Dysregulated Intrathymic Development in the IL-2-Deficient Mouse Leads to Colitis-Inducing Thymocytes

Journal of Immunology

Volumn 158, Issue 1, 1997, Pages 104-111

  Lúdvíksson, Björn R ^a,b   Gray, Belinda ^a   Strober, Warren ^a   Ehrhardt, Rolf O ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HEMOCYANIN; INTERLEUKIN 12; INTERLEUKIN 2; THYMUS INDEPENDENT ANTIGEN; TRINITROPHENYL KEYHOLE LIMPET HEMOCYANIN;

ANIMAL; APOPTOSIS; ARTICLE; CELL DIFFERENTIATION; COLITIS; DRUG EFFECT; GENETICS; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; MOUSE; MOUSE MUTANT; PATHOLOGY; T LYMPHOCYTE; THYMUS;

ANIMALS; ANTIGENS, T-INDEPENDENT; APOPTOSIS; CELL DIFFERENTIATION; COLITIS; HEMOCYANIN; INTERLEUKIN-12; INTERLEUKIN-2; LYMPHOCYTE ACTIVATION; MICE; MICE, MUTANT STRAINS; T-LYMPHOCYTES; THYMUS GLAND;

EID: 0030637062     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (42)

1. Sadlack, B., H. Merz, H. Schorle, A. Schimpl, A. C. Feller, and I. Horak. 1993. Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene. Cell 75:253.
2. Schorle, H., T. Holtschke, T. Hunig, A. Schimpl, and I. Horak. 1991. Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting. Nature 352:621.
3. Ehrhardt, R. O., B. R. Lúdvíksson, B. Gray, M. Neurath, and W. Strober. Induction and analysis of colonic inflammation in IL-2-deficient mice. J. Immunol. In press.
4. + T cells. Eur J. Immunol. 25:3053.
5. Suzuki, H., T. M. Kundig, C. Furlonger, A. Wakehan, E. Timms, T. Matsuyama, R. Schimst, J. J. L. Simard, P. Ohashi, H. Griesser, et al. 1995. Deregulated T cell activation and autoimmunity in mice lacking interleukin-2 receptor β. Science 268:1472.
6. Miller, J. F., and R. A. Flavell. 1994. T-cell tolerance and autoimmunity in transgenic models of central and peripheral tolerance. Curr. Opin. Immunol. 6:892.
7. Sprent, J. 1993. The thymus and T-cell tolerance. Ann. NY Acad. Sci. 681:5.
8. Le, P. T., H. T. Maecker, and J. E. Cook. 1995. In situ detection and characterization of apoptotic thymocytes in human thymus: expression of bcl-2 in vivo does not prevent apoptosis. J. Immunol. 154:4371.
9. Kisielow, P., and A. Miazek. 1995. Positive selection of T cells: rescue trom programmed cell death and differentiation require continual engagement of the T cell receptor. J. Exp. Med. 181:1975.
10. Surh, C. D., and J. Sprent. 1994. T-cell apoptosis detected in situ during positive and negative selection in the thymus. Nature 372:100.
11. + cell lines in response to TCR engagement. J. Immunol. 154:5011.
12. + thymocytes in vitro. J. Immunol. 154: 3636.
13. McConkey, D., P. Hartzell, S. Chow, S. Orrenius, and M. Jondal. 1990. Interleukin-1 inhibits T cell receptor-mediated apoptosis in immature thymocytes. J. Biol. Chem. 265:3009.
14. - thymocytes. J. Immunol. 143: 513.
15. - double-negative thymocytes. J. Immunol. 144:3039.
16. Tentori, L., D. L. Longo, J. C. Zuniga-Pflucker, C. Wing, and A. M. Kruisbeek. 1988. Essential role of the interleukin-2-imerteukin-2 receptor pathway in thymocyte maturation in vivo. J. Exp. Med. 168:1741.
17. Renauld, J. C., A. Vink, J. Louahed, and J. van Snick. 1995. Interleukin-9 is a major anti-apoptotic factor for thymic lymphomas. Blood 85:1300.
18. Migliorati, G., I. Nicoletti, C. Pagliacci, L. D'Adamio, and C. Riccardi. 1993. Interleukin-4 protects double-negative and CD4 single-positive thymocytes from dexamethasone-induced apoptosis. Blood 81:1352.
19. Mossalayi, M. D., F. Mentz, F. Ouaaz, A. H. Dalloul, C. Blanc, P. Debre, and F. W. Ruscetti. 1995. Early human thymocyte proliferation is regulated by an externally controlled autocrine transforming growth factor-β1 mechanism. Blood 85:3594.
20. Kelner, G. S., and A. Zlotnik. 1995. Cytokine production profile of early thymocytes and the characterization of a new class of chemokine. J. Leukocyte Biol. 57:778.
21. Godfrey, D. I., J. Kennedy, M. K. Gately, J. Hakimi, B. R. Hubbard, and A. Zlotnik. 1994. IL-12 influences intrathymic T cell development. J. Immunol. 152:2729.
22. - thymocytes. Int. Immunol. 7:213.
23. Carding, S. R., A. C. Hayday, and K. Bottomly. 1991. Cytokines in T-cell development. Immunol. Today 12:239.
24. Uckun, F. M., L. Tuel-Ahlgren, and V. E. A. Obuz. 1991. Interleukin-7 receptor engagement stimulates tyrosine phosphorylation, inositol phospholipid turnover, proliferation, and selective differentiation to the CD4 lineage by human fetal thymocytes. Proc. Natl. Acad. Sci. USA 88:6323.
25. - postnatal human thymocytes. Int. Arch. Allergy Immunol. 102:321.
26. Kramer, S., C. Mamalaki, I. Horak, A. Schimpl, D. Kioussis, and T. Hung. 1994. Thymic selection and peptide-induced activation of T cell receptor-transgenic CD8 T cells in interleukin-2-deficient mice. Eur. J. Immunol. 24:2317.
27. Hanke, T., R. Mitnacht, R. Boyd, and T. Hunig. 1994. Induction of interleukin-2 receptor β-chain expression by self-recognition in the thymus. J. Exp. Med. 180: 1629.
28. Krèmer, S., A. Schimpl, and T. Húnig. 1995. Immunopathology of interleukin (IL)-2-deficient mice: thymus dependence and suppression by thymus-dependent cells with an intact IL-2 gene. J. Exp. Med. 182:1769.
29. Hollander, G. A., S. J. Simpson, E. Mizoguchi, A. Nichogiannopoulou, J. She, J.-C. Gutierrez-Ramos, A. K. Bhan, S. J. Burakoff, B. Wang, and C. Terhorst. 1995. Severe colitis in mice with aberrant thymic selection. Immunity 3:27.
30. Bendelac, A., P. Matzinger, R. A. Seder, W. E. Paul, and R. H. Schwartz. 1992. Activation events during thymic selection. J. Exp. Med. 175:731.
31. + thymocytes. Eur. J. Immunol. 23: 739.
32. Doherty, T. M., R. A. Seder, and A. Sher. 1996. Induction and regulation of IL-15 expression in murine macrophages. J. Immunol. 156:735.
33. + T cells to enhance priming for IFN-γ production and diminishes IL-4 inhibition of such priming. Proc. Natl. Acad. Sci. USA 90:10188.
34. Rudolph, U., M. J. Finegold, S. S. Rich, G. R. Harriman, Y. Srinivasan, P. Brabet, G. Boulay, A. Bradley, and L. Birnbaumer. 1995. Ulcerative colitis and adenocarcinoma of the colon in Gi2α-deficient mice. Nat. Genet. 10:143.
35. LeGros, G. G., S. S. Ben-Sasson, R. Seder, F. D. Finkelman, and W. E. Paul. 1990. Generation of interleukin-4 (IL-4)-producing cells in vivo and in vitro: IL-2 and IL-4 are required for in vitro generation of IL-4-producing cells. J. Exp. Med. 172:921.
36. Ben-Sasson, S. S., G. G. LeGros, D. H. Conrad, F. D. Finkelman, and W. E. Paul. 1990. IL-4 production by T cells from naive donors: IL-2 is required for IL-4 production. J. Immunol. 145:1127.
37. Szabo, S. J., N. G. Jacobson, A. S. Dighe, U. Gubler, and K. M. Murphy. 1995. Developmental commitment to the Th2 lineage by extinction of IL-12 signaling. Immunity 2:665.
38. + T cells. Annu. Rev. Immunol. 12:635.
39. Racke, M. K., A. Bonomo, D. E. Scott, B. Canella, A. Levine, C. S. Raine, E. M. Shevach, and M. Rocken. 1994. Cytokine-induced immune deviation as a therapy for inflammatory autoimmune disease. J. Exp. Med. 180:1961.
40. Leonardo, M. J. 1991. Interleukin-2 programs mouse αβ T lymphocytes for apoptosis. Nature 353:858.
41. Critchfield, J. M., M. K. Racke, J. C. Zuniga-Pflucker, C. S. Raine, J. Goverman, and M. J. Lenardo. 1994. T cell deletion in high antigen dose therapy of autoimmune encephalomyelitis. Science 263:1139.
42. Kneitz, B., T. Herrmann, S. Yonehara, and A. Schimpl. 1995. Normal clonal expansion but impaired Fas-mediated cell death and anergy induction in interleukin-2-deficient mice. Eur. J. Immunol. 25:2572.