Tropomyosin isoforms in intestinal mucosa: Production of autoantibodies to tropomyosin isoforms in ulcerative colitis

Gastroenterology

Volumn 114, Issue 5, 1998, Pages 912-922

  Geng, X ^a   Biancone, L ^a   Hui Hui Dai, ^a   Lin, J J C ^a   Yoshizaki, N ^a   Dasgupta, A ^a   Pallone, F ^a   Das, K M ^a  

^a ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; IMMUNOGLOBULIN G; TROPOMYOSIN;

ADULT; AGED; ANTIBODY RESPONSE; ARTICLE; CLINICAL ARTICLE; COLON MUCOSA; CROHN DISEASE; FEMALE; HUMAN; HUMAN TISSUE; INTESTINE EPITHELIUM; INTESTINE MUCOSA; INTESTINE MUSCLE; JEJUNUM MUCOSA; MALE; PRIORITY JOURNAL; ULCERATIVE COLITIS;

EID: 0031958070     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0016-5085(98)70310-5     Document Type: Article

References (48)

1. P Brandtzaeg Autoimmunity and ulcerative colitis: can two enigmas make sense together? Gastroenterology 109 1995 307 312
2. K Baklien P Brandtzaeg Comparative mapping of the local distribution of immunoglobulin-forming cells in ulcerative colitis and Crohn's disease of the colon Clin Exp Immunol 22 1975 197 209
3. T Hibi M Ohara K Toda A Hara H Ogata Y Iwao N Watanabe M Watanabe Y Hamada K Kobayashi S Aiso M Tsuchiya In vitro anticolon antibody production by mucosal or peripheral blood lymphocytes from patients with ulcerative colitis Gut 31 1990 1371 1376
4. SR Targan CJ Landers L Cobb RP MacDermott A Vidrich Perinuclear anti-neutrophil cytoplasmic antibodies are spontaneously produced by mucosal B cells in ulcerative colitis patients J Immunol 155 1995 3262 3267
5. MG Scott MH Nahm K Macke GS Nash MJ Bertovich RP MacDermott Spontaneous secretion of IgG subclasses by intestinal mononuclear cells: differences between ulcerative colitis, Crohn's disease and controls Clin Exp Immunol 66 1986 209 215
6. P Brandtzaeg T Halstensen K Kett Immunopathology of inflammatory bowel disease RP MacDermott WF Stenson Inflammatory bowel disease 1992 Elsevier New York 95 136
7. DC Heiner Significance of immunoglobulin G subclasses Am J Med 76 1984 1 6
8. KM Das R Dubin T Nagai Isolation and characterization of colonic tissue-bound antibodies from patients with idiopathic ulcerative colitis Proc Natl Acad Sci USA 74 1978 4528 4532
9. F Takahashi KM Das Isolation and characterization of a colonic autoantigen specifically recognized by colon tissue-bound IgG from idiopathic ulcerative colitis J Clin Invest 76 1985 311 318
10. TS Halstensen TE Mollnes P Garred O Fausa P Brandtzaeg Epithelial deposition of immunoglobulin G1 and activated complement (C3b and terminal complement complex) in ulcerative colitis Gastroenterology 98 1990 1264 1271
11. TS Halstensen KM Das P Brandtzaeg Epithelial deposits of immunoglobulin G1 and activated complement co-localize with the 40 kDa colonic autoantigen in ulcerative colitis Gut 34 1993 650 657
12. TS Halstensen TE Mollnes P Garred O Gausa P Brandtzaeg Surface epithelium-related activation of complement differs in Crohn's disease and ulcerative colitis Gut 33 1992 902 908
13. KM Das A Dasgupta A Mandal X Geng Autoimmunity to cytoskeletal protein tropomyosin(s): a new clue to the pathogenetic mechanism for ulcerative colitis J Immunol 150 1993 2487 2493
14. JJ-C Lin KS Warren DD Wamboldt Tropomyosin isoforms in nonmuscle cells Int Rev Cytol 170 1997 1 38
15. RE Novy JL-C Lin JJ-C Lin Human fibroblast tropomyosin isoforms: characterization of cDNA clones and analysis of tropomyosin isoform expression in human tissues and in normal and transformed cells Cell Motil Cytoskeleton 25 1993 267 281
16. CB Daul M Slattery G Reese SB Lehrer Identification of the major brown shrimp ( Penaeus aztecus ) allergen as the muscle protein tropomyosin Int Arch Allerg Immunol 105 1994 49 55
17. JG Dohlman A Lupas M Carson Long charge-rich alpha-helices in systemic autoantigens Biochem Biophys Res Commun 195 1993 686 696
18. RE Novy LF Liu C-S Lin DM Helfman JJ-C Lin Expression of smooth muscle and nonmuscle tropomyosin in E. coli and characterization of bacterially produced tropomyosins Biochem Biophys Acta 1162 1993 255 265
19. SC Truelove LJ Witts Cortisone in ulcerative colitis. Final report on a therapeutic trial BMJ 2 1955 1041 1048
20. WR Best KM Becktel JW Singleton F Kern Development of a Crohn's disease activity index. National cooperative Crohn's disease study Gastroenterology 70 1976 439 444
21. DM Bull MA Bookman Isolation and functional characterization of human mucosal lymphoid cells J Clin Invest 59 1977 966 974
22. F Pallone S Fais O Squarcia L Biancone P Pozzili M Boirivant Activation of peripheral and intestinal lamina propria lymphocytes in Crohn's disease. In vivo state of activation and in vitro response to stimulation as defined by the expression of early activation antigens Gut 28 1987 745 753
23. L Biancone A Mandal H Yang T Dasgupta AO Paoluzi A Marcheggiano P Paoluzi F Pallone KM Das Production of immunoglobulin G and G1 antibodies to cytoskeletal protein by lamina propria cells in ulcerative colitis Gastroenterology 109 1995 3 12
24. C Fiocchi JR Battisto RG Farmer Gut mucosal lymphocytes in inflammatory bowel disease. Isolation and preliminary functional characterization Dig Dis Sci 24 1979 705 717
25. RP MacDermott GS Nash MH Nahm Antibody secretion by intestinal mononuclear cells from normal controls and inflammatory bowel disease patients Immunol Invest 18 1989 449 457
26. H Miyazaki H Kawasaki C Hirayama Studies on lymphocyte subpopulations in human biopsy specimens by colonoscopy Dig Dis Sci 30 1985 143 148
27. O Squarcia S Fais M Boirivant MC DiPaolo A Marcheggiano C Iannoni P Paoluzi F Pallone Phenotypes and spontaneous immunoglobulin production in mononuclear cells suspensions isolated from colonic biopsies of patients with mild active and quiescent ulcerative colitis Gastroenterol Clin Biol 15 1991 194 198
28. RP MacDermott GS Nash MJ Bertovich MV Sedine MJ Bragdon MG Beale Alterations of IgM, IgG and IgA synthesis and secretion by peripheral blood and intestinal mononuclear cells from patients with ulcerative colitis and Crohn's disease Gastroenterology 81 1981 844 852
29. PR Klaster MY LeWit AH Kolk An ELISA-inhibition test using monoclonal antibody for the serology of leprosy Clin Exp Immunol 139 1985 77 84
30. T Aki T Kodama A Fujikawa K Miura S Shigeta T Wada T Jyo Y Murooka S Oka K Ono Immunochemical characterization of recombinant and native tropomyosin as a new allergen from the house dust mite, Dermatophagoides farinae J Allergy Clin Immunol 96 1995 74 83
31. LO Goodwin JP Lees-Miller MA Leonard SB Chaley DM Helfman Four fibroblast tropomyosin isoforms are expressed from the rat alpha-tropomyosin gene via alternative RNA splicing and the use of two promoters J Biol Chem 266 1991 8408 8410
32. JP Lees-Miller DM Helfman The molecular basis for tropomyosin isoform diversity Bioessays 13 1991 429 437
33. DR Burgess KO Broschat JM Hayden Tropomyosin distinguishes between the two actin-binding sites of willin and affects actin-binding properties of other brush border proteins J Cell Biol 104 1987 29 31
34. LA Sung JJ-C Lin Erythrocyte tropomodulin binds the N-terminus of hTM5, a tropomyosin encoded by the Y-TM gene Biochem Biophys Res Commun 201 1994 627 634
35. VM Fowler V Bennett Erythrocyte membrane tropomyosin: purification and properties J Biol Chem 259 1984 5978 5989
36. MS Mooseker Organization, chemistry and assembly of the cytoskeletal apparatus of the intestinal brush border Annu Rev Cell Biol 1 1985 209 211
37. DD Bikle S Munson N Morrison J Eisman Zipper protein, a newly described tropomyosin-like protein of the intestinal brush border J Biol Chem 268 1993 620 626
38. L Biancone G Monteleone F Pallone Serum IgG against specific tropomyosin (TM) isoform in ulcerative colitis patients and unaffected relatives (abstr) Gastroenterology 110 1996 A864
39. S Sakamaki S Hayashi N Takayanagi Y Niitsu Autoantibodies in sera of patients with UC recognize tropomyosin peptide associated with HLA-DPw9 (abstr) Gastroenterology 110 1996 A1007
40. UY Khoo I Bjarnason A Donaghy R Williams A MacPherson Antibodies to colon epithelial cells from the serum and colonic mucosal washings in ulcerative colitis Gut 37 1995 63 70
41. P Bini JE Gabay A Teitel M Melchior J-L Zhou KB Elkon Antineutrophil cytoplasmic autoantibodies in Wegner's granulomatosis recognize conformational epitope(s) on proteinase 3' J Immunol 149 1992 1409 1415
42. A Mizoguchi E Mizoguchi C Chiba GM Spiekermann S Tonegawa C Nagler-Anderson AK Bhan Cytokine imbalance and autoantibody production in T cell receptor-α mutant mice with inflammatory bowel disease J Exp Med 183 1996 847 856
43. A Mizoguchi E Mizoguchi C Chiba AK Bhan Role of appendix in the development of inflammatory bowel diseases in TCR-α mutant mice J Exp Med 184 1996 707 715
44. N Yoshizaki K Kesari J Lin KM Das Expression of a tropomyosin-related protein on the surface of colon epithelial cells and its possible functional significance (abstr) Gastroenterology 110 1996 A1051
45. L Liao R Sindhwani M Rojkind S Factor L Leinwand B Diamond Antibody-mediated autoimmune myocarditis depends on genetically determined target organ sensitivity J Exp Med 181 1995 1123 1131
46. N New NR Rose KW Beisel A Herskowitz G Gurri-Glass SW Craig Cardiac myosin induces myocarditis in genetically predisposed mice J Immunol 139 1987 3630 3636
47. PG Fenderson VA Fischetti MW Cunningham Tropomyosin shares immunologic epitopes with group A streptococcal M proteins J Immunol 142 1989 2475 2480
48. RB Sartor Cytokines in intestinal inflammation: pathophysiological and clinical considerations Gastroenterology 106 1994 533 539