메뉴 건너뛰기




Volumn 88, Issue 20, 1996, Pages 1442-1455

Structure and function of the p53 tumor suppressor gene: Clues for rational cancer therapeutic strategies

Author keywords

[No Author keywords available]

Indexed keywords

CANCER VACCINE; CHLORMETHINE; CISPLATIN; ETOPOSIDE; GROWTH FACTOR; INTERLEUKIN 3; INTERLEUKIN 6; MEMBRANE RECEPTOR; OKADAIC ACID; PROTEIN BCL 2; PROTEIN KINASE INHIBITOR; PROTEIN P53;

EID: 0029845760     PISSN: 00278874     EISSN: None     Source Type: Journal    
DOI: 10.1093/jnci/88.20.1442     Document Type: Review
Times cited : (668)

References (288)
  • 1
    • 0029922621 scopus 로고    scopus 로고
    • p53 tumor suppressor gene. From the basic research laboratory to the clinic - An abridged historical perspective
    • In press
    • Harris CC. p53 tumor suppressor gene. From the basic research laboratory to the clinic - an abridged historical perspective. Carcinogenesis. In press.
    • Carcinogenesis
    • Harris, C.C.1
  • 2
  • 4
    • 0028071555 scopus 로고
    • Mutations in the p53 tumor suppressor gene: Clues to cancer etiology and molecular pathogenesis
    • Greenblatt MS, Bennett WP, Hollstein M, Harris CC. Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis. Cancer Res 1994;54:4855-78.
    • (1994) Cancer Res , vol.54 , pp. 4855-4878
    • Greenblatt, M.S.1    Bennett, W.P.2    Hollstein, M.3    Harris, C.C.4
  • 5
    • 0027235369 scopus 로고
    • A death in the life of p53
    • Lane DP. A death in the life of p53 [news; see comment citations in Medline]. Nature 1993;362:786-7.
    • (1993) Nature , vol.362 , pp. 786-787
    • Lane, D.P.1
  • 6
    • 0028456527 scopus 로고
    • Relationship of p53 to the control of apoptotic cell death
    • Oren M. Relationship of p53 to the control of apoptotic cell death. Semin Cancer Biol 1994;5:221-7.
    • (1994) Semin Cancer Biol , vol.5 , pp. 221-227
    • Oren, M.1
  • 7
    • 0027999617 scopus 로고
    • Structure and function of p53 in normal cells and their aberrations in cancer cells: Projection on the hematologic cell lineages
    • Prokocimer M, Rotter V. Structure and function of p53 in normal cells and their aberrations in cancer cells: projection on the hematologic cell lineages. Blood 1994;84:2391-411.
    • (1994) Blood , vol.84 , pp. 2391-2411
    • Prokocimer, M.1    Rotter, V.2
  • 9
    • 0029972806 scopus 로고    scopus 로고
    • p53: Puzzle and paradigm
    • Ko LJ., Prives C. p53: puzzle and paradigm. Genes Dev 1996;10:1054-72.
    • (1996) Genes Dev , vol.10 , pp. 1054-1072
    • Ko, L.J.1    Prives, C.2
  • 10
    • 0027109075 scopus 로고
    • Cancer. p53, guardian of the genome
    • Lane DP. Cancer. p53, guardian of the genome [news; see comment citations in Medline]. Nature 1992;358:15-6.
    • (1992) Nature , vol.358 , pp. 15-16
    • Lane, D.P.1
  • 11
    • 9244232804 scopus 로고    scopus 로고
    • Nitric oxide-induced p53 accumulation and regulation of inducible nitric oxide synthase expression by wild-type p53
    • Forrester K, Ambs S, Lupold SE, Kapust RB, Spillare EA, Weinberg WC, et al. Nitric oxide-induced p53 accumulation and regulation of inducible nitric oxide synthase expression by wild-type p53. Proc Natl Acad Sci USA 1996;93:2442-7.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 2442-2447
    • Forrester, K.1    Ambs, S.2    Lupold, S.E.3    Kapust, R.B.4    Spillare, E.A.5    Weinberg, W.C.6
  • 12
    • 0021616838 scopus 로고
    • UV irradiation stimulates levels of p53 cellular tumor antigen in nontransformed mouse cells
    • Maltzman W, Czyzyk L. UV irradiation stimulates levels of p53 cellular tumor antigen in nontransformed mouse cells. Mol Cell Biol 1984;4:1689-94.
    • (1984) Mol Cell Biol , vol.4 , pp. 1689-1694
    • Maltzman, W.1    Czyzyk, L.2
  • 14
    • 0026496885 scopus 로고
    • A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia
    • Kastan MB, Zhan Q, el-Deiry WS, Carrier F, Jacks T, Walsh WV, et al. A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia. Cell 1992;71:587-97.
    • (1992) Cell , vol.71 , pp. 587-597
    • Kastan, M.B.1    Zhan, Q.2    El-Deiry, W.S.3    Carrier, F.4    Jacks, T.5    Walsh, W.V.6
  • 16
    • 0028936626 scopus 로고
    • Differential sensitivity of p53(-) and p53(+) cells to caffeine-induced radiosensitization and override of G2 delay
    • Powell SN, DeFrank JS, Connell P, Eogan M, Preffer F, Dombkowski D, et al. Differential sensitivity of p53(-) and p53(+) cells to caffeine-induced radiosensitization and override of G2 delay. Cancer Res 1995; 55:1643-8.
    • (1995) Cancer Res , vol.55 , pp. 1643-1648
    • Powell, S.N.1    DeFrank, J.S.2    Connell, P.3    Eogan, M.4    Preffer, F.5    Dombkowski, D.6
  • 17
    • 0028204160 scopus 로고
    • DNA strand breaks: The DNA template alterations that trigger p53-dependent DNA damage response pathways
    • Nelson WG, Kastan MB. DNA strand breaks: the DNA template alterations that trigger p53-dependent DNA damage response pathways. Mol Cell Biol 1994;14:1815-23.
    • (1994) Mol Cell Biol , vol.14 , pp. 1815-1823
    • Nelson, W.G.1    Kastan, M.B.2
  • 18
    • 0025639158 scopus 로고
    • The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53
    • Scheffner M, Wemess BA, Huibregtse JM, Levine AJ, Howley PM. The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53. Cell 1990;63:1129-36.
    • (1990) Cell , vol.63 , pp. 1129-1136
    • Scheffner, M.1    Wemess, B.A.2    Huibregtse, J.M.3    Levine, A.J.4    Howley, P.M.5
  • 19
    • 0027332996 scopus 로고
    • Differential induction of transcriptionally active p53 following UV or ionizing radiation: Defects in chromosome instability syndromes?
    • Lu X, Lane DP. Differential induction of transcriptionally active p53 following UV or ionizing radiation: defects in chromosome instability syndromes? Cell 1993;75:765-78.
    • (1993) Cell , vol.75 , pp. 765-778
    • Lu, X.1    Lane, D.P.2
  • 20
    • 0027970713 scopus 로고
    • DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts
    • Di Leonardo A, Linke SP, Clarkin K, Wahl GM. DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts. Genes Dev 1994;8:2540-51.
    • (1994) Genes Dev , vol.8 , pp. 2540-2551
    • Di Leonardo, A.1    Linke, S.P.2    Clarkin, K.3    Wahl, G.M.4
  • 21
    • 0029897210 scopus 로고    scopus 로고
    • Sensitivity and selectivity of the DNA damage sensor responsible for activating p53-dependent G1 arrest
    • Huang LC, Clarkin KC, Wahl GM. Sensitivity and selectivity of the DNA damage sensor responsible for activating p53-dependent G1 arrest. Proc Natl Acad Sci U S A 1996;93:4827-32.
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 4827-4832
    • Huang, L.C.1    Clarkin, K.C.2    Wahl, G.M.3
  • 22
    • 0029055808 scopus 로고
    • Activation of p53 sequence-specific DNA binding by short single strands of DNA requires the p53 C-terminus
    • Jayaraman J, Prives C. Activation of p53 sequence-specific DNA binding by short single strands of DNA requires the p53 C-terminus. Cell 1995; 81:1021-9.
    • (1995) Cell , vol.81 , pp. 1021-1029
    • Jayaraman, J.1    Prives, C.2
  • 23
    • 0028228913 scopus 로고
    • Human p53 directs DNA strand reassociation and is photolabelled by 8-azido ATP
    • Brain R, Jenkins JR. Human p53 directs DNA strand reassociation and is photolabelled by 8-azido ATP. Oncogene 1994;9:1775-80.
    • (1994) Oncogene , vol.9 , pp. 1775-1780
    • Brain, R.1    Jenkins, J.R.2
  • 24
    • 0027284915 scopus 로고
    • p53-catalyzed annealing of complementary single-stranded nucleic acids
    • Oberosler P, Hloch P, Ramsperger U, Stahl H. p53-catalyzed annealing of complementary single-stranded nucleic acids. EMBO J 1993;12:2389-96.
    • (1993) EMBO J , vol.12 , pp. 2389-2396
    • Oberosler, P.1    Hloch, P.2    Ramsperger, U.3    Stahl, H.4
  • 25
    • 0026018256 scopus 로고
    • DNA binding domain is contained in the C-terminus of wild type p53 protein
    • Foord OS, Bhattacharya P, Reich Z, Rotter V. DNA binding domain is contained in the C-terminus of wild type p53 protein. Nucleic Acids Res 1991;19:5191-8.
    • (1991) Nucleic Acids Res , vol.19 , pp. 5191-5198
    • Foord, O.S.1    Bhattacharya, P.2    Reich, Z.3    Rotter, V.4
  • 27
    • 0029013273 scopus 로고
    • p53 and its 14kDa C-terminal domain recognize primary DNA damage in the form of insertion/deletion mismatches
    • Lee S, Elenbaas B, Levine A, Griffith J. p53 and its 14kDa C-terminal domain recognize primary DNA damage in the form of insertion/deletion mismatches. Cell 1995;81:1013-20.
    • (1995) Cell , vol.81 , pp. 1013-1020
    • Lee, S.1    Elenbaas, B.2    Levine, A.3    Griffith, J.4
  • 28
    • 0027496935 scopus 로고
    • The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases
    • Harper JW, Adami GR, Wei N, Keyomarsi K, Elledge SJ. The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases.Cell 1993;75:805-16.
    • (1993) Cell , vol.75 , pp. 805-816
    • Harper, J.W.1    Adami, G.R.2    Wei, N.3    Keyomarsi, K.4    Elledge, S.J.5
  • 31
    • 0028569767 scopus 로고
    • Interaction of the p53-regulated protein GADD45 with proliferating cell nuclear antigen
    • Smith ML, Chen IT, Zhan Q, Bae I. Chen CY, Gilmer TM, et al. Interaction of the p53-regulated protein GADD45 with proliferating cell nuclear antigen [see comment citations in Medline]. Science 1994;266:1376-80.
    • (1994) Science , vol.266 , pp. 1376-1380
    • Smith, M.L.1    Chen, I.T.2    Zhan, Q.3    Bae, I.4    Chen, C.Y.5    Gilmer, T.M.6
  • 32
    • 0028074603 scopus 로고
    • Differential effects by the p21 CDK inhibitor on PCNA-dependent DNA replication and repair
    • Li R, Waga S, Hannon GJ, Beach D, Stillman B. Differential effects by the p21 CDK inhibitor on PCNA-dependent DNA replication and repair. Nature 1994;371:534-7.
    • (1994) Nature , vol.371 , pp. 534-537
    • Li, R.1    Waga, S.2    Hannon, G.J.3    Beach, D.4    Stillman, B.5
  • 33
    • 0028238213 scopus 로고
    • Immediate early up-regulation of bax expression by p53 but not TGF beta 1: A paradigm for distinct apoptotic pathways
    • Selvakumaran M, Lin HK, Miyashita T, Wang HG, Krajewski S, Reed JC, et al. Immediate early up-regulation of bax expression by p53 but not TGF beta 1: a paradigm for distinct apoptotic pathways. Oncogene 1994; 9:1791-8.
    • (1994) Oncogene , vol.9 , pp. 1791-1798
    • Selvakumaran, M.1    Lin, H.K.2    Miyashita, T.3    Wang, H.G.4    Krajewski, S.5    Reed, J.C.6
  • 34
    • 0028883179 scopus 로고
    • Tumor suppressor p53 is a direct transcriptional activator of the human bax gene
    • Miyashita T, Reed JC. Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Cell 1995;80:293-9.
    • (1995) Cell , vol.80 , pp. 293-299
    • Miyashita, T.1    Reed, J.C.2
  • 35
    • 0028335717 scopus 로고
    • Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo
    • Miyashita T, Krajewski S, Krajewska M, Wang, HG, Lin HK, Lieberman DA, et al. Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo. Oncogene 1994;9:1799-805.
    • (1994) Oncogene , vol.9 , pp. 1799-1805
    • Miyashita, T.1    Krajewski, S.2    Krajewska, M.3    Wang, H.G.4    Lin, H.K.5    Lieberman, D.A.6
  • 37
    • 0027316149 scopus 로고
    • The p53 activation domain binds the TATA box-binding polypeptide in Holo-TFIID, and a neighboring p53 domain inhibits transcription
    • Liu X, Miller CW, Koeffler PH, Berk AJ. The p53 activation domain binds the TATA box-binding polypeptide in Holo-TFIID, and a neighboring p53 domain inhibits transcription. Mol Cell Biol 1993;13:3291-300.
    • (1993) Mol Cell Biol , vol.13 , pp. 3291-3300
    • Liu, X.1    Miller, C.W.2    Koeffler, P.H.3    Berk, A.J.4
  • 38
    • 0027446860 scopus 로고
    • Direct interaction between the transcriptional activation domain of human p53 and the TATA box-binding protein
    • Truant R, Xiao H, Ingles CJ, Greenblatt J. Direct interaction between the transcriptional activation domain of human p53 and the TATA box-binding protein. J Biol Chem 1993;268:2284-7.
    • (1993) J Biol Chem , vol.268 , pp. 2284-2287
    • Truant, R.1    Xiao, H.2    Ingles, C.J.3    Greenblatt, J.4
  • 39
    • 0027522235 scopus 로고
    • Cooperative DNA binding of p53 with TFIID (TBP): A possible mechanism for transcriptional activation
    • published erratum appears in Genes Dev 1993:7:2652
    • Chen X, Farmer G, Zhu H, Prywes R, Prives C. Cooperative DNA binding of p53 with TFIID (TBP): a possible mechanism for transcriptional activation [published erratum appears in Genes Dev 1993:7:2652]. Genes Dev 1993;7:1837-49.
    • (1993) Genes Dev , vol.7 , pp. 1837-1849
    • Chen, X.1    Farmer, G.2    Zhu, H.3    Prywes, R.4    Prives, C.5
  • 40
    • 0028791870 scopus 로고
    • p53 inhibits DNA replication in vitro in a DNA-binding-dependent manner
    • Miller SD, Farmer G, Prives C. p53 inhibits DNA replication in vitro in a DNA-binding-dependent manner. Mol Cell Biol 1995;15:6554-60.
    • (1995) Mol Cell Biol , vol.15 , pp. 6554-6560
    • Miller, S.D.1    Farmer, G.2    Prives, C.3
  • 41
    • 0029028158 scopus 로고
    • A direct effect of activated human p53 on nuclear DNA replication
    • Cox LS, Hupp T, Midgley CA, Lane DP. A direct effect of activated human p53 on nuclear DNA replication. EMBO J 1995;14:2099-105.
    • (1995) EMBO J , vol.14 , pp. 2099-2105
    • Cox, L.S.1    Hupp, T.2    Midgley, C.A.3    Lane, D.P.4
  • 42
    • 0027358857 scopus 로고
    • Inhibition of DNA replication factor RPA by p53
    • Dutta A, Ruppert JM, Aster JC, Winchester E. Inhibition of DNA replication factor RPA by p53 [see comment citation in Medline]. Nature 1993; 365:79-82.
    • (1993) Nature , vol.365 , pp. 79-82
    • Dutta, A.1    Ruppert, J.M.2    Aster, J.C.3    Winchester, E.4
  • 43
    • 0028989236 scopus 로고
    • p53 modulation of TFIIH-associated nucleotide excision repair activity
    • Wang XW, Yeh H, Schaeffer L, Roy R, Moncollin V, Egly JM, et al. p53 modulation of TFIIH-associated nucleotide excision repair activity. Nat Genet 1995;10:188-95.
    • (1995) Nat Genet , vol.10 , pp. 188-195
    • Wang, X.W.1    Yeh, H.2    Schaeffer, L.3    Roy, R.4    Moncollin, V.5    Egly, J.M.6
  • 44
    • 0001655748 scopus 로고
    • Hepatitis B virus X protein inhibits p53 sequence-specific DNA binding, transcriptional activity, and association with transcription factor ERCC3
    • Wang XW, Forrester K, Yeh H, Feitelson MA, Gu JR, Harris CC. Hepatitis B virus X protein inhibits p53 sequence-specific DNA binding, transcriptional activity, and association with transcription factor ERCC3. Proc Natl Acad Sci U S A 1994;91:2230-4.
    • (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 2230-2234
    • Wang, X.W.1    Forrester, K.2    Yeh, H.3    Feitelson, M.A.4    Gu, J.R.5    Harris, C.C.6
  • 45
    • 0027983521 scopus 로고
    • Binding of basal transcription factor TFIIH to the acidic activation domains of VP16 and p53
    • Xiao H, Pearson A, Coulombe B, Truant R, Zhang S, Regier JL, et al. Binding of basal transcription factor TFIIH to the acidic activation domains of VP16 and p53. Mol Cell Biol 1994;14:7013-24.
    • (1994) Mol Cell Biol , vol.14 , pp. 7013-7024
    • Xiao, H.1    Pearson, A.2    Coulombe, B.3    Truant, R.4    Zhang, S.5    Regier, J.L.6
  • 46
    • 0029880959 scopus 로고    scopus 로고
    • Functional interactions between p53 and the TFIIH complex are affected by tumour-associated mutations
    • Leveillard T, Andera L, Bissonnette N, Schaeffer L, Bracco L, Egly JM. et al. Functional interactions between p53 and the TFIIH complex are affected by tumour-associated mutations. EMBO J 1996;15:1615-24.
    • (1996) EMBO J , vol.15 , pp. 1615-1624
    • Leveillard, T.1    Andera, L.2    Bissonnette, N.3    Schaeffer, L.4    Bracco, L.5    Egly, J.M.6
  • 49
    • 0028070989 scopus 로고
    • p53-dependent apoptosis in the absence of transcriptional activation of p53-target genes
    • Caelles C, Helmberg A, Karin M. p53-dependent apoptosis in the absence of transcriptional activation of p53-target genes [see comment citation in Medline]. Nature 1994;370:220-3.
    • (1994) Nature , vol.370 , pp. 220-223
    • Caelles, C.1    Helmberg, A.2    Karin, M.3
  • 50
    • 0029092356 scopus 로고
    • Induction of apoptosis in HeLa cells by trans-activation-deficient p53
    • Haupt Y, Rowan S, Shaulian E, Vousden KH, Oren M. Induction of apoptosis in HeLa cells by trans-activation-deficient p53. Genes Dev 1995; 9:2170-83.
    • (1995) Genes Dev , vol.9 , pp. 2170-2183
    • Haupt, Y.1    Rowan, S.2    Shaulian, E.3    Vousden, K.H.4    Oren, M.5
  • 51
    • 0028034199 scopus 로고
    • Myc-mediated apoptosis requires wild-type p53 in a manner independent of cell cycle arrest and the ability of p53 to induce p21Waf1/cip1
    • Wagner AJ, Kokontis JM, Hay N. Myc-mediated apoptosis requires wild-type p53 in a manner independent of cell cycle arrest and the ability of p53 to induce p21Waf1/cip1. Genes Dev 1994;8:2817-30.
    • (1994) Genes Dev , vol.8 , pp. 2817-2830
    • Wagner, A.J.1    Kokontis, J.M.2    Hay, N.3
  • 53
    • 0029595337 scopus 로고
    • c-Myc induces apoptosis in epithelial cells by both p53-dependent and p53-independent mechanisms
    • Sakamuro D, Eviner V, Elliott KJ, Showe L, White E, Prendergast GC. c-Myc induces apoptosis in epithelial cells by both p53-dependent and p53-independent mechanisms. Oncogene 1995;11:2411-8.
    • (1995) Oncogene , vol.11 , pp. 2411-2418
    • Sakamuro, D.1    Eviner, V.2    Elliott, K.J.3    Showe, L.4    White, E.5    Prendergast, G.C.6
  • 54
    • 0014253229 scopus 로고
    • Alterations in pancreatic and hepatic ultrastructure following acute cycloheximide intoxication
    • Harris C, Grady H, Svoboda D. Alterations in pancreatic and hepatic ultrastructure following acute cycloheximide intoxication. J Ultrastruct Res 1968;22:240-51.
    • (1968) J Ultrastruct Res , vol.22 , pp. 240-251
    • Harris, C.1    Grady, H.2    Svoboda, D.3
  • 55
    • 0027516430 scopus 로고
    • Protein or RNA synthesis inhibition induces apoptosis of mature human CD4+ T cell blasts
    • Martin SJ. Protein or RNA synthesis inhibition induces apoptosis of mature human CD4+ T cell blasts. Immunol Lett 1993;35:125-34.
    • (1993) Immunol Lett , vol.35 , pp. 125-134
    • Martin, S.J.1
  • 56
    • 0026515825 scopus 로고
    • Ultraviolet B-induced DNA fragmentation (apoptosis) in activated T-lymphocytes and Jurkat cells is augmented by inhibition of RNA and protein synthesis
    • Bazar LS, Deeg HJ. Ultraviolet B-induced DNA fragmentation (apoptosis) in activated T-lymphocytes and Jurkat cells is augmented by inhibition of RNA and protein synthesis. Exp Hematol 1992;20:80-6.
    • (1992) Exp Hematol , vol.20 , pp. 80-86
    • Bazar, L.S.1    Deeg, H.J.2
  • 57
    • 0029036351 scopus 로고
    • Apoptosis is induced in BHK cells by the tsBN462/13 mutation in the CCG1/TAFJI250 subunit of the TFIID basal transcription factor
    • Sekiguchi T, Nakashima T, Hayashida T, Kuraoka A, Hashimoto S, Tsuchida N, et al. Apoptosis is induced in BHK cells by the tsBN462/13 mutation in the CCG1/TAFJI250 subunit of the TFIID basal transcription factor. Exp Cell Res 1995;218:490-8.
    • (1995) Exp Cell Res , vol.218 , pp. 490-498
    • Sekiguchi, T.1    Nakashima, T.2    Hayashida, T.3    Kuraoka, A.4    Hashimoto, S.5    Tsuchida, N.6
  • 58
    • 0029785723 scopus 로고    scopus 로고
    • Blockage of RNA polymerase as a possible trigger for UV light-induced apoptosis
    • In press
    • Ljungman M, Zhang F. Blockage of RNA polymerase as a possible trigger for UV light-induced apoptosis. Oncogene. In press.
    • Oncogene
    • Ljungman, M.1    Zhang, F.2
  • 60
    • 0028978183 scopus 로고
    • Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control
    • Deng C, Zhang P, Harper JW, Elledge SJ, Leder P. Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control. Cell 1995;82:675-84.
    • (1995) Cell , vol.82 , pp. 675-684
    • Deng, C.1    Zhang, P.2    Harper, J.W.3    Elledge, S.J.4    Leder, P.5
  • 61
    • 0028803770 scopus 로고
    • Failure of programmed cell death and differentiation as causes of tumors: Some simple mathmatical models
    • Tomlinson IP, Bodmer WF. Failure of programmed cell death and differentiation as causes of tumors: some simple mathmatical models. Proc Natl Acad Sci U S A 1995;92:11130-4.
    • (1995) Proc Natl Acad Sci U S A , vol.92 , pp. 11130-11134
    • Tomlinson, I.P.1    Bodmer, W.F.2
  • 62
    • 0030025773 scopus 로고    scopus 로고
    • Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours
    • Graeber TG, Osmanian C, Jacks T, Housman DE, Koch CJ, Lowe SW, et al. Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours [see comment citations in Medline]. Nature 1996; 379:88-91.
    • (1996) Nature , vol.379 , pp. 88-91
    • Graeber, T.G.1    Osmanian, C.2    Jacks, T.3    Housman, D.E.4    Koch, C.J.5    Lowe, S.W.6
  • 63
    • 0025937489 scopus 로고
    • Constitutive c-myc expression in an IL-3-dependent myeloid cell line suppresses cell cycle arrest and accelerates apoptosis
    • Askew DS, Ashmun RA, Simmons BC, Cleveland JL. Constitutive c-myc expression in an IL-3-dependent myeloid cell line suppresses cell cycle arrest and accelerates apoptosis. Oncogene 1991;6:1915-22.
    • (1991) Oncogene , vol.6 , pp. 1915-1922
    • Askew, D.S.1    Ashmun, R.A.2    Simmons, B.C.3    Cleveland, J.L.4
  • 64
    • 0026639932 scopus 로고
    • The adenovirus E1A proteins induce apoptosis, which is inhibited by the E1B 19-kDa and Bcl-2 proteins
    • published erratum appears in Proc Natl Acad Sci U S A 1992;89:9974
    • Rao L, Debbas M, Sabbatini P, Hockenbery D, Korsmeyer S, White E. The adenovirus E1A proteins induce apoptosis, which is inhibited by the E1B 19-kDa and Bcl-2 proteins [published erratum appears in Proc Natl Acad Sci U S A 1992;89:9974]. Proc Natl Acad Sci U S A 1992;89:7742-6.
    • (1992) Proc Natl Acad Sci U S A , vol.89 , pp. 7742-7746
    • Rao, L.1    Debbas, M.2    Sabbatini, P.3    Hockenbery, D.4    Korsmeyer, S.5    White, E.6
  • 66
    • 0028087776 scopus 로고
    • Tumour biology. p53, guardian of Rb
    • White E. Tumour biology. p53, guardian of Rb [news; see comment citation in Medline]. Nature 1994;371:21-2.
    • (1994) Nature , vol.371 , pp. 21-22
    • White, E.1
  • 67
    • 0028334011 scopus 로고
    • Altered cell cycle regulation in the lens of HPV-16 E6 or E7 transgenic mice: Implications for tumor suppressor gene function in development
    • Pan H, Griep AE. Altered cell cycle regulation in the lens of HPV-16 E6 or E7 transgenic mice: implications for tumor suppressor gene function in development. Genes Dev 1994;8:1285-99.
    • (1994) Genes Dev , vol.8 , pp. 1285-1299
    • Pan, H.1    Griep, A.E.2
  • 68
    • 0027934570 scopus 로고
    • p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens
    • Morgenbesser SD, Williams BO, Jacks T, DePinho RA. p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens [see comment citation in Medline]. Nature 1994;371:72-4.
    • (1994) Nature , vol.371 , pp. 72-74
    • Morgenbesser, S.D.1    Williams, B.O.2    Jacks, T.3    DePinho, R.A.4
  • 70
  • 71
    • 0026444519 scopus 로고
    • The molecular genetics of lung cancer
    • Carbone DP, Minna JA. The molecular genetics of lung cancer. Adv Intern Med 1992;37:153-71.
    • (1992) Adv Intern Med , vol.37 , pp. 153-171
    • Carbone, D.P.1    Minna, J.A.2
  • 72
    • 0029586291 scopus 로고
    • Molecular genetics of lung cancer
    • Greenblatt MS, Harris CC. Molecular genetics of lung cancer. Cancer Surv 1995;25:293-313.
    • (1995) Cancer Surv , vol.25 , pp. 293-313
    • Greenblatt, M.S.1    Harris, C.C.2
  • 73
    • 0027768579 scopus 로고
    • Braking the cycle
    • Hunter T. Braking the cycle. Cell 1993;75:839-41.
    • (1993) Cell , vol.75 , pp. 839-841
    • Hunter, T.1
  • 74
    • 0029033861 scopus 로고
    • The retinoblastoma protein and cell cycle control
    • Weinberg RA. The retinoblastoma protein and cell cycle control. Cell 1995;81:323-30.
    • (1995) Cell , vol.81 , pp. 323-330
    • Weinberg, R.A.1
  • 75
    • 0026718812 scopus 로고
    • The p53 tumor suppressor protein, a modulator of cell proliferation
    • Ullrich SJ, Anderson CW, Mercer WE, Appella E. The p53 tumor suppressor protein, a modulator of cell proliferation. J Biol Chem 1992;267: 15259-62.
    • (1992) J Biol Chem , vol.267 , pp. 15259-15262
    • Ullrich, S.J.1    Anderson, C.W.2    Mercer, W.E.3    Appella, E.4
  • 76
    • 0028455516 scopus 로고
    • Post-translational modification of p53
    • Meek DW. Post-translational modification of p53. Semin Cancer Biol 1994;5:203-10.
    • (1994) Semin Cancer Biol , vol.5 , pp. 203-210
    • Meek, D.W.1
  • 78
    • 0025267454 scopus 로고
    • The p53 nuclear localisation signal is structurally linked to a p34cdc2 kinase motif
    • Addison C, Jenkins JR, Sturzbecher HW. The p53 nuclear localisation signal is structurally linked to a p34cdc2 kinase motif. Oncogene 1990;5: 423-6.
    • (1990) Oncogene , vol.5 , pp. 423-426
    • Addison, C.1    Jenkins, J.R.2    Sturzbecher, H.W.3
  • 79
    • 0025441236 scopus 로고
    • p53 interacts with p34cdc2 in mammalian cells: Implications for cell cycle control and oncogenesis
    • Sturzbecher HW, Maimets T, Chumakov P, Brain R, Addison C, Simanis V, et al. p53 interacts with p34cdc2 in mammalian cells: implications for cell cycle control and oncogenesis. Oncogene 1990;5:795-801.
    • (1990) Oncogene , vol.5 , pp. 795-801
    • Sturzbecher, H.W.1    Maimets, T.2    Chumakov, P.3    Brain, R.4    Addison, C.5    Simanis, V.6
  • 80
    • 0025143302 scopus 로고
    • The p53 tumour suppressor protein is phosphorylated at serine 389 by casein kinase II
    • Meek DW, Simon S, Kikkawa U, Eckhart W. The p53 tumour suppressor protein is phosphorylated at serine 389 by casein kinase II. EMBO J 1990;9:3253-60.
    • (1990) EMBO J , vol.9 , pp. 3253-3260
    • Meek, D.W.1    Simon, S.2    Kikkawa, U.3    Eckhart, W.4
  • 81
    • 0025224761 scopus 로고
    • Human cells contain a DNA-activated protein kinase that phosphorylates simian virus 40 T antigen, mouse p53, and the human Ku autoantigen
    • Lees-Miller SP, Chen YR, Anderson CW. Human cells contain a DNA-activated protein kinase that phosphorylates simian virus 40 T antigen, mouse p53, and the human Ku autoantigen. Mol Cell Biol 1990;10:6472-81.
    • (1990) Mol Cell Biol , vol.10 , pp. 6472-6481
    • Lees-Miller, S.P.1    Chen, Y.R.2    Anderson, C.W.3
  • 82
    • 0026663552 scopus 로고
    • Phosphorylation of the p53 tumour-suppressor protein at three N-terminal sites by a novel casein kinase I-like enzyme
    • Milne DM, Palmer RH, Campbell DG, Meek DW. Phosphorylation of the p53 tumour-suppressor protein at three N-terminal sites by a novel casein kinase I-like enzyme. Oncogene 1992;7:1361-9.
    • (1992) Oncogene , vol.7 , pp. 1361-1369
    • Milne, D.M.1    Palmer, R.H.2    Campbell, D.G.3    Meek, D.W.4
  • 83
    • 0026437598 scopus 로고
    • Characterization of the tumor suppressor protein p53 as a protein kinase C substrate and a S100b-binding protein
    • Baudier J, Delphin C, Grunwald D, Khochbin S, Lawrence JJ. Characterization of the tumor suppressor protein p53 as a protein kinase C substrate and a S100b-binding protein. Proc Natl Acad Sci U S A 1992; 89:11627-31.
    • (1992) Proc Natl Acad Sci U S A , vol.89 , pp. 11627-11631
    • Baudier, J.1    Delphin, C.2    Grunwald, D.3    Khochbin, S.4    Lawrence, J.J.5
  • 84
    • 0028363749 scopus 로고
    • Phosphorylation of the tumor suppressor protein p53 by mitogen-activated protein kinases
    • Milne DM, Campbell DG, Caudwell FB, Meek DW. Phosphorylation of the tumor suppressor protein p53 by mitogen-activated protein kinases. J Biol Chem 1994;269:9253-60.
    • (1994) J Biol Chem , vol.269 , pp. 9253-9260
    • Milne, D.M.1    Campbell, D.G.2    Caudwell, F.B.3    Meek, D.W.4
  • 85
    • 0028966941 scopus 로고
    • p53 is phosphorylated in vitro and in vivo by an ultraviolet radiation-induced protein kinase characteristic of the c-Jun kinase, JNK1
    • Milne DM, Campbell LE, Campbell DG, Meek DW. p53 is phosphorylated in vitro and in vivo by an ultraviolet radiation-induced protein kinase characteristic of the c-Jun kinase, JNK1. J Biol Chem 1995; 270:5511-8.
    • (1995) J Biol Chem , vol.270 , pp. 5511-5518
    • Milne, D.M.1    Campbell, L.E.2    Campbell, D.G.3    Meek, D.W.4
  • 86
    • 0029003061 scopus 로고
    • Increased and altered DNA binding of human p53 by S and G2/M but not G1 cyclin-dependent kinases
    • Wang Y, Prives C. Increased and altered DNA binding of human p53 by S and G2/M but not G1 cyclin-dependent kinases. Nature 1995;376:88-91.
    • (1995) Nature , vol.376 , pp. 88-91
    • Wang, Y.1    Prives, C.2
  • 87
    • 0028519273 scopus 로고
    • Allosteric activation of latent p53 tetramers
    • Hupp TR, Lane DP. Allosteric activation of latent p53 tetramers. Curr Biol 1995;4:865-75.
    • (1995) Curr Biol , vol.4 , pp. 865-875
    • Hupp, T.R.1    Lane, D.P.2
  • 88
    • 0026448672 scopus 로고
    • Regulation of the specific DNA binding function of p53
    • Hupp TR, Meek DW, Midgley CA, Lane DP. Regulation of the specific DNA binding function of p53. Cell 1992;71:875-86.
    • (1992) Cell , vol.71 , pp. 875-886
    • Hupp, T.R.1    Meek, D.W.2    Midgley, C.A.3    Lane, D.P.4
  • 89
    • 0028051952 scopus 로고
    • The protein kinase C activator, phorbol ester, cooperates with the wild-type p53 species of Ras-transformed embryo fibroblasts growth arrest
    • Delphin C, Baudier J. The protein kinase C activator, phorbol ester, cooperates with the wild-type p53 species of Ras-transformed embryo fibroblasts growth arrest. J Biol Chem 1994;269:29579-87.
    • (1994) J Biol Chem , vol.269 , pp. 29579-29587
    • Delphin, C.1    Baudier, J.2
  • 90
    • 0028143464 scopus 로고
    • The carboxy-terminal serine 392 phosphorylation site of human p53 is not required for wild-type activities
    • Fiscella M, Zambrano N, Ullrich SJ, Unger T, Lin D, Cho B, et al. The carboxy-terminal serine 392 phosphorylation site of human p53 is not required for wild-type activities. Oncogene 1994;9:3249-57.
    • (1994) Oncogene , vol.9 , pp. 3249-3257
    • Fiscella, M.1    Zambrano, N.2    Ullrich, S.J.3    Unger, T.4    Lin, D.5    Cho, B.6
  • 91
    • 0028037663 scopus 로고
    • Tumor-promoting phorbol ester transiently down-modulates the p53 level and blocks the cell cycle
    • Skouv J, Jensen PO, Forchhammer J, Larsen JK, Lund LR. Tumor-promoting phorbol ester transiently down-modulates the p53 level and blocks the cell cycle. Cell Growth Differ 1994;5:329-40.
    • (1994) Cell Growth Differ , vol.5 , pp. 329-340
    • Skouv, J.1    Jensen, P.O.2    Forchhammer, J.3    Larsen, J.K.4    Lund, L.R.5
  • 92
    • 0027756186 scopus 로고
    • p53: At the crossroads of molecular carcinogenesis and risk assessment
    • Harris CC. p53: at the crossroads of molecular carcinogenesis and risk assessment. Science 1993;262:1980-1.
    • (1993) Science , vol.262 , pp. 1980-1981
    • Harris, C.C.1
  • 93
  • 94
    • 0029996282 scopus 로고    scopus 로고
    • Deletions and insertions in the p53 tumor suppressor gene in human cancers: Confirmation of the DNA polymerase slippage/misalignment model
    • Greenblatt MS, Grollman AP, Harris CC. Deletions and insertions in the p53 tumor suppressor gene in human cancers: confirmation of the DNA polymerase slippage/misalignment model. Cancer Res 1996;56:2130-6.
    • (1996) Cancer Res , vol.56 , pp. 2130-2136
    • Greenblatt, M.S.1    Grollman, A.P.2    Harris, C.C.3
  • 95
    • 0027532034 scopus 로고
    • Short direct repeats flanking deletions, and duplicating insertions in p53 gene in human cancers
    • Jego N, Thomas G, Hamelin R. Short direct repeats flanking deletions, and duplicating insertions in p53 gene in human cancers. Oncogene 1993;8:209-13.
    • (1993) Oncogene , vol.8 , pp. 209-213
    • Jego, N.1    Thomas, G.2    Hamelin, R.3
  • 96
    • 0025762012 scopus 로고
    • Gene deletions causing human genetic disease: Mechanisms of mutagenesis and the role of the local DNA sequence environment
    • Krawczak M, Cooper DN. Gene deletions causing human genetic disease: mechanisms of mutagenesis and the role of the local DNA sequence environment. Hum Genet 1991;86:425-41.
    • (1991) Hum Genet , vol.86 , pp. 425-441
    • Krawczak, M.1    Cooper, D.N.2
  • 97
    • 0026669469 scopus 로고
    • p53 function and dysfunction
    • Vogelstein B, Kinzler KW. p53 function and dysfunction. Cell 1992;70: 523-6.
    • (1992) Cell , vol.70 , pp. 523-526
    • Vogelstein, B.1    Kinzler, K.W.2
  • 98
    • 0028922929 scopus 로고
    • p53 transcriptional activation mediated by coactivators TAFII40 and TAFII60
    • Thut CJ, Chen JL, Klemm R, Tjian R. p53 transcriptional activation mediated by coactivators TAFII40 and TAFII60. Science 1995;267:100-4.
    • (1995) Science , vol.267 , pp. 100-104
    • Thut, C.J.1    Chen, J.L.2    Klemm, R.3    Tjian, R.4
  • 99
    • 0028979005 scopus 로고
    • Human TAFII31 protein is a transcriptional coactivator of the p53 protein
    • Lu H, Levine AJ. Human TAFII31 protein is a transcriptional coactivator of the p53 protein. Proc Natl Acad Sci U S A 1995;92:5154-8.
    • (1995) Proc Natl Acad Sci U S A , vol.92 , pp. 5154-5158
    • Lu, H.1    Levine, A.J.2
  • 100
    • 0025193635 scopus 로고
    • Transcriptional activation by wild-type but not transforming mutants of the p53 anti-oncogene
    • Raycroft L, Wu HY, Lozano G. Transcriptional activation by wild-type but not transforming mutants of the p53 anti-oncogene. Science 1990; 249:1049-51.
    • (1990) Science , vol.249 , pp. 1049-1051
    • Raycroft, L.1    Wu, H.Y.2    Lozano, G.3
  • 101
    • 0025024469 scopus 로고
    • Presence of a potent transcription activating sequence in the p53 protein
    • Fields S, Jang SK. Presence of a potent transcription activating sequence in the p53 protein. Science 1990;249:1046-9.
    • (1990) Science , vol.249 , pp. 1046-1049
    • Fields, S.1    Jang, S.K.2
  • 102
    • 0027451298 scopus 로고
    • p53 binds to the TATA-binding protein-TATA complex
    • Martin DW, Munoz RM, Subler MA, Deb S. p53 binds to the TATA-binding protein-TATA complex. J Biol Chem 1993;268:13062-7.
    • (1993) J Biol Chem , vol.268 , pp. 13062-13067
    • Martin, D.W.1    Munoz, R.M.2    Subler, M.A.3    Deb, S.4
  • 103
    • 0027318117 scopus 로고
    • Specific repression of TATA-mediated but not initiator-mediated transcription by wild-type p53
    • Mack DH, Vartikar J, Pipas JM, Laimins LA. Specific repression of TATA-mediated but not initiator-mediated transcription by wild-type p53. Nature 1993;363:281-3.
    • (1993) Nature , vol.363 , pp. 281-283
    • Mack, D.H.1    Vartikar, J.2    Pipas, J.M.3    Laimins, L.A.4
  • 104
    • 0028303752 scopus 로고
    • Several hydrophobic amino acids in the p53 amino-terminal domain are required for transcriptional activation, binding to mdm-2 and the adenovirus 5 E1B 55-kD protein
    • Lin J, Chen J, Elenbaas B, Levine AJ. Several hydrophobic amino acids in the p53 amino-terminal domain are required for transcriptional activation, binding to mdm-2 and the adenovirus 5 E1B 55-kD protein. Genes Dev 1994;8:1235-46.
    • (1994) Genes Dev , vol.8 , pp. 1235-1246
    • Lin, J.1    Chen, J.2    Elenbaas, B.3    Levine, A.J.4
  • 105
    • 0028952841 scopus 로고
    • Crystal structure of the tetramerization domain of the p53 tumor suppressor at 1.7 angstroms
    • Jeffrey PD, Gorina S, Pavletich NP. Crystal structure of the tetramerization domain of the p53 tumor suppressor at 1.7 angstroms. Science 1995;267:1498-502.
    • (1995) Science , vol.267 , pp. 1498-1502
    • Jeffrey, P.D.1    Gorina, S.2    Pavletich, N.P.3
  • 106
    • 0028124665 scopus 로고
    • High-resolution structure of the oligomerization domain of p53 by multidimensional NMR
    • published erratum appears in Science 1995;267:1515
    • Clore GM, Omichinski JG, Sakaguchi K, Zambrano N, Sakamoto H, Appella E, et al. High-resolution structure of the oligomerization domain of p53 by multidimensional NMR [see comment citation in Medline] [published erratum appears in Science 1995;267:1515]. Science 1994; 265:386-91.
    • (1994) Science , vol.265 , pp. 386-391
    • Clore, G.M.1    Omichinski, J.G.2    Sakaguchi, K.3    Zambrano, N.4    Sakamoto, H.5    Appella, E.6
  • 107
    • 84970061891 scopus 로고
    • Solution structure of the tetrameric minimum transforming domain of p53
    • published erratum appears in Nat Struct Biol 1995;2:81
    • Lee W, Harvey TS, Yin Y, Yau P, Litchfield D, Arrowsmith CH. Solution structure of the tetrameric minimum transforming domain of p53 [published erratum appears in Nat Struct Biol 1995;2:81]. Nat Struc Biol 1994;1:877-90.
    • (1994) Nat Struc Biol , vol.1 , pp. 877-890
    • Lee, W.1    Harvey, T.S.2    Yin, Y.3    Yau, P.4    Litchfield, D.5    Arrowsmith, C.H.6
  • 109
    • 0025732215 scopus 로고
    • Mutational hotspot in the p53 gene in human hepatocellular carcinomas
    • Hsu IC, Metcalf RA, Sun T, Welsh JA, Wang NJ, Harris CC. Mutational hotspot in the p53 gene in human hepatocellular carcinomas [see comment citation in Medline]. Nature 1991;350:427-8.
    • (1991) Nature , vol.350 , pp. 427-428
    • Hsu, I.C.1    Metcalf, R.A.2    Sun, T.3    Welsh, J.A.4    Wang, N.J.5    Harris, C.C.6
  • 110
    • 0025828517 scopus 로고
    • Selective G to T mutations of p53 gene in hepatocellular carcinoma from southern Africa
    • Bressac B, Kew M, Wands J, Ozturk M. Selective G to T mutations of p53 gene in hepatocellular carcinoma from southern Africa [see comment citation in Medline]. Nature 1991;350:429-31.
    • (1991) Nature , vol.350 , pp. 429-431
    • Bressac, B.1    Kew, M.2    Wands, J.3    Ozturk, M.4
  • 111
    • 0026518760 scopus 로고
    • p53 mutations cluster at codon 249 in hepatitis B virus-positive hepatocellular carcinomas from China
    • Scorsone KA, Zhou YZ, Butel JS, Slagle BL. p53 mutations cluster at codon 249 in hepatitis B virus-positive hepatocellular carcinomas from China. Cancer Res 1992;52:1635-8.
    • (1992) Cancer Res , vol.52 , pp. 1635-1638
    • Scorsone, K.A.1    Zhou, Y.Z.2    Butel, J.S.3    Slagle, B.L.4
  • 112
    • 0027210367 scopus 로고
    • Aberrations of p53 gene in human hepatocellular carcinoma from China
    • Li D, Cao Y, He L, Wang NJ, Gu JR. Aberrations of p53 gene in human hepatocellular carcinoma from China. Carcinogenesis 1993;14:169-73.
    • (1993) Carcinogenesis , vol.14 , pp. 169-173
    • Li, D.1    Cao, Y.2    He, L.3    Wang, N.J.4    Gu, J.R.5
  • 113
    • 0030043019 scopus 로고    scopus 로고
    • The 1995 Walter Hubert Lecture-Molecular epidemiology of human cancer: Insights from the mutational analysis of the p53 tumour suppressor gene
    • Harris CC. The 1995 Walter Hubert Lecture-Molecular epidemiology of human cancer: insights from the mutational analysis of the p53 tumour suppressor gene. Br J Cancer 1996;73:261-9.
    • (1996) Br J Cancer , vol.73 , pp. 261-269
    • Harris, C.C.1
  • 114
    • 0028343058 scopus 로고
    • Geographic variation of p53 mutational profile in nonmalignant human liver
    • Aguilar F, Harris CC, Sun T, Hollstein M, Cerutti P. Geographic variation of p53 mutational profile in nonmalignant human liver. Science 1994; 264:1317-9.
    • (1994) Science , vol.264 , pp. 1317-1319
    • Aguilar, F.1    Harris, C.C.2    Sun, T.3    Hollstein, M.4    Cerutti, P.5
  • 115
    • 0027337609 scopus 로고
    • Aflatoxin B1 induces the transversion of G→T in codon 249 of the p53 tumor suppressor gene in human hepatocytes
    • Aguilar F, Hussain SP, Cerutti P. Aflatoxin B1 induces the transversion of G→T in codon 249 of the p53 tumor suppressor gene in human hepatocytes. Proc Natl Acad Sci U S A 1993;90:8586-90.
    • (1993) Proc Natl Acad Sci U S A , vol.90 , pp. 8586-8590
    • Aguilar, F.1    Hussain, S.P.2    Cerutti, P.3
  • 116
    • 0028300183 scopus 로고
    • Hepatocarcinoma-specific mutant p53-249ser induces mitotic activity but has no effect on transforming growth factor beta 1-mediated apoptosis
    • Ponchel F, Puisieux A, Tabone E, Michot JP, Froschl G, Morel AP, et al. Hepatocarcinoma-specific mutant p53-249ser induces mitotic activity but has no effect on transforming growth factor beta 1-mediated apoptosis. Cancer Res 1994;54:2064-8.
    • (1994) Cancer Res , vol.54 , pp. 2064-2068
    • Ponchel, F.1    Puisieux, A.2    Tabone, E.3    Michot, J.P.4    Froschl, G.5    Morel, A.P.6
  • 117
    • 0029027667 scopus 로고
    • Effects of p53 mutants on wild-type p53-mediated transactivation are cell type dependent
    • Forrester K, Lupold SE, Ott VL, Chay CH, Band V, Wang XW, et al. Effects of p53 mutants on wild-type p53-mediated transactivation are cell type dependent. Oncogene 1995;10:2103-11.
    • (1995) Oncogene , vol.10 , pp. 2103-2111
    • Forrester, K.1    Lupold, S.E.2    Ott, V.L.3    Chay, C.H.4    Band, V.5    Wang, X.W.6
  • 118
    • 0025784335 scopus 로고
    • HBV X protein alters the DNA binding specificity of CREB and ATF-2 by protein-protein interactions
    • Maguire HF, Hoeffler JP, Siddiqui A. HBV X protein alters the DNA binding specificity of CREB and ATF-2 by protein-protein interactions. Science 1991;252:842-4.
    • (1991) Science , vol.252 , pp. 842-844
    • Maguire, H.F.1    Hoeffler, J.P.2    Siddiqui, A.3
  • 119
    • 0024797064 scopus 로고
    • The X gene of hepatitis B virus induced growth stimulation and tumorigenic transformation of mouse NIH3T3 cells
    • Shirakata Y, Kawada M, Fujiki Y, Sano H, Oda M, Yaginuma K, et al. The X gene of hepatitis B virus induced growth stimulation and tumorigenic transformation of mouse NIH3T3 cells. Jpn J Cancer Res 1989;80:617-21.
    • (1989) Jpn J Cancer Res , vol.80 , pp. 617-621
    • Shirakata, Y.1    Kawada, M.2    Fujiki, Y.3    Sano, H.4    Oda, M.5    Yaginuma, K.6
  • 120
    • 0025098651 scopus 로고
    • The preS2/S region of integrated hepatitis B virus DNA encodes a transcriptional transactivator
    • Kekule AS, Lauer U, Meyer M, Caselmann WH, Hofschneider PH, Koshy R. The preS2/S region of integrated hepatitis B virus DNA encodes a transcriptional transactivator. Nature 1990;343:457-61.
    • (1990) Nature , vol.343 , pp. 457-461
    • Kekule, A.S.1    Lauer, U.2    Meyer, M.3    Caselmann, W.H.4    Hofschneider, P.H.5    Koshy, R.6
  • 121
    • 0023627343 scopus 로고
    • Transcriptional trans-activating function of hepatitis B virus
    • Twu JS, Schloemer RH. Transcriptional trans-activating function of hepatitis B virus. J Virol 1987;61:3448-53.
    • (1987) J Virol , vol.61 , pp. 3448-3453
    • Twu, J.S.1    Schloemer, R.H.2
  • 122
    • 0023833938 scopus 로고
    • Trans-activation of viral enhancers by the hepatitis B virus X protein
    • Spandau DF, Lee CH. Trans-activation of viral enhancers by the hepatitis B virus X protein. J Virol 1988;62:427-34.
    • (1988) J Virol , vol.62 , pp. 427-434
    • Spandau, D.F.1    Lee, C.H.2
  • 123
    • 0025231364 scopus 로고
    • A trans-activator function is generated by integration of hepatitis B virus preS/S sequences in human hepatocellular carcinoma DNA
    • Caselmann WH, Meyer M, Kekule AS, Lauer U, Hofschneider PH, Koshy R. A trans-activator function is generated by integration of hepatitis B virus preS/S sequences in human hepatocellular carcinoma DNA. Proc Natl Acad Sci U S A 1990;87:2970-4.
    • (1990) Proc Natl Acad Sci U S A , vol.87 , pp. 2970-2974
    • Caselmann, W.H.1    Meyer, M.2    Kekule, A.S.3    Lauer, U.4    Hofschneider, P.H.5    Koshy, R.6
  • 124
    • 0028135497 scopus 로고
    • Hepatitis B virus HBx protein activates Ras-GTP complex formation and establishes a Ras, Raf, MAP kinase signaling cascade
    • Benn J, Schneider RJ. Hepatitis B virus HBx protein activates Ras-GTP complex formation and establishes a Ras, Raf, MAP kinase signaling cascade. Proc Natl Acad Sci U S A 1994;91:10350-4.
    • (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 10350-10354
    • Benn, J.1    Schneider, R.J.2
  • 126
    • 0028960362 scopus 로고
    • Selective accumulation of the X transcript of hepatitis B virus in patients negative for hepatitis B surface antigen with hepatocellular carcinoma
    • Paterlini P, Poussin K, Kew M, Franco D, Brechot C. Selective accumulation of the X transcript of hepatitis B virus in patients negative for hepatitis B surface antigen with hepatocellular carcinoma. Hepatology 1995;21:313-21.
    • (1995) Hepatology , vol.21 , pp. 313-321
    • Paterlini, P.1    Poussin, K.2    Kew, M.3    Franco, D.4    Brechot, C.5
  • 127
    • 0027157304 scopus 로고
    • Hepatitis B x antigen and p53 are associated in vitro and in liver tissues from patients with primary hepatocellular carcinoma
    • Feitelson MA, Zhu M, Duan LX, London WT. Hepatitis B x antigen and p53 are associated in vitro and in liver tissues from patients with primary hepatocellular carcinoma. Oncogene 1993;8:1109-17.
    • (1993) Oncogene , vol.8 , pp. 1109-1117
    • Feitelson, M.A.1    Zhu, M.2    Duan, L.X.3    London, W.T.4
  • 128
    • 0028843480 scopus 로고
    • Functional inactivation but not structural mutation of p53 causes liver cancer
    • Ueda H, Ullrich SJ, Gangemi JD, Kappel CA, Ngo L, Feitelson MA, et al. Functional inactivation but not structural mutation of p53 causes liver cancer. Nat Genet 1995;9:41-7.
    • (1995) Nat Genet , vol.9 , pp. 41-47
    • Ueda, H.1    Ullrich, S.J.2    Gangemi, J.D.3    Kappel, C.A.4    Ngo, L.5    Ma, F.6
  • 129
    • 0024539935 scopus 로고
    • Instability of integrated hepatitis B virus DNA with inverted repeat structure in a transgenic mouse
    • Hino O, Nomura K, Ohtake K, Kawaguchi T, Sugano H, Kitagawa T. Instability of integrated hepatitis B virus DNA with inverted repeat structure in a transgenic mouse. Cancer Genet Cytogenet 1989;37:273-8.
    • (1989) Cancer Genet Cytogenet , vol.37 , pp. 273-278
    • Hino, O.1    Nomura, K.2    Ohtake, K.3    Kawaguchi, T.4    Sugano, H.5    Kitagawa, T.6
  • 130
    • 0025990943 scopus 로고
    • Evidence for increased in vitro recombination with insertion of human hepatitis B virus DNA
    • Hino O, Tabata S, Hotta Y. Evidence for increased in vitro recombination with insertion of human hepatitis B virus DNA. Proc Natl Acad Sci U S A 1991;88:9248-52.
    • (1991) Proc Natl Acad Sci U S A , vol.88 , pp. 9248-9252
    • Hino, O.1    Tabata, S.2    Hotta, Y.3
  • 131
    • 0026060757 scopus 로고
    • Tumor suppressor p53: Analysis of wild-type and mutant p53 complexes
    • Milner J, Medcalf EA, Cook AC. Tumor suppressor p53: analysis of wild-type and mutant p53 complexes. Mol Cell Biol 1991;11:12-9.
    • (1991) Mol Cell Biol , vol.11 , pp. 12-19
    • Milner, J.1    Medcalf, E.A.2    Cook, A.C.3
  • 132
    • 0028915813 scopus 로고
    • Alternatively spliced forms in the carboxy-terminal domain of the p53 protein regulate its ability to promote annealing of complementary single strands of nucleic acids
    • Wu L, Bayle JH, Elenbaas B, Pavletich NP, Levine AJ. Alternatively spliced forms in the carboxy-terminal domain of the p53 protein regulate its ability to promote annealing of complementary single strands of nucleic acids. Mol Cell Biol 1995;15:497-504.
    • (1995) Mol Cell Biol , vol.15 , pp. 497-504
    • Wu, L.1    Bayle, J.H.2    Elenbaas, B.3    Pavletich, N.P.4    Levine, A.J.5
  • 133
    • 0028987037 scopus 로고
    • p53 binds single-stranded DNA ends through the C-terminal domain and internal DNA segments via the middle domain
    • Bakalkin G, Selivanova G, Yakovleva T, Kiseleva E, Kashuba E, Magnusson KP, et al. p53 binds single-stranded DNA ends through the C-terminal domain and internal DNA segments via the middle domain. Nucleic Acids Res 1995;23:362-9.
    • (1995) Nucleic Acids Res , vol.23 , pp. 362-369
    • Bakalkin, G.1    Selivanova, G.2    Yakovleva, T.3    Kiseleva, E.4    Kashuba, E.5    Magnusson, K.P.6
  • 134
    • 0028978120 scopus 로고
    • Serine phosphorylation in the NH2 terminus of p53 facilitates transactivation
    • Mayr GA, Reed M, Wang P, Wang Y, Schweds JF, Tegtmeyer P. Serine phosphorylation in the NH2 terminus of p53 facilitates transactivation. Cancer Res 1995;55:2410-7.
    • (1995) Cancer Res , vol.55 , pp. 2410-2417
    • Mayr, G.A.1    Reed, M.2    Wang, P.3    Wang, Y.4    Schweds, J.F.5    Tegtmeyer, P.6
  • 135
    • 0027361046 scopus 로고
    • Redox modulation of p53 conformation and sequence-specific DNA binding in vitro
    • Hainaut P, Milner J. Redox modulation of p53 conformation and sequence-specific DNA binding in vitro. Cancer Res 1993;53:4469-73.
    • (1993) Cancer Res , vol.53 , pp. 4469-4473
    • Hainaut, P.1    Milner, J.2
  • 136
    • 0027250493 scopus 로고
    • Activation of the cryptic DNA binding function of mutant forms of p53
    • Hupp TR, Meek DW, Midgley CA, Lane DP. Activation of the cryptic DNA binding function of mutant forms of p53. Nucleic Acids Res 1993; 21:3167-74.
    • (1993) Nucleic Acids Res , vol.21 , pp. 3167-3174
    • Hupp, T.R.1    Meek, D.W.2    Midgley, C.A.3    Lane, D.P.4
  • 138
    • 0027983669 scopus 로고
    • Crystal structure of a p53 tumor suppressor-DNA complex: Understanding tumorigenic mutations
    • Cho Y, Gorina S, Jeffrey PD, Pavletich NP. Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations [see comment citation in Medline]. Science 1994;265:346-55.
    • (1994) Science , vol.265 , pp. 346-355
    • Cho, Y.1    Gorina, S.2    Jeffrey, P.D.3    Pavletich, N.P.4
  • 139
    • 0027489384 scopus 로고
    • Clinical implications of the p53 tumor-suppressor gene
    • Harris CC, Hollstein M. Clinical implications of the p53 tumor-suppressor gene [see comment citations in Medline]. N Engl J Med 1993;329:1318-27.
    • (1993) N Engl J Med , vol.329 , pp. 1318-1327
    • Harris, C.C.1    Hollstein, M.2
  • 140
    • 0028242277 scopus 로고
    • Cancer therapy meets p53
    • Kinzler KW, Vogelstein B. Cancer therapy meets p53 [see comment citation in Medline]. N Engl J Med 1994;331:49-50.
    • (1994) N Engl J Med , vol.331 , pp. 49-50
    • Kinzler, K.W.1    Vogelstein, B.2
  • 141
    • 0027420768 scopus 로고
    • The clinical applications of new DNA diagnostic technology on the management of cancer patients
    • Rowley JD, Aster JC, Sklar J. The clinical applications of new DNA diagnostic technology on the management of cancer patients. JAMA 1993;270:2331-7.
    • (1993) JAMA , vol.270 , pp. 2331-2337
    • Rowley, J.D.1    Aster, J.C.2    Sklar, J.3
  • 142
    • 0028911725 scopus 로고
    • Molecular markers in cancer: Can we make better predictions?
    • Sidransky D. Molecular markers in cancer: can we make better predictions? Int J Cancer 1995;64:1-2.
    • (1995) Int J Cancer , vol.64 , pp. 1-2
    • Sidransky, D.1
  • 143
    • 0027752439 scopus 로고
    • What should oncologists know about cytogenetics in solid tumors?
    • Cin PD, Trent JM. What should oncologists know about cytogenetics in solid tumors? Ann Oncol 1993;4:821-4.
    • (1993) Ann Oncol , vol.4 , pp. 821-824
    • Cin, P.D.1    Trent, J.M.2
  • 145
    • 0029648080 scopus 로고
    • Translational research and epithelial carcinogenesis: Molecular diagnostic assays now - Molecular screening assays soon?
    • Birrer MJ. Translational research and epithelial carcinogenesis: molecular diagnostic assays now - molecular screening assays soon? [editorial; comment]. J Natl Cancer Inst 1995;87:1041-3.
    • (1995) J Natl Cancer Inst , vol.87 , pp. 1041-1043
    • Birrer, M.J.1
  • 147
    • 0027078647 scopus 로고
    • A functional screen for germ line p53 mutations based on transcriptional activation
    • Frebourg T, Barbier N, Kassel J, Ng YS, Romero P, Friend SH. A functional screen for germ line p53 mutations based on transcriptional activation. Cancer Res 1992;52:6976-8.
    • (1992) Cancer Res , vol.52 , pp. 6976-6978
    • Frebourg, T.1    Barbier, N.2    Kassel, J.3    Ng, Y.S.4    Romero, P.5    Friend, S.H.6
  • 148
    • 0021692341 scopus 로고
    • Inactivation of p53 gene expression by an insertion of Moloney murine leukemia virus-like DNA sequences
    • Wolf D, Rotter V. Inactivation of p53 gene expression by an insertion of Moloney murine leukemia virus-like DNA sequences. Mol Cell Biol 1984;4:1402-10.
    • (1984) Mol Cell Biol , vol.4 , pp. 1402-1410
    • Wolf, D.1    Rotter, V.2
  • 149
    • 0021870861 scopus 로고
    • Overproduction of p53 antigen makes established cells highly tumorigenic
    • Eliyahu D, Michalovitz D, Oren M, Overproduction of p53 antigen makes established cells highly tumorigenic. Nature 1985;316:158-60.
    • (1985) Nature , vol.316 , pp. 158-160
    • Eliyahu, D.1    Michalovitz, D.2    Oren, M.3
  • 152
    • 0026572475 scopus 로고
    • Mutant p53 can induce tumorigenic conversion of human bronchial epithelial cells and reduce their responsiveness to a negative growth factor, transforming growth factor type beta 1
    • Gerwin BI, Spillare E, Forrester K, Lehman TA, Kispert J, Welsh JA, et al. Mutant p53 can induce tumorigenic conversion of human bronchial epithelial cells and reduce their responsiveness to a negative growth factor, transforming growth factor type beta 1. Proc Natl Acad Sci U S A 1992;89:2759-63.
    • (1992) Proc Natl Acad Sci U S A , vol.89 , pp. 2759-2763
    • Gerwin, B.I.1    Spillare, E.2    Forrester, K.3    Lehman, T.A.4    Kispert, J.5    Welsh, J.A.6
  • 153
    • 0028040742 scopus 로고
    • Gain-of-function mutations of the p53 gene induce lymphohematopoietic metastatic potential and tissue invasiveness
    • Hsiao M, Low J, Dorn E, Ku D, Pattengale P, Yeargin J, et al. Gain-of-function mutations of the p53 gene induce lymphohematopoietic metastatic potential and tissue invasiveness. Am J Pathol 1994;145:702-14.
    • (1994) Am J Pathol , vol.145 , pp. 702-714
    • Hsiao, M.1    Low, J.2    Dorn, E.3    Ku, D.4    Pattengale, P.5    Yeargin, J.6
  • 154
    • 0028025563 scopus 로고
    • Apoptosis in cancer therapy: Crossing the threshold
    • Fisher DE. Apoptosis in cancer therapy: crossing the threshold. Cell 1994;78:539-42.
    • (1994) Cell , vol.78 , pp. 539-542
    • Fisher, D.E.1
  • 155
    • 0028329172 scopus 로고
    • Apoptosis. Its significance in cancer and cancer therapy
    • published erratum appears in Cancer 1994; 73:3108
    • Kerr JF, Winterford CM, Harmon BV. Apoptosis. Its significance in cancer and cancer therapy [published erratum appears in Cancer 1994; 73:3108]. Cancer 1994;73:2013-26.
    • (1994) Cancer , vol.73 , pp. 2013-2026
    • Kerr, J.F.1    Winterford, C.M.2    Harmon, B.V.3
  • 157
    • 0029247959 scopus 로고
    • Implications of apoptotic cell death regulation in cancer therapy
    • McDonnell TJ, Meyn RE, Robertson LE. Implications of apoptotic cell death regulation in cancer therapy. Semin Cancer Biol 1995;6:53-60.
    • (1995) Semin Cancer Biol , vol.6 , pp. 53-60
    • McDonnell, T.J.1    Meyn, R.E.2    Robertson, L.E.3
  • 158
    • 0029244997 scopus 로고
    • Survival factors, intracellular signal transduction, and the activation of endonucleases in apoptosis
    • Eastman A. Survival factors, intracellular signal transduction, and the activation of endonucleases in apoptosis. Semin Cancer Biol 1995;6:45-52.
    • (1995) Semin Cancer Biol , vol.6 , pp. 45-52
    • Eastman, A.1
  • 160
    • 0027451668 scopus 로고
    • p53-dependent apoptosis modulates the cytotoxicity of anticancer agents
    • Lowe SW, Ruley HE, Jacks T, Housman DE. p53-dependent apoptosis modulates the cytotoxicity of anticancer agents. Cell 1993;74:957-67.
    • (1993) Cell , vol.74 , pp. 957-967
    • Lowe, S.W.1    Ruley, H.E.2    Jacks, T.3    Housman, D.E.4
  • 161
    • 0027319521 scopus 로고
    • p53 is required for radiation-induced apoptosis in mouse thymocytes
    • Lowe SW, Schmitt EM, Smith SW, Osborne BA, Jacks T. p53 is required for radiation-induced apoptosis in mouse thymocytes [see comment citation in Medline]. Nature 1993;362:847-9.
    • (1993) Nature , vol.362 , pp. 847-849
    • Lowe, S.W.1    Schmitt, E.M.2    Smith, S.W.3    Osborne, B.A.4    Jacks, T.5
  • 162
    • 0027258466 scopus 로고
    • Thymocyte apoptosis induced by p53-dependent and independent pathways
    • Clarke AR, Purdie CA, Harrison DJ, Morris RG, Bud CC, Hooper ML, et al. Thymocyte apoptosis induced by p53-dependent and independent pathways [see comment citation in Medline]. Nature 1993;362:849-52.
    • (1993) Nature , vol.362 , pp. 849-852
    • Clarke, A.R.1    Purdie, C.A.2    Harrison, D.J.3    Morris, R.G.4    Bud, C.C.5    Hooper, M.L.6
  • 163
    • 0028864149 scopus 로고
    • A mutant p53 antagonizes the deregulated c-myc-mediated enhancement of apoptosis and decrease in leukemogenicity
    • Lotem J, Sachs L. A mutant p53 antagonizes the deregulated c-myc-mediated enhancement of apoptosis and decrease in leukemogenicity. Proc Natl Acad Sci U S A 1995;92:9672-6.
    • (1995) Proc Natl Acad Sci U S A , vol.92 , pp. 9672-9676
    • Lotem, J.1    Sachs, L.2
  • 164
    • 8944263468 scopus 로고    scopus 로고
    • Association between cisplatin resistance and mutation of p53 gene and reduced Bax expression in ovarian carcinoma cell systems
    • Perego P, Giarola M, Righetti SC, Supino R, Caserini C, Delia D, et al. Association between cisplatin resistance and mutation of p53 gene and reduced Bax expression in ovarian carcinoma cell systems. Cancer Res 1996;56:556-62.
    • (1996) Cancer Res , vol.56 , pp. 556-562
    • Perego, P.1    Giarola, M.2    Righetti, S.C.3    Supino, R.4    Caserini, C.5    Delia, D.6
  • 165
    • 0027168859 scopus 로고
    • Apoptosis and its modulation in human promyelocytic HL-60 cells treated with DNA topoisomerase I and II inhibitors
    • Bertrand R, Solary E, Jenkins J, Pommier Y. Apoptosis and its modulation in human promyelocytic HL-60 cells treated with DNA topoisomerase I and II inhibitors. Exp Cell Res 1993;207:388-97.
    • (1993) Exp Cell Res , vol.207 , pp. 388-397
    • Bertrand, R.1    Solary, E.2    Jenkins, J.3    Pommier, Y.4
  • 166
    • 0028168146 scopus 로고
    • Anaplastic Wilms' tumour, a subtype displaying poor prognosis, harbours p53 gene mutations
    • Bardeesy N, Falkoff D, Petruzzi MJ, Nowaik N, Zabel B, Adam M, et al. Anaplastic Wilms' tumour, a subtype displaying poor prognosis, harbours p53 gene mutations. Nat Genet 1994;7:91-7.
    • (1994) Nat Genet , vol.7 , pp. 91-97
    • Bardeesy, N.1    Falkoff, D.2    Petruzzi, M.J.3    Nowaik, N.4    Zabel, B.5    Adam, M.6
  • 168
    • 0027361941 scopus 로고
    • Analysis of p53 mutations in a large series of lymphoid hematologic malignancies of childhood
    • Wada M, Bartram CR, Nakamura H, Hachiya M, Chen DL, Borenstein J, et al. Analysis of p53 mutations in a large series of lymphoid hematologic malignancies of childhood. Blood 1993;82:3163-9.
    • (1993) Blood , vol.82 , pp. 3163-3169
    • Wada, M.1    Bartram, C.R.2    Nakamura, H.3    Hachiya, M.4    Chen, D.L.5    Borenstein, J.6
  • 169
    • 0028271490 scopus 로고
    • Mutations of the p53 tumor suppressor gene occur infrequently in Wilms' tumor
    • Malkin D, Sexsmith E, Yeger H, Williams BR, Coppes MJ. Mutations of the p53 tumor suppressor gene occur infrequently in Wilms' tumor. Cancer Res 1994;54:2077-9.
    • (1994) Cancer Res , vol.54 , pp. 2077-2079
    • Malkin, D.1    Sexsmith, E.2    Yeger, H.3    Williams, B.R.4    Coppes, M.J.5
  • 170
    • 0029075026 scopus 로고
    • Amplification of the dihydrofolate reductase gene is a mechanism of acquired resistance to methotrexate in patients with acute lymphoblastic leukemia and is correlated with p53 gene mutations
    • Goker E, Waltham M, Kheradpour A, Trippelt T, Mazumdar M, Elisseyeff Y, et al. Amplification of the dihydrofolate reductase gene is a mechanism of acquired resistance to methotrexate in patients with acute lymphoblastic leukemia and is correlated with p53 gene mutations. Blood 1995;86:677-84.
    • (1995) Blood , vol.86 , pp. 677-684
    • Goker, E.1    Waltham, M.2    Kheradpour, A.3    Trippelt, T.4    Mazumdar, M.5    Elisseyeff, Y.6
  • 171
    • 0027436745 scopus 로고
    • p53 gene mutation in B-cell chronic lymphocytic leukemia is associated with drug resistance and is independent of MDR1/MDR3 gene expression
    • el Rouby S, Thomas A, Costin D, Rosenberg CR, Potmesie M, Silber R, et al. p53 gene mutation in B-cell chronic lymphocytic leukemia is associated with drug resistance and is independent of MDR1/MDR3 gene expression. Blood 1993;82:3452-9.
    • (1993) Blood , vol.82 , pp. 3452-3459
    • El Rouby, S.1    Thomas, A.2    Costin, D.3    Rosenberg, C.R.4    Potmesie, M.5    Silber, R.6
  • 173
    • 0026768030 scopus 로고
    • The pattern of p53 mutations in Burkitt's lymphoma differs from that of solid tumors
    • Bhatia KG, Gutierrez MI, Huppi K, Siwarski D, Magrath IT. The pattern of p53 mutations in Burkitt's lymphoma differs from that of solid tumors. Cancer Res 1992;52:4273-6.
    • (1992) Cancer Res , vol.52 , pp. 4273-4276
    • Bhatia, K.G.1    Gutierrez, M.I.2    Huppi, K.3    Siwarski, D.4    Magrath, I.T.5
  • 175
    • 0029155714 scopus 로고
    • Accumulation of p53 protein as a possible predictor of response to adjuvant combination chemotherapy with cyclophosphamide, methotrexate, fluorouracil, and prednisone for breast cancer
    • Elledge RM, Gray R, Mansour E, Yu Y, Clarke GM, Ravdin P, et al. Accumulation of p53 protein as a possible predictor of response to adjuvant combination chemotherapy with cyclophosphamide, methotrexate, fluorouracil, and prednisone for breast cancer. J Natl Cancer Inst 1995; 87:1254-6.
    • (1995) J Natl Cancer Inst , vol.87 , pp. 1254-1256
    • Elledge, R.M.1    Gray, R.2    Mansour, E.3    Yu, Y.4    Clarke, G.M.5    Ravdin, P.6
  • 176
    • 0028840535 scopus 로고
    • Aberrant p53 expression predicts clinical resistance to cisplatin-based chemotherapy in locally advanced non-small cell lung cancer
    • Rusch V, Klimstra D, Venkatraman E, Oliver J, Martini M, Gralla R, et al. Aberrant p53 expression predicts clinical resistance to cisplatin-based chemotherapy in locally advanced non-small cell lung cancer. Cancer Res 1995;55:5038-42.
    • (1995) Cancer Res , vol.55 , pp. 5038-5042
    • Rusch, V.1    Klimstra, D.2    Venkatraman, E.3    Oliver, J.4    Martini, M.5    Gralla, R.6
  • 177
    • 0028875410 scopus 로고
    • Complete sequencing of the p53 gene provides prognostic information in breast cancer patients, particularly in relation to adjuvant systemic therapy and radiotherapy
    • Bergh J, Norberg T, Sjogren S, Lindgren A, Holmberg L. Complete sequencing of the p53 gene provides prognostic information in breast cancer patients, particularly in relation to adjuvant systemic therapy and radiotherapy. Nat Med 1995;1:1029-34.
    • (1995) Nat Med , vol.1 , pp. 1029-1034
    • Bergh, J.1    Norberg, T.2    Sjogren, S.3    Lindgren, A.4    Holmberg, L.5
  • 178
    • 0029052261 scopus 로고
    • Assessment of apoptosis in oesopliageal carcinoma preoperatively treated by chemotherapy and radiotherapy
    • Moreira LF, Naomoto Y, Hamada M, Kamikawa Y, Orita K. Assessment of apoptosis in oesopliageal carcinoma preoperatively treated by chemotherapy and radiotherapy. Anticancer Res 1995;15:639-44.
    • (1995) Anticancer Res , vol.15 , pp. 639-644
    • Moreira, L.F.1    Naomoto, Y.2    Hamada, M.3    Kamikawa, Y.4    Orita, K.5
  • 179
    • 0028821701 scopus 로고
    • Pretreatmem p53 protein expression correlates with decreased survival in patients with end-stage head and neck cancer
    • Sauter ER, Ridge JA, Litwin S, Langer CJ. Pretreatmem p53 protein expression correlates with decreased survival in patients with end-stage head and neck cancer. Clin Cancer Res 1995;1:1407-12.
    • (1995) Clin Cancer Res , vol.1 , pp. 1407-1412
    • Sauter, E.R.1    Ridge, J.A.2    Litwin, S.3    Langer, C.J.4
  • 180
    • 13344249778 scopus 로고    scopus 로고
    • A comparative study of p53 gene mutations, protein accumulation and response to cisplatin-based chemotherapy in advanced ovarian carcinoma
    • Righetti SC, Torre GD, Pilotti S, Menard S, Ottone F, Colnaghi MI, et al. A comparative study of p53 gene mutations, protein accumulation and response to cisplatin-based chemotherapy in advanced ovarian carcinoma. Cancer Res 1996;56:689-93.
    • (1996) Cancer Res , vol.56 , pp. 689-693
    • Righetti, S.C.1    Torre, G.D.2    Pilotti, S.3    Menard, S.4    Ottone, F.5    Colnaghi, M.I.6
  • 181
    • 0028978530 scopus 로고
    • Gamma-radiation-induced apoptosis in human colorectal adenoma and carcinoma cell lines can occur in the absence of wild type p53
    • Bracey TS, Miller JC, Preece A, Paraskeva C. Gamma-radiation-induced apoptosis in human colorectal adenoma and carcinoma cell lines can occur in the absence of wild type p53. Oncogene 1995;10:2391-6.
    • (1995) Oncogene , vol.10 , pp. 2391-2396
    • Bracey, T.S.1    Miller, J.C.2    Preece, A.3    Paraskeva, C.4
  • 182
    • 0028882315 scopus 로고
    • Cytokines inhibit p53-mediated apoptosis but not p53-mediated G1 arrest
    • Lin Y, Benchimol S. Cytokines inhibit p53-mediated apoptosis but not p53-mediated G1 arrest. Mol Cell Biol 1995;15:6045-54.
    • (1995) Mol Cell Biol , vol.15 , pp. 6045-6054
    • Lin, Y.1    Benchimol, S.2
  • 183
    • 0028958705 scopus 로고
    • Growth factor modulation of p53-mediated growth arrest versus apoptosis
    • Canman CE, Gilmer TM, Coutts SB, Kastan MB. Growth factor modulation of p53-mediated growth arrest versus apoptosis. Genes Dev 1995;9: 600-11.
    • (1995) Genes Dev , vol.9 , pp. 600-611
    • Canman, C.E.1    Gilmer, T.M.2    Coutts, S.B.3    Kastan, M.B.4
  • 184
    • 0028294898 scopus 로고
    • Down-regulation of wild-type p53 activity interferes with apoptosis of IL-3-dependent hematopoietic cells following IL-3-withdrawal
    • Gottlieb E, Haffner R, von Ruden T, Wagner EF, Oren M. Down-regulation of wild-type p53 activity interferes with apoptosis of IL-3-dependent hematopoietic cells following IL-3-withdrawal. EMBO J 1994;13:1368-74.
    • (1994) EMBO J , vol.13 , pp. 1368-1374
    • Gottlieb, E.1    Haffner, R.2    Von Ruden, T.3    Wagner, E.F.4    Oren, M.5
  • 186
    • 0028028068 scopus 로고
    • Receptor blockade with monoclonal antibodies as anti-cancer therapy
    • Baselga J, Mendelsohn J. Receptor blockade with monoclonal antibodies as anti-cancer therapy. Pharmacol Ther 1994;64:127-54.
    • (1994) Pharmacol Ther , vol.64 , pp. 127-154
    • Baselga, J.1    Mendelsohn, J.2
  • 187
    • 0028242807 scopus 로고
    • Cytokine-induced modulation of tumor suppressor gene expression in ovarian cancer cells: Up-regulation of p53 gene expression and induction of apoptosis by tumor necrosis factor-alpha
    • Gotlieb WH, Watson JM, Rezai A. Johnson M, Martinez-Maza O, Berek JS. Cytokine-induced modulation of tumor suppressor gene expression in ovarian cancer cells: up-regulation of p53 gene expression and induction of apoptosis by tumor necrosis factor-alpha. Am J Obstet Gynecol 1994; 170:1121-30.
    • (1994) Am J Obstet Gynecol , vol.170 , pp. 1121-1130
    • Gotlieb, W.H.1    Watson, J.M.2    Rezai, A.3    Johnson, M.4    Martinez-Maza, O.5    Berek, J.S.6
  • 188
    • 0028837203 scopus 로고
    • Involvement of the tumor suppressor gene p53 in tumor necrosis factor-induced differentiation of the leukemic cell line K562
    • Ehinger M, Nilsson E, Persson AM, Olsson I, Gullberg U. Involvement of the tumor suppressor gene p53 in tumor necrosis factor-induced differentiation of the leukemic cell line K562. Cell Growth Differ 1995;6:9-17.
    • (1995) Cell Growth Differ , vol.6 , pp. 9-17
    • Ehinger, M.1    Nilsson, E.2    Persson, A.M.3    Olsson, I.4    Gullberg, U.5
  • 189
    • 0029151321 scopus 로고
    • Modulation of interleukin-6-induced plasma protein secretion in hepatoma cells by p53 species
    • Wang L, Rayanade RJ, Garcia D, Patel K, Pan H, Sehgal PB. Modulation of interleukin-6-induced plasma protein secretion in hepatoma cells by p53 species. J Biol Chem 1995;270:23159-65.
    • (1995) J Biol Chem , vol.270 , pp. 23159-23165
    • Wang, L.1    Rayanade, R.J.2    Garcia, D.3    Patel, K.4    Pan, H.5    Sehgal, P.B.6
  • 191
    • 0028879323 scopus 로고
    • Regulation of p53-mediated apoptosis and cell cycle arrest by Steel factor
    • Abrahamson JL, Lee JM, Bernstein A. Regulation of p53-mediated apoptosis and cell cycle arrest by Steel factor. Mol Cell Biol 1995;15:6953-60.
    • (1995) Mol Cell Biol , vol.15 , pp. 6953-6960
    • Abrahamson, J.L.1    Lee, J.M.2    Bernstein, A.3
  • 192
    • 0026652346 scopus 로고
    • A cDNA encoding a pRB-binding protein with properties of the transcription factor E2F
    • Helin K, Lees JA, Vidai M, Dyson N, Harlow E, Fattaey A. A cDNA encoding a pRB-binding protein with properties of the transcription factor E2F. Cell 1992;70:337-50.
    • (1992) Cell , vol.70 , pp. 337-350
    • Helin, K.1    Lees, J.A.2    Vidai, M.3    Dyson, N.4    Harlow, E.5    Fattaey, A.6
  • 193
    • 0028220204 scopus 로고
    • p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest
    • Dulic V, Kaufmann WK, Wilson SJ, Tlsty TD, Lees E, Harper JW, et al. p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest. Cell 1994;76:1013-23.
    • (1994) Cell , vol.76 , pp. 1013-1023
    • Dulic, V.1    Kaufmann, W.K.2    Wilson, S.J.3    Tlsty, T.D.4    Lees, E.5    Harper, J.W.6
  • 194
    • 0027442926 scopus 로고
    • A genetic analysis of the E2F1 gene distinguishes regulation by Rb, p107, and adenovirus E4
    • Cress WD, Johnson DG, Nevins JR. A genetic analysis of the E2F1 gene distinguishes regulation by Rb, p107, and adenovirus E4. Mol Cell Biol 1993;13:6314-25.
    • (1993) Mol Cell Biol , vol.13 , pp. 6314-6325
    • Cress, W.D.1    Johnson, D.G.2    Nevins, J.R.3
  • 195
    • 0026766083 scopus 로고
    • Expression cloning of a cDNA encoding a retinoblastoma-binding protein with E2F-like properties
    • Kaelin WG Jr, Krek W, Sellers WR, DeCaprio JA, Ajchenbaum F, Fuchs CS, et al. Expression cloning of a cDNA encoding a retinoblastoma-binding protein with E2F-like properties. Cell 1992;70:351-64.
    • (1992) Cell , vol.70 , pp. 351-364
    • Kaelin Jr., W.G.1    Krek, W.2    Sellers, W.R.3    DeCaprio, J.A.4    Ajchenbaum, F.5    Fuchs, C.S.6
  • 197
    • 0028907874 scopus 로고
    • A family of proteins structurally and functionally related to the E6-AP ubiquitin-protein ligase
    • published erratum appears in Proc Natl Sci U S A 1995;92:5249
    • Huibregtse JM, Scheffner M, Beaudenon S, Howley PM. A family of proteins structurally and functionally related to the E6-AP ubiquitin-protein ligase [published erratum appears in Proc Natl Sci U S A 1995;92:5249]. Proc Natl Acad Sci U S A 1995;92:2563-7.
    • (1995) Proc Natl Acad Sci U S A , vol.92 , pp. 2563-2567
    • Huibregtse, J.M.1    Scheffner, M.2    Beaudenon, S.3    Howley, P.M.4
  • 198
    • 0030021996 scopus 로고    scopus 로고
    • Inactivation of p53 enhances sensitivity to multiple chemotherapeutic agents
    • Hawkins DS, Demers GW, Galloway DA. Inactivation of p53 enhances sensitivity to multiple chemotherapeutic agents. Cancer Res 1996;56:892-8.
    • (1996) Cancer Res , vol.56 , pp. 892-898
    • Hawkins, D.S.1    Demers, G.W.2    Galloway, D.A.3
  • 199
    • 0026740449 scopus 로고
    • Amplification of a gene encoding a p53-associated protein in human sarcomas
    • Oliner JD, Kinzler KW, Meltzer PS, George DL. Vogelstein B. Amplification of a gene encoding a p53-associated protein in human sarcomas [see comment citations in Medline]. Nature 1992;358:80-3.
    • (1992) Nature , vol.358 , pp. 80-83
    • Oliner, J.D.1    Kinzler, K.W.2    Meltzer, P.S.3    George, D.L.4    Vogelstein, B.5
  • 201
    • 0028675002 scopus 로고
    • The new genetic medicines
    • Cohen JS, Hogan ME. The new genetic medicines. Sci Am 1994;271:76-82.
    • (1994) Sci Am , vol.271 , pp. 76-82
    • Cohen, J.S.1    Hogan, M.E.2
  • 203
    • 0029262020 scopus 로고
    • Antisense approaches to cancer gene therapy
    • Mercola D, Cohen JS. Antisense approaches to cancer gene therapy. Cancer Gene Ther 1995;2:47-59.
    • (1995) Cancer Gene Ther , vol.2 , pp. 47-59
    • Mercola, D.1    Cohen, J.S.2
  • 204
    • 0029124132 scopus 로고
    • Microinjection of monoclonal antibody PAb421 into human SW480 colorectal carcinoma cells restores the transcription activation function to mutant p53
    • Abarzua P, LoSardo JE, Gubler ML, Neri A. Microinjection of monoclonal antibody PAb421 into human SW480 colorectal carcinoma cells restores the transcription activation function to mutant p53. Cancer Res 1995;55:3490-4.
    • (1995) Cancer Res , vol.55 , pp. 3490-3494
    • Abarzua, P.1    LoSardo, J.E.2    Gubler, M.L.3    Neri, A.4
  • 205
    • 0029145215 scopus 로고
    • Geldanamycin selectively destabilizes and conformationally alters mutated p53
    • Blagosklonny MV, Toretsky J, Neckers L. Geldanamycin selectively destabilizes and conformationally alters mutated p53. Oncogene 1995;11. 933-9.
    • (1995) Oncogene , vol.11 , pp. 933-939
    • Blagosklonny, M.V.1    Toretsky, J.2    Neckers, L.3
  • 206
    • 0028845158 scopus 로고
    • Small peptides activate the latent sequence-specific DNA binding function of p53
    • Hupp TR, Sparks A, Lane DP. Small peptides activate the latent sequence-specific DNA binding function of p53. Cell 1995;83:237-45.
    • (1995) Cell , vol.83 , pp. 237-245
    • Hupp, T.R.1    Sparks, A.2    Lane, D.P.3
  • 207
    • 0029125555 scopus 로고
    • Specific DNA binding by different classes of human p53 mutants
    • Rolley N, Butcher S, Milner J. Specific DNA binding by different classes of human p53 mutants. Oncogene 1995;11:763-70.
    • (1995) Oncogene , vol.11 , pp. 763-770
    • Rolley, N.1    Butcher, S.2    Milner, J.3
  • 208
    • 0029033209 scopus 로고
    • DNA damage, p53 and anticancer therapies
    • Milner J. DNA damage, p53 and anticancer therapies. Nat Med 1995; 1:879-80.
    • (1995) Nat Med , vol.1 , pp. 879-880
    • Milner, J.1
  • 209
    • 0030051756 scopus 로고    scopus 로고
    • Antisense-oligonucleotide therapy
    • Askari FK, McDonnell WM. Antisense-oligonucleotide therapy. N Engl J Med 1996;334:316-8.
    • (1996) N Engl J Med , vol.334 , pp. 316-318
    • Askari, F.K.1    McDonnell, W.M.2
  • 210
    • 0025880971 scopus 로고
    • Drug-target interactions: Only the first step in the commitment to a programmed cell death?
    • Dive C, Hickman JA. Drug-target interactions: only the first step in the commitment to a programmed cell death? Br J Cancer 1991;64:192-6.
    • (1991) Br J Cancer , vol.64 , pp. 192-196
    • Dive, C.1    Hickman, J.A.2
  • 211
    • 0024988359 scopus 로고
    • Activation of programmed cell death by anticancer agents: Cisplatin as a model system
    • Eastman A. Activation of programmed cell death by anticancer agents: cisplatin as a model system. Cancer Cells 1990;2:275-80.
    • (1990) Cancer Cells , vol.2 , pp. 275-280
    • Eastman, A.1
  • 212
    • 0026689242 scopus 로고
    • Apoptosis: A different type of cell death
    • Gerschenson LE, Rotello RJ. Apoptosis: a different type of cell death. FASEB J 1992;6:2450-5.
    • (1992) FASEB J , vol.6 , pp. 2450-2455
    • Gerschenson, L.E.1    Rotello, R.J.2
  • 214
    • 0025899138 scopus 로고
    • Programmed cell death: Apoptosis and oncogenesis
    • Williams GT. Programmed cell death: apoptosis and oncogenesis. Cell 1991;65:1097-8.
    • (1991) Cell , vol.65 , pp. 1097-1098
    • Williams, G.T.1
  • 215
    • 0030046508 scopus 로고    scopus 로고
    • Life, death, and the pursuit of apoptosis
    • White E. Life, death, and the pursuit of apoptosis. Genes Dev 1996;10:1-15.
    • (1996) Genes Dev , vol.10 , pp. 1-15
    • White, E.1
  • 216
    • 0028943734 scopus 로고
    • Apoptosis in the pathogenesis and treatment of disease
    • Thompson CB. Apoptosis in the pathogenesis and treatment of disease. Science 1995;267:1456-62.
    • (1995) Science , vol.267 , pp. 1456-1462
    • Thompson, C.B.1
  • 217
    • 0028979438 scopus 로고
    • Overexpression of Bcl-XS sensitizes MCF-7 cells to chemotherapy-induced apoptosis
    • Sumantran VN, Ealovega MW, Nunez G, Clarke MF, Wicha MS. Overexpression of Bcl-XS sensitizes MCF-7 cells to chemotherapy-induced apoptosis. Cancer Res 1995;55:2507-10.
    • (1995) Cancer Res , vol.55 , pp. 2507-2510
    • Sumantran, V.N.1    Ealovega, M.W.2    Nunez, G.3    Clarke, M.F.4    Wicha, M.S.5
  • 220
    • 0028958705 scopus 로고
    • Growth factor modulation of p53-mediated growth arrest versus apoptosis
    • Canman CE, Gilmer TM, Coutts SB, Kastan MB. Growth factor modulation of p53-mediated growth arrest versus apoptosis. Genes Dev 1995; 9:600-11.
    • (1995) Genes Dev , vol.9 , pp. 600-611
    • Canman, C.E.1    Gilmer, T.M.2    Coutts, S.B.3    Kastan, M.B.4
  • 221
    • 0025784539 scopus 로고
    • Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6
    • Yonish-Rouach E, Resnitzky D, Lotem J, Sachs L, Kimchi A, Oren M. Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6. Nature 1991;352:345-7.
    • (1991) Nature , vol.352 , pp. 345-347
    • Yonish-Rouach, E.1    Resnitzky, D.2    Lotem, J.3    Sachs, L.4    Kimchi, A.5    Oren, M.6
  • 222
    • 0030021748 scopus 로고    scopus 로고
    • Specific loss of apoptotic but not cell cycle arrest function in a human tumour derived p53 mutant
    • Rowan S, Ludwig RL, Haupt Y, Bates S, Lux X, Oren M, et al. Specific loss of apoptotic but not cell cycle arrest function in a human tumour derived p53 mutant. EMBO J 1996;15:827-38.
    • (1996) EMBO J , vol.15 , pp. 827-838
    • Rowan, S.1    Ludwig, R.L.2    Haupt, Y.3    Bates, S.4    Lux, X.5    Oren, M.6
  • 223
    • 0025850903 scopus 로고
    • Antigen processing. Proteasomes in the pathway
    • Robertson M. Antigen processing. Proteasomes in the pathway [news; see comment citations in Medline]. Nature 1991;353:300-1.
    • (1991) Nature , vol.353 , pp. 300-301
    • Robertson, M.1
  • 224
    • 0026507564 scopus 로고
    • Characterization of peptides bound to the class 1 MHC molecule HLA-A2.1 by mass spectrometry
    • Hunt DF, Henderson RA, Shabanowitz J, Sakaguchi K, Michel H, Sevilin N, et al. Characterization of peptides bound to the class 1 MHC molecule HLA-A2.1 by mass spectrometry [see comment citations in Medline]. Science 1992;255:1261-3.
    • (1992) Science , vol.255 , pp. 1261-1263
    • Hunt, D.F.1    Henderson, R.A.2    Shabanowitz, J.3    Sakaguchi, K.4    Michel, H.5    Sevilin, N.6
  • 225
    • 0028810350 scopus 로고
    • New tumor antigens recognized by T cells
    • Van Den Eynde B, Brichard VJ. New tumor antigens recognized by T cells. Curr Biol 1995;7:674-81.
    • (1995) Curr Biol , vol.7 , pp. 674-681
    • Van Den Eynde, B.1    Brichard, V.J.2
  • 226
    • 0029893672 scopus 로고    scopus 로고
    • Dendritic cells in anti-tumor immune responses. II. Dendritic cells grown from bone marrow precursors, but not mature DC from tumor-bearing mice are effective antigen carriers in the therapy of established tumors
    • In press
    • Gabrilovich DI, Nadaf S, Corak J, Berzofsky JA, Carbone DP. Dendritic cells in anti-tumor immune responses. II. Dendritic cells grown from bone marrow precursors, but not mature DC from tumor-bearing mice are effective antigen carriers in the therapy of established tumors. Cellular Immunol In press.
    • Cellular Immunol
    • Gabrilovich, D.I.1    Nadaf, S.2    Corak, J.3    Berzofsky, J.A.4    Carbone, D.P.5
  • 227
    • 0029997017 scopus 로고    scopus 로고
    • Dendritic cells in anti-tumor immune responses. I. Defective antigen presentation in tumor-bearing hosts
    • In press
    • Gabrilovich DI, Ciernik IF, Carbone DP. Dendritic cells in anti-tumor immune responses. I. Defective antigen presentation in tumor-bearing hosts. Cellular Immunol. In press.
    • Cellular Immunol.
    • Gabrilovich, D.I.1    Ciernik, I.F.2    Carbone, D.P.3
  • 228
    • 0028198310 scopus 로고
    • Evidence for selection against human lung cancers bearing p53 missense mutations which occur within the HLA A*0201 peptide consensus motif
    • Wiedenfeld EA, Fernandez-Vina M, Berzofsky JA, Carbone DP. Evidence for selection against human lung cancers bearing p53 missense mutations which occur within the HLA A*0201 peptide consensus motif. Cancer Res 1994;54:1175-7.
    • (1994) Cancer Res , vol.54 , pp. 1175-1177
    • Wiedenfeld, E.A.1    Fernandez-Vina, M.2    Berzofsky, J.A.3    Carbone, D.P.4
  • 231
    • 0029978501 scopus 로고    scopus 로고
    • p53 as a target for cancer vaccines: Recombinant canarypox virus vectors expressing p53 protect mice against lethal tumor cell challenge
    • Roth J, Dittmer D, Rea D, Tartaglia J, Paoletti E, Levine AJ. p53 as a target for cancer vaccines: recombinant canarypox virus vectors expressing p53 protect mice against lethal tumor cell challenge. Proc Natl Acad Sci USA 1996;93:4781-6.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 4781-4786
    • Roth, J.1    Dittmer, D.2    Rea, D.3    Tartaglia, J.4    Paoletti, E.5    Levine, A.J.6
  • 232
    • 0029038135 scopus 로고
    • Apoptosis, cancer and the p53 tumour suppressor gene
    • Lee JM, Bernstein A. Apoptosis, cancer and the p53 tumour suppressor gene. Cancer Metastasis Rev 1995;14:149-61.
    • (1995) Cancer Metastasis Rev , vol.14 , pp. 149-161
    • Lee, J.M.1    Bernstein, A.2
  • 233
    • 0029103231 scopus 로고
    • Systemic gene therapy with p53 reduces growth and metastases of a malignant human breast cancer in nude mice
    • Lesoon-Wood LA, Kim WH, Kleinman HK, Weintraub BD, Mixson AJ. Systemic gene therapy with p53 reduces growth and metastases of a malignant human breast cancer in nude mice. Hum Gene Ther 1995; 6:395-405.
    • (1995) Hum Gene Ther , vol.6 , pp. 395-405
    • Lesoon-Wood, L.A.1    Kim, W.H.2    Kleinman, H.K.3    Weintraub, B.D.4    Mixson, A.J.5
  • 234
    • 0028963221 scopus 로고
    • In vivo molecular therapy with p53 adenovirus for microscopic residual head and neck squamous carcinoma
    • Clayman GL, el-Naggar AK, Roth JA, Zhang WW, Goepfert H, Taylor DL, et al. In vivo molecular therapy with p53 adenovirus for microscopic residual head and neck squamous carcinoma. Cancer Res 1995;55:1-6.
    • (1995) Cancer Res , vol.55 , pp. 1-6
    • Clayman, G.L.1    El-Naggar, A.K.2    Roth, J.A.3    Zhang, W.W.4    Goepfert, H.5    Taylor, D.L.6
  • 235
    • 0029017333 scopus 로고
    • Apoptosis induction mediated by wild-type p53 adenoviral gene transfer in squamous cell carcinoma of the head and neck
    • Liu TJ, el-Naggar AK, McDonnell TJ, Stick KD, Wang M, Taylor DL, et al. Apoptosis induction mediated by wild-type p53 adenoviral gene transfer in squamous cell carcinoma of the head and neck. Cancer Res 1995;55:3117-22.
    • (1995) Cancer Res , vol.55 , pp. 3117-3122
    • Liu, T.J.1    El-Naggar, A.K.2    McDonnell, T.J.3    Stick, K.D.4    Wang, M.5    Taylor, D.L.6
  • 236
    • 0029101393 scopus 로고
    • Gene therapy in oncology - Outlook, benefits and risks
    • Kiehntopf M, Brach MA, Hernnann F. Gene therapy in oncology - outlook, benefits and risks. Onkologie 1995;1(18 Suppl):16-26.
    • (1995) Onkologie , vol.1 , Issue.18 SUPPL. , pp. 16-26
    • Kiehntopf, M.1    Brach, M.A.2    Hernnann, F.3
  • 238
    • 0029202841 scopus 로고
    • Immunotherapy and gene therapy of cancer
    • Ettinghausen SE, Rosenberg SA. Immunotherapy and gene therapy of cancer. Adv Surg 1995;28:223-54.
    • (1995) Adv Surg , vol.28 , pp. 223-254
    • Ettinghausen, S.E.1    Rosenberg, S.A.2
  • 239
  • 241
    • 0028171454 scopus 로고
    • p53 gene mutations are associated with decreased sensitivity of human lymphoma cells to DNA damaging agents
    • Fan S, el-Deiry WS, Bae I, Freeman J, Jondle D, Bhatia K, et al. p53 gene mutations are associated with decreased sensitivity of human lymphoma cells to DNA damaging agents. Cancer Res 1994;54:5824-30.
    • (1994) Cancer Res , vol.54 , pp. 5824-5830
    • Fan, S.1    El-Deiry, W.S.2    Bae, I.3    Freeman, J.4    Jondle, D.5    Bhatia, K.6
  • 242
    • 0028880293 scopus 로고
    • The control of apoptosis and drug resistance in ovarian cancer: Influence of p53 and Bcl-2
    • Eliopoulos AG, Kerr DJ, Herod J, Hodgkins L, Krajewski S, Reed JC, et al. The control of apoptosis and drug resistance in ovarian cancer: influence of p53 and Bcl-2. Oncogene 1995;11:1217-28.
    • (1995) Oncogene , vol.11 , pp. 1217-1228
    • Eliopoulos, A.G.1    Kerr, D.J.2    Herod, J.3    Hodgkins, L.4    Krajewski, S.5    Reed, J.C.6
  • 243
    • 0027972061 scopus 로고
    • Differential induction of etoposide-mediated apoptosis in human leukemia HL-60 and K562 cells
    • Ritke MK, Rusnak JM, Lazo JS, Allan WP, Dive C, Heer S, et al. Differential induction of etoposide-mediated apoptosis in human leukemia HL-60 and K562 cells. Mol Pharmacol 1994;46:605-11.
    • (1994) Mol Pharmacol , vol.46 , pp. 605-611
    • Ritke, M.K.1    Rusnak, J.M.2    Lazo, J.S.3    Allan, W.P.4    Dive, C.5    Heer, S.6
  • 244
    • 0027196091 scopus 로고
    • Constitutive expression of human Bcl-2 modulates nitrogen mustard and camptothecin induced apoptosis
    • Walton MI, Whysong D, O'Connor PM, Hockenbery D, Korsmeyer SJ, Kohn KW. Constitutive expression of human Bcl-2 modulates nitrogen mustard and camptothecin induced apoptosis. Cancer Res 1993;53:1853-61.
    • (1993) Cancer Res , vol.53 , pp. 1853-1861
    • Walton, M.I.1    Whysong, D.2    O'Connor, P.M.3    Hockenbery, D.4    Korsmeyer, S.J.5    Kohn, K.W.6
  • 245
    • 0029114967 scopus 로고
    • p53 expression is required for thymocyte apoptosis induced by adenosine deaminase deficiency
    • Benveniste P, Cohen A. p53 expression is required for thymocyte apoptosis induced by adenosine deaminase deficiency. Proc Natl Acad Sci USA 1995;92:8373-7.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 8373-8377
    • Benveniste, P.1    Cohen, A.2
  • 246
    • 0028072523 scopus 로고
    • DNA damage can induce apoptosis in proliferating lymphoid cells via p53-independent mechanisms inhibitable by Bcl-2
    • Strasser A, Harris AW, Jacks T, Cory S. DNA damage can induce apoptosis in proliferating lymphoid cells via p53-independent mechanisms inhibitable by Bcl-2 [see comment citation in Medline]. Cell 1994;79:329-39.
    • (1994) Cell , vol.79 , pp. 329-339
    • Strasser, A.1    Harris, A.W.2    Jacks, T.3    Cory, S.4
  • 247
    • 0029360394 scopus 로고
    • Induction of apoptosis by beta-lapachone in human prostate cancer cells
    • Li CJ, Wang C, Pardee AB. Induction of apoptosis by beta-lapachone in human prostate cancer cells. Cancer Res 1995;55:3712-5.
    • (1995) Cancer Res , vol.55 , pp. 3712-3715
    • Li, C.J.1    Wang, C.2    Pardee, A.B.3
  • 248
    • 0028982219 scopus 로고
    • Beta-lapachone-mediated apoptosis in human promyelocytic leukemia (HL-60) and human prostate cancer cells: A p53-independent response
    • Planchon SM, Wuerzberger S, Frydman B, Witiak DT, Hutson P, Church DK, et al. Beta-lapachone-mediated apoptosis in human promyelocytic leukemia (HL-60) and human prostate cancer cells: a p53-independent response. Cancer Res 1995;55:3706-11.
    • (1995) Cancer Res , vol.55 , pp. 3706-3711
    • Planchon, S.M.1    Wuerzberger, S.2    Frydman, B.3    Witiak, D.T.4    Hutson, P.5    Church, D.K.6
  • 249
    • 0028609620 scopus 로고
    • Mcl-1, a member of the Bcl-2 family, delays apoptosis induced by c-Myc overexpression in Chinese hamster ovary cells
    • Reynolds JE, Yang T, Qian L, Jenkinson JD, Zhou P, Eastman A, et al. Mcl-1, a member of the Bcl-2 family, delays apoptosis induced by c-Myc overexpression in Chinese hamster ovary cells. Cancer Res 1994;54:6348-52.
    • (1994) Cancer Res , vol.54 , pp. 6348-6352
    • Reynolds, J.E.1    Yang, T.2    Qian, L.3    Jenkinson, J.D.4    Zhou, P.5    Eastman, A.6
  • 250
    • 0028885513 scopus 로고
    • Wild type p53 and c-myc co-operation in generating apoptosis of a rat hepatocellular carcinoma cell line (FAA-HTC1)
    • Saito Y, Ogawa K. Wild type p53 and c-myc co-operation in generating apoptosis of a rat hepatocellular carcinoma cell line (FAA-HTC1). Oncogene 1995;11:1013-8.
    • (1995) Oncogene , vol.11 , pp. 1013-1018
    • Saito, Y.1    Ogawa, K.2
  • 251
    • 0028847563 scopus 로고
    • Modulation of p53-mediated transcriptional repression and apoptosis by the adenovirus E1B 19K protein
    • Sabbatini P, Chiou SK, Rao L, White E. Modulation of p53-mediated transcriptional repression and apoptosis by the adenovirus E1B 19K protein. Mol Cell Biol 1995;15:1060-70.
    • (1995) Mol Cell Biol , vol.15 , pp. 1060-1070
    • Sabbatini, P.1    Chiou, S.K.2    Rao, L.3    White, E.4
  • 252
    • 0029147167 scopus 로고
    • Adenovirus E1A proteins induce apoptosis by both p53-dependent and p53-independent mechanisms
    • Teodoro JG, Shore GC, Branton PE. Adenovirus E1A proteins induce apoptosis by both p53-dependent and p53-independent mechanisms. Oncogene 1995;11:467-74.
    • (1995) Oncogene , vol.11 , pp. 467-474
    • Teodoro, J.G.1    Shore, G.C.2    Branton, P.E.3
  • 253
    • 0029143395 scopus 로고
    • Essential role for p53-mediated transcription in E1A-induced apoptosis
    • Sabbatini P, Lin J, Levine AJ, White E. Essential role for p53-mediated transcription in E1A-induced apoptosis. Genes Dev 1995;9:2184-92.
    • (1995) Genes Dev , vol.9 , pp. 2184-2192
    • Sabbatini, P.1    Lin, J.2    Levine, A.J.3    White, E.4
  • 254
    • 0029063175 scopus 로고
    • Activated H-ras rescues E1A-induced apoptosis and cooperates with E1A to overcome p53-dependent growth arrest
    • Lin HJ, Eviner V, Prendergast GC, White E. Activated H-ras rescues E1A-induced apoptosis and cooperates with E1A to overcome p53-dependent growth arrest. Mol Cell Biol 1995;15:4536-44.
    • (1995) Mol Cell Biol , vol.15 , pp. 4536-4544
    • Lin, H.J.1    Eviner, V.2    Prendergast, G.C.3    White, E.4
  • 255
    • 0029081551 scopus 로고
    • Apoptosis of rat vascular smooth muscle cells is regulated by p53-dependent and -independent pathways
    • Bennett MR, Evan GI, Schwartz SM. Apoptosis of rat vascular smooth muscle cells is regulated by p53-dependent and -independent pathways. Circ Res 1995;77:266-73.
    • (1995) Circ Res , vol.77 , pp. 266-273
    • Bennett, M.R.1    Evan, G.I.2    Schwartz, S.M.3
  • 256
    • 0028873247 scopus 로고
    • p53-independent apoptotic and necrotic cell deaths induced by adenovirus infection: Suppression by E1B 19K and Bcl-2 proteins
    • Subramanian T, Tarodi B, Chinnadurai G. p53-independent apoptotic and necrotic cell deaths induced by adenovirus infection: suppression by E1B 19K and Bcl-2 proteins. Cell Growth Differ 1995;6:131-7.
    • (1995) Cell Growth Differ , vol.6 , pp. 131-137
    • Subramanian, T.1    Tarodi, B.2    Chinnadurai, G.3
  • 257
    • 0028222124 scopus 로고
    • p53 and E2F-1 cooperate to mediate apoptosis
    • Wu X, Levine AJ. p53 and E2F-1 cooperate to mediate apoptosis. Proc Natl Acad Sci U S A 1994;91:3602-6.
    • (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 3602-3606
    • Wu, X.1    Levine, A.J.2
  • 258
    • 0027947383 scopus 로고
    • Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis
    • Qin XQ, Livingston DM, Kaelin WG Jr, Adams PD. Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis. Proc Natl Acad Sci USA 1994;91:10918-22.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 10918-10922
    • Qin, X.Q.1    Livingston, D.M.2    Kaelin Jr., W.G.3    Adams, P.D.4
  • 259
    • 0028971751 scopus 로고
    • Direction of p21ras-generated signals towards cell growth or apoptosis is determined by protein kinase C and Bcl-2
    • Chen CY, Faller DV. Direction of p21ras-generated signals towards cell growth or apoptosis is determined by protein kinase C and Bcl-2. Oncogene 1995;11:1487-98.
    • (1995) Oncogene , vol.11 , pp. 1487-1498
    • Chen, C.Y.1    Faller, D.V.2
  • 260
    • 0029029743 scopus 로고
    • R-Ras promotes apoptosis caused by growth factor deprivation via a Bcl-2 suppressible mechanism
    • Wang HG, Millan JA, Cox AD, Der CJ, Rapp UR, Beck T, et al. R-Ras promotes apoptosis caused by growth factor deprivation via a Bcl-2 suppressible mechanism. J Cell Biol 1995;129:1103-14.
    • (1995) J Cell Biol , vol.129 , pp. 1103-1114
    • Wang, H.G.1    Millan, J.A.2    Cox, A.D.3    Der, C.J.4    Rapp, U.R.5    Beck, T.6
  • 262
    • 0027261321 scopus 로고
    • Suppression of apoptosis allows differentiation and development of a multipotent hemopoietic cell line in the absence of added growth factors
    • Faibairn LJ, Cowling GJ, Reipert BM, Dexter TM. Suppression of apoptosis allows differentiation and development of a multipotent hemopoietic cell line in the absence of added growth factors. Cell 1993;74:823-32.
    • (1993) Cell , vol.74 , pp. 823-832
    • Faibairn, L.J.1    Cowling, G.J.2    Reipert, B.M.3    Dexter, T.M.4
  • 263
    • 0029002318 scopus 로고
    • Prevention of myeloma cell apoptosis by ectopic bcl-2 expression or interleukin 6-mediated up-regulation of bcl-xL
    • Schwarze MM, Hawley RG. Prevention of myeloma cell apoptosis by ectopic bcl-2 expression or interleukin 6-mediated up-regulation of bcl-xL. Cancer Res 1995;55:2262-5.
    • (1995) Cancer Res , vol.55 , pp. 2262-2265
    • Schwarze, M.M.1    Hawley, R.G.2
  • 264
    • 0028903234 scopus 로고
    • Apoptosis of human vascular smooth muscle cells derived from normal vessels and coronary atherosclerotic plaques
    • Bennett MR, Evan GI, Schwartz SM. Apoptosis of human vascular smooth muscle cells derived from normal vessels and coronary atherosclerotic plaques. J Clin Invest 1995;95:2266-74.
    • (1995) J Clin Invest , vol.95 , pp. 2266-2274
    • Bennett, M.R.1    Evan, G.I.2    Schwartz, S.M.3
  • 265
    • 0027243086 scopus 로고
    • The proto-oncogene bcl-2 can selectively rescue neurotrophic factor-dependent neurons from apoptosis
    • Allsopp TE, Wyatt S, Paterson HF, Davies AM. The proto-oncogene bcl-2 can selectively rescue neurotrophic factor-dependent neurons from apoptosis. Cell 1993;73:295-307.
    • (1993) Cell , vol.73 , pp. 295-307
    • Allsopp, T.E.1    Wyatt, S.2    Paterson, H.F.3    Davies, A.M.4
  • 266
    • 0026454763 scopus 로고
    • Prevention of programmed cell death of sympathetic neurons by the bcl-2 proto-oncogene
    • Garcia I, Martinou I, Tsujimoto Y, Martinou JC. Prevention of programmed cell death of sympathetic neurons by the bcl-2 proto-oncogene. Science 1992;258:302-4.
    • (1992) Science , vol.258 , pp. 302-304
    • Garcia, I.1    Martinou, I.2    Tsujimoto, Y.3    Martinou, J.C.4
  • 267
    • 0027940391 scopus 로고
    • Neurons from mouse embryos with a null mutation in the tumour suppressor gene p53 undergo normal cell death in the absence of neurotrophins
    • Davies AM, Rosenthal A. Neurons from mouse embryos with a null mutation in the tumour suppressor gene p53 undergo normal cell death in the absence of neurotrophins. Neurosci Lett 1994;182:112-4.
    • (1994) Neurosci Lett , vol.182 , pp. 112-114
    • Davies, A.M.1    Rosenthal, A.2
  • 268
    • 0028982748 scopus 로고
    • Viral proteins E1B19K and p35 protect sympathetic neurons from cell death induced by NGF deprivation
    • Martinou I, Fernandez PA, Missotten M, White E, Allet B, Sadone R, et al. Viral proteins E1B19K and p35 protect sympathetic neurons from cell death induced by NGF deprivation. J Cell Biol 1995;128:201-8.
    • (1995) J Cell Biol , vol.128 , pp. 201-208
    • Martinou, I.1    Fernandez, P.A.2    Missotten, M.3    White, E.4    Allet, B.5    Sadone, R.6
  • 269
    • 0028846718 scopus 로고
    • Membrane-asociated CD19-LYN complex is an endogenous p53-independent and Bcl-2-independent regulator of apoptosis in human Blineage lymphoma cells
    • Myers DE, Jun X, Waddick KG, Forsyth C, Cheestrom LM, Gunther RL, et al. Membrane-asociated CD19-LYN complex is an endogenous p53-independent and Bcl-2-independent regulator of apoptosis in human Blineage lymphoma cells. Proc Natl Acad Sci U S A 1995;92:9575-9.
    • (1995) Proc Natl Acad Sci U S A , vol.92 , pp. 9575-9579
    • Myers, D.E.1    Jun, X.2    Waddick, K.G.3    Forsyth, C.4    Cheestrom, L.M.5    Gunther, R.L.6
  • 270
    • 0028926737 scopus 로고
    • Inhibition by differentiation-inducing agents of wild-type p53-dependent apoptosis in HL-60 cells
    • Noguchi K, Nakajima M, Naito M, Tsuruo T. Inhibition by differentiation-inducing agents of wild-type p53-dependent apoptosis in HL-60 cells. Jpn J Cancer Res 1995;86:217-23.
    • (1995) Jpn J Cancer Res , vol.86 , pp. 217-223
    • Noguchi, K.1    Nakajima, M.2    Naito, M.3    Tsuruo, T.4
  • 271
    • 0029166590 scopus 로고
    • Potentiation of apoptosis by treatment with the protein kinase C-specific inhibitor safingol in mitomycin C-treated gastric cancer cells
    • Schwartz GK, Haimovitz-Friedman A, Dhupar SK, Ehleiter D, Maslak P, Lai L, et al. Potentiation of apoptosis by treatment with the protein kinase C-specific inhibitor safingol in mitomycin C-treated gastric cancer cells. J Natl Cancer Inst 1995;87:1394-9.
    • (1995) J Natl Cancer Inst , vol.87 , pp. 1394-1399
    • Schwartz, G.K.1    Haimovitz-Friedman, A.2    Dhupar, S.K.3    Ehleiter, D.4    Maslak, P.5    Lai, L.6
  • 272
    • 0026620588 scopus 로고
    • Second-messenger pathways involved in the regulation of survival in germinal-centre B cells and in Burkitt lymphoma lines
    • Knox KA, Finney M, Milner AE, Gregory CD, Wakelam MJ, Michell RH, et al. Second-messenger pathways involved in the regulation of survival in germinal-centre B cells and in Burkitt lymphoma lines, Int J Cancer 1992;52:959-66.
    • (1992) Int J Cancer , vol.52 , pp. 959-966
    • Knox, K.A.1    Finney, M.2    Milner, A.E.3    Gregory, C.D.4    Wakelam, M.J.5    Michell, R.H.6
  • 273
    • 0029033619 scopus 로고
    • Bcl-x and Bcl-2 inhibit TNF and Fas-induced apoptosis and activation of phospholipase A2 in breast carcinoma cells
    • Jaattela M, Benedict M, Tewari M, Shayman JA, Dixit VM. Bcl-x and Bcl-2 inhibit TNF and Fas-induced apoptosis and activation of phospholipase A2 in breast carcinoma cells. Oncogene 1995;10:2297-305.
    • (1995) Oncogene , vol.10 , pp. 2297-2305
    • Jaattela, M.1    Benedict, M.2    Tewari, M.3    Shayman, J.A.4    Dixit, V.M.5
  • 274
    • 0029010631 scopus 로고
    • Protooncogene bcl-2 gene transfer abrogates Fas/APO-1 antibody-mediated apoptosis of human malignant glioma cells and confers resistance to chemotherapeutic drugs and therapeutic irradiation
    • Weller M, Malipiero U, Aguzzi A, Reed JC, Fontana A. Protooncogene bcl-2 gene transfer abrogates Fas/APO-1 antibody-mediated apoptosis of human malignant glioma cells and confers resistance to chemotherapeutic drugs and therapeutic irradiation. J Clin Invest 1995;95:2633-43.
    • (1995) J Clin Invest , vol.95 , pp. 2633-2643
    • Weller, M.1    Malipiero, U.2    Aguzzi, A.3    Reed, J.C.4    Fontana, A.5
  • 275
    • 0028816320 scopus 로고
    • Detection of apoptosis and expression of apoptosis-related proteins during human intrahepatic bile duct development
    • Terada T, Nakanuma Y. Detection of apoptosis and expression of apoptosis-related proteins during human intrahepatic bile duct development. Am J Pathol 1995;146:67-74.
    • (1995) Am J Pathol , vol.146 , pp. 67-74
    • Terada, T.1    Nakanuma, Y.2
  • 276
    • 0028059445 scopus 로고
    • Functional complementation of the adenovirus E1B 19-kilodalton protein with Bcl-2 in the inhibition of apoptosis in infected cells
    • Chiou SK, Tseng CC, Rao L, White E. Functional complementation of the adenovirus E1B 19-kilodalton protein with Bcl-2 in the inhibition of apoptosis in infected cells. J Virol 1994;68:6553-66.
    • (1994) J Virol , vol.68 , pp. 6553-6566
    • Chiou, S.K.1    Tseng, C.C.2    Rao, L.3    White, E.4
  • 277
    • 0029058323 scopus 로고
    • The baculovirus p35 protein inhibits Fas- and tumor necrosis factor-induced apoptosis
    • Beidler DR, Tewari M, Friesen PD, Poirier G, Dixit VM. The baculovirus p35 protein inhibits Fas- and tumor necrosis factor-induced apoptosis, J Biol Chem 1995;270:16526-8.
    • (1995) J Biol Chem , vol.270 , pp. 16526-16528
    • Beidler, D.R.1    Tewari, M.2    Friesen, P.D.3    Poirier, G.4    Dixit, V.M.5
  • 278
    • 0028912996 scopus 로고
    • Tumor necrosis factor alpha-induced apoptosis in human neuronal cells: Protection by the antioxidant N-acetylcysteine and the genes bcl-2 and crmA
    • Talley AK, Dewhurst S, Perry SW, Douard SG, Gummulurru S, Fine SM, et al. Tumor necrosis factor alpha-induced apoptosis in human neuronal cells: protection by the antioxidant N-acetylcysteine and the genes bcl-2 and crmA. Mol Cell Biol 1995;15:2359-66.
    • (1995) Mol Cell Biol , vol.15 , pp. 2359-2366
    • Talley, A.K.1    Dewhurst, S.2    Perry, S.W.3    Douard, S.G.4    Gummulurru, S.5    Fine, S.M.6
  • 279
    • 0029059370 scopus 로고
    • Soluble antigen can cause enhanced apoptosis of germinal-centre B cells
    • Pulendran B, Kannourakis G, Nouri S, Smith KG, Nossal GJ. Soluble antigen can cause enhanced apoptosis of germinal-centre B cells [see comment citation in Medline]. Nature 1995;375:331-4.
    • (1995) Nature , vol.375 , pp. 331-334
    • Pulendran, B.1    Kannourakis, G.2    Nouri, S.3    Smith, K.G.4    Nossal, G.J.5
  • 280
    • 0028963244 scopus 로고
    • Regulation of apoptosis induced by the retinoid N-(4-hydroxyphenyl) retinamide and effect of deregulated bcl-2
    • Delia D, Aiello A, Formelli F, Fontanella E, Costa A, Miyashita T, et al. Regulation of apoptosis induced by the retinoid N-(4-hydroxyphenyl) retinamide and effect of deregulated bcl-2. Blood 1995;85:359-67.
    • (1995) Blood , vol.85 , pp. 359-367
    • Delia, D.1    Aiello, A.2    Formelli, F.3    Fontanella, E.4    Costa, A.5    Miyashita, T.6
  • 281
    • 0028983107 scopus 로고
    • p53 independent G0/G1 arrest and apoptosis induced by a novel retinoid in human breast cancer cells
    • Shao ZM, Dawson MI, Li XS, Rishi AK, Sheikh MS, Han QX, et al. p53 independent G0/G1 arrest and apoptosis induced by a novel retinoid in human breast cancer cells. Oncogene 1995;11:493-504.
    • (1995) Oncogene , vol.11 , pp. 493-504
    • Shao, Z.M.1    Dawson, M.I.2    Li, X.S.3    Rishi, A.K.4    Sheikh, M.S.5    Han, Q.X.6
  • 282
    • 0028815882 scopus 로고
    • Regulation of apoptosis in normal and malignant ovarian epithelial cells by transforming growth factor beta
    • Havrilesky LJ, Hurteau JA, Whitaker RS, Elbendary A, Wu S, Rodriguez GC, et al. Regulation of apoptosis in normal and malignant ovarian epithelial cells by transforming growth factor beta. Cancer Res 1995; 55:944-8.
    • (1995) Cancer Res , vol.55 , pp. 944-948
    • Havrilesky, L.J.1    Hurteau, J.A.2    Whitaker, R.S.3    Elbendary, A.4    Wu, S.5    Rodriguez, G.C.6
  • 283
    • 0028936340 scopus 로고
    • Acceleration of apoptosis in transforming growth factor beta 1-treated M1 cells ectopically expressing B-myb
    • Bies J, Wolff L. Acceleration of apoptosis in transforming growth factor beta 1-treated M1 cells ectopically expressing B-myb. Cancer Res 1995; 55:501-4.
    • (1995) Cancer Res , vol.55 , pp. 501-504
    • Bies, J.1    Wolff, L.2
  • 284
    • 0026584374 scopus 로고
    • In vitro apoptosis in the human hepatoma cell line induced by transforming growth factor beta 1
    • Lin JK, Chou CK. In vitro apoptosis in the human hepatoma cell line induced by transforming growth factor beta 1. Cancer Res 1992;52:385-8.
    • (1992) Cancer Res , vol.52 , pp. 385-388
    • Lin, J.K.1    Chou, C.K.2
  • 285
    • 0028540185 scopus 로고
    • Antiapoptosis potential of bcl-2 oncogene by dephosphorylation
    • Haldar S, Jena N, Croce CM. Antiapoptosis potential of bcl-2 oncogene by dephosphorylation. Biochem Cell Biol 1994;72:455-62.
    • (1994) Biochem Cell Biol , vol.72 , pp. 455-462
    • Haldar, S.1    Jena, N.2    Croce, C.M.3
  • 288
    • 9544244796 scopus 로고    scopus 로고
    • Retrovirus-mediated wild-type p53 gene transfer to tumors of patients with lung cancer
    • Roth JA, Nguyen D, Lawrence DD, Kemp BL, Carrisco CH, Ferson DZ, et al. Retrovirus-mediated wild-type p53 gene transfer to tumors of patients with lung cancer. Nat Med 1996;2:985-91.
    • (1996) Nat Med , vol.2 , pp. 985-991
    • Roth, J.A.1    Nguyen, D.2    Lawrence, D.D.3    Kemp, B.L.4    Carrisco, C.H.5    Ferson, D.Z.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.