메뉴 건너뛰기




Volumn 14, Issue 4, 1999, Pages 327-339

The development of telomerase inhibitors: The G-quartet approach

Author keywords

G guartet; G4 DNA; Quadruplex; Telomerase inhibitors; Telomere

Indexed keywords

GUANINE; POLYNUCLEOTIDE; TELOMERASE; TRANSFERASE INHIBITOR;

EID: 0032718247     PISSN: 02669536     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (97)

References (106)
  • 1
    • 0027123418 scopus 로고
    • NMR study of parallel-stranded tetraplex formation by the hexadeoxynucleotide d(Tg4T)
    • Aboul-ela F., Murchie A.I.H., Lilley D.M.J. (1992) NMR study of parallel-stranded tetraplex formation by the hexadeoxynucleotide d(Tg4T). Nature, 360, 280.
    • (1992) Nature , vol.360 , pp. 280
    • Aboul-ela, F.1    Murchie, A.I.H.2    Lilley, D.M.J.3
  • 7
    • 0031866861 scopus 로고    scopus 로고
    • Identification of a series of potent telomerase inhibitors using a time-resolved fluorescence based assay
    • Bare L.A., Trinh L., Wu S., Devlin J.J. (1998) Identification of a series of potent telomerase inhibitors using a time-resolved fluorescence based assay. Drug Development Research, 43, 109.
    • (1998) Drug Development Research , vol.43 , pp. 109
    • Bare, L.A.1    Trinh, L.2    Wu, S.3    Devlin, J.J.4
  • 13
    • 84984775429 scopus 로고    scopus 로고
    • Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2
    • Broccoli D., Smogorzewska A., Chong L., deLange T. (1997) Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2. Nature Genetics, 17, 231.
    • (1997) Nature Genetics , vol.17 , pp. 231
    • Broccoli, D.1    Smogorzewska, A.2    Chong, L.3    DeLange, T.4
  • 14
    • 0030993152 scopus 로고    scopus 로고
    • Inhibition of telomerase activity by cisplatin in human testicular cancer cells
    • Burger A.M., Double J.A., Newell D.R. (1997) Inhibition of telomerase activity by cisplatin in human testicular cancer cells. European Journal of Cancer, 33, 638.
    • (1997) European Journal of Cancer , vol.33 , pp. 638
    • Burger, A.M.1    Double, J.A.2    Newell, D.R.3
  • 16
    • 0033553516 scopus 로고    scopus 로고
    • p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis
    • Chin L., Artandi S.E., Shen Q., Tam A., Lee S.L., Gottlieb G.J., Greider C.W, DePinho R.A. (1999) p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis. Cell, 97, 527.
    • (1999) Cell , vol.97 , pp. 527
    • Chin, L.1    Artandi, S.E.2    Shen, Q.3    Tam, A.4    Lee, S.L.5    Gottlieb, G.J.6    Greider, C.W.7    DePinho, R.A.8
  • 20
    • 0027278767 scopus 로고
    • A tetrameric structure with protonated cytosine.Cytosine base pairs
    • Gehring K., Leroy J.L., Guéron M. (1993) A tetrameric structure with protonated cytosine.cytosine base pairs. Nature, 363, 561.
    • (1993) Nature , vol.363 , pp. 561
    • Gehring, K.1    Leroy, J.L.2    Guéron, M.3
  • 23
    • 0022402513 scopus 로고
    • Identification of a specific telomere terminal transferase activity in Tetrahymena extracts
    • Greider C.W., Blackburn E.H. (1985) Identification of a specific telomere terminal transferase activity in Tetrahymena extracts. Cell, 43, 405.
    • (1985) Cell , vol.43 , pp. 405
    • Greider, C.W.1    Blackburn, E.H.2
  • 25
    • 0026608237 scopus 로고
    • Interaction of the dye ethidium bromide with DNA containing guanine repeats
    • Guo Q., Lu M., Marky L.A., Kallenbach N.R. (1992) Interaction of the dye ethidium bromide with DNA containing guanine repeats. Biochemistry, 31, 2451.
    • (1992) Biochemistry , vol.31 , pp. 2451
    • Guo, Q.1    Lu, M.2    Marky, L.A.3    Kallenbach, N.R.4
  • 26
    • 0033594341 scopus 로고    scopus 로고
    • Interactions of TMPyP4 and TMPyP2 with quadruplex DNA. Structural basis for the differential effects on telomerase inhibition
    • Han F.X.G., Wheelhouse R.T., Hurley L.H. (1999a) Interactions of TMPyP4 and TMPyP2 with quadruplex DNA. Structural basis for the differential effects on telomerase inhibition. Journal of the American Chemical Society, 121, 3561.
    • (1999) Journal of the American Chemical Society , vol.121 , pp. 3561
    • Han, F.X.G.1    Wheelhouse, R.T.2    Hurley, L.H.3
  • 27
    • 0039129145 scopus 로고    scopus 로고
    • Accelerated assembly of G-quadruplex structures by a small molecule
    • Han H.Y., Cliff C.L., Hurley L.H. (1999b) Accelerated assembly of G-quadruplex structures by a small molecule. Biochemistry, 38, 6981.
    • (1999) Biochemistry , vol.38 , pp. 6981
    • Han, H.Y.1    Cliff, C.L.2    Hurley, L.H.3
  • 28
    • 0033556134 scopus 로고    scopus 로고
    • A DNA polymerase stop assay for G-quadruplex-interactive compounds
    • Han H.Y., Hurley L.H., Salazar M. (1999c) A DNA polymerase stop assay for G-quadruplex-interactive compounds. Nucleic Acids Research, 27, 537.
    • (1999) Nucleic Acids Research , vol.27 , pp. 537
    • Han, H.Y.1    Hurley, L.H.2    Salazar, M.3
  • 29
    • 0029821295 scopus 로고    scopus 로고
    • Molecular anchoring of duplex and triplex DNA by disubstituted anthracene-9,10-diones: Calorimetric, UV melting, and competition dialysis studies
    • Haq I., Ladbury J.E., Chowdhry B.Z., Jenkins T.C. (1996) Molecular anchoring of duplex and triplex DNA by disubstituted anthracene-9,10-diones: calorimetric, UV melting, and competition dialysis studies. Journal of the American Chemical Society, 118, 10693.
    • (1996) Journal of the American Chemical Society , vol.118 , pp. 10693
    • Haq, I.1    Ladbury, J.E.2    Chowdhry, B.Z.3    Jenkins, T.C.4
  • 31
    • 0025896273 scopus 로고
    • Monovalent cation induced structural transitions in telo-meric DNAs: G-DNA folding intermediates
    • Hardin C.C., Henderson E., Watson T., Prosser J.K. (1991) Monovalent cation induced structural transitions in telo-meric DNAs: G-DNA folding intermediates. Biochemistry, 30, 4460.
    • (1991) Biochemistry , vol.30 , pp. 4460
    • Hardin, C.C.1    Henderson, E.2    Watson, T.3    Prosser, J.K.4
  • 33
    • 0023663911 scopus 로고
    • Telomeric DNA oligonucleotides form novel intramolecular structures containing guanine-guanine base pairs
    • Henderson E., Hardin C.C., Walk S.K., Tinoco I. Jr, Blackburn E.H. (1987) Telomeric DNA oligonucleotides form novel intramolecular structures containing guanine-guanine base pairs. Cell, 51, 899.
    • (1987) Cell , vol.51 , pp. 899
    • Henderson, E.1    Hardin, C.C.2    Walk, S.K.3    Tinoco I., Jr.4    Blackburn, E.H.5
  • 34
    • 0033153424 scopus 로고    scopus 로고
    • Disease states associated with telomerase deficiency appear earlier in mice with short telomeres
    • Herrera E., Samper E., Martin-Caballero J., Flores J.M., Lee H.W., Blasco M.A. (1999) Disease states associated with telomerase deficiency appear earlier in mice with short telomeres. EMBO Journal, 18, 2950.
    • (1999) EMBO Journal , vol.18 , pp. 2950
    • Herrera, E.1    Samper, E.2    Martin-Caballero, J.3    Flores, J.M.4    Lee, H.W.5    Blasco, M.A.6
  • 38
    • 0026657684 scopus 로고
    • Thermodynamics and structure of a DNA tetraplex - A spectroscopic and calorimetric study of the tetramolecular complexes of d(TG3T) and d(TG3T2G3T)
    • Jin R.Z., Gaffney B.L., Wang C., Jones R.A., Breslauer K.J. (1992) Thermodynamics and structure of a DNA tetraplex - a spectroscopic and calorimetric study of the tetramolecular complexes of d(TG3T) and d(TG3T2G3T). Proceedings of the National Academy of Sciences, USA, 89, 8832.
    • (1992) Proceedings of the National Academy of Sciences, USA , vol.89 , pp. 8832
    • Jin, R.Z.1    Gaffney, B.L.2    Wang, C.3    Jones, R.A.4    Breslauer, K.J.5
  • 39
    • 0026591751 scopus 로고
    • Crystal structure of four-stranded oxytricha telomeric DNA
    • Kang C.H., Zhang X., Ratliff R., Moyzis R., Rich A. (1992) Crystal structure of four-stranded Oxytricha telomeric DNA. Nature, 356, 126.
    • (1992) Nature , vol.356 , pp. 126
    • Kang, C.H.1    Zhang, X.2    Ratliff, R.3    Moyzis, R.4    Rich, A.5
  • 40
    • 0033605145 scopus 로고    scopus 로고
    • p53-And ATM-dependent apoptosis induced by telomeres lacking TRF2
    • Karlseder J., Broccoli D., Dai Y.M., Hardy S., deLange T. (1999) p53-And ATM-dependent apoptosis induced by telomeres lacking TRF2. Science, 283, 1321.
    • (1999) Science , vol.283 , pp. 1321
    • Karlseder, J.1    Broccoli, D.2    Dai, Y.M.3    Hardy, S.4    DeLange, T.5
  • 45
    • 0032566005 scopus 로고    scopus 로고
    • Targeted therapy of human malignant glioma in a mouse model by 2-5A antisense directed against telomerase RNA
    • Kondo S., Kondo Y., Li G., Silverman R.H., Cowell J.K. (1998a) Targeted therapy of human malignant glioma in a mouse model by 2-5A antisense directed against telomerase RNA. Oncogene, 16, 3323.
    • (1998) Oncogene , vol.16 , pp. 3323
    • Kondo, S.1    Kondo, Y.2    Li, G.3    Silverman, R.H.4    Cowell, J.K.5
  • 47
    • 0031590739 scopus 로고    scopus 로고
    • Inhibition of telomerase activity by PKC inhibitors in human nasopharyngeal cancer cells in culture
    • Ku W.C., Cheng A.J., Wang T.C.V. (1997) Inhibition of telomerase activity by PKC inhibitors in human nasopharyngeal cancer cells in culture. Biochemistry and Biophysics Research Communications, 241, 730.
    • (1997) Biochemistry and Biophysics Research Communications , vol.241 , pp. 730
    • Ku, W.C.1    Cheng, A.J.2    Wang, T.C.V.3
  • 48
    • 0031800617 scopus 로고    scopus 로고
    • Telomere elongation by hnRNP A1 and a derivative that interacts with telomeric repeats and telomerase
    • La Branche H., Dupuis S., Ben-David Y., Bani M.R., Wellinger R.J., Chabot B. (1998) Telomere elongation by hnRNP A1 and a derivative that interacts with telomeric repeats and telomerase. Nature Genetics, 19, 199.
    • (1998) Nature Genetics , vol.19 , pp. 199
    • La Branche, H.1    Dupuis, S.2    Ben-David, Y.3    Bani, M.R.4    Wellinger, R.J.5    Chabot, B.6
  • 51
    • 0030755955 scopus 로고    scopus 로고
    • Protein phosphatase 2A inhibits nuclear telomerase activity in human breast cancer cells
    • Li H., Zhao L.L., Funder J.W., Liu J.P. (1997) Protein phosphatase 2A inhibits nuclear telomerase activity in human breast cancer cells. Journal of Biological Chemistry, 272, 16729.
    • (1997) Journal of Biological Chemistry , vol.272 , pp. 16729
    • Li, H.1    Zhao, L.L.2    Funder, J.W.3    Liu, J.P.4
  • 53
    • 0026563442 scopus 로고
    • Structure and stability of sodium and potassium complexes of dT4G4 and dT4G4T
    • Lu M., Guo Q., Kallenbach N.R. (1992) Structure and stability of sodium and potassium complexes of dT4G4 and dT4G4T. Biochemistry, 31, 2455.
    • (1992) Biochemistry , vol.31 , pp. 2455
    • Lu, M.1    Guo, Q.2    Kallenbach, N.R.3
  • 54
    • 0027523698 scopus 로고
    • Thermodynamics of G-tetraplex formation by telomeric DNAs
    • Lu M., Guo Q., Kallenbach N.R. (1993) Thermodynamics of G-tetraplex formation by telomeric DNAs. Biochemistry, 32, 598.
    • (1993) Biochemistry , vol.32 , pp. 598
    • Lu, M.1    Guo, Q.2    Kallenbach, N.R.3
  • 55
    • 0031000884 scopus 로고    scopus 로고
    • Long G tails at both ends of human chromosomes suggest a C strand degradation mechanism for telomere shortening
    • Makarov V.L., Hirose Y., Langmore J.P. (1997) Long G tails at both ends of human chromosomes suggest a C strand degradation mechanism for telomere shortening. Cell, 88, 657.
    • (1997) Cell , vol.88 , pp. 657
    • Makarov, V.L.1    Hirose, Y.2    Langmore, J.P.3
  • 57
    • 0033557230 scopus 로고    scopus 로고
    • Telomerase protein rather than its RNA is the target of phosphorothioate-modified oligonucleotides
    • Matthes E., Lehmann C. (1999) Telomerase protein rather than its RNA is the target of phosphorothioate-modified oligonucleotides. Nucleic Acids Research, 27, 1152.
    • (1999) Nucleic Acids Research , vol.27 , pp. 1152
    • Matthes, E.1    Lehmann, C.2
  • 59
    • 0032508468 scopus 로고    scopus 로고
    • Following G-quartet formation by UV-spectroscopy
    • Mergny J.L., Phan A.T., Lacroix L. (1998) Following G-quartet formation by UV-spectroscopy. FEBS Letters, 435, 74.
    • (1998) FEBS Letters , vol.435 , pp. 74
    • Mergny, J.L.1    Phan, A.T.2    Lacroix, L.3
  • 61
    • 0029148328 scopus 로고
    • Structure and dynamics of intèrstrand guanine association in quadruplex telomeric DNA
    • Miura T., Thomas G.J. (1995) Structure and dynamics of intèrstrand guanine association in quadruplex telomeric DNA. Biochemistry, 34, 9645.
    • (1995) Biochemistry , vol.34 , pp. 9645
    • Miura, T.1    Thomas, G.J.2
  • 64
    • 0030898989 scopus 로고    scopus 로고
    • TLP1: A gene encoding a protein component of mammalian telomerase is a novel member of WD repeats family
    • Nakayama J., Saito M., Nakamura H., Matsuura A., Ishikawa F. (1997) TLP1: a gene encoding a protein component of mammalian telomerase is a novel member of WD repeats family. Cell, 88, 875.
    • (1997) Cell , vol.88 , pp. 875
    • Nakayama, J.1    Saito, M.2    Nakamura, H.3    Matsuura, A.4    Ishikawa, F.5
  • 68
    • 0015844590 scopus 로고
    • A theory of marginotomy. The incomplete copying of template margin in enzymic synthesis of polynucleotides and biological significance of the phenomenon
    • Olovnikov A.M. (1973) A theory of marginotomy. The incomplete copying of template margin in enzymic synthesis of polynucleotides and biological significance of the phenomenon. Journal of Theoretical Biology, 41, 181.
    • (1973) Journal of Theoretical Biology , vol.41 , pp. 181
    • Olovnikov, A.M.1
  • 69
    • 0032080678 scopus 로고    scopus 로고
    • Telomerase from human leukemic cells: Properties and its interaction with deoxynucleotide analogs
    • Pai R.B., Pai B., Kukhanova M. (1998) Telomerase from human leukemic cells: properties and its interaction with deoxynucleotide analogs. Cancer Research, 58, 1909.
    • (1998) Cancer Research , vol.58 , pp. 1909
    • Pai, R.B.1    Pai, B.2    Kukhanova, M.3
  • 73
    • 0000217902 scopus 로고    scopus 로고
    • The telomerase challenge - An unusual problem in drug discovery
    • Pitts A.E., Corey D.R. (1999) The telomerase challenge - an unusual problem in drug discovery. Drug Discovery Today, 4, 155.
    • (1999) Drug Discovery Today , vol.4 , pp. 155
    • Pitts, A.E.1    Corey, D.R.2
  • 78
    • 0023788886 scopus 로고
    • Formation of parallel four-stranded complexes by guanine-rich motifs in DNA and its applications for meiosis
    • Sen D., Gilbert W. (1988) Formation of parallel four-stranded complexes by guanine-rich motifs in DNA and its applications for meiosis. Nature, 334, 364.
    • (1988) Nature , vol.334 , pp. 364
    • Sen, D.1    Gilbert, W.2
  • 79
    • 0031605324 scopus 로고    scopus 로고
    • Stability and structure of model DNA triplexes and quadruplexes and their interactions with small ligands
    • Moldave, K. (ed.), Academic Press: San Diego, CA
    • Shafer R/H. (1998) Stability and structure of model DNA triplexes and quadruplexes and their interactions with small ligands. In Progress in Nucleic Acid Research. Moldave, K. (ed.), Vol. 59, p. 55. Academic Press: San Diego, CA.
    • (1998) Progress in Nucleic Acid Research , vol.59 , pp. 55
    • Shafer, R.H.1
  • 81
    • 0029395466 scopus 로고
    • Aging and cancer: Are telomeres and telomerase the connection?
    • Shay J.W. (1995) Aging and cancer: are telomeres and telomerase the connection? Molecular Medicine Today, 1, 378.
    • (1995) Molecular Medicine Today , vol.1 , pp. 378
    • Shay, J.W.1
  • 82
    • 0026554887 scopus 로고
    • Quadruplex structure of Oxytricha telomeric DNA oligonucleotides
    • Smith F.W., Feigon J. (1992) Quadruplex structure of Oxytricha telomeric DNA oligonucleotides. Nature, 356, 164.
    • (1992) Nature , vol.356 , pp. 164
    • Smith, F.W.1    Feigon, J.2
  • 83
    • 0031040086 scopus 로고    scopus 로고
    • TRF1, a mammalian telomeric protein
    • Smith S., deLange T. (1997) TRF1, a mammalian telomeric protein. Trends in Genetics 13, 21.
    • (1997) Trends in Genetics , vol.13 , pp. 21
    • Smith, S.1    DeLange, T.2
  • 84
    • 0040164390 scopus 로고    scopus 로고
    • Nanoseconds molecular dynamics simulations of parallel and anti-parallel guanine quadruplex DNA molecules
    • Spackova N., Berger I., Sponer J. (1999) Nanoseconds molecular dynamics simulations of parallel and anti-parallel guanine quadruplex DNA molecules. Journal of the American Chemical Society, 121, 5519.
    • (1999) Journal of the American Chemical Society , vol.121 , pp. 5519
    • Spackova, N.1    Berger, I.2    Sponer, J.3
  • 88
    • 0033135161 scopus 로고    scopus 로고
    • The saccharomyces cerevisiae Sgs1 helicase efficiently unwinds G-G paired DNAs
    • Sun H., Bennett R.J., Maizels N. (1999b) The Saccharomyces cerevisiae Sgs1 helicase efficiently unwinds G-G paired DNAs. Nucleic Acids Research, 21, 1978.
    • (1999) Nucleic Acids Research , vol.21 , pp. 1978
    • Sun, H.1    Bennett, R.J.2    Maizels, N.3
  • 89
    • 0024843757 scopus 로고
    • Telomeric DNA dimerizes by formation of guanine tetrads between hairpin loops
    • Sundquist W.I., Klug A. (1989) Telomeric DNA dimerizes by formation of guanine tetrads between hairpin loops. Nature, 342, 825.
    • (1989) Nature , vol.342 , pp. 825
    • Sundquist, W.I.1    Klug, A.2
  • 90
    • 0010359476 scopus 로고    scopus 로고
    • Inhibition of telomerase activity by antisense oligonucleotides in HeLa cells
    • Tao M., Wada A., Takai K., Takaku H. (1998) Inhibition of telomerase activity by antisense oligonucleotides in HeLa cells. Nucleic Acids Symposium Series, 39, 85.
    • (1998) Nucleic Acids Symposium Series , vol.39 , pp. 85
    • Tao, M.1    Wada, A.2    Takai, K.3    Takaku, H.4
  • 91
    • 0031027618 scopus 로고    scopus 로고
    • Control of telomere length by the human telomeric protein TRF1
    • van Steensel B., de Lange T. (1997) Control of telomere length by the human telomeric protein TRF1. Nature, 385, 740.
    • (1997) Nature , vol.385 , pp. 740
    • Van Steensel, B.1    De Lange, T.2
  • 92
    • 0032489012 scopus 로고    scopus 로고
    • TRF2 protects human telomeres from end-to-end fusions
    • van Steensel B., Smogorzewska A., de Lange T. (1998) TRF2 protects human telomeres from end-to-end fusions. Cell, 92, 401.
    • (1998) Cell , vol.92 , pp. 401
    • Van Steensel, B.1    Smogorzewska, A.2    De Lange, T.3
  • 94
    • 0026687030 scopus 로고
    • Guanine residues in d(T2AG3) and d(T2G4) form parallel-stranded potassium cation stabilized G-quadruplexes with antiglycosidic torsion angles in solution
    • Wang Y., Patel D.J. (1992) Guanine residues in d(T2AG3) and d(T2G4) form parallel-stranded potassium cation stabilized G-quadruplexes with antiglycosidic torsion angles in solution. Biochemistry, 31, 8112.
    • (1992) Biochemistry , vol.31 , pp. 8112
    • Wang, Y.1    Patel, D.J.2
  • 95
    • 0027918585 scopus 로고
    • Solution structure of the human telomeric repeat d[AG3(T2AG3)3] G-tetraplex
    • Wang Y., Patel D.J. (1993) Solution structure of the human telomeric repeat d[AG3(T2AG3))3] G-tetraplex. Structure, 1, 263.
    • (1993) Structure , vol.1 , pp. 263
    • Wang, Y.1    Patel, D.J.2
  • 96
    • 0029081052 scopus 로고
    • Solution structure of the oxytricha telomeric repeat d[G(4) (T(4)G(4)) (3)] G-tetraplex
    • Wang Y., Patel D.J. (1995) Solution structure of the Oxytricha telomeric repeat d[G(4) (T(4)G(4)) (3)] G-tetraplex. Journal of Molecular Biology, 251, 76.
    • (1995) Journal of Molecular Biology , vol.251 , pp. 76
    • Wang, Y.1    Patel, D.J.2
  • 98
    • 0032495774 scopus 로고    scopus 로고
    • Cationic porphyrins as telomerase inhibitors: The interaction of tetra (Af-methyl-4-pyridyl) porphyrin with quadruplex DNA
    • Wheelhouse R.T., Sun D., Han H., Han E.X., Hurley L.H. (1998) Cationic porphyrins as telomerase inhibitors: the interaction of tetra (Af-methyl-4-pyridyl) porphyrin with quadruplex DNA. Journal of the American Chemical Society, 120, 3261.
    • (1998) Journal of the American Chemical Society , vol.120 , pp. 3261
    • Wheelhouse, R.T.1    Sun, D.2    Han, H.3    Han, E.X.4    Hurley, L.H.5
  • 99
    • 0024787884 scopus 로고
    • Monovalent cation induced structure of telomeric DNA: The G-quartet model
    • Williamson J.R., Raghuraman M.K., Cech T.R. (1989) Monovalent cation induced structure of telomeric DNA: the G-quartet model. Cell, 59, 871.
    • (1989) Cell , vol.59 , pp. 871
    • Williamson, J.R.1    Raghuraman, M.K.2    Cech, T.R.3
  • 100
    • 0033049185 scopus 로고    scopus 로고
    • Both transcriptional and posttranscriptional mechanisms regulate human telomerase template RNA levels
    • Yi X.M., Tesmer V.M., SavreTrain I., Shay J.W., Wright W.E. (1999) Both transcriptional and posttranscriptional mechanisms regulate human telomerase template RNA levels. Molecular and Cellular Biology, 19, 3989.
    • (1999) Molecular and Cellular Biology , vol.19 , pp. 3989
    • Yi, X.M.1    Tesmer, V.M.2    SavreTrain, I.3    Shay, J.W.4    Wright, W.E.5
  • 101
    • 0032403264 scopus 로고    scopus 로고
    • Attenuation of telomerase activity by a hammerhead ribozyme targeting the template region of telomerase RNA in endometrial carcinoma cells
    • Yokoyama Y., Takahashi Y., Shinohara A., Lian Z.L., Wan X.Y., Niwa K., Tamaya T. (1998) Attenuation of telomerase activity by a hammerhead ribozyme targeting the template region of telomerase RNA in endometrial carcinoma cells. Cancer Research, 58, 5406.
    • (1998) Cancer Research , vol.58 , pp. 5406
    • Yokoyama, Y.1    Takahashi, Y.2    Shinohara, A.3    Lian, Z.L.4    Wan, X.Y.5    Niwa, K.6    Tamaya, T.7
  • 105
    • 0029563009 scopus 로고
    • Telomeres: Beginning to understand the end
    • Zakian V.A. (1995) Telomeres: beginning to understand the end. Science, 270, 1601.
    • (1995) Science , vol.270 , pp. 1601
    • Zakian, V.A.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.