Ro 09-2210 exhibits potent anti-proliferative effects on activated T cells by selectively blocking MKK activity

Biochemistry

Volumn 37, Issue 26, 1998, Pages 9579-9585

  Williams, D H ^b   Wilkinson, S E ^a   Purton, T ^a   Lamont, A ^b   Flotow, H ^a   Murray, E J ^a  

^a ROCHE PRODUCTS LTD   (United Kingdom)

^b Peptide Therapeutics   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOSUPPRESSIVE AGENT; RO 09 2210; UNCLASSIFIED DRUG;

ARTICLE; DRUG EFFECT; DRUG ISOLATION; DRUG POTENCY; HUMAN; HUMAN CELL; LYMPHOCYTE ACTIVATION; LYMPHOCYTE PROLIFERATION; MULTIPLE SCLEROSIS; NONHUMAN; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; T LYMPHOCYTE ACTIVATION;

DNA-BINDING PROTEINS; HUMANS; IMMUNOSUPPRESSIVE AGENTS; JURKAT CELLS; LYMPHOCYTE ACTIVATION; MAP KINASE KINASE 1; MAP KINASE KINASE KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; NFATC TRANSCRIPTION FACTORS; NUCLEAR PROTEINS; PROTEIN-SERINE-THREONINE KINASES; PROTEIN-TYROSINE KINASES; RAS PROTEINS; SALICYLIC ACIDS; SIGNAL TRANSDUCTION; T-LYMPHOCYTES; TRANSCRIPTION FACTOR AP-1; TRANSCRIPTION FACTORS;

EID: 0032581040     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi972914c     Document Type: Article

References (50)

1. Peyron, J.F., Aussel, C., Ferrua, B., Haring, H., and Fehlmann, M. (1989) Biochem. J. 258, 505-510.
2. Weiss, A. (1993) Cell 73, 209-212.
3. Chan, A. C., Iwashima, M., Turck, C. W., and Weiss, A. (1992) Cell 71, 649-662.
4. Kong, G., Dalton, M., Wardenburg, J. B., Straus, D., Kurosaki, T., and Chan, A. C. (1996) Mol. Cell. Biol. 16, 5026-5035.
5. Wardenburg, J. B., Fu, C., Jackman, J. K., Flotow, H., Wilkinson, S. E., Williams, S. E., Williams, D. H., Johnson, R., Kong, G., Chan, A. C., and Findell, P. R. (1996) J. Biol. Chem. 271, 19641-19644.
6. Katzav, S., Sutherland, Packham, Taolin, Y., and Weiss, A. (1994) J. Biol. Chem. 269, 32579-32585.
7. Weiss, A., Koretzky, G., Schatzman, R., and Kadlecek, T. (1991) Proc. Natl. Acad. Sci. U.S.A. 88, 5484-5488.
8. Da Silva, A. J., Rosenfield, J. M., Mueller, I., Bouton, A., and Hirai Hand Rudd, C. E. (1997) J. Immunol. 158, 2007-2016.
9. Izquierdo, M., Leevers, S. J., Marshall, C. J., and Cantrell, D. A. (1993) J. Exp. Med. 178, 1199.
10. Kyriakis, J. M., Banerjee, P., Nikolakaki, E., Dai, T., Rubie, E. A., Ahmad, M. F., Avruch, J., and Woodget, J. R. (1994) Nature 365, 156-160.
11. Marais, R., Light, Y., Paterson, H. F., and Marshall, C. J. (1995) EMBO J. 14, 3136-3145.
12. Pelech, S. (1996) Curr. Biol. 6, 551-553.
13. Farrar, M. A., Alberola-Iia, J., and Perlmutter, R. M. (1996) Nature 383, 178-181.
14. Luo, Z., Tzivion, G., Belshaw, P. J., Vavvas, D., Marshall, M., and Avruch, J. (1996) Nature 383, 181-185.
15. Van Aelst, L., Barr, M., Marcus, S., Polverino, A., and Wigler, M. (1993) Proc. Natl. Acad. Sci. U.S.A. 90, 6213-6217.
16. Huang, W., Alessandrini, A., Crews, C. A., and Erikson, R. L. (1993) Proc. Natl. Acad. Sci. U.S.A. 90, 10947-10951.
17. Durand, D. B., Shaw, J.-P., Bush, M. R., Replogle, R. E., Balagaje, R., and Crabtree, G. R. (1988) Mol. Cell. Biol. 8, 1715.
18. Shaw, J.-P., Utz, P. J., Durand, D. B., Toole, J. J., Emmel, E. A., and Crabtree, G. R. (1988) Science 241, 202.
19. Kang, S.-M., Tran, A.-C., Grille, M., and Lenardo, M. J. (1992) Science 256, 1452.
20. Ullman, K. S., Flanagan, W. M., Edwards, C. A., and Crabtree, G. R. (1991) Science 254, 558.
21. Jain, J., McCaffrey, P. G., Valge-Archer, V. E., and Rao, A. (1992) Nature 356, 801.
22. Rayter, S. I., Woodrow, M., Lucas, S. C., Cantrell, D. D., and Downward, J. (1992) EMBO J. 11, 4549.
23. Davis, P. D., Hill, C. H., Keech, E., Lawton, G., Nixon, J. S., Sedgwick, A. D., Wadsworth, J., Westmacott, D., and Wilkinson, S. E. (1989) FEBS Lett. 259, 61-63.
24. Elliott, L. H., Wilkinson, S. E., Sedgwick, A. D., Hill, C. H, Lawton, G., Davis, P. D., and Nixon, J. S. (1990) Biochem. Biophys. Res. Commun. 171, 148-154.
25. Flotow, H., Purton, T. J., Whitaker, D., Williams, D. H., and Wilkinson, S. E. Inflammation Res. (in press).
26. Birchall, A. M., Bishop, J., Bradshaw, D., Cline, A., Coffey, J., Elliott, L. H., Gibson, V. M., Greenham, A., Hallam, T. J., Harris, W., Hill, C. H., Hutchings, A., Lamont, A. G., Lawton, G., Lewis, E. J., Maw, A., Nixon, J. S., Pole, D., Wadsworth, J., and Wilkinson, S. E. (1994) J. Pharmacol. Exp. Ther. 268, 922-929.
27. Williams, D. H., Woodrow, M., Cantrell, D. A., and Murray, E. J. (1995) Eur. J. Immunol. 25, 42-47.
28. Woodrow, M., Clipstone, N., and Cantrell, D. L. (1993) J. Exp. Med. 178, 1517-1522.
29. Warne, P. H., Viciana, P. R., and Downward, J. (1993) Nature 364, 352-355.
30. Votjek, A. B., Hollenburg, S. M., and Cooper, J. A. (1993) Cell 74, 205-214.
31. Zhang, X.-F., Settleman, J., Kyrakis, J. M., Takeuchi-Suzuki, E., Elleledge, S. J., Marshall, M. S., Bruder, J. T., Rapp, U. R., and Avruch, J. (1993) Nature 364, 308-313.
32. Owaki, H., Varma, R., Gillis, B., Bruder, J. T., Rapp, U. R., Davis, L. S., and Geppert, T. D. (1993) EMBO J. 12, 4367-4373.
33. Howe, L. R., Leevers, S. J., Gomez, N., Nakielny, S., Cohen, P., and Marshall, C. J. (1992) Cell 71, 335-342.
34. Li, P., and Sedivy, J. M. (1993) Proc. Natl. Acad. Sci. U.S.A. 90, 9247-9251.
35. Folgueira, L., Algeciras, A., MacMorran, W. S., Bren, G. D., and Paya, C. V. (1996a) J. Virol. 70, 2332-2338.
36. DiDonato, J., Mercurio, F., Rosette, C., Wu-Li, J., Suyang, H., Ghosh, S., and Karin, M. (1996) Mol. Cell. Biol. 16, 1295-1304.
37. Lee, F. S., Hagler, J., Chen, Z. J., and Maniatis, T. (1997) Cell 88, 213-222.
38. Kuno, K., Ishikawa, Y., Ernst, M. K., Ogata, M., Rice, N., Mukaida, N., and Matsushima, K. (1995) J. Biol. Chem. 270, 27914-27919.
39. McElhinny, J. A., Trushin, S. A., Bren, G. D., Chester, A., and Paya, C. V. (1996) Mol. Cell. Biol. 16, 899-906.
40. Schwartz, E. M., Van Antwerp, D., and Verma, I. M. (1996) Mol. Cell Biol. 16, 3554-3559.
41. Diaz-Meco, M. T., Dominguez, I., Sanz, L., Dent, G., Lozzano, J., Municio, M. M., Berra, E., Hay, R. T., Sturgill, T. W., and Moscat, J. (1994) EMBO J. 13, 2842-2848.
42. Folgueira, L., McElhinney, J. A., Bren, G. D., MacMorran, W. S., Diaz-Meco, M. T., Moscat, J., and Paya, C. V. (1996) J. Virol. 70, 223-231.
43. Regnier, C. H., Song, H. Y., Gao, X., Goeddel, D. V., Cao, Z., and Rothe, M. (1997) Cell 90, 373-383.
44. DiDonato, J., Hayakawa, M., Rothwart, D., Zandi, E., and Karin, M. (1997) Nature 388, 548-554.
45. Imbert, V., Rupec, R. A., Livolsi, A., Pahl, H., Traenckner, B.-M., Mueller-Dieckmann, C., Farahifar, D., Rossi, B., Auberger, P., Baeurle, P. A., and Peyron, J.-F. (1996) Cell 86, 787-798.
46. Singh, S., Darnay, B. G., and Aggarwal, B. A. (1996) J. Biol. Chem. 271, 31049-31054.
47. Dudley, D. T., Pang, L., Decker, S. J., Bridges, A. J., and Saltiel, A. R. (1995) Proc. Natl. Acad. Sci. U.S.A. 92, 7686-7689.
48. Alessi, D. R., Cuenda, A., Cohen, P., Dudley, D. T., and Saltiel, A. R. (1995) J. Biol. Chem. 270, 27489-27494.
49. Chen, D., Waters, S. B., Holt, K. H., and Pessin, J. E. (1996) J. Biol. Chem. 271, 6328-6332.
50. Gardner, A. M., and Johnson, G. L. (1996) J. Biol. Chem. 271, 14560-14566.