T cell receptor-αβ-deficient mice fail to develop colitis in the absence of a microbial environment

American Journal of Pathology

Volumn 150, Issue 1, 1997, Pages 91-97

  Dianda, Lee ^a   Hanby, Andrew M ^a   Wright, Nicholas A ^a   Sebesteny, Andor ^a   Hayday, Adrian C ^b   Owen, Michael J ^a  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^b YALE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

T LYMPHOCYTE RECEPTOR ALPHA CHAIN;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL COLONIZATION; BACTERIAL FLORA; COLITIS; CONTROLLED STUDY; ENTEROCOCCUS FAECALIS; ESCHERICHIA COLI; GERMFREE ANIMAL; HISTOLOGY; LACTOBACILLUS PLANTARUM; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; COLITIS; DISEASE SUSCEPTIBILITY; GERM-FREE LIFE; MICE; MICE, MUTANT STRAINS; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; SPECIFIC PATHOGEN-FREE ORGANISMS;

EID: 0031012926     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (23)

1. Strober W, Ehrhardt RO: Chronic intestinal inflammation: an unexpected outcome in cytokine or T cell receptor mutant mice. Cell 1993, 75:203-205
2. Sadlack B, Merz H, Schorle H, Schimpl A, Feller AC, Horak I: Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene. Cell 1993, 75:253-261
3. Mombaerts P, Mizoguchi E, Grusby MJ, Glimcher LH, Bhan AK, Tonegawa S: Spontaneous development of inflammatory bowel disease in T cell receptor mutant mice. Cell 1993, 75:275-282
4. Kühn R, Löhler J, Rennick D, Rajewsky K, Müller W: Interleukin-10-deficient mice develop chronic enterocolitis. Cell 1993, 75:263-274
5. Shull MM, Ormsby I, Kier AB, Pawlowski S, Diebold RJ, Yin M, Allen R, Sidman C, Proetzel G, Calvin D, Annunziata N, Doetschman T: Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease. Nature 1992, 693-699
6. Holländer GA, Simpson SJ, Mizoguchi E, Nichogiannopoulou A, She J, Gutierrez-Ramos J-C, Bhan AK, Burakoff SJ, Wang B, Terhorst C: Severe colitis in mice with aberrant thymic selection. Immunity 1995, 3:27-38
7. Ma A, Datta M, Margosian E, Chen J, Horak I: T cells, but not B cells, are required for bowel inflammation in interleukin 2-deficient mice. J Exp Med 1995, 182:1567-1572
8. Klapproth J-M, Donnenberg MS, Abraham JM, Mobley HLT, James SP: Products of enteropathogenic Escherichia coli inhibit lymphocyte activation and lymphokine production. Infect Immun 1995, 63:2248-2254
9. Philpott KL, Viney JL, Kay G, Rastan S, Gardiner EM, Chae S, Hayday AC, Owen MJ: Lymphoid development in mice congenitally lacking T cell receptor αβexpressing cells. Science 1992, 256:1448-1452
10. Sebesteny A, Lee P: Unidirectional air flow surgical isolation for hysterectomy of mice. Lab Anim 1973, 7:271-277
11. Goodlad RA, Ratcliffe B, Fordham JP, Wright NA: Does dietary fibre stimulate intestinal epithelial cell proliferation in germ-free rats? Gut 1989, 30:820-825
12. Mombaerts P, Clarke AR, Rudnicki MA, Iacomini J, Itohara S, Lafaille JJ, Wang L, Ichikawa Y, Jaenisch R, Hooper ML, Tonegawa S: Mutations in T-cell antigen receptor genes α and βblock thymocyte development at different stages. Nature 1992, 360:225-231
13. Dianda L, Gulbranson-Judge A, Pao W, Hayday AC, MacLennan ICM, Owen MJ: Germinal center formation in mice lacking αβ T cells. Eur J immunol 1996, 26:1603-1607
14. + T cells. Nature 1994, 369:654-658
15. Wen L, Pao W, Wong FS, Peng Q, Craft J, Zheng B, Kelso G, Dianda L, Owen MJ, Hayday AC: Germinal center formation, immunoglobulin class switching, and autoantibody production driven by "non-αα" T cells. J Exp Med 1996, 183:2271-2282
16. Mizoguchi A, Mizoguchi E, Chiba C, Spiekermann GM, Tonegawa S, Nagler-Anderson C, Bhan AK: Cytokine imbalance and autoantibody production in T cell receptor-α mutant mice with inflammatory bowel disease. J Exp Med 1996, 183:847
17. + T cells induce or protect from chronic intestinal inflammation in CB-17 SCID mice, Int Immunol 1993, 5:1461-1471
18. + T cells. Immunity 1994, 1:553-562
19. + T cells in the pathogenesis of murine inflammatory bowel disease. Eur J Immunol 1994, 24:2803-2812
20. + T cell population in severe-combined immunodeficient mice expressing a rearranged, transgenic class I-restricted αβ T cell receptor. Eur J Immunol 1995, 25:1643-1653
21. + T cells are responsible for murine interleukin-2-deficient colitis. Eur J Immunol 1995, 25:2618-2625
22. Pao W, Wen L, Smith AL, Gulbranson-Judge A, Zheng B, Kelsoe G, MacLennan ICM, Owen MJ, Hayday AC: γδ T cell help of B cells is induced by repeated para- sitic infection, in the absence of other T cells. Curr Biol 1996, 6:1317-1325
23. Duchmann R, Kaiser I, Hermann E, Mayet W, Ewe K, Meyer zum Buschenfelde K-H: Tolerance exists towards resident intestinal flora but is broken in active inflammatory bowel disease. Clin Exp Immunol 1995, 102:448-452