γδ T cells in host defense and epithelial cell biology

Clinical Immunology and Immunopathology

Volumn 86, Issue 2, 1998, Pages 121-133

  Boismenu, Richard ^a   Havran, Wendy L ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LIGAND; LYMPHOCYTE ANTIGEN RECEPTOR;

ANTIGEN RECOGNITION; CELL TRANSFORMATION; EPITHELIUM CELL; HOST RESISTANCE; HUMAN; INFECTION; NONHUMAN; PRIORITY JOURNAL; REVIEW; T LYMPHOCYTE SUBPOPULATION; ANIMAL; BIOLOGICAL MODEL; DISEASE MODEL; EPITHELIUM; IMMUNITY; IMMUNOLOGY; T LYMPHOCYTE;

ANIMALS; DISEASE MODELS, ANIMAL; EPITHELIUM; HUMANS; IMMUNITY; INFECTION; MODELS, IMMUNOLOGICAL; RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA; T-LYMPHOCYTES;

EID: 0031987359     PISSN: 00901229     EISSN: None     Source Type: Journal    
DOI: 10.1006/clin.1997.4468     Document Type: Article

References (129)

1. Englehard V. Structure of peptides associated with MHC class I molecules. Curr. Opin. Immunol. 6:1994;13-23.
2. Rotzschke O., Falk K. Origin, structure, and motifs of naturally processed MHC class II ligands. Curr. Opin. Immunol. 6:1994;45-51.
3. Tanaka Y., Morita C. T., Tanaka Y., Nieves E., Brenner M. B., Bloom B. R. Natural and synthetic non-peptide antigens recognized by human γδ T cells. Nature. 375:1995;155-158.
4. Schild H., Mavaddat N., Litzenberger C., Ehrich E. W., Davis M. M., Bluestone J. A., Matis L., Draper R. K., Chien Y.-h. The nature of major histocompatibility complex recognition by γδ T cells. Cell. 76:1994;29-37.
5. Havran W. L., Boismenu R. Activation and function of γδ T cells. Curr. Opin. Immunol. 6:1994;442-446.
6. Allison J. P., Havran W. L. The immunobiology of T cells with invariant γδ antigen receptors. Annu. Rev. Immunol. 9:1991;679-705.
7. Haas W., Pereira P., Tonegawa S. Gamma/Delta T cells. Annu. Rev. Immunol. 11:1993;637-685.
8. Kabelitz D. Human γδ T lymphocytes. Int. Arch. Allergy Immunol. 102:1993;1-9.
9. Sim G.-K. Intraepithelial lymphocytes and the immune system. Adv. Immunol. 58:1995;297-331.
10. Wallace M., Malkovsky M., Carding S. R. Gamma/delta T lymphocytes in viral infections. J. Leukocyte Biol. 58:1995;277-283.
11. Krangel M. S., Yssel H., Brocklehurst C., Spits H. A distinct wave of human T cell receptor γ/δ lymphocytes in the early fetal thymus: Evidence for controlled gene rearrangement and cytokine production. J. Exp. Med. 172:1990;847-859.
12. McVay L. D., Carding S. R., Bottomly K., Hayday A. C. Regulated expression and structure of T cell receptor γ/δ transcripts in human thymic ontogeny. EMBO J. 10:1991;83-91.
13. +. J. Immunol. 151:1993;4523-4527.
14. Goldman J. P., Spencer D. M., Raulet D. H. Ordered rearrangement of variable region genes of the T cell receptor γ locus correlates with transcription of the unrearranged genes. J. Exp. Med. 177:1993;729-739.
15. Wilson A., Held W., MacDonald H. R. Two waves of recombinase gene expression in developing thymocytes. J. Exp. Med. 179:1994;1355-1360.
16. Appasamy P. M., Kenniston T. W., Weng Y., Holt E. C., Kost J., Chambers W. H. Interleukin 7 induced expression of specific T cell receptor γ variable region genes in murine fetal liver cultures. J. Exp. Med. 178:1993;2201-2206.
17. ---. J. Immunol. 154:1995;3726-3731.
18. Hsiang Y.-h. H., Spencer D., Wang S., Speck N., Raulet D. H. The role of viral enhancer 'core' motif-related sequences in regulating T cell receptor-γ and -δ gene expression. J. Immunol. 150:1993;3905-3916.
19. Lauzurica P., Krangel M. S. Enhance-dependent and -independent steps in the rearrangement of a human T cell receptor δ transgene. J. Exp. Med. 179:1994;43-55.
20. Itohara S., Mombaerts P., Lafille J. J., Iacomini J., Nelson A., Clarke A. R., Hooper M. L., Farr A., Tonegawa S. T cell receptor δ gene mutant mice: Independent generation of αβ T cells and programmed rearrangements of γδ TCR genes. Cell. 72:1993;337-348.
21. Asarnow D. M., Cado D., Raulet D. H. Invariant T cell receptor γ gene junctional sequences. Nature. 362:1993;158-160.
22. Foster C. A., Yokozeki H., Rappersberger K., Koning F., Volc-Platzer B., Rieger A., Coligan J. E., Wolf K., Stingl G. Human epidermal T cells predominantly belong to the lineage expressing ab T cell receptor. J. Exp. Med. 171:1990;997-1013.
23. Dupuy P., Heslan M., Fraitag S., Hercend T., Dubertret L., Bagot M. T cell receptor γδ bearing lymphocytes in normal and inflammatory human skin. J. Invest. Dermatol. 94:1990;764-768.
24. Christmas S. E., Brew R., Thornton S. M., Deniz G., Flanagan B. F. Extensive TCR junctional diversity of Vγ9/Vδ2 clones from human female reproductive tissues. J. Immunol. 155:1995;2453-2458.
25. Holoshitz J., Vila L. M., Keroack B. J., McKinley D. R., Bayne N. K. Dual antigenic recognition by cloned human gamma delta T cells. J. Clin. Invest. 89:1992;308-314.
26. Kronenberg M. Antigens recognized by γδ T cells. Curr. Opin. Immunol. 6:1994;64-71.
27. Rock E. P., Sibbald P. R., Davis M. M., Chien Y.-H. CDR3 length in antigen-specific immune receptors. J. Exp. Med. 179:1994;323-328.
28. Sciammas R., Johnson R. M., Sperling A. I., Brady W., Linsley P. S., Fitch F. W., Spear P. G., Bluestone J. A. Unique antigen recognition by a herpesvirus-specific TCR γδ cell. J. Immunol. 152:1994;5392-5398.
29. Weintraub B. C., Jackson M. R., Hedrick S. M. γδ T cells can recognize nonclassical MHC in the absence of conventional antigenic peptides. J. Immunol. 153:1994;3051-3058.
30. Kaliyaperumal A., Falchetto R., Cox A., Dick R., Shabanowitz J., Chien Y.-h., Matis L., Hunt D. F., Bluestone J. A. Functional expression and recognition of nonclassical MHC Class I T10b is not peptide-dependent. J. Immunol. 155:1995;2379-2386.
31. Kabelitz D. Function and specificity of human γ/δ-positive T cells. Crit. Rev. Immunol. 11:1992;281-303.
32. O'Brien R. L., Born W. Heat shock proteins as antigens for γδ T cells. Semin. Immunol. 3:1991;81-87.
33. Schoel B., Spenger S., Kaufmann S. H. E. Phosphate is essential for stimulation of Vγ9Vδ2 T lymphocytes by mycobacterial low molecular weight ligand. Eur. J. Immunol. 24:1994;1886-1892.
34. Constant P., Davodeau F., Peyrat M.-A., Poquet Y., Puzo G., Bonneville M., Fournie J.-J. Stimulation of human γδ T cells by nonpeptidic mycobacterial ligands. Science. 264:1994;267-270.
35. Tanaka Y., Sano S., Nieves E., De Libero G., Rosa D., Modlin R. L., Brenner M. B., Bloom B. R., Morita C. T. Nonpeptide ligands for human γδ T cells. Proc. Natl. Acad. Sci. USA. 91:1994;8175-8179.
36. Bukowski J. F., Morita C. T., Tanaka Y., Bloom B. R., Brenner M. B., Band H. Vγ2Vδ2 TCR-dependent recognition of non-peptide antigens and Daudi cells analyzed by TCR gene transfer. J. Immunol. 154:1995;998-1006.
37. Burk M. R., Mori L., De Libero G. Human Vγ9-Vδ2 cells are stimulated in a cross-reactive fashion by a variety of phosphorylated metabolites. Eur. J. Immunol. 25:1995;2052-2058.
38. Bukowski J. F., Morita C. T., Brenner M. B. Recognition and destruction of virus-infected cells by human γδ T cells. J. Immunol. 153:1994;5133-5140.
39. Holoshitz J., Romzek N. C., Jia Y., Wagner L., Vila L. M., Chen S.-J., Wilson J. M., Karp D. R. MHC-independent presentation of mycobacteria to human γδ T cells. Int. Immunol. 5:1993;1437-1443.
40. Kaufmann S. H. E. Immunity to intracellular bacteria and protozoa. Immunologist. 3:1995;221-225.
41. Strominger J. L. The gamma delta T cell receptor and class Ib MHC related proteins: Enigmatic molecules of immune recognition. Cell. 57:1989;895-898.
42. Srivastava P. K., Maki R. G. Stress-induced proteins in immune response to cancer. Curr. Top. Microbiol. Immunol. 167:1991;109-117.
43. Finberg R. W. Heat shock proteins and gamma delta T cells. Semin. Immunopathol. 13:1991;55-67.
44. Kim H. T., Nelson E. L., Clayberger C., Sanjanwala M., Sklar J., Krensky A. M. γδ T cell recognition of tumor Ig peptide. J. Immunol. 154:1995;1614-1623.
45. Morita C. T., Beckman E. M., Bukowski J. F., Tanaka Y., Band H., Bloom B. R., Golan D. E., Brenner M. B. Direct presentation of nonpeptide prenyl pyrophosphate antigens to human γδ T cells. Immunity. 3:1995;495-507.
46. Havran W. L., Chien Y.-H., Allison J. P. Recognition of self-antigens by skin-derived T cells with invariant γδ antigen receptors. Science. 252:1991;1430-1432.
47. Kaminski M. J., Bergstresser P. R., Takashima A. In vivo activation of mouse dendritic epidermal T cells in sites of contact dermatitis. Eur. J. Immunol. 23:1993;1715-1718.
48. Tigelaar R. E., Lewis J. M. Immunobiology of mouse dendritic epidermal T cells: A decade later, some answers, but still more questions. J. Invest. Dermatol. 105:1995;43S-49S.
49. +. J. Immunol. 155:1995;2888-2894.
50. Boismenu R., Havran W. L. Modulation of epithelial cell growth by intraepithelial γδ T cells. Science. 266:1994;1253-1255.
51. Housley R. M., Morris C. F., Boyle W., Ring B., Blitz R., Tarpley J. E., Aukerman S. L., Devine P. L., Whitehead R. H., Pierce G. F. Keratinocyte growth factor induces proliferation of hepatocytes and epithelial cells throughout the rat gastrointestinal tract. J. Clin. Invest. 94:1994;1764-1777.
52. Mombaerts P., Mizoguchi E., Grusby M. J., Glimcher L. H., Bhan A. K., Tonegawa S. Spontaneous development of inflammatory bowel disease in T cell receptor mutant mice. Cell. 75:1993;275-282.
53. Kaufmann S. H. E. Immunity to intracellular bacteria. Annu. Rev. Immunol. 11:1993;129-163.
54. Ueta C., Tsuyuguchi I., Kawasumi H., Takashima T., Toba H., Kishimoto S. Increase γ/δ T cells in hospital workers who are in close contact with tuberculosis patients. Infect. Immunol. 62:1994;5434-5441.
55. Mombaerts P., Arnoldi J., Russ F., Tonegawa S., Kaufmann S. H. E. Different roles of αβ and γδ T cells in immunity against an intracellular pathogen. Nature. 365:1993;53-56.
56. Boom W. H., Balaji K. N., Nayak R., Tsukaguchi K., Chervenak K. A. Characterization of a 10- to 14-kilodalton protease-sensitive Mycobacterium tuberculosis H37Ra antigen that stimulates human γδ T cells. Infect. Immun. 62:1994;5511-5518.
57. ++. Infect. Immunol. 63:1995;2288-2294.
58. Balaji K. N., Schwander S. K., Rich E. A., Boom W. H. Alveolar macrophages as accessory cells for human γδ T cells activated by Mycobacterium tuberculosis. J. Immunol. 154:1995;5959-5968.
59. Vila L. M., Haftel H. M., Park H.-S., Lin M.-S., Romzek N. C., Hanash S. M., Holoshitz J. Expansion of mycobacterium-reactive γδ T cells by a subset of memory helper T cells. Infect. Immun. 63:1995;1211-1217.
60. Caldwell C. W., Everett E. D., McDonald G., Yesus Y. W., Roland W. E. Lymphocytosis of γ/δ T cells in human Ehrlichiosis. Am. J. Clin. Pathol. 103:1995;761-766.
61. Ferrick D. A., Schrenzel M. D., Mulvania T., Hsieh B., Ferlin W. G., Lepper H. Differential production of interferon-γ and interleukin-4 in response to Th1- and Th2-stimulating pathogens by γδ T cells in vivo. Nature. 373:1995;255-257.
62. Munoz M. G., Witkin S. S. Autoimmunity to spermatozoa, asymptomatic Chlamydia trachomatis genital tract infection and γδ T lymphocytes in seminal fluid from the male partners of couples with unexplained infertility. Human Reprod. 10:1995;1070-1074.
63. Witkin S. S., Sultan K. N., Neal G. S., Jeremias J., Grifo J. A., Rosenwaks Z. Unsuspected Chlamydia trachomatis infection and in-vitro fertilization outcome. Am. J. Obstet. Gynecol. 171:1994;1208-1214.
64. Lusso P., Garzino-Demo A., Crowley R. W., Malnati M. S. Infection of γ/δ T lymphocytes by human herpesvirus 6: Transcriptional induction of CD4 and susceptibility to HIV infection. J. Exp. Med. 181:1995;1303-1310.
65. Boullier S. M., Cochet M., Poccia F., Gougeon M. L. CDR3-independent γδ Vδ1+ T cell expansion in the peripheral blood of HIV-1 infected persons. J. Immunol. 154:1995;1418-1425.
66. Rzepczyk C. M., Anderson K., Stamatiou S., Townsend E., Allworth A., McCormack J., Whitby M. γδ T cells: Their immunobiology and role in malaria infections. Int. J. Parasitol. 27:1997;191-200.
67. Jones S. M., Goodier M. R., Langhorne J. The response of γδ T cells to Plasmodium falciparum is dependent on activated CD4+ T cells and the recognition of MHC class I molecules. Immunology. 89:1996;405-412.
68. Schwartz E., Shapiro R., Shina S., Bank I. Delayed expansion of Vδ2+ and Vδ1+ γδ T cells after acute Plasmodium falciparum and Plasmodium vivax malaria. J. Allergy Clin. Immunol. 97:1996;1387-1392.
69. Kowalczyk D., Skorupski W., Drews M., Nowak J. Different pattern of T cell receptor delta gene rearrangement in tumor-infiltrating lymphocytes and peripheral blood in patients with solid tumors. Cancer Immunol. Immunother. 39:1994;275-278.
70. Olive C., Nicol D., Falk M. C. Characterisation of gamma delta T cells in renal cell carcinoma patients by polymerase chain reaction analysis of T cell receptor transcripts. Cancer Immunol. Immunother. 44:1997;27-34.
71. Choudhary A., Davodeau F., Moreau A., Peyrat M.-A., Bonneville M., Jotereau F. Selective lysis of autologous tumor cells by recurrent γδ tumor-infiltrating lymphocytes from renal carcinoma. J. Immunol. 154:1995;3932-3940.
72. Spinozzi F., Bertotto A. Cellular mechanisms in the pathogenesis of bronchial asthma. Immunol. Today. 16:1995;407-408.
73. Spinozzi F., Agea E., Bistoni O., Forenza N., Monaco A., Bassotti G., Nicoletti I., Riccardi C., Grignani F., Bertotto A. Increased allergen-specific, steroid-sensitive γδ T cells in bronchoaleveolar lavage fluid from patients with asthma. Annu. Intern. Med. 124:1996;223-227.
74. Mombaerts P., Clarke A. R., Rudnicki M. A., Iacomini J., Itohara S., Lafille J. J., Wang L., Ichikawa Y., Jaenisch R., Hooper M. L., Tonegawa S. Mutations in T cell antigen receptor genes α and β block thymocyte development at different stages. Nature. 360:1992;225-231.
75. Ladel C. H., Blum C., Dreher A., Reifenberg K., Kaufmann S. H. E. Protective role of γ/δ T cells and α/β T cells in tuberculosis. Eur. J. Immunol. 25:1995;2877-2881.
76. Emoto M., Nishimura H., Sakai T., Hiromatsu K., Gomi H., Itohara S., Yoshikai Y. Mice deficient in γδ T cells are resistant to lethal infection with salmonella choleraesuis. Infect. Immun. 63:1995;3736-3738.
77. Sadlack B., Merz H., Schorle H., Schimpl A., Feller A. C., Horak I. Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene. Cell. 75:1993;253-261.
78. Kuhn R., Lohler J., Rennick D., Rajewsky K., Muller W. Interleukin-10-deficient mice develop chronic enterocolitis. Cell. 75:1993;263-274.
79. Powrie F. T cells in inflammatory bowel disease: Protective and pathogenic roles. Immunity. 3:1995;171-174.
80. Giacomelli R., Parzanese I., Frieri G., Passacantando A., Pizzuto F., Pimpo T., Cipriani P., Viscido A., Caprilli R., Tonietti G. Increase of circulating γδ T lymphocytes in the peripheral blood of patients affected by active inflammatory bowel disease. Clin. Exp. Immunol. 98:1994;83-88.
81. Komano H., Fujiura Y., Kawaguchi M., Matsumoto S., Hashimoto Y., Obano S., Mombaerts P., Tonegawa S., Yamamoto H., Itohara S., Nanno M., Ishikawa H. Homeostatic regulation of intestinal epithelia by intraepithelial γδ T cells. Proc. Natl. Acad. Sci. USA. 92:1995;6147-6151.
82. Finch P. W., Pricolo V., Wu A., Finkelstein S. D. Increased expression of keratinocyte growth factor messenger RNA associated with inflammatory bowel disease. Gastroenterology. 110:1996;441-451.
83. Boismenu R., Feng L., Xia Y. Y., Chang J. C. C., Havran W. L. Chemokine expression by intraepithelial γδ T cells: Implications for the recruitment of inflammatory cells to damaged epithelia. J. Immunol. 157:1996;985-992.
84. De Maria A., Ferrazin A., Ferrini S., Ciccone E., Terragna A., Moretta L. Selective increase of a subset of T cell receptor γδ T lymphocytes in the peripheral blood of patients with human immunodeficiency virus type 1 infection. J. Infect. Dis. 165:1992;917-919.
85. Hyjek E. M., Bartkowiak J., Drozdz R., Wasik T. J., Jasinski M., Kaneko Y., Lischner H. W., Kozbor D. Evidence for B cell-mediated activation of Vδ1+ T lymphocytes during progression of HIV infection. J. Immunol. 158:1997;464-474.
86. Nikolopoulou V., Skoutelis A., Thomopoulos K., Salsaa B., Zoumbos N. An increased number of circulating γ/δ TCR + T cells in patients with chronic viral hepatitis. FEBS Immunol. Med. Microbiol. 10:1995;115-118.
87. Ogasawara T., Emoto M., Kiyotani K., Shimokata K., Yoshida T., Nagai Y., Yoshikai Y. Sendai virus pneumonia: Evidence for the early recruitment of γδ T cells during the disease course. J. Virol. 68:1994;4022-4027.
88. Munk M. E., Fazioli R. A., Calich V. L. G., Kaufmann S. H. E. Paracoccidioides brasiliensis-stimulated human γ/δT cells support antibody production by B cells. Infect. Immunol. 63:1995;1608-1610.
89. Worku S., Bjorkman A., Troye-Blomberg M., Jemaneh L., Farnert A., Christensson B. Lymphocyte activation and subset redistribution in the peripheral blood in acute malaria illness. Clin. Exp. Immunol. 108:1997;34-41.
90. +. Clin. Exp. Immunol. 102:1995;167-173.
91. Zocchi M. R., Ferrarini M., Migone N., Casorati G. T-cell receptor Vδ gene usage by tumor reactive γδ T lymphocytes infiltrating human lung cancer. Immunology. 81:1994;234-239.
92. Mori S., Suzushima H., Nishikawa K., Miyake H., Yonemura Y., Tsuji N., Kawaguchi T., Asou N., Kawakita M., Takatsuki K. Smoldering γδ T-cell granular lymphocytic leukemia associated with pure red cell aplasia. Acta Haematol. 94:1995;32-35.
93. Falk M. C., Ng G., Zhang G. Y., G\Fanning G. C., Roy L. P., Bannister K. M., Thomas A. C., Clarkson A. R., Woodroffe A. J., Knight J. F. Infiltration of the kidney by αβ and γδ T cells: Effect on progression in IgA nephropathy. Kidney Int. 47:1995;177-185.
94. McVay L. D., Li B., Biancaniello R., Creighton M. A., Bachwich D., Lichtenstein G., Rombeau J. L., Carding S. R. Changes in human mucosal γδ T cell repertoire and function associated with the disease process in inflammatory bowel disease. Mol. Med. 3:1997;183-203.
95. Stinissen P., Vandevyver C., Medaer R., Vandegaer L., Nies J., Tuyls L., Hafler D. A., Raus J., Zhang J. Increased frequency of γδ T cells in cerebrospinal fluid and peripheral blood of patients with multiple sclerosis: Reactivity, cytotoxicity, and T cell receptor gene rearrangements. J. Immunol. 154:1995;4883-4894.
96. Stinissen P., Raus J., Zhang J. Autoimmune pathogenesis of multiple sclerosis: Role of autoreactive T lymphocytes and new immunotherapeutic strategies. Crit. Rev. Immunol. 17:1997;33-75.
97. Olive C., Gatenby P. A., Serjeantson S. W. Persistence of γ/δ T cell oligoclonality in the peripheral blood of rheumatoid arthritis patients. Immunol. Cell Biol. 72:1994;7-11.
98. Olive C., Gatenby P. A., Serjeantson S. W. T-cell receptor γ/δ usage in rheumatoid arthritis. Persistence of oligoclonality in the periphery. Ann. N.Y. Acad. Sci. 756:1995;183-185.
99. +. Arthritis Rheum. 38:1995;1277-1282.
100. +. Rheumatol. Int. 4:1994;163-168.
101. +. J. Neurol. Sci. 121:1994;39-45.
102. ++. Infect. Immun. 63:1995;3000-3004.
103. Fu Y.-X., Roark C. E., Kelly K., Drevets D., Campbell P., O'Brien R., Born W. Immune protection and control of inflammatory tissue necrosis by γδ T cells. J. Immunol. 153:1994;3101-3115.
104. Skeen M. J., Ziegler H. K. Activation of γδ T cells for production of IFN-γ is mediated by bacteria via macrophage-derived cytokines IL-1 and IL-12. J. Immunol. 154:1995;5832-5841.
105. Mukasa A., Hiromatsu K., Matsusaki G., O'Brien R., Born W., Nomoto K. Bacterial infection of the testis leading to autoaggressive immunity triggers apparently opposed responses of αβ and γδ T cells. J. Immunol. 155:1995;2047-2056.
106. Ladel C. H., Flesch I. E. A., Arnoldi J., Kaufmann S. H. E. Studies with MHC-deficient knock-out mice reveal impact of both MHC I- and MHC II-dependent T cell responses on Listeria monocytogenes infection. J. Immunol. 153:1994;3116-3122.
107. Muller D., Pakpreo P., Filla J., Pederson K., Cigel F., Malkovska V. Increased gamma-delta T-lymphocytes responses to Mycobacterium bovis BCG in major histocompatibility complex class I-deficient mice. Infect. Immun. 63:1995;2361-2366.
108. +. Immunology. 85:1995;531-537.
109. van der Heyde H. C., Manning D. D., Weidanz W. P. Role of CD4+ T cells in the expansion of the CD4-, CD8- γδ T cell subset in the spleens of mice during blood-stage malaria. J. Immunol. 151:1993;6311-6317.
110. Van Der Hyde H. C., Elloso M. M., Chang W. L., Pepper B. J., Batchelder J., Weidanz W. P. Expansion of the γδ T cell subset in vivo during bloodstage malaria in B cell-deficient mice. J. Leukocyte Biol. 60:1996;221-229.
111. Langhorne J., Mombaerts P., Tonegawa S. αβ and γδ T cells in the immune response to the erythrocytic stages of malaria in mice. Int. Immunol. 7:1995;1005-1011.
112. Mixter P. F., Camerini V., Stone B. J., Miller V. L., Kronenberg M. Mouse T lymphocytes that express a γδ T-cell antigen receptor contribute to resistance to Salmonella infection in vivo. Infect. Immun. 62:1994;4618-4621.
113. Arai T., Hiromatsu K., Nishimura H., Kimura Y., Kobayashi N., Ishida H., Nimura Y., Yoshikai Y. Effects of in vivo administration of anti-IL-10 monoclonal antibody on the host defence mechanism against murine Salmonella infection. Immunology. 85:1995;381-388.
114. Weintraub B. C., Eckmann L., Okamoto S., Hense M., Hedrick S. M., Fierer J. Role of αβ and γδ T cells in the host response to Salmonella infection as demonstrated in T cell receptor-deficient mice of defined Ity genotypes. Infect. Immun. 65:1997;2306-2312.
115. Sandor M., Sperling A. I., Cook G. A., Weinstock J. V., Lynch R. G., Bluestone J. A. Two waves of γδ T cells expressing different Vδ genes are recruited into schistosome-induced liver granulomas. J. Immunol. 155:1995;275-284.
116. Hisaeda H., Nagasawa H., Maeda K.-I., Maekawa Y., Ishikawa H., Ito Y., Good R. A., Himeno K. γδ T cells play an important role in hsp65 expression and in acquiring protective immune responses against infection with Toxoplasma gondii. J. Immunol. 154:1995;244-251.
117. Sayles P. C., Rakhmilevich A. L., Johnson L. L. γδ T cells and acute primary Toxoplasma gondii infection in mice. J. Infect. Dis. 171:1995;249-252.
118. Kasper L. H., Matsuura T., Fonseka S., Arruda J., Channon J. Y., Khan I. A. Induction of gamma delta T cells during acute murine infection with Toxoplasma gondii. J. Immunol. 157:1996;5521-5527.
119. Holt P. G. Immune tolerance and protection against allergic sensitization. Allergy. 50:1995;34-36.
120. McMenamin C., McKersey M., Kuhnlein P., Hunig T., Holt P. G. Gamma delta T cells down-regulate primary IgE responses in rats to inhaled soluble protein antigens. J. Immunol. 154:1995;4390-4394.
121. Peterman G. M., Spencer C., Sperling A. I., Bluestone J. A. Role of γδ T cells in murine collagen-induced arthritis. J. Immunol. 151:1993;6546-6558.
122. Enk A. H., Katz S. I. Contact sensitivity as a model for T-cell activation in skin. J. Invest. Dermatol. 105:1995;80S-83S.
123. Simpson S. J., Hollander G. A., Mizoguchi E., Allen D., Bhan A. K., Wang B., Terhorst C. Expression of pro-inflammatory cytokines by TCR αβ+ and TCR γδ+ T cells in an experimental model of colitis. Eur. J. Immunol. 27:1997;17-25.
124. Kaminski M. J., Cruz P. D., Bergstresser P. R., Takashima A. Killing of skin-derived tumor cells by mouse dendritic epidermal T cells. Cancer Res. 53:1993;4014-4019.
125. Schuhmachers G., Ariizumi K., Mathew P. A., Bennett M., Kumar V., Takashima A. 2B4, a new member of the immunoglobulin gene superfamily, is expressed on murine dendritic epidermal T cells and plays a functional role in their killing of skin tumors. J. Invest. Dermatol. 105:1995;592-596.
126. Peng S. L., Madaio M. P., Hayday A. C., Craft J. Propagation and regulation of systemic autoimmunity by γδ T cells. J. Immunol. 157:1996;5689-5698.
127. Rajan A. J., Gao Y. L., Raine C. S., Brosnan C. F. A pathogenic role for gamma delta T cells in relapsing-remitting experimental allergic encephalomyelitis in the SJL mouse. J. Immunol. 157:1996;941-949.
128. Kobayashi Y., Kawai K., Ito K., Honda H., Sobue G., Yoshikai Y. Aggravation of murine experimental allergic encephalomyelitis by administration of T cell receptor gamma delta-specific antibody. J. Neuroimmunol. 73:1997;169-174.
129. Olive C. Modulation of experimental allergic encephalomyelitis in mice by immunization with a peptide specific for the γδ T cell receptor. Immunol. Cell Biol. 75:1997;102-106.