-
1
-
-
0029956081
-
Specific p53 mutations are associated with de novo resistance to doxorubicin in breast cancer patients
-
Aas T, Børresen A-L, Geisler S, Smith-Sørensen B, Johnsen H, Varhaug JE, Akslen LA, Lønning PE (1996) Specific p53 mutations are associated with de novo resistance to doxorubicin in breast cancer patients. Nat Med 2: 811
-
(1996)
Nat Med
, vol.2
, pp. 811
-
-
Aas, T.1
Børresen, A.-L.2
Geisler, S.3
Smith-Sørensen, B.4
Johnsen, H.5
Varhaug, J.E.6
Akslen, L.A.7
Lønning, P.E.8
-
2
-
-
0029124132
-
Microinjection of monoclonal antibody PAb421 into human SW480 colorectal carcinoma cells restores the transcription activation function to mutant p53
-
Abarzúa P, LoSardo JE, Gubler ML, Neri A (1995) Microinjection of monoclonal antibody PAb421 into human SW480 colorectal carcinoma cells restores the transcription activation function to mutant p53. Cancer Res 55: 3490
-
(1995)
Cancer Res
, vol.55
, pp. 3490
-
-
Abarzúa, P.1
Losardo, J.E.2
Gubler, M.L.3
Neri, A.4
-
4
-
-
0030011897
-
New insights into p53 function from structural studies
-
Arrowsmith CH, Morin P (1996) New insights into p53 function from structural studies. Oncogene 12: 1379
-
(1996)
Oncogene
, vol.12
, pp. 1379
-
-
Arrowsmith, C.H.1
Morin, P.2
-
5
-
-
0030013337
-
Transcriptional activation by p53, but not induction of the p21 gene, is essential for oncogene-mediated apoptosis
-
Attardi LD, Lowe SW, Brugarolas J, Jacks T (1996) Transcriptional activation by p53, but not induction of the p21 gene, is essential for oncogene-mediated apoptosis. EMBO J 15: 3693
-
(1996)
EMBO J
, vol.15
, pp. 3693
-
-
Attardi, L.D.1
Lowe, S.W.2
Brugarolas, J.3
Jacks, T.4
-
6
-
-
0031587821
-
Recruitment of p300/CBP in p53-dependent signal pathways
-
Avantaggiata ML, Ogryzko V, Gardner K, Giordano A, Levine AS, Kelly K (1997) Recruitment of p300/CBP in p53-dependent signal pathways. Cell 89: 1175
-
(1997)
Cell
, vol.89
, pp. 1175
-
-
Avantaggiata, M.L.1
Ogryzko, V.2
Gardner, K.3
Giordano, A.4
Levine, A.S.5
Kelly, K.6
-
7
-
-
0029670589
-
p53 in signaling checkpoint arrest or apoptosis
-
Bates S, Vousden KH (1996) p53 in signaling checkpoint arrest or apoptosis. Curr Opin Genet Dev 6: 12
-
(1996)
Curr Opin Genet Dev
, vol.6
, pp. 12
-
-
Bates, S.1
Vousden, K.H.2
-
9
-
-
0030965298
-
Tolerance of high levels of wild-type p53 in transformed epithelial cells dependent on auto-regulation by Mdm-2
-
Blaydes JP, Gire V, Rowson JM, Wynford-Thomas D (1997) Tolerance of high levels of wild-type p53 in transformed epithelial cells dependent on auto-regulation by Mdm-2. Oncogene 14: 1859
-
(1997)
Oncogene
, vol.14
, pp. 1859
-
-
Blaydes, J.P.1
Gire, V.2
Rowson, J.M.3
Wynford-Thomas, D.4
-
10
-
-
0029818380
-
Identification of novel mdm2 binding peptides by phage display
-
Böttger V, Böttger A, Howard SF, Picksley SM, Chène P, Garcia-Echeverria C, Hochkeppel H-K, Lane DP (1996) Identification of novel mdm2 binding peptides by phage display. Oncogene 13: 2141
-
(1996)
Oncogene
, vol.13
, pp. 2141
-
-
Böttger, V.1
Böttger, A.2
Howard, S.F.3
Picksley, S.M.4
Chène, P.5
Garcia-Echeverria, C.6
Hochkeppel, H.-K.7
Lane, D.P.8
-
11
-
-
0029669929
-
T cells from baxα transgenic mice show accelerated apoptosis in response to stimuli but do not show restored DNA damage-induced cell death in the absence of p53
-
Brady HJM, Salomons GS, Bobeldijk RC, Berns AJM (1996) T cells from baxα transgenic mice show accelerated apoptosis in response to stimuli but do not show restored DNA damage-induced cell death in the absence of p53. EMBO J 15: 1221
-
(1996)
EMBO J
, vol.15
, pp. 1221
-
-
Brady, H.J.M.1
Salomons, G.S.2
Bobeldijk, R.C.3
Berns, A.J.M.4
-
12
-
-
0031400827
-
Nuclear accumulation of mutant p53 protein: A possible predictor of failure of intravesical therapy in bladder cancer
-
Caliskan M, Türkeri LN, Mansuroglu B, Toktas G, Aksoy B, Ünlüer E, Akdas A (1997) Nuclear accumulation of mutant p53 protein: a possible predictor of failure of intravesical therapy in bladder cancer. Br. J Urol 79: 373
-
(1997)
Br. J Urol
, vol.79
, pp. 373
-
-
Caliskan, M.1
Türkeri, L.N.2
Mansuroglu, B.3
Toktas, G.4
Aksoy, B.5
Ünlüer, E.6
Akdas, A.7
-
13
-
-
0029857892
-
DNA sequence analysis of exons 2 through 11 and immunohistochemical staining are required to detect all known p53 alterations in human malignancies
-
Casey G, Lopez ME, Ramos JC, Plummer SJ, Arboleda MJ, Shaughnessy M, Karlan B, Slamon DJ (1996) DNA sequence analysis of exons 2 through 11 and immunohistochemical staining are required to detect all known p53 alterations in human malignancies. Oncogene 13: 1971
-
(1996)
Oncogene
, vol.13
, pp. 1971
-
-
Casey, G.1
Lopez, M.E.2
Ramos, J.C.3
Plummer, S.J.4
Arboleda, M.J.5
Shaughnessy, M.6
Karlan, B.7
Slamon, D.J.8
-
15
-
-
0031404849
-
p53 as a target for anti-cancer immunotherapy
-
Chen HL, Carbone DP (1997) p53 as a target for anti-cancer immunotherapy. Mol Med Today 3: 160
-
(1997)
Mol Med Today
, vol.3
, pp. 160
-
-
Chen, H.L.1
Carbone, D.P.2
-
16
-
-
0029913730
-
1 arrest and apoptosis functions of the p53 tumor suppressor protein
-
1 arrest and apoptosis functions of the p53 tumor suppressor protein. Mol Cell Biol 16: 2445
-
(1996)
Mol Cell Biol
, vol.16
, pp. 2445
-
-
Chen, J.1
Wu, X.2
Lin, J.3
Levine, A.J.4
-
17
-
-
0029802591
-
p53 levels, functional domains, and DNA damage determine the extent of the apoptotic response of tumor cells
-
Chen X, Ko LJ, Jayaraman L, Prives C (1996) p53 levels, functional domains, and DNA damage determine the extent of the apoptotic response of tumor cells. Genes Dev 10: 2438
-
(1996)
Genes Dev
, vol.10
, pp. 2438
-
-
Chen, X.1
Ko, L.J.2
Jayaraman, L.3
Prives, C.4
-
18
-
-
0028098165
-
Molecular abnormalities of mdm2 and p53 genes in adult soft tissue sarcomas
-
Cordon-Cardo C, Latres E, Drobnjak M, Oliva MR, Pollack D, Woodruff JM, Marechal V, Chen J, Brennan MF, Levine AJ (1994) Molecular abnormalities of mdm2 and p53 genes in adult soft tissue sarcomas. Cancer Res 54: 794
-
(1994)
Cancer Res
, vol.54
, pp. 794
-
-
Cordon-Cardo, C.1
Latres, E.2
Drobnjak, M.3
Oliva, M.R.4
Pollack, D.5
Woodruff, J.M.6
Marechal, V.7
Chen, J.8
Brennan, M.F.9
Levine, A.J.10
-
19
-
-
0028913739
-
A p53-dependent mouse spindle checkpoint
-
Cross SM, Sanchez CA, Morgan CA, Schimke MK, Ramel S, Idzerda RL, Raskind WH, Reid BJ (1995) A p53-dependent mouse spindle checkpoint. Science 267: 1353
-
(1995)
Science
, vol.267
, pp. 1353
-
-
Cross, S.M.1
Sanchez, C.A.2
Morgan, C.A.3
Schimke, M.K.4
Ramel, S.5
Idzerda, R.L.6
Raskind, W.H.7
Reid, B.J.8
-
20
-
-
0028841560
-
Gas1-induced growth suppression requires a transactivation-independent p53 function
-
Del Sal G, Ruaro EM, Utrera R, Cole CN, Levine AJ, Schneider C (1995) Gas1-induced growth suppression requires a transactivation-independent p53 function. Mol Cell Biol 15: 7152
-
(1995)
Mol Cell Biol
, vol.15
, pp. 7152
-
-
Del Sal, G.1
Ruaro, E.M.2
Utrera, R.3
Cole, C.N.4
Levine, A.J.5
Schneider, C.6
-
21
-
-
0028882740
-
Failure to dephosphorylate retinoblastoma protein in drug-resistant cells
-
Dou QP, Lui VWY (1995) Failure to dephosphorylate retinoblastoma protein in drug-resistant cells. Cancer Res 55: 5222
-
(1995)
Cancer Res
, vol.55
, pp. 5222
-
-
Dou, Q.P.1
Lui, V.W.Y.2
-
22
-
-
0029043805
-
A simple p53 functional assay for screening cell lines, blood, and tumors
-
Flaman J-M, Frebourg T, Moreau V, Charbonnier F, Martin C, Chappuis P, Sappino A-P, Limacher J-M, Bron L, Benhattar J, Tada M, Van Meir EG, Estreicher A, Iggo RD (1995) A simple p53 functional assay for screening cell lines, blood, and tumors. Proc Natl Acad Sci USA 92: 3963
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, pp. 3963
-
-
Flaman, J.-M.1
Frebourg, T.2
Moreau, V.3
Charbonnier, F.4
Martin, C.5
Chappuis, P.6
Sappino, A.-P.7
Limacher, J.-M.8
Bron, L.9
Benhattar, J.10
Tada, M.11
Van Meir, E.G.12
Estreicher, A.13
Iggo, R.D.14
-
23
-
-
8244233169
-
Neoangiogenesis and p53 protein in lung cancer: Their prognostic role and their relation with vascular endothelial growth factor (VEGF) expression
-
Fontanini G, Vignati S, Lucchi M, Mussi A, Calcinai A, Boldrini L, Chiné S, Silvestri V, Angeletti CA, Basolo F, Bevilacqua G (1997) Neoangiogenesis and p53 protein in lung cancer: their prognostic role and their relation with vascular endothelial growth factor (VEGF) expression. Br J Cancer 75: 1295
-
(1997)
Br J Cancer
, vol.75
, pp. 1295
-
-
Fontanini, G.1
Vignati, S.2
Lucchi, M.3
Mussi, A.4
Calcinai, A.5
Boldrini, L.6
Chiné, S.7
Silvestri, V.8
Angeletti, C.A.9
Basolo, F.10
Bevilacqua, G.11
-
24
-
-
0029783722
-
A mutant p53 that discriminates between p53-responsive genes cannot induce apoptosis
-
Friedlander P, Haupt Y, Prives C, Oren M (1996) A mutant p53 that discriminates between p53-responsive genes cannot induce apoptosis. Mol Cell Biol 16: 4961
-
(1996)
Mol Cell Biol
, vol.16
, pp. 4961
-
-
Friedlander, P.1
Haupt, Y.2
Prives, C.3
Oren, M.4
-
25
-
-
0029935682
-
Involvement of the CD95 (APO-1/Fas) receptor/ligand system in drug-induced apoptosis in leukemia cells
-
Friesen C, Herr I, Krammer PH, Debatin K-M (1996) Involvement of the CD95 (APO-1/Fas) receptor/ligand system in drug-induced apoptosis in leukemia cells. Nat Med 2: 574
-
(1996)
Nat Med
, vol.2
, pp. 574
-
-
Friesen, C.1
Herr, I.2
Krammer, P.H.3
Debatin, K.-M.4
-
28
-
-
0029023560
-
Dissection of the genetic programs of p53-mediated G1 growth arrest and apoptosis: Blocking p53-induced apoptosis unmasks G1 arrest
-
Guillouf C, Graña X, Selvakumaran M, De Luca A, Giordano A, Hoffman B, Liebermann DA (1995) Dissection of the genetic programs of p53-mediated G1 growth arrest and apoptosis: blocking p53-induced apoptosis unmasks G1 arrest. Blood 85: 2691
-
(1995)
Blood
, vol.85
, pp. 2691
-
-
Guillouf, C.1
Graña, X.2
Selvakumaran, M.3
De Luca, A.4
Giordano, A.5
Hoffman, B.6
Liebermann, D.A.7
-
29
-
-
0030951637
-
Tumour suppressors: A developing role for p53
-
Hall PA, Lane DP (1997) Tumour suppressors: a developing role for p53. Curr Biol 7: R144
-
(1997)
Curr Biol
, vol.7
-
-
Hall, P.A.1
Lane, D.P.2
-
31
-
-
0030298504
-
Adenovirus-mediated transfer of HPV 16 E6/E7 antisense RNA to human cervical cancer cells
-
Hamada K, Sakaue M, Alemany R, Zhang W-W, Horio Y, Roth JA, Mitchell MF (1996) Adenovirus-mediated transfer of HPV 16 E6/E7 antisense RNA to human cervical cancer cells. Gynecol Oncol 63: 219
-
(1996)
Gynecol Oncol
, vol.63
, pp. 219
-
-
Hamada, K.1
Sakaue, M.2
Alemany, R.3
Zhang, W.-W.4
Horio, Y.5
Roth, J.A.6
Mitchell, M.F.7
-
32
-
-
0031051042
-
p53; from inductive signal to cellular effect
-
Hansen R, Oren M (1997) p53; from inductive signal to cellular effect. Curr Opin Genet Dev 7: 46
-
(1997)
Curr Opin Genet Dev
, vol.7
, pp. 46
-
-
Hansen, R.1
Oren, M.2
-
33
-
-
0029766527
-
The growth-inhibitory function of p53 is separable from transactivation, apoptosis and suppression of transformation by E1a and Ras
-
Hansen RS, Braithwaite AW (1996) The growth-inhibitory function of p53 is separable from transactivation, apoptosis and suppression of transformation by E1a and Ras. Oncogene 13: 995
-
(1996)
Oncogene
, vol.13
, pp. 995
-
-
Hansen, R.S.1
Braithwaite, A.W.2
-
34
-
-
0029845760
-
Structure and function of the p53 tumor suppressor gene: Clues for rational cancer therapeutic strategies
-
Harris CC (1996) Structure and function of the p53 tumor suppressor gene: clues for rational cancer therapeutic strategies. J Natl Cancer Inst 88: 1442
-
(1996)
J Natl Cancer Inst
, vol.88
, pp. 1442
-
-
Harris, C.C.1
-
35
-
-
0030254295
-
p53-mediated apoptosis: Mechanisms and regulation
-
Haupt Y, Oren M (1996) p53-mediated apoptosis: mechanisms and regulation. Behring Inst Mitt 97: 32
-
(1996)
Behring Inst Mitt
, vol.97
, pp. 32
-
-
Haupt, Y.1
Oren, M.2
-
36
-
-
0028999429
-
p53-mediated apoptosis in HeLa cells can be overcome by excess pRB
-
Haupt Y, Rowan S, Oren M (1995) p53-mediated apoptosis in HeLa cells can be overcome by excess pRB. Oncogene 10: 1563
-
(1995)
Oncogene
, vol.10
, pp. 1563
-
-
Haupt, Y.1
Rowan, S.2
Oren, M.3
-
37
-
-
0029092356
-
Induction of apoptosis in HeLa cells by trans-activation-deficient p53
-
Haupt Y, Rowan S, Shaulian E, Vousden KH, Oren M (1995) Induction of apoptosis in HeLa cells by trans-activation-deficient p53. Genes Dev 9: 2170
-
(1995)
Genes Dev
, vol.9
, pp. 2170
-
-
Haupt, Y.1
Rowan, S.2
Shaulian, E.3
Vousden, K.H.4
Oren, M.5
-
38
-
-
0029985647
-
Cell type-specific inhibition of p53-mediated apoptosis by Mdm2
-
Haupt Y, Barak Y, Oren M (1996) Cell type-specific inhibition of p53-mediated apoptosis by Mdm2. EMBO J 15: 1596
-
(1996)
EMBO J
, vol.15
, pp. 1596
-
-
Haupt, Y.1
Barak, Y.2
Oren, M.3
-
39
-
-
0030905284
-
Mdm2 promotes the rapid degradation of p53
-
Haupt Y, Maya R, Kazaz A, Oren M (1997) Mdm2 promotes the rapid degradation of p53. Nature 387: 296
-
(1997)
Nature
, vol.387
, pp. 296
-
-
Haupt, Y.1
Maya, R.2
Kazaz, A.3
Oren, M.4
-
40
-
-
0030917202
-
ONYX-015, an E1B gene-attenuated adenovirus, causes tumor-specific cytolysis and antitumoral efficacy that can be augmented by standard chemotherapeutic agents
-
Heise C, Sampson-Johannes A, Williams A, McCormick F, Von Hoff DD, Kirn DH (1997) ONYX-015, an E1B gene-attenuated adenovirus, causes tumor-specific cytolysis and antitumoral efficacy that can be augmented by standard chemotherapeutic agents. Nat Med 3: 639
-
(1997)
Nat Med
, vol.3
, pp. 639
-
-
Heise, C.1
Sampson-Johannes, A.2
Williams, A.3
McCormick, F.4
Von Hoff, D.D.5
Kirn, D.H.6
-
41
-
-
0030639352
-
p53 gene alterations in human tumors: Perspectives for cancer control
-
Hollstein M, Soussi T, Thomas G, von Brevern M-C, Bartsch H (1997) p53 gene alterations in human tumors: perspectives for cancer control. Recent Results Cancer Res 143: 369
-
(1997)
Recent Results Cancer Res
, vol.143
, pp. 369
-
-
Hollstein, M.1
Soussi, T.2
Thomas, G.3
Von Brevern, M.-C.4
Bartsch, H.5
-
42
-
-
0028845158
-
Small peptides activate the latent sequence-specific DNA binding function of p53
-
Hupp TR, Sparks A, Lane DP (1995) Small peptides activate the latent sequence-specific DNA binding function of p53. Cell 83: 237
-
(1995)
Cell
, vol.83
, pp. 237
-
-
Hupp, T.R.1
Sparks, A.2
Lane, D.P.3
-
43
-
-
0030988482
-
Insertion of the adenoviral E3 region into a recombinant viral vector prevents antiviral humoral and cellular immune responses and permits long-term gene expression
-
Ilan Y, Droguett G, Chowdhury NR, Li Y, Sengupta K, Thummala NR, Davidson A, Chowdhury JR, Horwitz MS (1997) Insertion of the adenoviral E3 region into a recombinant viral vector prevents antiviral humoral and cellular immune responses and permits long-term gene expression. Proc Natl Acad Sci USA 94: 2587
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 2587
-
-
Ilan, Y.1
Droguett, G.2
Chowdhury, N.R.3
Li, Y.4
Sengupta, K.5
Thummala, N.R.6
Davidson, A.7
Chowdhury, J.R.8
Horwitz, M.S.9
-
44
-
-
0030802364
-
A novel p53-inducible gene, PAG608, encodes a nuclear zinc finger protein whose overexpression promotes apoptosis
-
Israeli D, Tessler E, Haupt Y, Elkeles A, Wilder S, Amson R, Telerman A, Oren M (1997) A novel p53-inducible gene, PAG608, encodes a nuclear zinc finger protein whose overexpression promotes apoptosis. EMBO J 16: 4384
-
(1997)
EMBO J
, vol.16
, pp. 4384
-
-
Israeli, D.1
Tessler, E.2
Haupt, Y.3
Elkeles, A.4
Wilder, S.5
Amson, R.6
Telerman, A.7
Oren, M.8
-
45
-
-
0029919728
-
Abrogation of wild-type p53 mediated growth-inhibition by nuclear exclusion
-
Knippschild U, Oren M, Deppert W (1996) Abrogation of wild-type p53 mediated growth-inhibition by nuclear exclusion. Oncogene 12: 1755
-
(1996)
Oncogene
, vol.12
, pp. 1755
-
-
Knippschild, U.1
Oren, M.2
Deppert, W.3
-
46
-
-
0029972806
-
p53: Puzzle and paradigm
-
Ko LJ, Prives C (1996) p53: puzzle and paradigm. Genes Dev 10: 1054
-
(1996)
Genes Dev
, vol.10
, pp. 1054
-
-
Ko, L.J.1
Prives, C.2
-
47
-
-
0029044606
-
Mdm2 protein confers the resistance of a human glioblastoma cell line to cisplatin-induced apoptosis
-
Kondo S, Barnett GH, Hara H, Morimura T, Takeuchi J (1995) Mdm2 protein confers the resistance of a human glioblastoma cell line to cisplatin-induced apoptosis. Oncogene 10: 2001
-
(1995)
Oncogene
, vol.10
, pp. 2001
-
-
Kondo, S.1
Barnett, G.H.2
Hara, H.3
Morimura, T.4
Takeuchi, J.5
-
48
-
-
0030916669
-
The proto-oncogene Bcl-2 and its role in regulating apoptosis
-
Kroemer G (1997) The proto-oncogene Bcl-2 and its role in regulating apoptosis. Nat Med 3: 614
-
(1997)
Nat Med
, vol.3
, pp. 614
-
-
Kroemer, G.1
-
50
-
-
0030941458
-
p53, the cellular gatekeeper for growth and division
-
Levine AJ (1997) p53, the cellular gatekeeper for growth and division. Cell 88: 323
-
(1997)
Cell
, vol.88
, pp. 323
-
-
Levine, A.J.1
-
51
-
-
0029554989
-
The spectrum of mutations at the p53 locus. Evidence for tissue-specific mutagenesis, selection of mutant alleles, and a "gain of function" phenotype
-
Levine AJ, Wu MC, Chang A, Silver A, Attiyeh EF, Lin J, Epstein CB (1995) The spectrum of mutations at the p53 locus. Evidence for tissue-specific mutagenesis, selection of mutant alleles, and a "gain of function" phenotype. Ann N Y Acad Sci 768: 111
-
(1995)
Ann N Y Acad Sci
, vol.768
, pp. 111
-
-
Levine, A.J.1
Wu, M.C.2
Chang, A.3
Silver, A.4
Attiyeh, E.F.5
Lin, J.6
Epstein, C.B.7
-
52
-
-
0028303752
-
Several hydrophobic amino acids in the p53 amino-terminal domain are required for transcriptional activation, binding to Mdm-2 and the adenovirus 5 E1B 55-kD protein
-
Lin J, Chen J, Elenbaas B, Levine AJ (1994) Several hydrophobic amino acids in the p53 amino-terminal domain are required for transcriptional activation, binding to Mdm-2 and the adenovirus 5 E1B 55-kD protein. Genes Dev 8: 1235
-
(1994)
Genes Dev
, vol.8
, pp. 1235
-
-
Lin, J.1
Chen, J.2
Elenbaas, B.3
Levine, A.J.4
-
53
-
-
0030926817
-
Two functional assays employed to detect an unusual mutation in the oligomerisation domain of p53 in a Li-Fraumeni like family
-
Lomax ME, Barnes DM, Gilchrist R, Picksley SM, Varley JM, Camplejohn RS (1997) Two functional assays employed to detect an unusual mutation in the oligomerisation domain of p53 in a Li-Fraumeni like family. Oncogene 14: 1869
-
(1997)
Oncogene
, vol.14
, pp. 1869
-
-
Lomax, M.E.1
Barnes, D.M.2
Gilchrist, R.3
Picksley, S.M.4
Varley, J.M.5
Camplejohn, R.S.6
-
54
-
-
0029742781
-
Differential activation of target cellular promoters by p53 mutants with impaired apoptotic function
-
Ludwig RL, Bates S, Vousden KH (1996) Differential activation of target cellular promoters by p53 mutants with impaired apoptotic function. Mol Cell Biol 16: 4952
-
(1996)
Mol Cell Biol
, vol.16
, pp. 4952
-
-
Ludwig, R.L.1
Bates, S.2
Vousden, K.H.3
-
55
-
-
0029164446
-
The WT1 gene product stabilizes p53 and inhibits p53-mediated apoptosis
-
Maheswaran S, Englert C, Bennett P, Heinrich G, Haber DA (1995) The WT1 gene product stabilizes p53 and inhibits p53-mediated apoptosis. Genes Dev 9: 2143
-
(1995)
Genes Dev
, vol.9
, pp. 2143
-
-
Maheswaran, S.1
Englert, C.2
Bennett, P.3
Heinrich, G.4
Haber, D.A.5
-
56
-
-
0029911677
-
Therapy of murine tumors with p53 wild-type and mutant sequence peptide-based vaccines
-
Mayordomo JI, Loftus DJ, Sakamoto H, De Cesare CM, Appasamy PM, Lotze MT, Storkus WJ, Appella E, DeLeo AB (1996) Therapy of murine tumors with p53 wild-type and mutant sequence peptide-based vaccines. J Exp Med 183: 1357
-
(1996)
J Exp Med
, vol.183
, pp. 1357
-
-
Mayordomo, J.I.1
Loftus, D.J.2
Sakamoto, H.3
De Cesare, C.M.4
Appasamy, P.M.5
Lotze, M.T.6
Storkus, W.J.7
Appella, E.8
DeLeo, A.B.9
-
57
-
-
0030978224
-
Wilms' tumor 1-KTS isoforms induce p53-independent apoptosis that can be partially rescued by expression of the epidermal growth factor receptor or the insulin receptor
-
Menke AL, Shvarts A, Riteco N, van Ham RCA, van der Eb AJ, Jochemsen AG (1997) Wilms' tumor 1-KTS isoforms induce p53-independent apoptosis that can be partially rescued by expression of the epidermal growth factor receptor or the insulin receptor. Cancer Res 57: 1353
-
(1997)
Cancer Res
, vol.57
, pp. 1353
-
-
Menke, A.L.1
Shvarts, A.2
Riteco, N.3
Van Ham, R.C.A.4
Van Der Eb, A.J.5
Jochemsen, A.G.6
-
58
-
-
0028292480
-
Identification of a p53-dependent negative response element in the bcl-2 gene
-
Miyashita T, Harigai M, Hanada M, Reed JC (1994) Identification of a p53-dependent negative response element in the bcl-2 gene. Cancer Res 54: 3131
-
(1994)
Cancer Res
, vol.54
, pp. 3131
-
-
Miyashita, T.1
Harigai, M.2
Hanada, M.3
Reed, J.C.4
-
59
-
-
0028823020
-
Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53
-
Montes de Oca Luna R, Wagner DS, Lozano G (1995) Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53. Nature 378: 203
-
(1995)
Nature
, vol.378
, pp. 203
-
-
Montes De Oca Luna, R.1
Wagner, D.S.2
Lozano, G.3
-
60
-
-
0030910037
-
p53 and ATM: Cell cycle, cell death and cancer
-
Morgan SE, Kastan MB (1997) p53 and ATM: Cell cycle, cell death and cancer. Adv Cancer Res 71: 1
-
(1997)
Adv Cancer Res
, vol.71
, pp. 1
-
-
Morgan, S.E.1
Kastan, M.B.2
-
61
-
-
0029803281
-
Wild-type p53 negatively regulates the expression of a microtubule-associated protein
-
Murphy M, Hinman A, Levine AJ (1996) Wild-type p53 negatively regulates the expression of a microtubule-associated protein. Genes Dev 10: 2971
-
(1996)
Genes Dev
, vol.10
, pp. 2971
-
-
Murphy, M.1
Hinman, A.2
Levine, A.J.3
-
62
-
-
0030993852
-
Immunohistochemical detection of Bcl-2 and p53 proteins and apoptosis in soft tissue sarcoma: Their correlations with prognosis
-
Nakanishi H, Ohsawa M, Naka N, Uchida A, Ochi T, Aozasa K (1997) Immunohistochemical detection of Bcl-2 and p53 proteins and apoptosis in soft tissue sarcoma: their correlations with prognosis. Oncology 54: 238
-
(1997)
Oncology
, vol.54
, pp. 238
-
-
Nakanishi, H.1
Ohsawa, M.2
Naka, N.3
Uchida, A.4
Ochi, T.5
Aozasa, K.6
-
64
-
-
0029835487
-
Gene therapy for lung cancer: Enhancement of tumor suppression by a combination of sequential systemic cisplatin and adenovirus-mediated p53 gene transfer
-
Nguyen DM, Spitz FR, Yen N, Cristiano RJ, Roth JA (1996) Gene therapy for lung cancer: enhancement of tumor suppression by a combination of sequential systemic cisplatin and adenovirus-mediated p53 gene transfer. J Thorac Cardiovasc Surg 112: 1372
-
(1996)
J Thorac Cardiovasc Surg
, vol.112
, pp. 1372
-
-
Nguyen, D.M.1
Spitz, F.R.2
Yen, N.3
Cristiano, R.J.4
Roth, J.A.5
-
65
-
-
0031133231
-
Gene delivery into malignant cells in vivo by a conjugated adenovirus/DNa complex
-
Nguyen DM, Wiehle SA, Roth JA, Cristiano RJ (1997) Gene delivery into malignant cells in vivo by a conjugated adenovirus/DNA complex. Cancer Gene Ther 4: 183
-
(1997)
Cancer Gene Ther
, vol.4
, pp. 183
-
-
Nguyen, D.M.1
Wiehle, S.A.2
Roth, J.A.3
Cristiano, R.J.4
-
66
-
-
0029003501
-
Wild-type human p53 and a temperature-sensitive mutant induce Fas/APO-1 expression
-
Owen-Schaub LB, Zhang W, Cusack JC, Angelo LS, Santee SM, Fujiwara T, Roth JA, Deisseroth AB, Zhang W-W, Kruzel E, Radinsky R (1995) Wild-type human p53 and a temperature-sensitive mutant induce Fas/APO-1 expression. Mol Cell Biol 15: 3032
-
(1995)
Mol Cell Biol
, vol.15
, pp. 3032
-
-
Owen-Schaub, L.B.1
Zhang, W.2
Cusack, J.C.3
Angelo, L.S.4
Santee, S.M.5
Fujiwara, T.6
Roth, J.A.7
Deisseroth, A.B.8
Zhang, W.-W.9
Kruzel, E.10
Radinsky, R.11
-
67
-
-
0027143217
-
The mdm2 gene is induced in response to UV light in a p53-dependent manner
-
Perry ME, Piette J, Zawadzki JA, Harvey D, Levine AJ (1993) The mdm2 gene is induced in response to UV light in a p53-dependent manner. Proc Natl Acad Sci USA 90: 11623
-
(1993)
Proc Natl Acad Sci USA
, vol.90
, pp. 11623
-
-
Perry, M.E.1
Piette, J.2
Zawadzki, J.A.3
Harvey, D.4
Levine, A.J.5
-
68
-
-
0027673764
-
The p53-mdm2 autoregulatory feedback loop: A paradigm for the regulation of growth control by p53?
-
Picksley SM, Lane DP (1993) The p53-mdm2 autoregulatory feedback loop: a paradigm for the regulation of growth control by p53? Bioessays 15: 689
-
(1993)
Bioessays
, vol.15
, pp. 689
-
-
Picksley, S.M.1
Lane, D.P.2
-
69
-
-
0031036879
-
The insulin-like growth factor I receptor as a physiologically relevant target of p53 in apoptosis caused by interleukin-3 withdrawal
-
Prisco M, Hongo A, Rizzo MG, Sacchi A, Baserga R (1997) The insulin-like growth factor I receptor as a physiologically relevant target of p53 in apoptosis caused by interleukin-3 withdrawal. Mol Cell Biol 17: 1084
-
(1997)
Mol Cell Biol
, vol.17
, pp. 1084
-
-
Prisco, M.1
Hongo, A.2
Rizzo, M.G.3
Sacchi, A.4
Baserga, R.5
-
70
-
-
0031018674
-
Somatic frameshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype
-
Rampino N, Yamamoto H, Ionov Y, Li Y, Sawai H, Reed JC, Perucho M (1997) Somatic frameshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype. Science 275: 967
-
(1997)
Science
, vol.275
, pp. 967
-
-
Rampino, N.1
Yamamoto, H.2
Ionov, Y.3
Li, Y.4
Sawai, H.5
Reed, J.C.6
Perucho, M.7
-
71
-
-
0029978501
-
p53 as a target for cancer vaccines: Recombinant canarypox virus vectors expressing p53 protect mice against lethal tumor cell challenge
-
Roth J, Dittmer D, Rea D, Tartaglia J, Paoletti E, Levine AJ (1996) p53 as a target for cancer vaccines: recombinant canarypox virus vectors expressing p53 protect mice against lethal tumor cell challenge. Proc Natl Acad Sci USA 93: 4781
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 4781
-
-
Roth, J.1
Dittmer, D.2
Rea, D.3
Tartaglia, J.4
Paoletti, E.5
Levine, A.J.6
-
72
-
-
0031025998
-
Gene therapy for cancer: What have we done and where are we going?
-
Roth JA, Cristiano RJ (1997) Gene therapy for cancer: what have we done and where are we going? J Natl Cancer Inst 89: 21
-
(1997)
J Natl Cancer Inst
, vol.89
, pp. 21
-
-
Roth, J.A.1
Cristiano, R.J.2
-
73
-
-
9544244796
-
Retrovirus-mediated wild-type p53 gene transfer to tumors of patients w ith lung cancer
-
Roth JA, Nguyen D, Lawrence DD, et al (1996) Retrovirus-mediated wild-type p53 gene transfer to tumors of patients w ith lung cancer. Nat Med 2: 985
-
(1996)
Nat Med
, vol.2
, pp. 985
-
-
Roth, J.A.1
Nguyen, D.2
Lawrence, D.D.3
-
74
-
-
0030021748
-
Specific loss of apoptotic hut not cell-cycle arrest function in a human tumor derived p53 mutant
-
Rowan S, Ludwig RL, Haupt Y, Bates S, Lu X, Oren M, Vousden KH (1996) Specific loss of apoptotic hut not cell-cycle arrest function in a human tumor derived p53 mutant. EMBO J 15: 827
-
(1996)
EMBO J
, vol.15
, pp. 827
-
-
Rowan, S.1
Ludwig, R.L.2
Haupt, Y.3
Bates, S.4
Lu, X.5
Oren, M.6
Vousden, K.H.7
-
75
-
-
0027464267
-
Cell cycle analysis of p53-induced cell death in murinc erythroleukemia cells
-
Ryan JJ, Danish R, Gottlieb CA, Clarke MF (1993) Cell cycle analysis of p53-induced cell death in murinc erythroleukemia cells. Mol Cell Biol 13: 711
-
(1993)
Mol Cell Biol
, vol.13
, pp. 711
-
-
Ryan, J.J.1
Danish, R.2
Gottlieb, C.A.3
Clarke, M.F.4
-
76
-
-
0029143395
-
Essential role for p53-mediated transcription in E1A-induced apoptosis
-
Sabbatini P, Lin J, Levine AJ, White E (1995) Essential role for p53-mediated transcription in E1A-induced apoptosis. Genes Dev 9: 2184
-
(1995)
Genes Dev
, vol.9
, pp. 2184
-
-
Sabbatini, P.1
Lin, J.2
Levine, A.J.3
White, E.4
-
78
-
-
0030961889
-
Restoration of the growth suppression function of mutant p53 by a synthetic peptide derived from the p53 C-terminal domain
-
Selivanova G, Iotsova V, Okan I, Fritsche M, Ström M, Groner B, Grafström RC, Wiman KG (1997) Restoration of the growth suppression function of mutant p53 by a synthetic peptide derived from the p53 C-terminal domain. Nat Med 3: 632
-
(1997)
Nat Med
, vol.3
, pp. 632
-
-
Selivanova, G.1
Iotsova, V.2
Okan, I.3
Fritsche, M.4
Ström, M.5
Groner, B.6
Grafström, R.C.7
Wiman, K.G.8
-
79
-
-
0030992749
-
Interaction between ATM protein and c-Abl in response to DNA damage
-
Shafman T, Khanna KK, Kedar P, Spring K, Kozlov S, Yen T, Hobson K, Gatei M, Zhang N, Watters D, Egerton M, Shiloh Y, Kharbanda S, Kufe D, Lavin MF (1997) Interaction between ATM protein and c-Abl in response to DNA damage. Nature 387: 520
-
(1997)
Nature
, vol.387
, pp. 520
-
-
Shafman, T.1
Khanna, K.K.2
Kedar, P.3
Spring, K.4
Kozlov, S.5
Yen, T.6
Hobson, K.7
Gatei, M.8
Zhang, N.9
Watters, D.10
Egerton, M.11
Shiloh, Y.12
Kharbanda, S.13
Kufe, D.14
Lavin, M.F.15
-
80
-
-
0030903281
-
Role of p53 in drug resistance in ovarian cancer
-
Shelling AN (1997) Role of p53 in drug resistance in ovarian cancer. Lancet 349: 744
-
(1997)
Lancet
, vol.349
, pp. 744
-
-
Shelling, A.N.1
-
82
-
-
0029849620
-
Cancer cell cycles
-
Sherr CJ (1996) Cancer cell cycles. Science 274: 1672
-
(1996)
Science
, vol.274
, pp. 1672
-
-
Sherr, C.J.1
-
83
-
-
0029996069
-
Clinical implications of the p53 gene
-
Sidransky D, Hollstein M (1996) Clinical implications of the p53 gene. Annu Rev Med 47: 285
-
(1996)
Annu Rev Med
, vol.47
, pp. 285
-
-
Sidransky, D.1
Hollstein, M.2
-
84
-
-
0030992313
-
Expression of p53, glutathione S-transferase-π, and Bcl-2 proteins and benefit from adjuvant radiotherapy in breast cancer
-
Silvestrini R, Veneroni S, Benini E, Daidone MG, Luisi A, Leutner M, Maucione A, Kenda R, Zucali R, Veronesi U (1997) Expression of p53, glutathione S-transferase-π, and Bcl-2 proteins and benefit from adjuvant radiotherapy in breast cancer. J Natl Cancer Inst 89: 639
-
(1997)
J Natl Cancer Inst
, vol.89
, pp. 639
-
-
Silvestrini, R.1
Veneroni, S.2
Benini, E.3
Daidone, M.G.4
Luisi, A.5
Leutner, M.6
Maucione, A.7
Kenda, R.8
Zucali, R.9
Veronesi, U.10
-
85
-
-
0030221787
-
The humoral response to the tumor-suppressor gene-product p53 in human cancer: Implications for diagnosis and therapy
-
Soussi T (1996) The humoral response to the tumor-suppressor gene-product p53 in human cancer: implications for diagnosis and therapy. Immunol Today 17: 354
-
(1996)
Immunol Today
, vol.17
, pp. 354
-
-
Soussi, T.1
-
87
-
-
0029787301
-
A novel p53 germline alteration identified in a late onset breast cancer kindred
-
Sun X-F, Johannsson O, Håkansson S, Sellberg G, Nordenskjöld B, Olsson H, Borg A (1996) A novel p53 germline alteration identified in a late onset breast cancer kindred. Oncogene 13: 407
-
(1996)
Oncogene
, vol.13
, pp. 407
-
-
Sun, X.-F.1
Johannsson, O.2
Håkansson, S.3
Sellberg, G.4
Nordenskjöld, B.5
Olsson, H.6
Borg, A.7
-
88
-
-
0026058990
-
Complex formation between the lymphotropic papovavirus large tumor antigen and the tumor suppressor protein p53
-
Symonds H, Chen JD, Van Dyke T (1991) Complex formation between the lymphotropic papovavirus large tumor antigen and the tumor suppressor protein p53. J Virol 65: 5417
-
(1991)
J Virol
, vol.65
, pp. 5417
-
-
Symonds, H.1
Chen, J.D.2
Van Dyke, T.3
-
89
-
-
0031041172
-
Regulation of apoptosis by viral gene products
-
Teodoro JG, Branton PE (1997) Regulation of apoptosis by viral gene products. J Virol 71: 1739
-
(1997)
J Virol
, vol.71
, pp. 1739
-
-
Teodoro, J.G.1
Branton, P.E.2
-
90
-
-
0030892137
-
Tolerance to p53 by A2.1-restricted cytotoxic T lymphocytes
-
Theobald M, Biggs J, Hernúndez, J, Lustgarten J, Labadie C, Sherman LA (1997) Tolerance to p53 by A2.1-restricted cytotoxic T lymphocytes. J Exp Med 185: 833
-
(1997)
J Exp Med
, vol.185
, pp. 833
-
-
Theobald, M.1
Biggs, J.2
Hernúndez, J.3
Lustgarten, J.4
Labadie, C.5
Sherman, L.A.6
-
91
-
-
0029888514
-
Biological and clinical importance of the p53 tumor suppressor gene
-
Velculescu VE, El-Deiry WS (1996) Biological and clinical importance of the p53 tumor suppressor gene. Clin Chem 42: 858
-
(1996)
Clin Chem
, vol.42
, pp. 858
-
-
Velculescu, V.E.1
El-Deiry, W.S.2
-
92
-
-
0031426571
-
Antisense technology and prospects for therapy of viral infections and cancer
-
Wagner RW, Flanagan WM (1997) Antisense technology and prospects for therapy of viral infections and cancer. Mol Med Today 3: 31
-
(1997)
Mol Med Today
, vol.3
, pp. 31
-
-
Wagner, R.W.1
Flanagan, W.M.2
-
93
-
-
0030026934
-
Loss of normal p53 function confers sensitization to Taxol by increasing G2/M arrest and apoptosis
-
Wahl AF, Donaldson KL, Fairchild C, Lee FY, Foster SA, Demers GW, Galloway DA (1996) Loss of normal p53 function confers sensitization to Taxol by increasing G2/M arrest and apoptosis. Nat Med 2: 72
-
(1996)
Nat Med
, vol.2
, pp. 72
-
-
Wahl, A.F.1
Donaldson, K.L.2
Fairchild, C.3
Lee, F.Y.4
Foster, S.A.5
Demers, G.W.6
Galloway, D.A.7
-
94
-
-
0030448650
-
Identification of a novel p53 functional domain that is necessary for efficient growth suppression
-
Walker KK, Levine AJ (1996) Identification of a novel p53 functional domain that is necessary for efficient growth suppression. Proc Natl Acad Sci USA 93: 15335
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 15335
-
-
Walker, K.K.1
Levine, A.J.2
-
96
-
-
0001166257
-
The XPB and XPD DNA helicases are components of the p53-mediated apoptosis pathway
-
Wang XW, Vermeulen W, Coursen JD, Gibson M, Lupold SE, Forrester K, Xu G, Elmore L, Yeh H, Hoeijmakers JHJ, Harris CC (1996) The XPB and XPD DNA helicases are components of the p53-mediated apoptosis pathway. Genes Dev 10: 1219
-
(1996)
Genes Dev
, vol.10
, pp. 1219
-
-
Wang, X.W.1
Vermeulen, W.2
Coursen, J.D.3
Gibson, M.4
Lupold, S.E.5
Forrester, K.6
Xu, G.7
Elmore, L.8
Yeh, H.9
Hoeijmakers, J.H.J.10
Harris, C.C.11
-
97
-
-
0029879676
-
The cytostatic function of c-Abl is controlled by multiple nuclear localization signals and requires the p53 and Rb tumor suppressor gene products
-
Wen S-T, Jackson PK, Van Etten RA (1996) The cytostatic function of c-Abl is controlled by multiple nuclear localization signals and requires the p53 and Rb tumor suppressor gene products. EMBO J 15: 1583
-
(1996)
EMBO J
, vol.15
, pp. 1583
-
-
Wen, S.-T.1
Jackson, P.K.2
Van Etten, R.A.3
-
98
-
-
0030046508
-
Life, death, and the pursuit of apoptosis
-
White E (1996) Life, death, and the pursuit of apoptosis. Genes Dev 10: 1
-
(1996)
Genes Dev
, vol.10
, pp. 1
-
-
White, E.1
-
99
-
-
0030895405
-
Transferrin-liposome-mediated p53 sensitization of squamous cell carcinoma of the head and neck to radiation in vitro
-
Xu L, Pirollo KF, Chang EH (1997) Transferrin-liposome-mediated p53 sensitization of squamous cell carcinoma of the head and neck to radiation in vitro. Hum Gene Ther 8: 467
-
(1997)
Hum Gene Ther
, vol.8
, pp. 467
-
-
Xu, L.1
Pirollo, K.F.2
Chang, E.H.3
-
100
-
-
0031038137
-
Bax suppresses tumorigenesis and stimulates apoptosis in vivo
-
Yin C, Knudson CM, Korsmeyer SJ, Van Dyke T (1997) Bax suppresses tumorigenesis and stimulates apoptosis in vivo. Nature 385: 637
-
(1997)
Nature
, vol.385
, pp. 637
-
-
Yin, C.1
Knudson, C.M.2
Korsmeyer, S.J.3
Van Dyke, T.4
-
101
-
-
0025784539
-
Wild-type p53 induces apoptosis of myeloid leukaemis cells that is inhibited by interleukin-6
-
Yonish-Rouach E, Resnitzky D, Lotem J, Sachs L, Kimchi A, Oren M (1991) Wild-type p53 induces apoptosis of myeloid leukaemis cells that is inhibited by interleukin-6. Nature 352: 345
-
(1991)
Nature
, vol.352
, pp. 345
-
-
Yonish-Rouach, E.1
Resnitzky, D.2
Lotem, J.3
Sachs, L.4
Kimchi, A.5
Oren, M.6
-
102
-
-
0030255520
-
The role of p53 as a transcription factor in the induction of apoptosis
-
Yonish-Rouach E, Choisy C, Deguin V, Breugnot C, May E (1996) The role of p53 as a transcription factor in the induction of apoptosis. Behring Inst Mitt 97: 60
-
(1996)
Behring Inst Mitt
, vol.97
, pp. 60
-
-
Yonish-Rouach, E.1
Choisy, C.2
Deguin, V.3
Breugnot, C.4
May, E.5
-
103
-
-
0029973738
-
Role for c-Abl tyrosine kinase in growth arrest response to DNA damage
-
Yuan Z-M, Huang Y, Whang Y, Sawyers C, Weichselbaum R, Kharbanda S, Kufe D (1996) Role for c-Abl tyrosine kinase in growth arrest response to DNA damage. Nature 382: 272
-
(1996)
Nature
, vol.382
, pp. 272
-
-
Yuan, Z.-M.1
Huang, Y.2
Whang, Y.3
Sawyers, C.4
Weichselbaum, R.5
Kharbanda, S.6
Kufe, D.7
-
104
-
-
0031020908
-
Regulation of DNA damage-induced apoptosis by the c-Abl tyrosine kinase
-
Yuan Z-M, Huang Y, Ishiko T, Kharbanda S, Weichselbaum R, Kufe D (1997) Regulation of DNA damage-induced apoptosis by the c-Abl tyrosine kinase. Proc Natl Acad Sci USA 94: 1437
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 1437
-
-
Yuan, Z.-M.1
Huang, Y.2
Ishiko, T.3
Kharbanda, S.4
Weichselbaum, R.5
Kufe, D.6
|