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Volumn 3, Issue 4, 1999, Pages 489-494

New targets for anti-inflammatory drugs

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFLAMMATORY AGENT; TRANSCRIPTION FACTOR;

EID: 0033178332     PISSN: 13675931     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1367-5931(99)80071-4     Document Type: Article
Times cited : (77)

References (56)
  • 1
    • 0033590513 scopus 로고    scopus 로고
    • Drug therapy: Treatment of asthma with drugs modifying the leukotriene pathway
    • Drazen JM, Israel E, O'Byrne PM: Drug therapy: Treatment of asthma with drugs modifying the leukotriene pathway. New Engl J Med 1999, 340:197-206.
    • (1999) New Engl J Med , vol.340 , pp. 197-206
    • Drazen, J.M.1    Israel, E.2    O'Byrne, P.M.3
  • 4
    • 0033611515 scopus 로고    scopus 로고
    • Anticytokine therapy - A new era in the treatment of rheumatoid arthritis
    • O'Dell JR: Anticytokine therapy - A new era in the treatment of rheumatoid arthritis. New Engl J Med 1999, 340:310-312.
    • (1999) New Engl J Med , vol.340 , pp. 310-312
    • O'Dell, J.R.1
  • 5
    • 0031686456 scopus 로고    scopus 로고
    • The future role of anti-tumor necrosis factor-alpha products in the treatment of Crohn's disease
    • Van Hogezand RA, Verspaget HW: The future role of anti-tumor necrosis factor-alpha products in the treatment of Crohn's disease. Drugs 1998, 56:299-305.
    • (1998) Drugs , vol.56 , pp. 299-305
    • Van Hogezand, R.A.1    Verspaget, H.W.2
  • 6
    • 0030996312 scopus 로고    scopus 로고
    • Anti-tumor necrosis factor-alpha therapy of rheumatoid arthritis
    • Feldmann M, Elliott MH, Woody JN, Maini RN: Anti-tumor necrosis factor-alpha therapy of rheumatoid arthritis. Adv Immunol 1997, 64:283-350.
    • (1997) Adv Immunol , vol.64 , pp. 283-350
    • Feldmann, M.1    Elliott, M.H.2    Woody, J.N.3    Maini, R.N.4
  • 9
    • 77956747089 scopus 로고    scopus 로고
    • Agents that block TNF-α synthesis or activity
    • Black R, Bird TA, Mahler JM: Agents that block TNF-α synthesis or activity. Annu Rept Med Chem 1997, 32:241-250.
    • (1997) Annu Rept Med Chem , vol.32 , pp. 241-250
    • Black, R.1    Bird, T.A.2    Mahler, J.M.3
  • 10
    • 0032516626 scopus 로고    scopus 로고
    • Feedback inhibition of macrophage tumor necrosis factor-α production by tristetraprolin
    • Carballo E, Lai WS, Blackshear PJ: Feedback inhibition of macrophage tumor necrosis factor-α production by tristetraprolin. Science 1998, 281:1001-1005.
    • (1998) Science , vol.281 , pp. 1001-1005
    • Carballo, E.1    Lai, W.S.2    Blackshear, P.J.3
  • 11
    • 0028810316 scopus 로고
    • Effects of murine recombinant interleukin 1 but not tumor necrosis factor in early cartilage damage in immune complex arthritis in mice
    • Van de Loo AAJ, van den Berg WB: Effects of murine recombinant interleukin 1 but not tumor necrosis factor in early cartilage damage in immune complex arthritis in mice. J Rheumatiol 1995, 22:2250-2258.
    • (1995) J Rheumatiol , vol.22 , pp. 2250-2258
    • Van De Loo, A.A.J.1    Van Den Berg, W.B.2
  • 12
    • 17444394445 scopus 로고    scopus 로고
    • Treatment of rheumatoid arthritis with recombinant human interleukin-1 receptor antagonist
    • Bresnihan B, Alvaro-Garcia JM, Cobby M, Doherty M, Domljan Z, Emery P, Nuki G, Pavelka K, Rau R, Rozman B: Treatment of rheumatoid arthritis with recombinant human interleukin-1 receptor antagonist. Arth Rheum 1998, 41:2196-2204. Clinical evaluation of IL-1Ra (Antril), an IL-1 receptor antagonist, demonstrates efficacy and safety in a large cohort of patients with active and severe RA. IL-1 Ra is the first biological agent to demonstrate a beneficial effect on the rate of joint erosion.
    • (1998) Arth Rheum , vol.41 , pp. 2196-2204
    • Bresnihan, B.1    Alvaro-Garcia, J.M.2    Cobby, M.3    Doherty, M.4    Domljan, Z.5    Emery, P.6    Nuki, G.7    Pavelka, K.8    Rau, R.9    Rozman, B.10
  • 13
    • 0029875804 scopus 로고    scopus 로고
    • Anticytokine treatment of established type II collagen induced arthritis in DBAP/1 mice: A comparative study using anti-TNF-α, IL-1α1B, and IL-1Ra
    • Joosten LAB, Helsen MMA, Van de Loo FAJ, Van de Berg WB: Anticytokine treatment of established type II collagen induced arthritis in DBAP/1 mice: A comparative study using anti-TNF-α, IL-1α1B, and IL-1Ra. Arth Rheum 1996, 39:797-809.
    • (1996) Arth Rheum , vol.39 , pp. 797-809
    • Joosten, L.A.B.1    Helsen, M.M.A.2    Van De Loo, F.A.J.3    Van De Berg, W.B.4
  • 16
    • 0032499260 scopus 로고    scopus 로고
    • Chemokines and leukocyte traffic
    • Baggiolini M: Chemokines and leukocyte traffic. Nature 1998, 392:565-568.
    • (1998) Nature , vol.392 , pp. 565-568
    • Baggiolini, M.1
  • 17
    • 0033083950 scopus 로고    scopus 로고
    • Opportunities for novel therapeutic agents acting at chemokine receptors
    • Saunders J, Tarby CM: Opportunities for novel therapeutic agents acting at chemokine receptors. Drug Discov Today 1999, 4:80-92. This paper reviews this extensive receptor family and the approaches used to modulate these targets.
    • (1999) Drug Discov Today , vol.4 , pp. 80-92
    • Saunders, J.1    Tarby, C.M.2
  • 18
    • 0001345942 scopus 로고    scopus 로고
    • Agents targeting transcription factors
    • Edited by Gallin JI, Snyderman R. Philadelphia: Lippincott, Williams and Wilkins; in press
    • Manning AM, Rao A: Agents targeting transcription factors. In Inflammation: Basic Principles and Clinical Correlates. Edited by Gallin JI, Snyderman R. Philadelphia: Lippincott, Williams and Wilkins; 1999:in press.
    • (1999) Inflammation: Basic Principles and Clinical Correlates
    • Manning, A.M.1    Rao, A.2
  • 19
    • 0032931433 scopus 로고    scopus 로고
    • Signal transduction and transcription factors in rheumatic disease
    • Firestein GS, Manning AM: Signal transduction and transcription factors in rheumatic disease. Arth Rheum 1999, 42:609-621.
    • (1999) Arth Rheum , vol.42 , pp. 609-621
    • Firestein, G.S.1    Manning, A.M.2
  • 20
    • 0029808748 scopus 로고    scopus 로고
    • Transcription factor AP-1 regulation by mitogen-activated protein kinese signal transduction pathways
    • Whitmarsh AJ, Davis RJ: Transcription factor AP-1 regulation by mitogen-activated protein kinese signal transduction pathways. J Mol Med 1996, 74:589-607.
    • (1996) J Mol Med , vol.74 , pp. 589-607
    • Whitmarsh, A.J.1    Davis, R.J.2
  • 21
    • 0001908214 scopus 로고    scopus 로고
    • Regulation of transcription by MAP kinase cascades
    • Treisman R: Regulation of transcription by MAP kinase cascades. Curr Opin Genet Dev 1996, 4:96-101.
    • (1996) Curr Opin Genet Dev , vol.4 , pp. 96-101
    • Treisman, R.1
  • 22
    • 0032935664 scopus 로고    scopus 로고
    • Mitogen-activated protein kinases: Specific messages from ubiquitous messengers
    • Schaeffer HJ, Weber MJ: Mitogen-activated protein kinases: Specific messages from ubiquitous messengers. Mol Cell Biol 1999, 4:2435-2444.
    • (1999) Mol Cell Biol , vol.4 , pp. 2435-2444
    • Schaeffer, H.J.1    Weber, M.J.2
  • 23
    • 0032054723 scopus 로고    scopus 로고
    • Signal transduction by the c-Jun N-terminal kinase (JNK) from inflammation to development
    • Ip YT, Davis RJ: Signal transduction by the c-Jun N-terminal kinase (JNK) from inflammation to development. Curr Opin Cell Biol 1998, 10:205-219. This reviews the important role played by the JNK signaling pathway in cell proliferation, apoptosis and tissue morphogenesis.
    • (1998) Curr Opin Cell Biol , vol.10 , pp. 205-219
    • Ip, Y.T.1    Davis, R.J.2
  • 24
    • 0032422785 scopus 로고    scopus 로고
    • Structural organization of MAP kinase signaling modules by scaffold proteins in yeast and mammals
    • Whitmarsh AJ, Davis RJ: Structural organization of MAP kinase signaling modules by scaffold proteins in yeast and mammals. Trends Biochem Sci 1 998, 23:481-485. Scaffold proteins have been recently identified in mammalian cells that facilitate MAPK activation and insulate MAPK modules to ensure signaling specifity.
    • (1998) Trends Biochem Sci , vol.23 , pp. 481-485
    • Whitmarsh, A.J.1    Davis, R.J.2
  • 27
    • 0032509479 scopus 로고    scopus 로고
    • Defective T cell differentiation in the absence of JNK1
    • Dong C, Yang DD, Wysk M, Whitmarsh AJ, Davis RJ, Flavell RA: Defective T cell differentiation in the absence of JNK1. Science 1998, 282:2092-2095. This is the first description of JNK1-deficient mice and demonstrates that JNK1 signaling plays a critical role in T cell receptor-initiated T helper cell proliferation, apoptosis and differentiation.
    • (1998) Science , vol.282 , pp. 2092-2095
    • Dong, C.1    Yang, D.D.2    Wysk, M.3    Whitmarsh, A.J.4    Davis, R.J.5    Flavell, R.A.6
  • 28
    • 0032191173 scopus 로고    scopus 로고
    • + T cells to Th1 cells requires MAP kinase JNK2
    • + T cells to Th1 cells requires MAP kinase JNK2. Immunity 1998, 9:575-585. JNK2-deficient mice revealed an important role of JNK2 in Th1 and Th2 responses. JNK2 is required for productive interferon γ in Th1 cells but not for IL-4 production in Th2 cells.
    • (1998) Immunity , vol.9 , pp. 575-585
    • Yang, D.D.1    Conge, D.2    Whitmarsh, A.J.3    Barrett, T.4    Davis, R.J.5    Rincon, M.6    Flavell, R.A.7
  • 29
  • 30
    • 0345251973 scopus 로고    scopus 로고
    • Pharmacological modulation of cytokine action and production through signaling pathways
    • Young PR: Pharmacological modulation of cytokine action and production through signaling pathways. Cyt Growth Factor Rev 1998, 9:239-257.
    • (1998) Cyt Growth Factor Rev , vol.9 , pp. 239-257
    • Young, P.R.1
  • 31
    • 0031024646 scopus 로고    scopus 로고
    • Activation of stress activated protein kinase-3 (SAPK3) by cytokines and cellular stresses is mediated via SAPKK3 (MKK6); comparison of the specificities of SAPK3 and SAPK2 (RK/p38)
    • Cuenda A, Cohen P, Buee-Scherrer V, Goedert M: Activation of stress activated protein kinase-3 (SAPK3) by cytokines and cellular stresses is mediated via SAPKK3 (MKK6); comparison of the specificities of SAPK3 and SAPK2 (RK/p38). EMBO J 1997, 16:295-305.
    • (1997) EMBO J , vol.16 , pp. 295-305
    • Cuenda, A.1    Cohen, P.2    Buee-Scherrer, V.3    Goedert, M.4
  • 32
    • 0030828701 scopus 로고    scopus 로고
    • Characterization of the structure and function of the fourth member of p38 group mitogen - Activated protein kinase, p38δ
    • Jiang Y, Gram H, Zhao M, New L, Gu J, Feng L, Di Padova F, Ulevitch RJ, Han J: Characterization of the structure and function of the fourth member of p38 group mitogen - Activated protein kinase, p38δ. J Biol Chem 1997, 272:30122-30128.
    • (1997) J Biol Chem , vol.272 , pp. 30122-30128
    • Jiang, Y.1    Gram, H.2    Zhao, M.3    New, L.4    Gu, J.5    Feng, L.6    Di Padova, F.7    Ulevitch, R.J.8    Han, J.9
  • 33
    • 0030783156 scopus 로고    scopus 로고
    • The search for physiological substrates of MAP and SAP kinases in mammalian cells
    • Cohen P: The search for physiological substrates of MAP and SAP kinases in mammalian cells. Trends Cell Biol 1997, 7:353-361.
    • (1997) Trends Cell Biol , vol.7 , pp. 353-361
    • Cohen, P.1
  • 36
    • 10744227768 scopus 로고    scopus 로고
    • Acquisition of sensitivity of stress-activated protein kinases to the p38 inhibitor, SB203580, by alteration of one or more amino acids within the ATP binding pocket
    • Gum RJ, McLaughlin MM, Kumar S, Wang Z, Bower MJ, Lee JC, Adams JL, Livi GP, Goldsmith EJ, Young PR: Acquisition of sensitivity of stress-activated protein kinases to the p38 inhibitor, SB203580, by alteration of one or more amino acids within the ATP binding pocket. J Biol Chem 1998, 273:15605-15610.
    • (1998) J Biol Chem , vol.273 , pp. 15605-15610
    • Gum, R.J.1    McLaughlin, M.M.2    Kumar, S.3    Wang, Z.4    Bower, M.J.5    Lee, J.C.6    Adams, J.L.7    Livi, G.P.8    Goldsmith, E.J.9    Young, P.R.10
  • 38
    • 0032102902 scopus 로고    scopus 로고
    • Conversion of SB 203580 insensitive MAP kinase family members to drug-sensitive forms by a single amino acid substitution
    • Eyers PA, Craxton M, Morrice N, Cohen P, Goedert M: Conversion of SB 203580 insensitive MAP kinase family members to drug-sensitive forms by a single amino acid substitution. Chem Biol 1998, 5:321-328. These finding explain how p38 inhibitors of the pyridinylimidazole class ATP-binding site in p38α and β but not in other MAPK family members.
    • (1998) Chem Biol , vol.5 , pp. 321-328
    • Eyers, P.A.1    Craxton, M.2    Morrice, N.3    Cohen, P.4    Goedert, M.5
  • 42
    • 0032956438 scopus 로고    scopus 로고
    • Ligand-activated retinoic acid receptor inhibits AP-1 transactivation by disrupting c-Jun/ C-Fos dimerization
    • Zhou X-F, Shen X-Q, Shemshedini L: Ligand-activated retinoic acid receptor inhibits AP-1 transactivation by disrupting c-Jun/ C-Fos dimerization. Mol Endocrinol 1999, 13:276-285.
    • (1999) Mol Endocrinol , vol.13 , pp. 276-285
    • Zhou, X.-F.1    Shen, X.-Q.2    Shemshedini, L.3
  • 43
    • 0031455626 scopus 로고    scopus 로고
    • Nuclear hormone receptor antagonism with AP-1 by inhibition of the JNK pathway
    • Caelles C, Gonzalez-Sancho JM, Munoz A: Nuclear hormone receptor antagonism with AP-1 by inhibition of the JNK pathway. Genes Dev 1997, 11:3351-3364.
    • (1997) Genes Dev , vol.11 , pp. 3351-3364
    • Caelles, C.1    Gonzalez-Sancho, J.M.2    Munoz, A.3
  • 44
    • 0030615201 scopus 로고    scopus 로고
    • Nuclear factor-κB, a pivotal transcription factor in chronic inflammatory diseases
    • Barnes PJ, Karin M: Nuclear factor-κB, a pivotal transcription factor in chronic inflammatory diseases. New Engl J Med 1997, 336:1066-1071.
    • (1997) New Engl J Med , vol.336 , pp. 1066-1071
    • Barnes, P.J.1    Karin, M.2
  • 45
    • 0030747128 scopus 로고    scopus 로고
    • NF-κB as a frequent target for immunosuppressive and anti-inflammatory molecules
    • Baeuerle PA, Baichwal VR: NF-κB as a frequent target for immunosuppressive and anti-inflammatory molecules. Adv Immunol 1997, 65:111-137.
    • (1997) Adv Immunol , vol.65 , pp. 111-137
    • Baeuerle, P.A.1    Baichwal, V.R.2
  • 46
    • 0030610362 scopus 로고    scopus 로고
    • A cytokine responsive IκB kinase that activates the transcription factor NF-κB
    • DiDonato JA, Hayakawa M, Rothwarf DM, Zandi E, Karin M: A cytokine responsive IκB kinase that activates the transcription factor NF-κB. Nature 1997, 388:853-862.
    • (1997) Nature , vol.388 , pp. 853-862
    • DiDonato, J.A.1    Hayakawa, M.2    Rothwarf, D.M.3    Zandi, E.4    Karin, M.5
  • 48
    • 17944401842 scopus 로고    scopus 로고
    • Identification of the receptor component of the IκBα-ubiquitin ligase
    • Yaron A, Hatzubai A, Davis M, Lavon I, Amit S, Manning AM, Andersen JS, Mann M, Mercurio F, Ben-Neriah Y: Identification of the receptor component of the IκBα-ubiquitin ligase. Nature 1998, 396:590-594. The identification of the E3 ligase that selectively phosphorylates IκB prior to degradation by the 26S proteasome is described.
    • (1998) Nature , vol.396 , pp. 590-594
    • Yaron, A.1    Hatzubai, A.2    Davis, M.3    Lavon, I.4    Amit, S.5    Manning, A.M.6    Andersen, J.S.7    Mann, M.8    Mercurio, F.9    Ben-Neriah, Y.10
  • 49
    • 0033106149 scopus 로고    scopus 로고
    • A ubiquitin ligase complex essential for the NF-κB, wart/wingless, and hedgehog signaling pathways
    • Maniatis T: A ubiquitin ligase complex essential for the NF-κB, wart/wingless, and hedgehog signaling pathways. Genes Dev 1999, 13:505-510. A review of the recent discoveries associated with ubiquitin-dependent proteolysis and the identification of a specific IκB E3 ligase.
    • (1999) Genes Dev , vol.13 , pp. 505-510
    • Maniatis, T.1
  • 50
    • 0031017618 scopus 로고    scopus 로고
    • MAP3K-related kinase involved in NF-κB induction by TNF, CD95 and IL-1
    • Malinin NL, Boldin MP, Kovalenko AV, Wallach D: MAP3K-related kinase involved in NF-κB induction by TNF, CD95 and IL-1. Nature 1997, 385:540-544.
    • (1997) Nature , vol.385 , pp. 540-544
    • Malinin, N.L.1    Boldin, M.P.2    Kovalenko, A.V.3    Wallach, D.4
  • 51
    • 0031285250 scopus 로고    scopus 로고
    • Activation of the IkB alpha complex by MEKK1, a kinase of the JNK pathway
    • Lee FS, Hagler J, Chen ZJ, Maniatis T: Activation of the IkB alpha complex by MEKK1, a kinase of the JNK pathway. Cell 1997, 88:213-222.
    • (1997) Cell , vol.88 , pp. 213-222
    • Lee, F.S.1    Hagler, J.2    Chen, Z.J.3    Maniatis, T.4
  • 52
    • 0000484820 scopus 로고    scopus 로고
    • Kinases in pro-inflammatory signal transduction pathways: New opportunities for drug discovery
    • Baichwal VR, Baeuerle PA: Kinases in pro-inflammatory signal transduction pathways: New opportunities for drug discovery. Annu Rept Med Chem 1998, 33:233-242.
    • (1998) Annu Rept Med Chem , vol.33 , pp. 233-242
    • Baichwal, V.R.1    Baeuerle, P.A.2
  • 54
    • 0033582285 scopus 로고    scopus 로고
    • Involvement of regulatory and catalytic subunits of phosphoinositide 3-kinase in NF-kappaB activation
    • Beraud C, Henzel WJ, Baeuerle PA: Involvement of regulatory and catalytic subunits of phosphoinositide 3-kinase in NF-kappaB activation. Proc Natl Acad Sci USA 1999, 96:429-434.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 429-434
    • Beraud, C.1    Henzel, W.J.2    Baeuerle, P.A.3
  • 55
    • 0032487857 scopus 로고    scopus 로고
    • The anti-inflammatory agents aspirin and salicylate inhibit the activity of IκB kinase-α
    • Yin MJ, Yamamoto Y, Gaynor RB: The anti-inflammatory agents aspirin and salicylate inhibit the activity of IκB kinase-α. Nature 1998, 396:77-80.
    • (1998) Nature , vol.396 , pp. 77-80
    • Yin, M.J.1    Yamamoto, Y.2    Gaynor, R.B.3


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