Persistent Clonal Expansions of Peripheral Blood CD4+ Lymphocytes in Chronic Inflammatory Bowel Disease

Journal of Immunology

Volumn 157, Issue 7, 1996, Pages 3183-3191

  Probert, Christopher S ^a,d   Chott, Andreas ^b   Turner, Jerrold R ^a   Saubermann, Lawrence J ^a   Stevens, Anthony C ^b   Bodinaku, Kujtim ^a   Elson, Charles O ^c   Balk, Steven P ^b   Blumberg, Richard S ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^c University of Alabama at Birmingham   (United States)

^d BRISTOL ROYAL INFIRMARY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; DNA;

AMINO ACID SEQUENCE; ARTICLE; BLOOD; CD4 LYMPHOCYTE COUNT; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL CLONE; CHEMISTRY; COMPARATIVE STUDY; CROHN DISEASE; DIVERTICULITIS; ENTERITIS; GENE REARRANGEMENT; GENETICS; HUMAN; IMMUNOLOGY; INTESTINE; LYMPHOCYTE ACTIVATION; MOLECULAR GENETICS; MONOZYGOTIC TWINS; NUCLEOTIDE SEQUENCE; PATHOLOGY; POLYMERASE CHAIN REACTION; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY; TIME; TWINS; ULCERATIVE COLITIS;

AMINO ACID SEQUENCE; BASE SEQUENCE; CD4 LYMPHOCYTE COUNT; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CLONE CELLS; COLITIS, ULCERATIVE; CROHN DISEASE; DISEASES IN TWINS; DIVERTICULITIS; DNA; DNA, COMPLEMENTARY; GENE REARRANGEMENT, BETA-CHAIN T-CELL ANTIGEN RECEPTOR; HUMANS; INFLAMMATORY BOWEL DISEASES; INTESTINES; LYMPHOCYTE ACTIVATION; MOLECULAR SEQUENCE DATA; POLYMERASE CHAIN REACTION; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; TIME FACTORS; TWINS, MONOZYGOTIC;

EID: 0030267661     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (55)

1. Konttinen, Y. T., V. Bergroth, D. Nordstrom, M. Segerberg-Konttinen, K. Seppala, and M. Salaspuro. 1987. Lymphocyte activation in vivo in the intestinal mucosa of patients with Crohn's disease. J. Clin. Lab. Immunol. 22:59.
2. Raedler, A., S. Fraenkel, G. Klose, K. Seyfarth, and H. G. Thiele. 1985. Involvement of the immune system in the pathogenesis of Crohn's disease: expression of the T9 antigen on peripheral immunocytes correlates with the severity of disease. Gastroenterology 88:978.
3. Raedler, A., S. Schreiber, A. de Weerth, A. Voss, S. Peters, and H. Greten. 1990. Assessment of in vivo activated T cells in patients with Crohn's disease. Hepatogastroenterology 37:67.
4. Matsuura, T., G. A. West, R. Youngman, J. S. Klein, and C. Fiocchi. 1993. Immune activation genes in inflammatory bowel disease. Gastroenterology 104: 48.
5. Mullin, G. E., A. J. Lazenby, M. L. Harris, T. M. Bayless, and S. P. James. 1992. Increased interleukin-2 messenger RNA in the intestinal mucosal lesions of Crohn's disease but not ulcerative colitis. Gastroenterology 102:1620.
6. MacDermott, R. P., G. S. Nash, M. J. Bertovich, M. V. Seiden, and M. J. Bragdon. 1981. Alterations of IgM, IgG, and IgA synthesis and secretion by peripheral blood and intestinal mononuclear cells from patients with ulcerative colitis and Crohn's disease. Gastroenterology 81:844.
7. Ligumsky, M., P. L. Simon, F. Karmeli, and D. Rachmilewitz. 1990. Role of interleukin-1 in inflammatory bowel disease - enhanced production during active disease. Gut 31:686.
8. Yang, H., J. I. Rotter, H. Toyoda, C. Landers, D. Tyran, C. K. McElree, and S. R. Targan. 1993. Ulcerative colitis: a genetically heterogeneous disorder defined by genetic (HLA class II) and subdinical (antineutrophil cytoplasmic antibodies) markers. J. Clin. Invest. 92:1880.
9. Forcione, D. G., B. Sands, K. J. Isselbacher, A. Rustgi, D. K. Podolsky, and S. Pillai. 1996. An increased risk of Crohn's disease in individuals who inherit the HLA class II DRB3*0301 allele. Proc. Natl. Acad. Sci. USA 93:5094.
10. Sartor, R. B. 1993. Microbial factors in the pathogenesis of Crohn's disease, ulcerative colitis, and experimental intestinal inflammation. In Inflammatory Bowel Disease. J. B. Kirsner and R. G. Shorter, eds. William & Wilkins, Baltimore, p. 96.
11. Das, K. M., A. Dasgupta, A. Mandal, and X. Geng. 1993. Autoimmunity to cytoskeletal protein tropomyosin: a clue to the pathogenetic mechanism for ulcerative colitis. J. Immunol. 150:2487.
12. Kalams, S. A., R. P. Johnson, A. K. Trocha, M. J. Dynan, H. S. Ngo, R. T. D'Aquila, J. T. Kurnick, and B. D. Walker. 1994. Longitudinal analysis of T cell receptor (TCR) gene usage by human immunodeficiency virus I envelope-specific cytotoxic T lymphocyte clones reveals a limited TCR repertoire. J. Exp. Med. 179:1261.
13. Wucherpfennig, K. W., J. Zhang, C. Witek, M. Matsui, Y. Modabber, K. Ota, and D. A. Hafler. 1994. Clonal expansion and persistence of human T cells specific for an immunodominant myelin basic protein peptide. J. Immunol. 152:5581.
14. Shalon, L., B. Gulwani-Akolkar, S. E. Fisher, P. N. Akolkar, A. Panja, L. Mayer, and J. Silver. 1994. Evidence for an altered T-cell receptor repertoire in Crohn's disease. Autoimmunity 17:301.
15. +, T cell receptor BV repertoire of lamina propria lymphocytes. Clin. Immunol. Immunopathol. 77:95.
16. + intestinal mucosa T cells in ulcerative colitis. J. Immunol. 156:3024.
17. Balk, S. P., E. C. Ebert, R. L. Blumenthal, F. V. McDermott, K. W. Wucherpfennig, S. B. Lanadau, and R. S. Blumberg. 1991. Oligoclonal expansion and CD1 recognition by human intestinal intraepithelial lymphocytes. Science 253: 1411.
18. Blumberg, R. S., C. E. Yockey, G. G. Gross, E. C. Ebert, and S. P. Balk. 1993. Human intestinal intraepithelial lymphocytes are derived from a limited number of T cell clones that utilize multiple Vβ T cell receptor genes. J. Immunol. 150: 5144.
19. Gross, G. G., V. L. Schwartz, C. Stevens, E. C. Ebert, R. S. Blumberg, and S. P. Balk. 1994. Distribution of dominant T cell receptor β chains in human intestinal intraepithelial T cells. J. Exp. Med. 180:1337.
20. Van Kerckhove, C., G. J. Russell, K. Deusch, K. Reich, A. K. Bhan, H. DerSimonian, and M. B. Brenner. 1992. Oligoclonality of human intestinal intraepithelial T cells. J. Exp. Med. 175:57.
21. Posnett, D. N., R. Sinha, S. Kabak, and C. Russo. 1994. Clonal populations of T cells in normal elderly humans: the T cell equivalent to "benign monoclonal gammaopathy." J. Exp. Med. 179:609.
22. + T cell expansions in normal individuals and patients with rheumatoid arthritis. J. Immunol. 154: 3538.
23. + subset. J. Immunol. 154:6182.
24. + T lymphocytes in normal, healthy individuals are oligoclonal and respond to human cytomegalovirus. J. Immunol. 155: 5046.
25. Taplin, M. E., G. J. Bubley, T. D. Shuster, M. E. Frantz, A. E. Spooner, G. K. Ogata, H. N. Keer, and S. P. Balk. 1995. Mutation of the androgen-receptor gene in metastatic androgen-independent prostate cancer. N. Engl. J. Med. 332:1393.
26. Stevens, A. C., M. L. Lipman, J. E. Spivack, G. Roddey, A. M. Bitton, M. A. Peppercorn, and T. B. Strom. 1995. Enhanced intramucosal cytotoxic lymphocyte gene expression in ulcerative colitis. Inflammatory Bowel Dis. 1:101.
27. Wright, D. K., and M. M. Manos. 1990. Sample preparation from paraffin-embedded tissues. In PCR Protocols: A Guide to Methods and Applications. M. A. Innis, D. H. Gelfand, J. J. Sninsky, and T. J. White, eds. Academic Press, San Diego, p. 153.
28. Concannon, P., L. A. Pickering, P. Kung, and L. Hood. 1986. Diversity and structure of human T-cell repertoire β-chain variable region genes. Proc. Natl. Acad. Sci. USA 83:6598.
29. Kimura, N., B. Toyonaga, Y. Yoshikai, R.-P. Du, and T. W. Mak. 1987. Sequences and repertoire of the human T cell receptor α and β chain variable genes in thymocytes. Eur. J. Immunol. 17:375.
30. Wilson, R. K., E. Lai, L. D. Kim, and L. Hood. 1990. Sequence and expression of a novel human T-cell receptor beta-chain variable gene segment subfamily. Immunogenetics 32:406.
31. Toyonaga, B., Y. Yoshikai, V. Vadasz, B. Chin, and T. W. Mak. 1985. Organization and sequences of the diversity, joining, and constant region genes of the human T-cell receptor beta chain. Proc. Natl. Acad. Sci. USA 82:8624.
32. WHO-IUSIS Nomenclature Subcommittee on TCR Designation. 1993. Nomenclature for T-cell receptor (TCR) gene segments of the immune system. Bull. W. H. O. 71:113.
33. Pannetier, C., J. Even, and P. Kourilsky. 1995. T-cell repertoire diversity and clonal expansions in normal and clinical samples. Immunol. Today 16:176.
34. Lahesmaa, R., M. C. Shanafelt, A. Allsup, C. Soderberg, J. Anzola, V. Freitas, C. Turck, L. Steinman, and G. Peltz. 1993. Preferential usage of T cell antigen receptor V region gene segment Vβ5.1 by Borrelia burgdorferi antigen-reactive T cell clones isolated from a patient with Lyme disease. J. Immunol. 150:4125.
35. Wang, X., L. Golkar, K. Uyemura, J. D. Ohmen, L. G. Villahermosa, T. T. Fajardo, Jr., R. V. Cellona, G. P. Walsh, and R. L. Modlin. 1993. T cells bearing Vβ6 T cell receptors in the cell-mediated immune response to Mycobacterium leprae. J. Immunol. 151:7105.
36. Wang, X. H., J. D. Ohmen, K. Uyemura, T. H. Rea, M. Kronenberg, and R. L. Modlin. 1993. Selection of T lymphocytes bearing limited T-cell receptor β chains in the response to a human pathogen. Proc. Natl. Acad. Sci. USA 90:188.
37. + type 2 T cell subsets in human leishmaniasis have distinct T cell receptor repertoires. J. Immunol. 151:7095.
38. Sioud, M., J. Kjeldsen-Kragh, S. Suleyman, O. Vinje, J. B. Natvig, and O. Forre. 1992. Limited heterogeneity of T cell receptor variable region gene usage in juvenile rheumatoid arthritis synovial T cells. Eur. J. Immunol. 22:2413.
39. Yamamoto, K., H. Sakoda, T. Nakajima, T. Kato, M. Okubo, M. Dohi, Y. Mizushima, K. Ito, and K. Nishioka. 1992. Accumulation of multiple T cell clonotypes in the synovial lesions of patients with rheumatoid arthritis revealed by a novel clonality analysis. Int. Immunol. 4:1219.
40. Li, Y., G. R. Sun, J. R. Tumang, M. K. Crow, and S. N. Friedman. 1994. CDR3 sequence motifs shared by oligoclonal rheumatoid arthritis synovial T cells. J. Clin. Invest. 94:2525.
41. + T cell expansions in the peripheral blood of rheumatoid arthritis patients. J. Exp. Med. 177:1623.
42. Zhang, J., S. Markovic-Plese, B. Lacet, J. Raus, H. L. Weiner, and D. A. Hafler. 1994. Increased frequency of interleukin-2-responsive T cells specific for myelin basic protein and proteolipid protein in peripheral blood and cerebrospinal fluid of patients with multiple sclerosis. J. Exp. Med. 179:973.
43. Allegretta, M., R. J. Albertini, M. D. Howell, L. R. Smith, R. Martin, H. F. McFarland, S. Sriram, S. Brostoff, and L. Steinman. 1994. Homologies between T cell receptor junctional sequences unique to multiple sclerosis and T cells mediating experimental allergic encephalomyelitis. J. Clin. Invest. 94:105.
44. + T cells in rheumatoid arthritis. J. Clin. Invest. 94:2068.
45. Sadlack, B., H. Merz, H. Schorle, A. Schimpl, A. C. Feller, and I. Horak. 1993. Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene. Cell 75:253.
46. Taurog, J. D., J. A. Richardson, J. T. Croft, W. A. Simmons, M. Zhou, J. L. Fernandez-Sueiro, E. Balish, and R. E. Hammer. 1994. The germfree state prevents development of gut and joint inflammatory disease in HLA-B27 transgenic rats. J. Exp. Med. 180:2359.
47. Liu, Y., H. J. Van Kruningen., A. B. West, R. W. Cartun, A. Cortot, and J. F. Colombel. 1995. Immunocytochemical evidence of Listeria, Escherichia coli, and streptococcus antigens in Crohn's disease. Gastroenterotogy 108:1396.
48. Cong, Y., S. L. Brandwein, R. P. McCabe, B. U. Ridwan, E. H. Birkenmeier, J. P. Sundberg, and C. O. Elson. 1995. TH1 response to enteric bacteria in colitic C3H/JeJBir mice. Clin. Immunol. Immunopathol. 76:S44.
49. Greenstein, A. J., H. D. Janowitz, and D. B. Sachar. 1976. Extra-intestinal complications of Crohn's disease and ulcerative colitis: study of 700 patients. Medicine 55:401.
50. Finegold, S. M., V. L. Sutter, and G. E. Mathisen. 1983. Normal indigenous intestinal flora. In Human Intestinal Microflora and Health and Disease. D. J. Hentges, ed. Academic Press, New York, p. 3.
51. Holdeman, L. V., U. J. Good, and W. E. C. Moore. 1976. Human fecal flora: variation in bacterial composition within individuals and a possible effect of emotional stress. Appl. Environ. Microbiol. 31:359.
52. Argaet, V. P., C. W. Schmidt, S. R. Burrows, S. L. Silins, M. G. Kurilla, D. L. Doolan, A. Suhrbier, D. J. Moss, E. Kieff, T. B. Sculley, and I. S. Misko. 1984. Dominant selection of an invariant T cell antigen receptor in response to persistent infection by Epstein-Barr virus. J. Exp. Med. 180:2335.
53. Hawes, G. E., L. Struyk, B. C. Godthelp, and P. J. van den Elsen. 1995. Limited restriction in the TCR-αβ V region usage of antigen-specific clones. J. Immunol. 154:555.
54. Utz, U., W. E. Biddison, H. F. McFarland, D. E. McFarlin, M. Flerlage, and R. Martin. 1993. Skewed T-cell receptor repertoire in genetically identical twins correlates with multiple sclerosis. Nature 364:243.
55. Wucherpfenning, K. W., and J. L. Strominger. 1995. Molecular mimicry in T-cell mediated autoimmunity: viral peptides activate human T cell clones specific for myelin basic protein. Cell 80:695.