor necrosis factor in early cartilage damage in immune complex arthritis in mice. J Rheumatiol 1995, 22:2250-2258.
-
(1995)
J Rheumatiol
, vol.22
, pp. 2250-2258
-
-
Van De Loo, A.A.J.1
Van Den Berg, W.B.2
-
12
-
-
17444394445
-
Treatment of rheumatoid arthritis with recombinant human interleukin-1 receptor antagonist
-
Bresnihan B, Alvaro-Garcia JM, Cobby M, Doherty M, Domljan Z, Emery P, Nuki G, Pavelka K, Rau R, Rozman B: Treatment of rheumatoid arthritis with recombinant human interleukin-1 receptor antagonist. Arth Rheum 1998, 41:2196-2204. Clinical evaluation of IL-1Ra (Antril), an IL-1 receptor antagonist, demonstrates efficacy and safety in a large cohort of patients with active and severe RA. IL-1 Ra is the first biological agent to demonstrate a beneficial effect on the rate of joint erosion.
-
(1998)
Arth Rheum
, vol.41
, pp. 2196-2204
-
-
Bresnihan, B.1
Alvaro-Garcia, J.M.2
Cobby, M.3
Doherty, M.4
Domljan, Z.5
Emery, P.6
Nuki, G.7
Pavelka, K.8
Rau, R.9
Rozman, B.10
-
13
-
-
0029875804
-
Anticytokine treatment of established type II collagen induced arthritis in DBAP/1 mice: A comparative study using anti-TNF-α, IL-1α1B, and IL-1Ra
-
Joosten LAB, Helsen MMA, Van de Loo FAJ, Van de Berg WB: Anticytokine treatment of established type II collagen induced arthritis in DBAP/1 mice: A comparative study using anti-TNF-α, IL-1α1B, and IL-1Ra. Arth Rheum 1996, 39:797-809.
-
(1996)
Arth Rheum
, vol.39
, pp. 797-809
-
-
Joosten, L.A.B.1
Helsen, M.M.A.2
Van De Loo, F.A.J.3
Van De Berg, W.B.4
-
16
-
-
0032499260
-
Chemokines and leukocyte traffic
-
Baggiolini M: Chemokines and leukocyte traffic. Nature 1998, 392:565-568.
-
(1998)
Nature
, vol.392
, pp. 565-568
-
-
Baggiolini, M.1
-
17
-
-
0033083950
-
Opportunities for novel therapeutic agents acting at chemokine receptors
-
Saunders J, Tarby CM: Opportunities for novel therapeutic agents acting at chemokine receptors. Drug Discov Today 1999, 4:80-92. This paper reviews this extensive receptor family and the approaches used to modulate these targets.
-
(1999)
Drug Discov Today
, vol.4
, pp. 80-92
-
-
Saunders, J.1
Tarby, C.M.2
-
18
-
-
0001345942
-
Agents targeting transcription factors
-
Edited by Gallin JI, Snyderman R. Philadelphia: Lippincott, Williams and Wilkins; in press
-
Manning AM, Rao A: Agents targeting transcription factors. In Inflammation: Basic Principles and Clinical Correlates. Edited by Gallin JI, Snyderman R. Philadelphia: Lippincott, Williams and Wilkins; 1999:in press.
-
(1999)
Inflammation: Basic Principles and Clinical Correlates
-
-
Manning, A.M.1
Rao, A.2
-
19
-
-
0032931433
-
Signal transduction and transcription factors in rheumatic disease
-
Firestein GS, Manning AM: Signal transduction and transcription factors in rheumatic disease. Arth Rheum 1999, 42:609-621.
-
(1999)
Arth Rheum
, vol.42
, pp. 609-621
-
-
Firestein, G.S.1
Manning, A.M.2
-
20
-
-
0029808748
-
Transcription factor AP-1 regulation by mitogen-activated protein kinese signal transduction pathways
-
Whitmarsh AJ, Davis RJ: Transcription factor AP-1 regulation by mitogen-activated protein kinese signal transduction pathways. J Mol Med 1996, 74:589-607.
-
(1996)
J Mol Med
, vol.74
, pp. 589-607
-
-
Whitmarsh, A.J.1
Davis, R.J.2
-
21
-
-
0001908214
-
Regulation of transcription by MAP kinase cascades
-
Treisman R: Regulation of transcription by MAP kinase cascades. Curr Opin Genet Dev 1996, 4:96-101.
-
(1996)
Curr Opin Genet Dev
, vol.4
, pp. 96-101
-
-
Treisman, R.1
-
22
-
-
0032935664
-
Mitogen-activated protein kinases: Specific messages from ubiquitous messengers
-
Schaeffer HJ, Weber MJ: Mitogen-activated protein kinases: Specific messages from ubiquitous messengers. Mol Cell Biol 1999, 4:2435-2444.
-
(1999)
Mol Cell Biol
, vol.4
, pp. 2435-2444
-
-
Schaeffer, H.J.1
Weber, M.J.2
-
23
-
-
0032054723
-
Signal transduction by the c-Jun N-terminal kinase (JNK) from inflammation to development
-
Ip YT, Davis RJ: Signal transduction by the c-Jun N-terminal kinase (JNK) from inflammation to development. Curr Opin Cell Biol 1998, 10:205-219. This reviews the important role played by the JNK signaling pathway in cell proliferation, apoptosis and tissue morphogenesis.
-
(1998)
Curr Opin Cell Biol
, vol.10
, pp. 205-219
-
-
Ip, Y.T.1
Davis, R.J.2
-
24
-
-
0032422785
-
Structural organization of MAP kinase signaling modules by scaffold proteins in yeast and mammals
-
Whitmarsh AJ, Davis RJ: Structural organization of MAP kinase signaling modules by scaffold proteins in yeast and mammals. Trends Biochem Sci 1 998, 23:481-485. Scaffold proteins have been recently identified in mammalian cells that facilitate MAPK activation and insulate MAPK modules to ensure signaling specifity.
-
(1998)
Trends Biochem Sci
, vol.23
, pp. 481-485
-
-
Whitmarsh, A.J.1
Davis, R.J.2
-
26
-
-
0030780804
-
Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the JNK3 gene
-
Yang DD, Kuan CY, Whitmarsh AJ, Rincon M, Zheng TS, Davis RJ, Rakic P, Flavell RA: Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the JNK3 gene. Science 1997, 389:865-870.
-
(1997)
Science
, vol.389
, pp. 865-870
-
-
Yang, D.D.1
Kuan, C.Y.2
Whitmarsh, A.J.3
Rincon, M.4
Zheng, T.S.5
Davis, R.J.6
Rakic, P.7
Flavell, R.A.8
-
27
-
-
0032509479
-
Defective T cell differentiation in the absence of JNK1
-
Dong C, Yang DD, Wysk M, Whitmarsh AJ, Davis RJ, Flavell RA: Defective T cell differentiation in the absence of JNK1. Science 1998, 282:2092-2095. This is the first description of JNK1-deficient mice and demonstrates that JNK1 signaling plays a critical role in T cell receptor-initiated T helper cell proliferation, apoptosis and differentiation.
-
(1998)
Science
, vol.282
, pp. 2092-2095
-
-
Dong, C.1
Yang, D.D.2
Wysk, M.3
Whitmarsh, A.J.4
Davis, R.J.5
Flavell, R.A.6
-
28
-
-
0032191173
-
+ T cells to Th1 cells requires MAP kinase JNK2
-
+ T cells to Th1 cells requires MAP kinase JNK2. Immunity 1998, 9:575-585. JNK2-deficient mice revealed an important role of JNK2 in Th1 and Th2 responses. JNK2 is required for productive interferon γ in Th1 cells but not for IL-4 production in Th2 cells.
-
(1998)
Immunity
, vol.9
, pp. 575-585
-
-
Yang, D.D.1
Conge, D.2
Whitmarsh, A.J.3
Barrett, T.4
Davis, R.J.5
Rincon, M.6
Flavell, R.A.7
-
29
-
-
0028880006
-
Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis
-
Xia Z, Dickens M, Raingeaud J, Davis RJ, Greenberg ME: Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science 1995, 270:1326-1331.
-
(1995)
Science
, vol.270
, pp. 1326-1331
-
-
Xia, Z.1
Dickens, M.2
Raingeaud, J.3
Davis, R.J.4
Greenberg, M.E.5
-
30
-
-
0345251973
-
Pharmacological modulation of cytokine action and production through signaling pathways
-
Young PR: Pharmacological modulation of cytokine action and production through signaling pathways. Cyt Growth Factor Rev 1998, 9:239-257.
-
(1998)
Cyt Growth Factor Rev
, vol.9
, pp. 239-257
-
-
Young, P.R.1
-
31
-
-
0031024646
-
Activation of stress activated protein kinase-3 (SAPK3) by cytokines and cellular stresses is mediated via SAPKK3 (MKK6); comparison of the specificities of SAPK3 and SAPK2 (RK/p38)
-
Cuenda A, Cohen P, Buee-Scherrer V, Goedert M: Activation of stress activated protein kinase-3 (SAPK3) by cytokines and cellular stresses is mediated via SAPKK3 (MKK6); comparison of the specificities of SAPK3 and SAPK2 (RK/p38). EMBO J 1997, 16:295-305.
-
(1997)
EMBO J
, vol.16
, pp. 295-305
-
-
Cuenda, A.1
Cohen, P.2
Buee-Scherrer, V.3
Goedert, M.4
-
32
-
-
0030828701
-
Characterization of the structure and function of the fourth member of p38 group mitogen - Activated protein kinase, p38δ
-
Jiang Y, Gram H, Zhao M, New L, Gu J, Feng L, Di Padova F, Ulevitch RJ, Han J: Characterization of the structure and function of the fourth member of p38 group mitogen - Activated protein kinase, p38δ. J Biol Chem 1997, 272:30122-30128.
-
(1997)
J Biol Chem
, vol.272
, pp. 30122-30128
-
-
Jiang, Y.1
Gram, H.2
Zhao, M.3
New, L.4
Gu, J.5
Feng, L.6
Di Padova, F.7
Ulevitch, R.J.8
Han, J.9
-
33
-
-
0030783156
-
The search for physiological substrates of MAP and SAP kinases in mammalian cells
-
Cohen P: The search for physiological substrates of MAP and SAP kinases in mammalian cells. Trends Cell Biol 1997, 7:353-361.
-
(1997)
Trends Cell Biol
, vol.7
, pp. 353-361
-
-
Cohen, P.1
-
34
-
-
14444279192
-
Identification of a novel inhibitor of mitogen-activated protein kinase
-
50 ∼60 nM).
-
(1998)
J Biol Chem
, vol.273
, pp. 18623-18632
-
-
Favata, M.F.1
Horiuchi, K.Y.2
Manos, E.J.3
Daulerio, A.J.4
Stradley, D.A.5
Feeser, W.S.6
Van Dyk, D.E.7
Pitts, W.J.8
Earl, R.A.9
Hobbs, F.10
-
36
-
-
10744227768
-
Acquisition of sensitivity of stress-activated protein kinases to the p38 inhibitor, SB203580, by alteration of one or more amino acids within the ATP binding pocket
-
Gum RJ, McLaughlin MM, Kumar S, Wang Z, Bower MJ, Lee JC, Adams JL, Livi GP, Goldsmith EJ, Young PR: Acquisition of sensitivity of stress-activated protein kinases to the p38 inhibitor, SB203580, by alteration of one or more amino acids within the ATP binding pocket. J Biol Chem 1998, 273:15605-15610.
-
(1998)
J Biol Chem
, vol.273
, pp. 15605-15610
-
-
Gum, R.J.1
McLaughlin, M.M.2
Kumar, S.3
Wang, Z.4
Bower, M.J.5
Lee, J.C.6
Adams, J.L.7
Livi, G.P.8
Goldsmith, E.J.9
Young, P.R.10
-
37
-
-
12644277392
-
The structural basis for the specificity of pyridinylimidazole inhibitors of p38 MAP kinase
-
Wilson KP, McCaffrey PG, Hsiao K, Pazhanisamy S, Gallulo V, Bemis GW, Fitzgibbon MJ, Caron PR, Murko MA: The structural basis for the specificity of pyridinylimidazole inhibitors of p38 MAP kinase. Chem Biol 1997, 4:423-431.
-
(1997)
Chem Biol
, vol.4
, pp. 423-431
-
-
Wilson, K.P.1
McCaffrey, P.G.2
Hsiao, K.3
Pazhanisamy, S.4
Gallulo, V.5
Bemis, G.W.6
Fitzgibbon, M.J.7
Caron, P.R.8
Murko, M.A.9
-
38
-
-
0032102902
-
Conversion of SB 203580 insensitive MAP kinase family members to drug-sensitive forms by a single amino acid substitution
-
Eyers PA, Craxton M, Morrice N, Cohen P, Goedert M: Conversion of SB 203580 insensitive MAP kinase family members to drug-sensitive forms by a single amino acid substitution. Chem Biol 1998, 5:321-328. These finding explain how p38 inhibitors of the pyridinylimidazole class ATP-binding site in p38α and β but not in other MAPK family members.
-
(1998)
Chem Biol
, vol.5
, pp. 321-328
-
-
Eyers, P.A.1
Craxton, M.2
Morrice, N.3
Cohen, P.4
Goedert, M.5
-
39
-
-
0032491233
-
Pyrroles and other heterocycles as inhibitors of p38 kinase
-
Hacker C, Sidler K, Luell S, Widmer WR, MacCoss M, O'Keefe SJ, Mantlo N, O'Neill EA, Orevillo C, de Laszlo SE et al.: Pyrroles and other heterocycles as inhibitors of p38 kinase. J Bioorg Med Chem Lett 1998, 8:2689-2694.
-
(1998)
J Bioorg Med Chem Lett
, vol.8
, pp. 2689-2694
-
-
Hacker, C.1
Sidler, K.2
Luell, S.3
Widmer, W.R.4
MacCoss, M.5
O'Keefe, S.J.6
Mantlo, N.7
O'Neill, E.A.8
Orevillo, C.9
De Laszlo, S.E.10
-
40
-
-
7844222102
-
6-amino-2-(4-fluorophenyl)-4-methoxy-3-(4-pyridyl)-1H-pyrrolo[2,3-b]pyridine (RWJ68356]: A potent and selective p38 kinase inhibitor
-
Henry JR, Rubert KC, Dodd JH, Turchi IJ, Wadsworth SA, Cavender DE, Fahmy B, Olini GC, Davis JE, Pellegrino-Gensey JL, et al.: 6-amino-2-(4-fluorophenyl)-4-methoxy-3-(4-pyridyl)-1H-pyrrolo[2,3-b]pyridine (RWJ68356]: A potent and selective p38 kinase inhibitor. J Med Chem 1998, 41:4196-4198.
-
(1998)
J Med Chem
, vol.41
, pp. 4196-4198
-
-
Henry, J.R.1
Rubert, K.C.2
Dodd, J.H.3
Turchi, I.J.4
Wadsworth, S.A.5
Cavender, D.E.6
Fahmy, B.7
Olini, G.C.8
Davis, J.E.9
Pellegrino-Gensey, J.L.10
-
41
-
-
0031474156
-
Synthetic glucocorticoids that dissociate transactivation and AP-1 transrepression exhibit anti-inflammatory activity in vivo
-
Vayssiere BM, Dupont S, Choquart A, Petit F, Garcia T, Marchandeau C, Gronemeyer H, Resche-Rigon M: Synthetic glucocorticoids that dissociate transactivation and AP-1 transrepression exhibit anti-inflammatory activity in vivo. Mol Endocrinol 1997, 11:1245-1255.
-
(1997)
Mol Endocrinol
, vol.11
, pp. 1245-1255
-
-
Vayssiere, B.M.1
Dupont, S.2
Choquart, A.3
Petit, F.4
Garcia, T.5
Marchandeau, C.6
Gronemeyer, H.7
Resche-Rigon, M.8
-
42
-
-
0032956438
-
Ligand-activated retinoic acid receptor inhibits AP-1 transactivation by disrupting c-Jun/ C-Fos dimerization
-
Zhou X-F, Shen X-Q, Shemshedini L: Ligand-activated retinoic acid receptor inhibits AP-1 transactivation by disrupting c-Jun/ C-Fos dimerization. Mol Endocrinol 1999, 13:276-285.
-
(1999)
Mol Endocrinol
, vol.13
, pp. 276-285
-
-
Zhou, X.-F.1
Shen, X.-Q.2
Shemshedini, L.3
-
43
-
-
0031455626
-
Nuclear hormone receptor antagonism with AP-1 by inhibition of the JNK pathway
-
Caelles C, Gonzalez-Sancho JM, Munoz A: Nuclear hormone receptor antagonism with AP-1 by inhibition of the JNK pathway. Genes Dev 1997, 11:3351-3364.
-
(1997)
Genes Dev
, vol.11
, pp. 3351-3364
-
-
Caelles, C.1
Gonzalez-Sancho, J.M.2
Munoz, A.3
-
44
-
-
0030615201
-
Nuclear factor-κB, a pivotal transcription factor in chronic inflammatory diseases
-
Barnes PJ, Karin M: Nuclear factor-κB, a pivotal transcription factor in chronic inflammatory diseases. New Engl J Med 1997, 336:1066-1071.
-
(1997)
New Engl J Med
, vol.336
, pp. 1066-1071
-
-
Barnes, P.J.1
Karin, M.2
-
45
-
-
0030747128
-
NF-κB as a frequent target for immunosuppressive and anti-inflammatory molecules
-
Baeuerle PA, Baichwal VR: NF-κB as a frequent target for immunosuppressive and anti-inflammatory molecules. Adv Immunol 1997, 65:111-137.
-
(1997)
Adv Immunol
, vol.65
, pp. 111-137
-
-
Baeuerle, P.A.1
Baichwal, V.R.2
-
46
-
-
0030610362
-
A cytokine responsive IκB kinase that activates the transcription factor NF-κB
-
DiDonato JA, Hayakawa M, Rothwarf DM, Zandi E, Karin M: A cytokine responsive IκB kinase that activates the transcription factor NF-κB. Nature 1997, 388:853-862.
-
(1997)
Nature
, vol.388
, pp. 853-862
-
-
DiDonato, J.A.1
Hayakawa, M.2
Rothwarf, D.M.3
Zandi, E.4
Karin, M.5
-
47
-
-
0030685825
-
IKK-1 and IKK-2: Cytokine-activated IκB kinases essential for NF-κB activation
-
Mercurio F, Zhu F, Murray BW, Shevchenko A, Bennett BL, Li JW, Young DB, Barbosa M, Mann M, Manning AM, Rao A: IKK-1 and IKK-2: Cytokine-activated IκB kinases essential for NF-κB activation. Science 1997, 278:860-866.
-
(1997)
Science
, vol.278
, pp. 860-866
-
-
Mercurio, F.1
Zhu, F.2
Murray, B.W.3
Shevchenko, A.4
Bennett, B.L.5
Li, J.W.6
Young, D.B.7
Barbosa, M.8
Mann, M.9
Manning, A.M.10
Rao, A.11
-
48
-
-
17944401842
-
Identification of the receptor component of the IκBα-ubiquitin ligase
-
Yaron A, Hatzubai A, Davis M, Lavon I, Amit S, Manning AM, Andersen JS, Mann M, Mercurio F, Ben-Neriah Y: Identification of the receptor component of the IκBα-ubiquitin ligase. Nature 1998, 396:590-594. The identification of the E3 ligase that selectively phosphorylates IκB prior to degradation by the 26S proteasome is described.
-
(1998)
Nature
, vol.396
, pp. 590-594
-
-
Yaron, A.1
Hatzubai, A.2
Davis, M.3
Lavon, I.4
Amit, S.5
Manning, A.M.6
Andersen, J.S.7
Mann, M.8
Mercurio, F.9
Ben-Neriah, Y.10
-
49
-
-
0033106149
-
A ubiquitin ligase complex essential for the NF-κB, wart/wingless, and hedgehog signaling pathways
-
Maniatis T: A ubiquitin ligase complex essential for the NF-κB, wart/wingless, and hedgehog signaling pathways. Genes Dev 1999, 13:505-510. A review of the recent discoveries associated with ubiquitin-dependent proteolysis and the identification of a specific IκB E3 ligase.
-
(1999)
Genes Dev
, vol.13
, pp. 505-510
-
-
Maniatis, T.1
-
50
-
-
0031017618
-
MAP3K-related kinase involved in NF-κB induction by TNF, CD95 and IL-1
-
Malinin NL, Boldin MP, Kovalenko AV, Wallach D: MAP3K-related kinase involved in NF-κB induction by TNF, CD95 and IL-1. Nature 1997, 385:540-544.
-
(1997)
Nature
, vol.385
, pp. 540-544
-
-
Malinin, N.L.1
Boldin, M.P.2
Kovalenko, A.V.3
Wallach, D.4
-
51
-
-
0031285250
-
Activation of the IkB alpha complex by MEKK1, a kinase of the JNK pathway
-
Lee FS, Hagler J, Chen ZJ, Maniatis T: Activation of the IkB alpha complex by MEKK1, a kinase of the JNK pathway. Cell 1997, 88:213-222.
-
(1997)
Cell
, vol.88
, pp. 213-222
-
-
Lee, F.S.1
Hagler, J.2
Chen, Z.J.3
Maniatis, T.4
-
52
-
-
0000484820
-
Kinases in pro-inflammatory signal transduction pathways: New opportunities for drug discovery
-
Baichwal VR, Baeuerle PA: Kinases in pro-inflammatory signal transduction pathways: New opportunities for drug discovery. Annu Rept Med Chem 1998, 33:233-242.
-
(1998)
Annu Rept Med Chem
, vol.33
, pp. 233-242
-
-
Baichwal, V.R.1
Baeuerle, P.A.2
-
53
-
-
0032588389
-
Activation of IkappaB kinase beta by protein kinase C isoforms
-
Lallena MJ, Diaz-Meco MT, Bren G, Payá CV, Moscat J: Activation of IkappaB kinase beta by protein kinase C isoforms. Mol Cell Biol 1999, 19:2180-2188.
-
(1999)
Mol Cell Biol
, vol.19
, pp. 2180-2188
-
-
Lallena, M.J.1
Diaz-Meco, M.T.2
Bren, G.3
Payá, C.V.4
Moscat, J.5
-
54
-
-
0033582285
-
Involvement of regulatory and catalytic subunits of phosphoinositide 3-kinase in NF-kappaB activation
-
Beraud C, Henzel WJ, Baeuerle PA: Involvement of regulatory and catalytic subunits of phosphoinositide 3-kinase in NF-kappaB activation. Proc Natl Acad Sci USA 1999, 96:429-434.
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 429-434
-
-
Beraud, C.1
Henzel, W.J.2
Baeuerle, P.A.3
-
55
-
-
0032487857
-
The anti-inflammatory agents aspirin and salicylate inhibit the activity of IκB kinase-α
-
Yin MJ, Yamamoto Y, Gaynor RB: The anti-inflammatory agents aspirin and salicylate inhibit the activity of IκB kinase-α. Nature 1998, 396:77-80.
-
(1998)
Nature
, vol.396
, pp. 77-80
-
-
Yin, M.J.1
Yamamoto, Y.2
Gaynor, R.B.3
-
56
-
-
0030992159
-
Discovery and analysis of inflammatory disease-related genes using cDNA microarrays
-
Heller RA, Schena M, Chai A, Shalon D, Bedilion T, Gilmore J, Woolley DE, Davis RW: Discovery and analysis of inflammatory disease-related genes using cDNA microarrays. Proc Natl Acad Sci USA 1997, 94:2150-2155.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 2150-2155
-
-
Heller, R.A.1
Schena, M.2
Chai, A.3
Shalon, D.4
Bedilion, T.5
Gilmore, J.6
Woolley, D.E.7
Davis, R.W.8
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