The telomerase challenge - An unusual problem in drug discovery

Drug Discovery Today

Volumn 4, Issue 4, 1999, Pages 155-161

  Pitts, Anne E ^a   Corey, David R ^a  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0000217902     PISSN: 13596446     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1359-6446(99)01322-7     Document Type: Review

References (90)

1. Moyzis, R.K. et al. (1988) Proc. Natl. Acad. Sci. U.S.A. 85, 6622-6626
2. Watson, J.D. (1972) Nat. New Biol. 239, 197-201
3. Olovnikov, A.M. (1973) J, Theor. Biol. 41, 181-190
4. Lingner, J., Cooper, J.P. and Cech, T.R. (1995) Science 269, 1533-1534
5. Harley, C.B., Futcher, A.B. and Greider, C.W. (1990) Nature 345, 458-460
6. Hastie, N.D. et al. (1990) Nature 346, 866-868
7. Fossel, M. (1998) J. Am. Med. Assoc. 279, 1732-1735
8. Rubin, H. (1998) Nat. Biotechnol. 16, 396-397
9. Faragher, R.G., Jones, C.J. and Kipling, D. (1998) Nat. Biotechnol. 16, 701-702
10. Greider, C.W. and Blackburn, E.H. (1985) Cell 43, 405-413
11. Morin, G.B. (1989) Cell 59, 521-529
12. Feng, J. et al. (1995) Science 269, 1236-1241
13. Nakamura, TM. et al. (1997) Science 277, 955-959
14. Meyerson, M. et al. (1997) Cell 90, 785-795
15. Harrington, L. et al. (1997) Genes Dev. 11, 3109-3115
16. Autexier, C. et al. (1996) EMBO J. 15, 5928-5935
17. Nakamura, T.M. and Cech, T.R. (1998) Cell 92, 587-590
18. Lundblad, V. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 8415-8416
19. Bryan, TM. et al. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 8479-8484
20. Nakayama, J. et al. (1998) Nat. Genet. 18, 65-68
21. Weinrich, S.L. et al. (1997) Nat. Genet. 17, 498-502
22. Beattie, T.L et al. (1998) Curr. Biol. 8, 177-180
23. Kim, N.W. et al. (1994) Science 266, 2011-2015
24. Counter, C.M. et al. (1994) Proc. Natl. Acad. Sci. U. S. A. 91, 2900-2904
25. Shay, J.W. and Bachetti, S. (1997) Eur. J. Cancer 33, 787-791
26. Holt, S.E., Shay, J.W. and Wright, W.E. (1996) Nat. Biotechnol. 14, 836-839
27. Kim, N.W. (1997) Eur. J. Cancer 33, 781-786
28. Hamalton, S.E. and Corey, D.R. (1996) Chem. Biol. 3, 863-867
29. Greider, C.W. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 90-92
30. Shay, J.W. (1998) Cancer J. Sci. Am. 4, S26-S34
31. Hiyama, E. et al. (1995) Nat. Med. 1, 249-255
32. Langford, L.A. et al. (1997) Hum. Pathol. 28, 416-420
33. Abanell, J. et al. (1997) J. Natl. Cancer Inst. 89, 1609-1615
34. Tahara, H. et al. (1995) Clin. Cancer Res. 1, 1245-1251
35. Ohyasniki, J.H. et al. (1997) Clin. Cancer Res. 3, 619-625
36. Hoos, A. et al. (1998) Int. J. Cancer 19, 8-12
37. Bodnar, A.G. et al. (1998) Science 279, 349-352
38. Vaziri, H. and Benchimol, S. (1998) Curr. Biol. 8, 279-282
39. Blasco, M. A. et al. (1997) Cell 91, 25-34
40. Lee, H-W. et al. (1998) Nature 392, 569-574
41. Wynford-Thomas, S. and Kipling, D. (1997) Nature 389, 551-552
42. Kipling, D. (1997) Hum. Mol. Genet. 6, 1999-2004
43. Yu, G.L. et al. (1990) Nature 344, 126-132
44. McEachern, M.J. and Blackburn, E.H. (1995) Science 376, 403-409
45. Singer, M.S. and Gottschling, D.E. (1994) Science 266, 404-409
46. Marusic, L. (1997) Mol. Cell. Biol. 17, 6394-6401
47. Broccoli, D., Young, J.W. and de Lange, T. (1995) Proc. Natl. Acad. Sci. U. S. A. 92, 9082-9086
48. Bryan, T.M. et al. (1995) EMBO J. 14, 4240-4248
49. Bryan, T.M. et al. (1997) Nat. Med. 3, 1271-1274
50. Bryan, T.M. et al. (1997) Hum. Mol. Genet. 6, 921-926
51. Nakamura, T.M., Cooper, J.P. and Cech, T.R. (1998) Science 282, 493-496
52. Lunblad, V. and Blackburn, E.H. (1993) Cell 73, 347-360
53. Sharma, S. et al. (1998) Leuk. Res. 22, 663-670
54. Ku, W-C., Cheng, A-J. and Wang, T-C.V. (1997) Biochem. Biophys. Res. Commun. 241, 730-776
55. Fujimoto, K. and Takahashi, M. (1997) Biochem. Biophys. Res. Commun. 241, 775-781
56. Strahl, C. and Blackburn, E.H. (1996) Mol. Cell. Biol. 16, 53-65
57. Gomez, D.E., Tejera, A.M. and Olivero, O.A. (1998) Biochem. Biophys. Res. Commun. 246, 107-110
58. Fletcher, T.M., Salazar, M. and Chen, S-F. (1996) Biochemistry 35, 15611-15617
59. Pai, R.B. et al. (1998) Cancer Res. 58, 1909-1913
60. Yegorov, YE. et al. (1996) FEBS Lett. 389, 115-118
61. Karamohamed, S. et al. (1998) Bio Techniques 24, 302-306
62. Lackey, D.B. (1998) Anal. Biochem. 263, 57-61
63. Henderson, E.R., Moore, M. and Malcolm, B.A. (1990) Biochemistry 29, 732-737
64. Sun, D. et al. (1997) J. Med. Chem. 40, 2113-2116
65. Wheelhouse, R.T. et al. (1998) J. Am. Chem. Soc. 120, 3261-3262
66. Hamilton, S.E. et al. (1997) Biochemistry 36, 11873-11880
67. Simmons, C.G. et al. (1997) Bioorg. Med. Chem. Lett. 7, 3001-3007
68. Basu, S. and Wickstrom, E. (199) Bioconjugate Chem. 8, 481-488
69. Pooga, M. et al. (1998) Nat. Biotechnol. 16, 857-861
70. Akhtar, S. and Agrawal, S. (1997) Trends Pharmacol. Sci. 18, 12-18
71. Norton, J.C. et al. (1996) Nat. Biotechnol. 14, 615-619
72. Pitts, A.E. and Corey, D.R. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 11549-11554
73. Mata, J.E. et al. (1997) Toxicol. Appl. Pharmacol. 144, 189-197
74. Kondo, S. et al. (1998) Oncogene 16, 3323-3330
75. Le Blancq, S.M. et al. (1998) Nucleic Acids Res. 19, 5790
76. Blackburn, E.H. and Challoner, P.B. (1984) Cell 36, 447-457
77. McEachern, M.J. and Blackburn, E.H. (1994) Proc. Natl. Acad. Sci. U. S. A. 91, 3453-3457
78. Bottius, E. et al. (1998) Mol. Cell. Biol. 18, 919-925
79. Kondo, Y. et al. (1998) Oncogene 16, 2243-2248
80. Ohnuma, T. et al. (1997) Anticancer Res. 17, 2455-2458
81. Bisoffi, M. et al. (1998) Eur.J. Cancer 34, 1242-1249
82. Glukhov, A.I. et al. (1998) Biochem. Biophys. Res. Commun. 248, 368-371
83. Fedoroff, O.Y. et al. (1998) Biochemistry 37, 12367-12374
84. Fletcher, T.M. et al. (1998) Biochemistry 37, 5536-5541
85. Burger, A.M., Double, J.A. and Newell, D.R. (1997) Eur.J. Cancer 33, 638-644
86. Kanazawa, Y. et al. (1996) Biochem. Biophys. Res. Commun. 225, 570-576
87. Wan, M.S.K., Fell, P.L. and Akhtar, S. (1998) Antisense Nucleic Acid Drug Dev. 8, 309-317
88. Sharma, H.W., Hsiao, R. and Narayanan, R. (1996) Antisense Nucleic Acid Drug Dev. 6, 3-7
89. Kondo, S. et al. (1998) FASEB J. 12, 801-811
90. Naasani, I. (1998) Biochem. Biophys. Res. Commun. 249, 391-396