메뉴 건너뛰기




Volumn 15, Issue 14, 1996, Pages 3693-3701

Transcriptional activation by p53, but not induction of the p21 gene, is essential for oncogene-mediated apoptosis

Author keywords

Apoptosis; G1 arrest; p21; p53; Transcriptional transactivation

Indexed keywords

ETOPOSIDE; ONCOPROTEIN; PROTEIN P21; PROTEIN P53;

EID: 0030013337     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1002/j.1460-2075.1996.tb00739.x     Document Type: Article
Times cited : (234)

References (43)
  • 2
    • 0028070989 scopus 로고
    • p53-dependent apoptosis in the absence of transcriptional activation of p53-target genes
    • Caelles, C., Helmberg, A. and Karin, M. (1994) p53-dependent apoptosis in the absence of transcriptional activation of p53-target genes. Nature, 370, 220-223.
    • (1994) Nature , vol.370 , pp. 220-223
    • Caelles, C.1    Helmberg, A.2    Karin, M.3
  • 3
    • 0028958705 scopus 로고
    • Growth factor modulation of p53-mediated growth arrest versus apoptosis
    • Canman, C.E., Gilmer, T.M., Coutts, S.B. and Kastan, M.B. (1995) Growth factor modulation of p53-mediated growth arrest versus apoptosis. Genes Dev., 9, 600-611.
    • (1995) Genes Dev. , vol.9 , pp. 600-611
    • Canman, C.E.1    Gilmer, T.M.2    Coutts, S.B.3    Kastan, M.B.4
  • 4
    • 0027983669 scopus 로고
    • Crystal structure of a p53 tumor suppressor-DNA complex: Understanding tumorigenic mutations
    • Cho, Y., Gorina, S., Jeffrey, P.D. and Pavletich, N.P. (1994) Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations. Science, 265, 346-355.
    • (1994) Science , vol.265 , pp. 346-355
    • Cho, Y.1    Gorina, S.2    Jeffrey, P.D.3    Pavletich, N.P.4
  • 5
    • 0027251720 scopus 로고
    • Wild-type p53 mediates apoptosis by E1A, which is inhibited by E1B
    • Debbas, M. and White, E. (1993) Wild-type p53 mediates apoptosis by E1A, which is inhibited by E1B. Genes Dev., 7, 546-554.
    • (1993) Genes Dev. , vol.7 , pp. 546-554
    • Debbas, M.1    White, E.2
  • 6
    • 0028978183 scopus 로고
    • CIPI/WAF1 undergo normal development, but are defective in G1 checkpoint control
    • CIPI/WAF1 undergo normal development, but are defective in G1 checkpoint control. Cell, 82, 675-684.
    • (1995) Cell , vol.82 , pp. 675-684
    • Deng, C.1    Zhang, P.2    Harper, J.W.3    Elledge, S.4    Leder, P.5
  • 8
    • 0028220204 scopus 로고
    • P53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest
    • Dulic, V., Kaufmann, W.K., Wilson, S.J., Tlsty, T.D., Lees, E., Harper, J.W., Elledge, S.J. and Reed, S.I. (1994) p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest. Cell, 76, 1013-1023.
    • (1994) Cell , vol.76 , pp. 1013-1023
    • Dulic, V.1    Kaufmann, W.K.2    Wilson, S.J.3    Tlsty, T.D.4    Lees, E.5    Harper, J.W.6    Elledge, S.J.7    Reed, S.I.8
  • 11
    • 0028137084 scopus 로고
    • p53: A glimpse at the puppet behind the shadow play
    • Friend, S. (1994) p53: a glimpse at the puppet behind the shadow play. Science, 265, 334-335.
    • (1994) Science , vol.265 , pp. 334-335
    • Friend, S.1
  • 12
    • 0029023560 scopus 로고
    • Dissection of the genetic programs of p53-mediated G1 growth arrest and apoptosis: Blocking p53-induced apoptosis unmasks G1 arrest
    • Guillouf, C., Grana, X., Selvakumaran, M., De Luca, A., Giordano, A., Hoffman, B. and Liebermann, D.A. (1995) Dissection of the genetic programs of p53-mediated G1 growth arrest and apoptosis: blocking p53-induced apoptosis unmasks G1 arrest. Blood, 85, 2691-2698.
    • (1995) Blood , vol.85 , pp. 2691-2698
    • Guillouf, C.1    Grana, X.2    Selvakumaran, M.3    De Luca, A.4    Giordano, A.5    Hoffman, B.6    Liebermann, D.A.7
  • 13
    • 0028899283 scopus 로고
    • Biochemical properties and biological effects of p53
    • Haffner, R. and Oren, M. (1995) Biochemical properties and biological effects of p53. Curr. Opin. Genet. Dev., 5, 84-90.
    • (1995) Curr. Opin. Genet. Dev. , vol.5 , pp. 84-90
    • Haffner, R.1    Oren, M.2
  • 14
    • 0027496935 scopus 로고
    • The p21 Cdk-interacting protein CIP1 is a potent inhibitor of G1 cyclin-dependent kinases
    • Harper, J.W., Adami, G.R., Wei, N., Keyomarsi, K. and Elledge, S.J. (1993) The p21 Cdk-interacting protein CIP1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell, 75, 805-816.
    • (1993) Cell , vol.75 , pp. 805-816
    • Harper, J.W.1    Adami, G.R.2    Wei, N.3    Keyomarsi, K.4    Elledge, S.J.5
  • 15
    • 0029092356 scopus 로고
    • Induction of apoptosis in HeLa cells by trans-activation-deficient p53
    • Haupt, Y., Rowan, S., Shaulian, E., Vousden, K.H. and Oren, M. (1995) Induction of apoptosis in HeLa cells by trans-activation-deficient p53. Genes Dev., 9, 2170-2183.
    • (1995) Genes Dev. , vol.9 , pp. 2170-2183
    • Haupt, Y.1    Rowan, S.2    Shaulian, E.3    Vousden, K.H.4    Oren, M.5
  • 20
    • 0027326586 scopus 로고
    • The tumor suppressor genes
    • Levine, A.J. (1993) The tumor suppressor genes. Annu. Rev. Biochem., 62, 623-651.
    • (1993) Annu. Rev. Biochem. , vol.62 , pp. 623-651
    • Levine, A.J.1
  • 21
    • 0028303752 scopus 로고
    • Several hydrophobic amino acids in the p53 amino-terminal domain are required for transcriptional activation, binding to mdm-2, and the adenovirus 5 E1B 55-kD protein
    • Lin, J., Chen, J., Elenbaas, B. and Levine, A.J. (1994) Several hydrophobic amino acids in the p53 amino-terminal domain are required for transcriptional activation, binding to mdm-2, and the adenovirus 5 E1B 55-kD protein. Genes Dev., 8, 1235-1246.
    • (1994) Genes Dev. , vol.8 , pp. 1235-1246
    • Lin, J.1    Chen, J.2    Elenbaas, B.3    Levine, A.J.4
  • 22
    • 0026801062 scopus 로고
    • Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53
    • Livingstone, L.R., White, A., Sprouse, J., Livanos, E., Jacks, T. and Tlsty, T.D. (1992) Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53. Cell, 70, 923-935.
    • (1992) Cell , vol.70 , pp. 923-935
    • Livingstone, L.R.1    White, A.2    Sprouse, J.3    Livanos, E.4    Jacks, T.5    Tlsty, T.D.6
  • 23
    • 0028884525 scopus 로고
    • Cancer therapy and p53
    • Lowe, S.W. (1995) Cancer therapy and p53. Curr. Opin. Oncol., 7, 547-553.
    • (1995) Curr. Opin. Oncol. , vol.7 , pp. 547-553
    • Lowe, S.W.1
  • 24
    • 0027262606 scopus 로고
    • Stabilization of the p53 tumor suppressor is induced by adenovirus-5 E1A and accompanies apoptosis
    • Lowe, S.W. and Ruley, H.E. (1993) Stabilization of the p53 tumor suppressor is induced by adenovirus-5 E1A and accompanies apoptosis. Genes Dev., 7, 535-545.
    • (1993) Genes Dev. , vol.7 , pp. 535-545
    • Lowe, S.W.1    Ruley, H.E.2
  • 25
    • 0027451668 scopus 로고
    • p53-dependent apoptosis modulates the cytoxicity of anticancer agents
    • Lowe, S.W., Ruley, H.E., Jacks, T. and Housman, D.E. (1993) p53-dependent apoptosis modulates the cytoxicity of anticancer agents. Cell, 74, 957-967.
    • (1993) Cell , vol.74 , pp. 957-967
    • Lowe, S.W.1    Ruley, H.E.2    Jacks, T.3    Housman, D.E.4
  • 27
    • 0028323294 scopus 로고
    • Abrogation of oncogene-associated apoptosis allows transformation of p53-deficient cells
    • Lowe, S.W., Jacks, T., Housman, D.E. and Ruley, H.E. (1994b) Abrogation of oncogene-associated apoptosis allows transformation of p53-deficient cells. Proc. Natl Acad. Sci. USA, 91, 2026-2030.
    • (1994) Proc. Natl Acad. Sci. USA , vol.91 , pp. 2026-2030
    • Lowe, S.W.1    Jacks, T.2    Housman, D.E.3    Ruley, H.E.4
  • 28
    • 0027315653 scopus 로고
    • p53 and the Li-Fraumeni syndrome
    • Malkin, D. (1993) p53 and the Li-Fraumeni syndrome. Cancer Genet. Cytogenet., 66, 83-92.
    • (1993) Cancer Genet. Cytogenet. , vol.66 , pp. 83-92
    • Malkin, D.1
  • 29
    • 0028883179 scopus 로고
    • Tumor suppressor p53 is a direct transcriptional activator of the human bax gene
    • Miyashita, T. and Reed, J.C. (1995) Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Cell, 80, 293-299.
    • (1995) Cell , vol.80 , pp. 293-299
    • Miyashita, T.1    Reed, J.C.2
  • 30
    • 0027691738 scopus 로고
    • Discerning the function of p53 by examining its molecular interactions
    • Oliner, J.D. (1993) Discerning the function of p53 by examining its molecular interactions. BioEssays, 15, 703-707.
    • (1993) BioEssays , vol.15 , pp. 703-707
    • Oliner, J.D.1
  • 31
    • 0027166048 scopus 로고
    • Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerate programmed cell death
    • Oltvai, Z.N., Milliman, C.L. and Korsmeyer, S.J. (1993) Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerate programmed cell death. Cell, 74, 609-619.
    • (1993) Cell , vol.74 , pp. 609-619
    • Oltvai, Z.N.1    Milliman, C.L.2    Korsmeyer, S.J.3
  • 33
    • 0028025564 scopus 로고
    • How loops, β sheets, and a helices help us to understand p53
    • Prives, C. (1994) How loops, β sheets, and a helices help us to understand p53. Cell, 78, 543-546.
    • (1994) Cell , vol.78 , pp. 543-546
    • Prives, C.1
  • 35
    • 0029143395 scopus 로고
    • Essential role for p53-mediated transcription in E1A-induced apoptosis
    • Sabbatini, P., Lin, J., Levine, A.J. and White, E. (1995) Essential role for p53-mediated transcription in E1A-induced apoptosis. Genes Dev., 9, 2184-2192.
    • (1995) Genes Dev. , vol.9 , pp. 2184-2192
    • Sabbatini, P.1    Lin, J.2    Levine, A.J.3    White, E.4
  • 38
    • 0028345217 scopus 로고
    • Overlapping domains on the p53 protein regulate its transcriptional activation and repression functions
    • Subler, M.A., Martin, D.W. and Deb, S. (1994) Overlapping domains on the p53 protein regulate its transcriptional activation and repression functions. Oncogene, 9, 1351-1359.
    • (1994) Oncogene , vol.9 , pp. 1351-1359
    • Subler, M.A.1    Martin, D.W.2    Deb, S.3
  • 40
    • 0028034199 scopus 로고
    • Myc-mediated apoptosis requires wild-type p53 in a manner independent of cell cycle arrest and the ability of p53 to induce p21 WAF1/CIP1
    • Wagner, A.J., Kokontis, J.M. and Hay, N. (1994) Myc-mediated apoptosis requires wild-type p53 in a manner independent of cell cycle arrest and the ability of p53 to induce p21 WAF1/CIP1. Genes Dev., 8, 2817-2830.
    • (1994) Genes Dev. , vol.8 , pp. 2817-2830
    • Wagner, A.J.1    Kokontis, J.M.2    Hay, N.3
  • 41
    • 0028849274 scopus 로고
    • p21 is necessary for the p53-mediated G1 arrest in human cancer cells
    • Waldman, T., Kinzler, K.W. and Vogelstein, B. (1995) p21 is necessary for the p53-mediated G1 arrest in human cancer cells. Cancer Res., 55, 5187-5190.
    • (1995) Cancer Res. , vol.55 , pp. 5187-5190
    • Waldman, T.1    Kinzler, K.W.2    Vogelstein, B.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.