Cutting edge: The expression in vivo of a second isoform of pTα: Implications for the mechanism of pTα action

Journal of Immunology

Volumn 161, Issue 1, 1998, Pages 11-16

  Barber, Domingo F ^a   Passoni, Lorena ^a   Wen, Li ^a   Geng, Liping ^a   Hayday, Adrian C ^a,b  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b YALE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

T LYMPHOCYTE RECEPTOR ALPHA CHAIN; T LYMPHOCYTE RECEPTOR BETA CHAIN; LYMPHOCYTE ANTIGEN RECEPTOR; MEMBRANE PROTEIN; MESSENGER RNA; PRE T CELL RECEPTOR ALPHA; PRE-T CELL RECEPTOR ALPHA;

ANIMAL CELL; ARTICLE; GENE EXPRESSION; GENE TARGETING; IMMUNOPRECIPITATION; MOUSE; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; THYMUS; TISSUE SPECIFICITY; ALTERNATIVE RNA SPLICING; ANIMAL; BIOSYNTHESIS; CELL CLONE; CELL SEPARATION; GENETICS; IMMUNOLOGY; ISOMERISM; LYMPHOCYTE ACTIVATION; METABOLISM; MOUSE MUTANT; PHYSIOLOGY; T LYMPHOCYTE SUBPOPULATION;

ALTERNATIVE SPLICING; ANIMALS; CELL SEPARATION; CLONE CELLS; ISOMERISM; LYMPHOCYTE ACTIVATION; MEMBRANE GLYCOPROTEINS; MICE; MICE, KNOCKOUT; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; RNA, MESSENGER; SIGNAL TRANSDUCTION; T-LYMPHOCYTE SUBSETS;

EID: 0032110231     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. Clevers, H., B. Alarcon, T. Wileman, and C. Terhorst. 1988. The T cell receptor/ CD3 complex: A dynamic protein ensemble. Annu. Rev. Immunol. 6:629.
2. Fehling, H. J., and H. von Boehmer. 1997. Early αβ T cell development in the thymus of normal and genetically altered mice. Curr. Opin. Immunol. 9:263.
3. Palmer D. B., A. C. Hayday, and M. J. Owen. 1993. Is TCR beta expression an essential event in early thymocyte development? Immunol. Today 14:460.
4. O'Shea, C. C., A. P. Thornell, I. R. Rosewell, B. Hayes, and M. J. Owen. 1997. Exit of the pre-TCR from the ER/cis-Golgi is necessary for signaling differentiation, proliferation, and allelic exclusion in immature thymocytes. Immunity 7:591.
5. Mombaerts P., A. R. Clark, M. A. Rudnicki, J. Iacomini, S. Itohara, J. J. Lafaille, L. Wang, Y. Ichikawa, R. Jaenish, M. L. Hooper, and S. Tonegawa. 1992. Mutations in T-cell antigen receptor a and β block thymocyte development in different stages. Nature 360:225.
6. + cells. Proc. Natl. Acad. Sci. USA 91:11948.
7. Bruno, L., B. Rocha, A. Rolink, H. von Boehmer, and H. R. Rodewald. 1995. Intra- and extra-thymic expression of the pre-T cell receptor α gene. Eur. J. Immunol. 25:1877.
8. Philpott, L. K., J. L. Viney, G. Kay, S. Rastan, E. M., Gardiner, S. Chae, A. C. Hayday, and M. J. Owen. Lymphoid development in mice congenitally lacking T cell receptor αβ-expressing cells. Science 256:1448.
9. Wen, L., D. F. Barber, W. Pao, F. S. Wong, M. J. Owen, and A. C. Hayday. 1998. Primary γδ clones can be defined phenotypically and functionally as Th1/Th2 cells and illustrate the association of CD4 with Th2 differentiation. J. Immunol. 160:1965.
10. White, J., M. Blackman, J. Bill, J. Kappler, P. Marrack, D. P. Gold, and W. Born. 1989. Two better cell lines for making hybridomas expressing specific T cell receptors. J. Immunol. 143:1822.
11. Jones, B., S. Mojolsness, C. Janeway, Jr., and A. C. Hayday. 1986. Transcripts of functionally rearranged gamma genes in primary T cells of adult immunocompetent mice. Nature 323:635.
12. Richman, A., and A. C. Hayday. 1989. Normal expression of a rearranged and mutated c-myc oncogene after transfection into fibroblasts. Science 246:494.
13. Fehling, H. J., C. Laplace., M. G., Mattei, C. Saint-Ruf, and H. von Boehmer. 1995. Genomic structure and chromosomal location of the mouse pre-T-cell receptor alpha gene. Immunogenetics 42:275.
14. Bruno, L., P. Res, M. Dessing, M. Cella, and H. Spits. 1997. Identification of a committed T cell precursor population in adult human peripheral blood. J. Exp. Med. 185:875.
15. Fehling, H. J., A. Krotkova, C. Saint-Ruf, and H. von Boehmer. 1995. Crucial role of the pre-T-cell receptor a gene in development of αβ but not γδ T cells. Nature 375:795.
16. Huffman, E. S., L. Passoni, T. Crompton, T. M. J. Leu, D. G. Schatz, A. Koff, M. J. Owen, and A. C. Hayday. 1996. Productive T-cell receptor β-chain gene rearrangement: coincident regulation of cell cycle and clonality during development in vivo. Genes Dev. 10:948.
17. Groettrup, M., K. Ungewiss, O. Azogui, R. Palacios, M. J. Owen, A. C. Hayday, and H. von Boehmer. 1993. A novel disulfide linked heterodimer on preT cells consists of the T cell receptor beta chain and a 33kd glycoprotein. Cell 75:283.
18. Brouns, G. S., E. de Vries, J. J. Neefjes, and J. Borst. 1996. Assembled pre-B cell receptor complexes are retained in the endoplasmic reticulum by a mechanism that is not selective for the pseudo-light chain, J. Biol. Chem. 271:19272.
19. Xu, Y., L. Davidson, F. W. Alt, and D. Baltimore. 1996. Function of the pre-T-cell receptor a chain in T-cell development and allelic exclusion at the T-cell receptor β locus. Proc. Natl. Acad. Sci. USA 93:2169.
20. Early, P., J. Rogers, M. Davis, K. Calame, M. Bond, R. Wall, and L. Hood. 1980. Two mRNAs can be produced from a single immunoglobulin μ gene by alternative RNA processing pathways. Cell 20:313.
21. Takase, K., K. Wakizaka, H. von Boehmer, I. Wada, H. Moriya, and T. Saito. 1997. A new 12-kilodalton dimer associated with pre-TCR complex and clonotype-independent CD3 complex on immature thymocytes. J. Immunol. 159:741.