Adenovirally transferred p16(INK4/CDKN2) and p53 genes cooperate to induce apoptotic tumor cell death

Nature Medicine

Volumn 3, Issue 3, 1997, Pages 313-319

  Sandig, Volker ^a   Brand, Karsten ^a,b   Herwig, Susanne ^a,b   Lukas, Jiri ^c   Bartek, Jiri ^c   Strauss, Michael ^b,c  

^a MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^b HUMBOLDT UNIVERSITY   (Germany)

^c DANISH CANCER SOCIETY RESEARCH CENTER   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS; APOPTOSIS; ARTICLE; CANCER INHIBITION; GENE THERAPY; GENE TRANSFER; HUMAN; HUMAN CELL; PRIORITY JOURNAL; TUMOR SUPPRESSOR GENE; ANIMAL; CELL CULTURE; GENE EXPRESSION REGULATION; GENE VECTOR; GENETICS; MOUSE;

ADENOVIRIDAE; MUS MUSCULUS;

CARRIER PROTEIN; PROTEIN P16INK4A; PROTEIN P53;

ADENOVIRIDAE; ANIMALS; APOPTOSIS; CARRIER PROTEINS; CYCLIN-DEPENDENT KINASE INHIBITOR P16; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE EXPRESSION REGULATION, VIRAL; GENE TRANSFER TECHNIQUES; GENES, TUMOR SUPPRESSOR; GENETIC VECTORS; HUMANS; MICE; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0030614944     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm0397-313     Document Type: Article

References (12)

1. Rosenberg, S.A. et al. Immunization of cancer patients using autologous cancer cells modified by insertion of the gene for interleukin-2. Hum. Gene Ther. 3, 75-90 (1992).
2. Culver, K.W. et al. In vivo gene transfer with retroviral vector producer cells for treatment of experimental brain tumors. Science 256, 1550-1552 (1992).
3. Zhang, Y. et al. Retroviral vector-mediated transduction of K-ras antisense RNA into human cancer cells inhibits expression of the malignant phenotype. Hum. Gene Ther. 4, 451-460 (1993).
4. Friedmann, T. Gene therapy of cancer through restoration of tumor-suppressor functions? Cancer 70 (Suppl.), 1810-1817 (1992).
5. Mulligan, R.C. The basic science of gene therapy. Science 260, 926-932 (1993).
6. Kremer, E.J. & Perricaudet, M. Adenovirus and adeno-associated virus mediated gene transfer. British Med. Bull. 51, 31-44 (1995).
7. Kozarsky, K.F. & Wilson, J.M. Gene therapy: Adenovirus vectors. Curr. Opin. Gen. Dev. 3, 499-503 (1993).
8. Kass-Eisler, A. et al. The impact of developmental stage, route of administration and the immune system on adenovirus-mediated gene transfer. Gene Therapy 1, 395-402 (1994).
9. Huard, J. et al. The route of administration is a major determinant of the transduction efficiency of rat tissues by adenoviral recombinants. Gene Therapy 2, 107-115 (1995).
10. Herz, J. & Gerard, R.D. Adenovirus-mediated low-density-lipoprotein receptor gene transfer accelerated cholesterol clearance in normal mice. Proc. Natl. Acad. Sci. USA 90, 2812-2816 (1993).
11. Liu, T.-J. et al. Growth suppression of human head and neck cancer cells by the introduction of a wild-type p53 gene via a recombinant adenovirus. Cancer Res. 54, 3662-3667 (1994).
12. Zhang W.-W. et al. High-efficiency gene transfer and high-level expression of wild-type p53 in human lung cancer cells mediated by recombinant adenovirus. Cancer Gene Ther. 1, 1-10 (1994).