Interactions of TMPyP4 and TMPyP2 with quadruplex DNA. Structural basis for the differential effects on telomerase inhibition

Journal of the American Chemical Society

Volumn 121, Issue 15, 1999, Pages 3561-3570

  Han, Frank Xiaoguang ^a   Wheelhouse, Richard T ^a   Hurley, Laurence H ^a  

^a UNIVERSITY OF TEXAS AT AUSTIN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5,10,15,20 TETRA (N METHYL 4 PYRIDYL)PORPHINE; OLIGONUCLEOTIDE; PORPHYRIN; TELOMERASE; UNCLASSIFIED DRUG;

ARTICLE; DNA BINDING; DNA FOOTPRINTING; DNA STRUCTURE; ENZYME REGULATION; PROTEIN DNA INTERACTION; REGULATORY MECHANISM; SEQUENCE ANALYSIS;

EID: 0033594341     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja984153m     Document Type: Article

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27. 4 CCAC], used in this study contains an artificial double-stranded stem (bold). This stem sequence is not present in the human telomeric sequence, and therefore the double stranded stem is presumably missing in the human telomeric structure. The addition of the double-stranded stem has been useful in defining a high affinity binding site for TMPyP2. It is doubtful, however, that this alternative site has any biological relevance.
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