-
1
-
-
0025040233
-
Suppression of human colorectal carcinoma cell growth by wild-type p53
-
Baker, S.J., Markowitz, S., Fearson, E.R., Willson, J.K.V. and Vogelstein. B. (1990) Suppression of human colorectal carcinoma cell growth by wild-type p53. Science, 249, 912-915.
-
(1990)
Science
, vol.249
, pp. 912-915
-
-
Baker, S.J.1
Markowitz, S.2
Fearson, E.R.3
Willson, J.K.V.4
Vogelstein, B.5
-
2
-
-
0022483186
-
Isolation of human-p53-specific monoclonal antibodies and their use in the studies of human p53 expression
-
Banks, L., Matlashewski, G. and Crawford, L. (1986) Isolation of human-p53-specific monoclonal antibodies and their use in the studies of human p53 expression. Eur. J. Biochem., 159, 529-534.
-
(1986)
Eur. J. Biochem.
, vol.159
, pp. 529-534
-
-
Banks, L.1
Matlashewski, G.2
Crawford, L.3
-
3
-
-
0026523614
-
Enhanced binding of a 95-kDa protein to p53 in cells undergoing p53-mediated growth arrest
-
Barak, Y. and Oren, M. (1992) Enhanced binding of a 95-kDa protein to p53 in cells undergoing p53-mediated growth arrest. EMBO J. 11, 2115-2121.
-
(1992)
EMBO J.
, vol.11
, pp. 2115-2121
-
-
Barak, Y.1
Oren, M.2
-
4
-
-
0027459198
-
mdm2 expression is induced by wild-type p53 activity
-
Barak, Y., Juven, T., Haffner, R and Oren, M. (1993) mdm2 expression is induced by wild-type p53 activity. EMBO J., 12, 461-468.
-
(1993)
EMBO J.
, vol.12
, pp. 461-468
-
-
Barak, Y.1
Juven, T.2
Haffner, R.3
Oren, M.4
-
5
-
-
0028049474
-
Regulation of mdm2 expression by p53: Alternative promoters produce transcripts with nonidentical translation potential
-
Barak, Y. Gottlieb, E., Juven, G.T. and Oren, M. (1994) Regulation of mdm2 expression by p53: alternative promoters produce transcripts with nonidentical translation potential. Genes Dev., 8, 1739-1749.
-
(1994)
Genes Dev.
, vol.8
, pp. 1739-1749
-
-
Barak, Y.1
Gottlieb, E.2
Juven, G.T.3
Oren, M.4
-
6
-
-
0027508092
-
The tumor suppressor p53 and the oncoprotein simian virus-40 T-Antigen bind to overlapping domains on the Mdm2 protein
-
Brown, D.R., Deb, S., Munoz, R.M., Subler, M.A. and Deb, S.R (1993) The tumor suppressor p53 and the oncoprotein simian virus-40 T-Antigen bind to overlapping domains on the Mdm2 protein. Mol. Cell. Biol., 13, 6849-6857.
-
(1993)
Mol. Cell. Biol.
, vol.13
, pp. 6849-6857
-
-
Brown, D.R.1
Deb, S.2
Munoz, R.M.3
Subler, M.A.4
Deb, S.R.5
-
7
-
-
0028070989
-
p53-dependent apoptosis in the absence of transcriptional activation of p53-target genes
-
Caelles, C., Helmberg, A. and Karin, M. (1994) p53-dependent apoptosis in the absence of transcriptional activation of p53-target genes. Nature, 370, 220-223.
-
(1994)
Nature
, vol.370
, pp. 220-223
-
-
Caelles, C.1
Helmberg, A.2
Karin, M.3
-
8
-
-
0023339504
-
Molecular analysis and chromosomal mapping of amplified genes isolated from a transformed mouse 3T3 cell line
-
Cahilly-Snyder, L., Yang-Feng, T., Francke, U. and George, D.L. (1987) Molecular analysis and chromosomal mapping of amplified genes isolated from a transformed mouse 3T3 cell line. Som. Cell Mol. Genet., 13, 235-244.
-
(1987)
Som. Cell Mol. Genet.
, vol.13
, pp. 235-244
-
-
Cahilly-Snyder, L.1
Yang-Feng, T.2
Francke, U.3
George, D.L.4
-
9
-
-
0028958705
-
Growth factor modulation of p53-mediated growth arrest versus apoptosis
-
Canman, C.E., Gilmer, T.M., Coutts, S.B. and Kastan, M.B. (1995) Growth factor modulation of p53-mediated growth arrest versus apoptosis. Genes Dev., 9, 600-611.
-
(1995)
Genes Dev.
, vol.9
, pp. 600-611
-
-
Canman, C.E.1
Gilmer, T.M.2
Coutts, S.B.3
Kastan, M.B.4
-
10
-
-
0028221013
-
Interactions between p53 and Mdm2 in a mammalian cell cycle checkpoint pathway
-
Chen, C.Y., Oliner, J.D., Zhan, Q., Fornace, A.J., Vogelstein, B. and Kastan, M.B. (1994) Interactions between p53 and Mdm2 in a mammalian cell cycle checkpoint pathway. Proc. Natl Acad. Sci. USA, 91, 2684-2688
-
(1994)
Proc. Natl Acad. Sci. USA
, vol.91
, pp. 2684-2688
-
-
Chen, C.Y.1
Oliner, J.D.2
Zhan, Q.3
Fornace, A.J.4
Vogelstein, B.5
Kastan, M.B.6
-
11
-
-
0027222956
-
Mapping of the p53 and mdm-2 interaction domains
-
Chen, J.D., Marechal, V. and Levine, A.J. (1993) Mapping of the p53 and mdm-2 interaction domains Mol. Cell. Biol., 13, 4107-4114.
-
(1993)
Mol. Cell. Biol.
, vol.13
, pp. 4107-4114
-
-
Chen, J.D.1
Marechal, V.2
Levine, A.J.3
-
12
-
-
0013568829
-
Regulation of transcription functions of the p53 tumour suppressor by the mdm-2 oncogene
-
Chen, J.D., Lin, J.Y. and Levine, A.J. (1995) Regulation of transcription functions of the p53 tumour suppressor by the mdm-2 oncogene Mol. Med., 1, 141-152.
-
(1995)
Mol. Med.
, vol.1
, pp. 141-152
-
-
Chen, J.D.1
Lin, J.Y.2
Levine, A.J.3
-
13
-
-
0028098165
-
Molecular abnormalities of mdm2 and p53 genes in adult soft tissue sarcomas
-
Cordon-Cardo, C. et al. (1994) Molecular abnormalities of mdm2 and p53 genes in adult soft tissue sarcomas. Cancer Res., 54, 794-799.
-
(1994)
Cancer Res.
, vol.54
, pp. 794-799
-
-
Cordon-Cardo, C.1
-
14
-
-
0028946095
-
Non-syntenic amplification of MDM2 and MYCN in human neuroblastoma
-
Corvi, R. et al. (1995) Non-syntenic amplification of MDM2 and MYCN in human neuroblastoma. Oncogene, 10, 1081-1086.
-
(1995)
Oncogene
, vol.10
, pp. 1081-1086
-
-
Corvi, R.1
-
15
-
-
0028131554
-
Transcriptional activation by p53 correlates with suppression of growth but not transformation
-
Crook, T., Marston, N.J., Sara, E.A. and Vousden, K.H. (1994) Transcriptional activation by p53 correlates with suppression of growth but not transformation. Cell, 79, 817-827.
-
(1994)
Cell
, vol.79
, pp. 817-827
-
-
Crook, T.1
Marston, N.J.2
Sara, E.A.3
Vousden, K.H.4
-
16
-
-
0028220204
-
1 arrest
-
1 arrest. Cell, 76, 1013-1023.
-
(1994)
Cell
, vol.76
, pp. 1013-1023
-
-
Dulic, V.1
Kaufmann, W.K.2
Wilson, S.J.3
Tlsty, T.D.4
Lees, E.5
Harper, J.W.6
Elledge, S.J.7
Reed, S.I.8
-
17
-
-
0027359827
-
WAF1, a potential mediator of p53 tumor suppression
-
El-Deiry, W.S. et al. (1993) WAF1, a potential mediator of p53 tumor suppression. Cell, 75, 817-825.
-
(1993)
Cell
, vol.75
, pp. 817-825
-
-
El-Deiry, W.S.1
-
18
-
-
0028294605
-
WAF1/CIP/ is induced in p53-mediated G1 arrest and apoptosis
-
El-Deiry, W.S. et al. (1994) WAF1/CIP/ is induced in p53-mediated G1 arrest and apoptosis. Cancer Res., 54, 1169-1174.
-
(1994)
Cancer Res.
, vol.54
, pp. 1169-1174
-
-
El-Deiry, W.S.1
-
19
-
-
0025853776
-
Tumorigenic potential associated with enhanced expression of a gene that is amplified in a mouse tumour line
-
Fakharzadeh, S., Trusko, R.S. and George, D.L. (1991) Tumorigenic potential associated with enhanced expression of a gene that is amplified in a mouse tumour line. EMBO J., 10, 1565-1569.
-
(1991)
EMBO J.
, vol.10
, pp. 1565-1569
-
-
Fakharzadeh, S.1
Trusko, R.S.2
George, D.L.3
-
20
-
-
0026724311
-
Structure and function of simian virus-40 large tumorantigen
-
Fanning, E. and Knippers, R. (1992) Structure and function of simian virus-40 large tumorantigen. Annu. Rev. Biochem., 61, 55-85.
-
(1992)
Annu. Rev. Biochem.
, vol.61
, pp. 55-85
-
-
Fanning, E.1
Knippers, R.2
-
21
-
-
0026770424
-
Wild-type p53 activates transcription in vitro
-
Farmer, G., Bargonetti, J., Zhu, H., Friedman, P., Prywes, R. and Prives, C. (1992) Wild-type p53 activates transcription in vitro. Nature, 358, 83-86.
-
(1992)
Nature
, vol.358
, pp. 83-86
-
-
Farmer, G.1
Bargonetti, J.2
Zhu, H.3
Friedman, P.4
Prywes, R.5
Prives, C.6
-
22
-
-
0027498314
-
The mdm-2 oncogene can overcome wild-type p53 suppression of transformed cell growth
-
Finlay, C.A. (1993) The mdm-2 oncogene can overcome wild-type p53 suppression of transformed cell growth. Mol. Cell. Biol., 13, 301-306
-
(1993)
Mol. Cell. Biol.
, vol.13
, pp. 301-306
-
-
Finlay, C.A.1
-
23
-
-
0026648674
-
Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation
-
Gavrieli, Y., Sherman, Y. and Ben-Sasson, S.A. (1992) Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J. cell Biol. 119, 493-501.
-
(1992)
J. Cell Biol.
, vol.119
, pp. 493-501
-
-
Gavrieli, Y.1
Sherman, Y.2
Ben-Sasson, S.A.3
-
24
-
-
0028294898
-
Down-regulation of wild-type p53 activity interferes with apoptosis of IL-3-dependent hematopoietic cells following IL-3 withdrawal
-
Gottlieb, E., Haffner, R., von Ruden, T., Wagner, E.F. and Oren, M. (1994) Down-regulation of wild-type p53 activity interferes with apoptosis of IL-3-dependent hematopoietic cells following IL-3 withdrawal. EMBO J., 13, 1368-1374.
-
(1994)
EMBO J.
, vol.13
, pp. 1368-1374
-
-
Gottlieb, E.1
Haffner, R.2
Von Ruden, T.3
Wagner, E.F.4
Oren, M.5
-
25
-
-
0028899283
-
p53: Biochemical properties and biological effects
-
Haffner, R. and Oren, M. (1995) p53: biochemical properties and biological effects. Curr. Opin. Genet. Dev., 5, 84-90.
-
(1995)
Curr. Opin. Genet. Dev.
, vol.5
, pp. 84-90
-
-
Haffner, R.1
Oren, M.2
-
26
-
-
0028147405
-
Physical and functional interaction between wild-type p53 and Mdm2 proteins
-
Haines, D.S., Landers, J.E., Engle, L.J. and George, D.L. (1994) Physical and functional interaction between wild-type p53 and Mdm2 proteins. Mol. Cell. Biol., 14, 1171-1178.
-
(1994)
Mol. Cell. Biol.
, vol.14
, pp. 1171-1178
-
-
Haines, D.S.1
Landers, J.E.2
Engle, L.J.3
George, D.L.4
-
27
-
-
9244246677
-
Monoclonal antibodies specific for simian virus 40 tumor antigens
-
Harlow, E., Crawford, L V., Pim, D.C. and Williamson, N.M. (1981) Monoclonal antibodies specific for simian virus 40 tumor antigens. J. Virol., 34, 752-763.
-
(1981)
J. Virol.
, vol.34
, pp. 752-763
-
-
Harlow, E.1
Crawford, L.V.2
Pim, D.C.3
Williamson, N.M.4
-
28
-
-
0027496935
-
The p21 CDK-interacting protein cip1 is a potent inhibitor of G1 cyclin-dependent kinases
-
Harper, J.W., Adami, G.R., Wei, N., Keyomarsi, K. and Elledge, S J. (1993) The p21 CDK-interacting protein cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell, 75, 805-816.
-
(1993)
Cell
, vol.75
, pp. 805-816
-
-
Harper, J.W.1
Adami, G.R.2
Wei, N.3
Keyomarsi, K.4
Elledge, S.J.5
-
29
-
-
0028999429
-
p53-mediated apoptosis in HeLa cells can be overcome by excess pRB
-
Haupt, Y., Rowan, S. and Oren, M. (1995a) p53-mediated apoptosis in HeLa cells can be overcome by excess pRB. Oncogene, 10, 1563-1571.
-
(1995)
Oncogene
, vol.10
, pp. 1563-1571
-
-
Haupt, Y.1
Rowan, S.2
Oren, M.3
-
30
-
-
0029092356
-
Induction of apoptosis in HeLa cells by trans-activation-deficient p53
-
Haupt, Y., Rowan, S., Shaulian, E., Vousden, H.K. and Oren, M. (1995b) Induction of apoptosis in HeLa cells by trans-activation-deficient p53. Genes Dev., 9, 2170-2183.
-
(1995)
Genes Dev.
, vol.9
, pp. 2170-2183
-
-
Haupt, Y.1
Rowan, S.2
Shaulian, E.3
Vousden, H.K.4
Oren, M.5
-
31
-
-
0025618980
-
Mutant p53 DNA clones from human colon carcinomas cooperate with ras in transforming primary rat cells - A comparison of the hot spot mutant phenotype
-
Hinds, P.W., Finlay, C A., Quartin, S.J., Baker, E.R., Fearon, B., Vogelstein, B. and Levine, A.J. (1990) Mutant p53 DNA clones from human colon carcinomas cooperate with ras in transforming primary rat cells - a comparison of the hot spot mutant phenotype. Cell Growth Differ, 1, 571-580.
-
(1990)
Cell Growth Differ
, vol.1
, pp. 571-580
-
-
Hinds, P.W.1
Finlay, C.A.2
Quartin, S.J.3
Baker, E.R.4
Fearon, B.5
Vogelstein, B.6
Levine, A.J.7
-
32
-
-
0027315291
-
Repression of endogenous p53 transactivation function in HeLa cervical carcinoma cells by human colon papillomavirus type-16 E6, human Mdm-2 and mutant p53
-
Hoppe-Seyler, F. and Butz, K. (1993) Repression of endogenous p53 transactivation function in HeLa cervical carcinoma cells by human colon papillomavirus type-16 E6, human Mdm-2 and mutant p53. J. Virol. 67, 3111-3117.
-
(1993)
J. Virol.
, vol.67
, pp. 3111-3117
-
-
Hoppe-Seyler, F.1
Butz, K.2
-
33
-
-
0028227260
-
Apoptosis or retinoblastoma: Alternative fates of photoreceptors expressing the HPV-16 E7 gene in the presence or absence or p53
-
Howes, K.A., Ransom, N., Papermaster, D.S., Lasudry, J.G.H., Albert, D.M. and Windle, J.J. (1994) Apoptosis or retinoblastoma: alternative fates of photoreceptors expressing the HPV-16 E7 gene in the presence or absence or p53. Genes Dev., 8, 1300-1310.
-
(1994)
Genes Dev.
, vol.8
, pp. 1300-1310
-
-
Howes, K.A.1
Ransom, N.2
Papermaster, D.S.3
Lasudry, J.G.H.4
Albert, D.M.5
Windle, J.J.6
-
34
-
-
0029028352
-
Mutational analysis of the carboxy-terminal portion of p53 using both yeast and mammalian cell assays in vivo
-
Ishioka, C., Englert, C., Winge, P., Yan, Y.X., Engelstein, M. and Friend, S.H. (1995) Mutational analysis of the carboxy-terminal portion of p53 using both yeast and mammalian cell assays in vivo. Oncogene, 10, 1485-1492.
-
(1995)
Oncogene
, vol.10
, pp. 1485-1492
-
-
Ishioka, C.1
Englert, C.2
Winge, P.3
Yan, Y.X.4
Engelstein, M.5
Friend, S.H.6
-
35
-
-
0027536952
-
Growth suppression of Friend virus-transformed erythroleukemia cells by p53 protein is accompanied by hemoglobin production and is sensitive to erythropoietin
-
Johnson, P., Chung, S. and Benchimol, S. (1993) Growth suppression of Friend virus-transformed erythroleukemia cells by p53 protein is accompanied by hemoglobin production and is sensitive to erythropoietin. Mol. Cell. Biol., 13, 1456-1463.
-
(1993)
Mol. Cell. Biol.
, vol.13
, pp. 1456-1463
-
-
Johnson, P.1
Chung, S.2
Benchimol, S.3
-
36
-
-
0028834902
-
Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53
-
Jones, S.N., Roe, A.E., Donehower, L.A. and Bradly, A. (1995) Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53. Nature, 378, 206-208.
-
(1995)
Nature
, vol.378
, pp. 206-208
-
-
Jones, S.N.1
Roe, A.E.2
Donehower, L.A.3
Bradly, A.4
-
37
-
-
0027501841
-
Wild type p53 can mediate sequence-specific transactivation of an internal promoter within the mdm2 gene
-
Juven, T., Barak, Y., Zauberman, A., George, D.L. and Oren, M. (1993) Wild type p53 can mediate sequence-specific transactivation of an internal promoter within the mdm2 gene. Oncogene, 8, 3411-3416.
-
(1993)
Oncogene
, vol.8
, pp. 3411-3416
-
-
Juven, T.1
Barak, Y.2
Zauberman, A.3
George, D.L.4
Oren, M.5
-
38
-
-
0029044606
-
Mdm2 protein confers the resistance of a human glioblastoma cell line to cisplatin-induced apoptosis
-
Kondo, S., Barnett, G.H., Hara, H., Morimura, T. and Takeuchi, J. (1995) Mdm2 protein confers the resistance of a human glioblastoma cell line to cisplatin-induced apoptosis. Oncogene, 10, 2001-2006.
-
(1995)
Oncogene
, vol.10
, pp. 2001-2006
-
-
Kondo, S.1
Barnett, G.H.2
Hara, H.3
Morimura, T.4
Takeuchi, J.5
-
39
-
-
0027508958
-
mdm2 gene amplification in metastatic osteosarcoma
-
Ladanyi, M., Cha, C., Lewis, R., Jhanwar, S.C., Huvos, A.G. and Healey, J.H. (1993) mdm2 gene amplification in metastatic osteosarcoma. Cancer Res., 53, 16-18.
-
(1993)
Cancer Res.
, vol.53
, pp. 16-18
-
-
Ladanyi, M.1
Cha, C.2
Lewis, R.3
Jhanwar, S.C.4
Huvos, A.G.5
Healey, J.H.6
-
40
-
-
0027109075
-
p53, guardian of the genome
-
Lane, D.P. (1992) p53, guardian of the genome. Nature, 358, 15-16.
-
(1992)
Nature
, vol.358
, pp. 15-16
-
-
Lane, D.P.1
-
41
-
-
0027232042
-
p53 mutation and mdm2 amplification in human soft tissue sarcomas
-
Leach, F.S. et al. (1993) p53 mutation and mdm2 amplification in human soft tissue sarcomas. Cancer Res., 53, 2231-2234.
-
(1993)
Cancer Res.
, vol.53
, pp. 2231-2234
-
-
Leach, F.S.1
-
42
-
-
0027326586
-
The tumor suppressor genes
-
Levine, A.J. (1993) The tumor suppressor genes. Annu. Rev. Biochem., 62, 623-651.
-
(1993)
Annu. Rev. Biochem.
, vol.62
, pp. 623-651
-
-
Levine, A.J.1
-
43
-
-
0028074603
-
Differential effects by the p21 CDK inhibitor on PCNA-dependent DNA replication and repair
-
Li, R., Waga, S., Hannon, G.J., Beach, D. and Stillman, B. (1994) Differential effects by the p21 CDK inhibitor on PCNA-dependent DNA replication and repair. Nature, 371, 534-537.
-
(1994)
Nature
, vol.371
, pp. 534-537
-
-
Li, R.1
Waga, S.2
Hannon, G.J.3
Beach, D.4
Stillman, B.5
-
44
-
-
0028303752
-
Several hydrophobic amino acids in the p53 amino-terminal domain are required for transcriptional activation, binding to Mdm-2 and the adenovirus 5 E1B 55-kD protein
-
Lin, J.Y, Chen, J.D., Elenbaas, B. and Levine, A.J. (1994) Several hydrophobic amino acids in the p53 amino-terminal domain are required for transcriptional activation, binding to Mdm-2 and the adenovirus 5 E1B 55-kD protein. Genes Dev., 8, 1235-1246.
-
(1994)
Genes Dev.
, vol.8
, pp. 1235-1246
-
-
Lin, J.Y.1
Chen, J.D.2
Elenbaas, B.3
Levine, A.J.4
-
45
-
-
0027283604
-
Hematopoietic cells from mice deficient in wild-type p53 are more resistant to induction of apoptosis by some agents
-
Lotem, J. and Sachs, L. (1993) Hematopoietic cells from mice deficient in wild-type p53 are more resistant to induction of apoptosis by some agents. Blood, 82, 1092-1096.
-
(1993)
Blood
, vol.82
, pp. 1092-1096
-
-
Lotem, J.1
Sachs, L.2
-
46
-
-
0028979005
-
Human TAF(II)31 protein is a transcriptional coactivator of the p53 protein
-
Lu, H. and Levine, A.J. (1995) Human TAF(II)31 protein is a transcriptional coactivator of the p53 protein. Proc. Natl Acad. Sci. USA, 92, 5154-5158.
-
(1995)
Proc. Natl Acad. Sci. USA
, vol.92
, pp. 5154-5158
-
-
Lu, H.1
Levine, A.J.2
-
47
-
-
0027218350
-
Interactions between SV40 large-tumor antigen and the growth suppressor proteins pRB and p53
-
Ludlow, J.W. (1993) Interactions between SV40 large-tumor antigen and the growth suppressor proteins pRB and p53. FASEB J., 7, 866-871.
-
(1993)
FASEB J.
, vol.7
, pp. 866-871
-
-
Ludlow, J.W.1
-
48
-
-
0029020147
-
Amplification of the mdm2 gene in human breast cancer and its association with Mdm2 and p53 protein status
-
McCann, A.H., Kirley, A., Caney, D.N., Corbally, N., Magee, H.M., Keating, G. and Dervan, P.A. (1995) Amplification of the mdm2 gene in human breast cancer and its association with Mdm2 and p53 protein status. Br. J. Cancer, 71, 981-985.
-
(1995)
Br. J. Cancer
, vol.71
, pp. 981-985
-
-
McCann, A.H.1
Kirley, A.2
Caney, D.N.3
Corbally, N.4
Magee, H.M.5
Keating, G.6
Dervan, P.A.7
-
49
-
-
0027079358
-
The transcriptional transactivation function of wild-type p53 is inhibited by SV40 large T-antigen and by HPV-16 E6-oncoprotein
-
Mietz, J A., Unger, T., Huibregtse, J.M. and Howley, P.M. (1992) The transcriptional transactivation function of wild-type p53 is inhibited by SV40 large T-antigen and by HPV-16 E6-oncoprotein. EMBO J., 11, 5013-5020.
-
(1992)
EMBO J.
, vol.11
, pp. 5013-5020
-
-
Mietz, J.A.1
Unger, T.2
Huibregtse, J.M.3
Howley, P.M.4
-
50
-
-
0026543204
-
p53 gene mutations in non-small-cell lung cancer cell lines and their correlation with the presence of ras mutations and clinical features
-
Mitsudomi, T. et al. (1992) p53 gene mutations in non-small-cell lung cancer cell lines and their correlation with the presence of ras mutations and clinical features. Oncogene, 7, 171-180.
-
(1992)
Oncogene
, vol.7
, pp. 171-180
-
-
Mitsudomi, T.1
-
51
-
-
0028883179
-
Tumor suppressor p53 is a direct transcriptional activator of the human box gene
-
Miyashita, T. and Reed, J.C. (1995) Tumor suppressor p53 is a direct transcriptional activator of the human box gene. Cell, 80, 293-299.
-
(1995)
Cell
, vol.80
, pp. 293-299
-
-
Miyashita, T.1
Reed, J.C.2
-
52
-
-
0028335717
-
Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo
-
Miyashita, T., Krajewski, S., Krajewska, M., Wang, H.W., Lin, H.K., Liebermann, D.A., Hoffman, B. and Reed, J.C. (1994) Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo. Oncogene, 9, 1799-1805.
-
(1994)
Oncogene
, vol.9
, pp. 1799-1805
-
-
Miyashita, T.1
Krajewski, S.2
Krajewska, M.3
Wang, H.W.4
Lin, H.K.5
Liebermann, D.A.6
Hoffman, B.7
Reed, J.C.8
-
53
-
-
0026649648
-
The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation
-
Momand, J., Zambetti, G P., Olson, D.C., George, D. and Levine, A J. (1992) The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation. Cell, 69, 1237-1245.
-
(1992)
Cell
, vol.69
, pp. 1237-1245
-
-
Momand, J.1
Zambetti, G.P.2
Olson, D.C.3
George, D.4
Levine, A.J.5
-
54
-
-
0028823020
-
Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53
-
Montes de Oca Luna, R., Wagner, D.S. and Lozano, G. (1995) Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53. Nature, 378, 203-206.
-
(1995)
Nature
, vol.378
, pp. 203-206
-
-
Montes De Oca Luna, R.1
Wagner, D.S.2
Lozano, G.3
-
55
-
-
0027199498
-
Interaction of adenoviral proteins with pRB and p53
-
Moran, E. (1993) Interaction of adenoviral proteins with pRB and p53 FASEB J., 7, 880-885.
-
(1993)
FASEB J.
, vol.7
, pp. 880-885
-
-
Moran, E.1
-
56
-
-
0027934570
-
p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens
-
Morgenbesser, S.D., Williams, B.O., Jacks, T. and DePinho, R.A. (1994) p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens. Nature, 371, 72-74.
-
(1994)
Nature
, vol.371
, pp. 72-74
-
-
Morgenbesser, S.D.1
Williams, B.O.2
Jacks, T.3
DePinho, R.A.4
-
57
-
-
0027944251
-
Cyclin G is a transcriptional target of the p53 tumor suppressor protein
-
Okamoto, K. and Beach, D. (1994) Cyclin G is a transcriptional target of the p53 tumor suppressor protein EMBO J., 13, 4816-4822.
-
(1994)
EMBO J.
, vol.13
, pp. 4816-4822
-
-
Okamoto, K.1
Beach, D.2
-
58
-
-
0026740449
-
Amplification of a gene encoding a p53-associated protein in human sarcomas
-
Oliner, J.D., Kinzler, K.W., Meltzer, P.S., George, D.L. and Vogelstein, B. (1992) Amplification of a gene encoding a p53-associated protein in human sarcomas Nature, 358, 80-83.
-
(1992)
Nature
, vol.358
, pp. 80-83
-
-
Oliner, J.D.1
Kinzler, K.W.2
Meltzer, P.S.3
George, D.L.4
Vogelstein, B.5
-
59
-
-
0027325132
-
Oncoprotein Mdm2 conceals the activation domain of tumour suppressor-p53
-
Oliner, J.D., Pietenpol, J.A., Thiagalingam, S , Gvuris, J., Kinzler, K.W. and Vogelstein, B. (1993) Oncoprotein Mdm2 conceals the activation domain of tumour suppressor-p53. Nature, 362, 857-860.
-
(1993)
Nature
, vol.362
, pp. 857-860
-
-
Oliner, J.D.1
Pietenpol, J.A.2
Thiagalingam, S.3
Gvuris, J.4
Kinzler, K.W.5
Vogelstein, B.6
-
60
-
-
0028456527
-
Relationship of p53 to the control of apoptotic cell death
-
Oren, M. (1994) Relationship of p53 to the control of apoptotic cell death. Semin Cancer Biol., 5, 305.1-305.7.
-
(1994)
Semin Cancer Biol.
, vol.5
-
-
Oren, M.1
-
61
-
-
0027994037
-
Analysis of the most representative tumor-derived p53 mutants reveals that changes in protein conformation are not correlated with loss of transactivation or inhibition of ceil proliferation
-
Ory, K., Legros, Y., Auguin, C. and Soussi, T. (1994) Analysis of the most representative tumor-derived p53 mutants reveals that changes in protein conformation are not correlated with loss of transactivation or inhibition of ceil proliferation. EMBO J., 13, 3496-3504.
-
(1994)
EMBO J.
, vol.13
, pp. 3496-3504
-
-
Ory, K.1
Legros, Y.2
Auguin, C.3
Soussi, T.4
-
62
-
-
0027291285
-
Upregulation of mdm-2 expression in Meth A tumor cells tolerating wild-type p53
-
Otto, A. and Deppert, W. (1993) Upregulation of mdm-2 expression in Meth A tumor cells tolerating wild-type p53. Oncogene, 8, 2591-2603.
-
(1993)
Oncogene
, vol.8
, pp. 2591-2603
-
-
Otto, A.1
Deppert, W.2
-
63
-
-
0029003501
-
Wild-type human p53 and a temperature-sensitive mutant induce Fas/APO-1 expression
-
Owen-Schaub, L.B. et al. (1995) Wild-type human p53 and a temperature-sensitive mutant induce Fas/APO-1 expression. Mol. Cell. Biol., 15, 3032-3040.
-
(1995)
Mol. Cell. Biol.
, vol.15
, pp. 3032-3040
-
-
Owen-Schaub, L.B.1
-
64
-
-
0028334011
-
Altered cell cycle regulation in the lens of HPV-16 E6 or E7 transgeneic mice: Implications for tumor suppressor gene function in development
-
Pan, H. and Griep, A.E (1994) Altered cell cycle regulation in the lens of HPV-16 E6 or E7 transgeneic mice: implications for tumor suppressor gene function in development Genes Dev., 8, 1285-1299.
-
(1994)
Genes Dev.
, vol.8
, pp. 1285-1299
-
-
Pan, H.1
Griep, A.E.2
-
65
-
-
0027143217
-
The mdm-2 gene is induced in response to UV light in a p53-dependent manner
-
Perry, M.E., Piette, J., Zawadzki, J.A., Harvey, D. and Levine, A.J. (1993) The mdm-2 gene is induced in response to UV light in a p53-dependent manner. Proc. Natl Acad. Sci. USA, 90, 11623-11627.
-
(1993)
Proc. Natl Acad. Sci. USA
, vol.90
, pp. 11623-11627
-
-
Perry, M.E.1
Piette, J.2
Zawadzki, J.A.3
Harvey, D.4
Levine, A.J.5
-
66
-
-
0027673764
-
The p53-mdm2 autoregulatory feedback loop: A paradigm for the regulation of growth control by p53?
-
Picksley, S.M. and Lane, D.P. (1993) The p53-mdm2 autoregulatory feedback loop: a paradigm for the regulation of growth control by p53? Bioessays, 15, 689-690.
-
(1993)
Bioessays
, vol.15
, pp. 689-690
-
-
Picksley, S.M.1
Lane, D.P.2
-
67
-
-
0027964904
-
Immunochemical analysis of the interaction of p53 with Mdm2; fine mapping of the Mdm2 binding site on p53 using synthetic peptides
-
Picksley, S.M., Vojtesek, B., Sparks, A. and Lane, D.P. (1994) Immunochemical analysis of the interaction of p53 with Mdm2; fine mapping of the Mdm2 binding site on p53 using synthetic peptides. Oncogene, 9, 2523-2529.
-
(1994)
Oncogene
, vol.9
, pp. 2523-2529
-
-
Picksley, S.M.1
Vojtesek, B.2
Sparks, A.3
Lane, D.P.4
-
68
-
-
0028209857
-
Sequence-specific transcriptional activation is essential for growth suppression by p53
-
Pietenpol, J A., Tokino, T. Thiagalingam, S., Eldeiry, W.S., Kinzler, K.W. and Vogelstein, B. (1994) Sequence-specific transcriptional activation is essential for growth suppression by p53. Prac. Natl Acad. Sci. USA, 91, 1998-2002.
-
(1994)
Prac. Natl Acad. Sci. USA
, vol.91
, pp. 1998-2002
-
-
Pietenpol, J.A.1
Tokino, T.2
Thiagalingam, S.3
Eldeiry, W.S.4
Kinzler, K.W.5
Vogelstein, B.6
-
69
-
-
0028210552
-
DNA damage increases the levels of mdm2 messenger RNA in wt p53 human cells
-
Price, B.D. and Park, S.J. (1994) DNA damage increases the levels of mdm2 messenger RNA in wt p53 human cells. Cancer Res., 54, 896-899.
-
(1994)
Cancer Res.
, vol.54
, pp. 896-899
-
-
Price, B.D.1
Park, S.J.2
-
70
-
-
0027285132
-
The p53 tumor suppressor protein: Meeting review
-
Prives, C. and Manfredi, J.J. (1993) The p53 tumor suppressor protein: meeting review. Genes Dev., 7, 529-534.
-
(1993)
Genes Dev.
, vol.7
, pp. 529-534
-
-
Prives, C.1
Manfredi, J.J.2
-
71
-
-
0027349854
-
p53 domains: Suppression, transformation, and transactivation
-
Reed, M., Wang, Y., Mayr, G., Enderson, M.E., Schwedes, J.F and Tegtmeyer, P. (1993) p53 domains: suppression, transformation, and transactivation. Gene Exp., 3, 95-106.
-
(1993)
Gene Exp.
, vol.3
, pp. 95-106
-
-
Reed, M.1
Wang, Y.2
Mayr, G.3
Enderson, M.E.4
Schwedes, J.F.5
Tegtmeyer, P.6
-
72
-
-
0027196974
-
Amplification and overexpression of the mdm2 gene in a subset of human malignant gliomas without p53 mutations
-
Reifenberger, G., Liu, L., Ichimura, K., Schmidt, E.E. and Collins, V.P. (1993) Amplification and overexpression of the mdm2 gene in a subset of human malignant gliomas without p53 mutations. Cancer Res., 53, 2736-2739.
-
(1993)
Cancer Res.
, vol.53
, pp. 2736-2739
-
-
Reifenberger, G.1
Liu, L.2
Ichimura, K.3
Schmidt, E.E.4
Collins, V.P.5
-
73
-
-
0029034047
-
p53-dependent growth arrest following calcium phosphate-mediated transfection of murine fibroblasts
-
Renzing, J. and Lane, D.P. (1995) p53-dependent growth arrest following calcium phosphate-mediated transfection of murine fibroblasts. Oncogene, 10, 1865-1868.
-
(1995)
Oncogene
, vol.10
, pp. 1865-1868
-
-
Renzing, J.1
Lane, D.P.2
-
74
-
-
0030021748
-
Specific loss of apoptotic but not cell-cycle arrest function in a human tumor derived p53 mutant
-
Rowan, S., Ludwig, R.L., Haupt, Y., Bates, S., Lu, X., Oren, M and Vousden, K H. (1996) Specific loss of apoptotic but not cell-cycle arrest function in a human tumor derived p53 mutant. EMBO J , 15, 827-838.
-
(1996)
EMBO J
, vol.15
, pp. 827-838
-
-
Rowan, S.1
Ludwig, R.L.2
Haupt, Y.3
Bates, S.4
Lu, X.5
Oren, M.6
Vousden, K.H.7
-
75
-
-
0028847563
-
Modulation of p53-mediated transcriptional repression and apoptosis by the adenovirus E1B 19K protein
-
Sabbatini, P, Chiou, S.K., Rao, L. and White, E. (1995a) Modulation of p53-mediated transcriptional repression and apoptosis by the adenovirus E1B 19K protein. Mol. Cell. Biol., 15, 1060-1070.
-
(1995)
Mol. Cell. Biol.
, vol.15
, pp. 1060-1070
-
-
Sabbatini, P.1
Chiou, S.K.2
Rao, L.3
White, E.4
-
76
-
-
0029143395
-
Essential role for p53-mediated transcription in apoptosis but not growth suppression
-
Sabbatini, P., Lin, J., Levine, J.A. and White, E. (1995b) Essential role for p53-mediated transcription in apoptosis but not growth suppression. Genes Der., 9, 2184-2192.
-
(1995)
Genes Der.
, vol.9
, pp. 2184-2192
-
-
Sabbatini, P.1
Lin, J.2
Levine, J.A.3
White, E.4
-
77
-
-
0025639158
-
The E6 oncoprotein encoded by human papillomavirus Type-16 and Type-18 promotes the degradation of p53
-
Scheffner, M., Werness, B.A., Huibregtse, J.M., Levine, A.J. and Howley, P.M. (1990) The E6 oncoprotein encoded by human papillomavirus Type-16 and Type-18 promotes the degradation of p53. Cell, 63, 1129-1136.
-
(1990)
Cell
, vol.63
, pp. 1129-1136
-
-
Scheffner, M.1
Werness, B.A.2
Huibregtse, J.M.3
Levine, A.J.4
Howley, P.M.5
-
78
-
-
0028238213
-
Immediate early up-regulation of bax expression by p53 but not TGF beta 1: A paradigm for distinct apoptotic pathways
-
Selvakumaran, M., Lin, H.K , Miyashita, T., Wang, H G., Krajewski, S., Reed, J.C., Hoffman, B. and Liebermann, D. (1994) Immediate early up-regulation of bax expression by p53 but not TGF beta 1: a paradigm for distinct apoptotic pathways. Oncogene, 9, 1791-1798.
-
(1994)
Oncogene
, vol.9
, pp. 1791-1798
-
-
Selvakumaran, M.1
Lin, H.K.2
Miyashita, T.3
Wang, H.G.4
Krajewski, S.5
Reed, J.C.6
Hoffman, B.7
Liebermann, D.8
-
79
-
-
0027169188
-
Tight DNA binding and oligomerization are dispensable for the ability of p53 to transactivate target genes and suppress transformation
-
Shaulian, E., Zauberman, A., Milner, J., Davies, E.A. and Oren, M. (1993) Tight DNA binding and oligomerization are dispensable for the ability of p53 to transactivate target genes and suppress transformation. EMBO J., 12, 2789-2797.
-
(1993)
EMBO J.
, vol.12
, pp. 2789-2797
-
-
Shaulian, E.1
Zauberman, A.2
Milner, J.3
Davies, E.A.4
Oren, M.5
-
80
-
-
0028575705
-
Relief of p53-mediated transcriptional repression by the adenovirus E1B 19-kDa protein or the cellular Bcl-2 protein
-
Shen, Y.Q. and Shenk, T. (1994) Relief of p53-mediated transcriptional repression by the adenovirus E1B 19-kDa protein or the cellular Bcl-2 protein. Proc. Natl Acad. Sci. USA, 91, 8940-8944.
-
(1994)
Proc. Natl Acad. Sci. USA
, vol.91
, pp. 8940-8944
-
-
Shen, Y.Q.1
Shenk, T.2
-
81
-
-
0028169994
-
p53-dependent apoptosis suppresses tumor growth and progression in vivo
-
Symonds, H., Krall, L., Remington, L., Saenz-Robles, M., Lowe, S., Jacks, T. and Van Dyke, T. (1994) p53-dependent apoptosis suppresses tumor growth and progression in vivo Cell, 78, 703-711.
-
(1994)
Cell
, vol.78
, pp. 703-711
-
-
Symonds, H.1
Krall, L.2
Remington, L.3
Saenz-Robles, M.4
Lowe, S.5
Jacks, T.6
Van Dyke, T.7
-
82
-
-
0028922929
-
p53 transcriptional activation mediated by coactivators TAFII40 and TAFII60
-
Thut, C.J., Chen, J.L., Klemm, R. and Tjian, R. (1995) p53 transcriptional activation mediated by coactivators TAFII40 and TAFII60. Science, 267, 100-104.
-
(1995)
Science
, vol.267
, pp. 100-104
-
-
Thut, C.J.1
Chen, J.L.2
Klemm, R.3
Tjian, R.4
-
83
-
-
0026535237
-
p53-A transdominant regulator of transcription whose function is ablated by mutations occurring in human cancer
-
Unger, T., Nau, M.M., Segal, S. and Minna, J.D. (1992) p53-A transdominant regulator of transcription whose function is ablated by mutations occurring in human cancer. EMBO J., 11, 1383-1390.
-
(1992)
EMBO J.
, vol.11
, pp. 1383-1390
-
-
Unger, T.1
Nau, M.M.2
Segal, S.3
Minna, J.D.4
-
84
-
-
0026669469
-
p53 function and dysfunction
-
Vogelstein, B. and Kinzler, K.W. (1992) p53 function and dysfunction. Cell, 70, 523-526.
-
(1992)
Cell
, vol.70
, pp. 523-526
-
-
Vogelstein, B.1
Kinzler, K.W.2
-
85
-
-
0026769713
-
An immunochemical analysis of the human nuclear phosphoprotein-p53-new monoclonal antibodies and epitope mapping using recombinant-p53
-
Vojtesek, B., Bartek, J., Midgley, C.A. and Lane, D.P. (1992) An immunochemical analysis of the human nuclear phosphoprotein-p53-new monoclonal antibodies and epitope mapping using recombinant-p53. J. Immuno. Methods, 151, 237-244.
-
(1992)
J. Immuno. Methods
, vol.151
, pp. 237-244
-
-
Vojtesek, B.1
Bartek, J.2
Midgley, C.A.3
Lane, D.P.4
-
86
-
-
0027236269
-
Interactions of human papillomavirus transforming proteins with the products of tumor suppressor genes
-
Vousden, K (1993) Interactions of human papillomavirus transforming proteins with the products of tumor suppressor genes. FASEB J. 7, 872-879.
-
(1993)
FASEB J.
, vol.7
, pp. 872-879
-
-
Vousden, K.1
-
87
-
-
0028352434
-
The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA
-
Waga, S., Hannon, G.J., Beach, D. and Stillman, B. (1994) The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA Nature, 369, 574-578.
-
(1994)
Nature
, vol.369
, pp. 574-578
-
-
Waga, S.1
Hannon, G.J.2
Beach, D.3
Stillman, B.4
-
89
-
-
0027244853
-
The p53 mdm-2 autoregulatory feedback loop
-
Wu, X.W., Bayle, J.H., Olson, D. and Levine, A.J. (1993) The p53 mdm-2 autoregulatory feedback loop. Genes Dev., 7, 1126-1132.
-
(1993)
Genes Dev.
, vol.7
, pp. 1126-1132
-
-
Wu, X.W.1
Bayle, J.H.2
Olson, D.3
Levine, A.J.4
-
90
-
-
0027717617
-
p21 is a universal inhibitor of cyclin kinases
-
Xiong, Y., Hannon, G.J., Zhang, H., Casso, D., Kobayashi, R. and Beach, D (1993) p21 is a universal inhibitor of cyclin kinases. Science, 366, 701-704.
-
(1993)
Science
, vol.366
, pp. 701-704
-
-
Xiong, Y.1
Hannon, G.J.2
Zhang, H.3
Casso, D.4
Kobayashi, R.5
Beach, D.6
-
91
-
-
0028089283
-
Adenovirus E1B oncoprotein tethers a transcriptional repression domain to p53
-
Yew, P.R., Liu, X. and Berk, A.J. (1994) Adenovirus E1B oncoprotein tethers a transcriptional repression domain to p53. Genes Dev. 8, 190-202.
-
(1994)
Genes Dev.
, vol.8
, pp. 190-202
-
-
Yew, P.R.1
Liu, X.2
Berk, A.J.3
-
92
-
-
0025784539
-
Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6
-
Yonish-Rouach, E., Resnitzky, D., Lotem, J., Scichs, L., Kimchi, A. and Oren, M. (1991) Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6. Nature, 352, 345-347.
-
(1991)
Nature
, vol.352
, pp. 345-347
-
-
Yonish-Rouach, E.1
Resnitzky, D.2
Lotem, J.3
Scichs, L.4
Kimchi, A.5
Oren, M.6
-
93
-
-
0028115501
-
Induction of apoptosis by transiently transfected metabolically stable wt p53 in transformed cell lines
-
Yonish-Rouach, E., Borde, J., Gotteland, M., Mishal, Z., Viron, A and May, E. (1994) Induction of apoptosis by transiently transfected metabolically stable wt p53 in transformed cell lines. Cell Death Differ., 1, 39-47.
-
(1994)
Cell Death Differ.
, vol.1
, pp. 39-47
-
-
Yonish-Rouach, E.1
Borde, J.2
Gotteland, M.3
Mishal, Z.4
Viron, A.5
May, E.6
-
94
-
-
0029125444
-
waf is contained in its N-terminal half ('half-WAF')
-
waf is contained in its N-terminal half ('half-WAF'). Oncogene, 11, 393-395.
-
(1995)
Oncogene
, vol.11
, pp. 393-395
-
-
Zakut, R.1
Givol, D.2
-
95
-
-
0027248782
-
Sequence-specific DNA binding by p53-identification of target sites and lack of binding to p53-Mdm2 complexes
-
Zauberman, A., Barak, Y., Ragimov, N., Levy, N. and Oren, M. (1993) Sequence-specific DNA binding by p53-identification of target sites and lack of binding to p53-Mdm2 complexes. EMBO J., 12, 2799-2808.
-
(1993)
EMBO J.
, vol.12
, pp. 2799-2808
-
-
Zauberman, A.1
Barak, Y.2
Ragimov, N.3
Levy, N.4
Oren, M.5
-
96
-
-
0029006743
-
Identification of p53 target genes through immune selection of genomic DNA: The cyclin G gene contains two distinct p53 binding sites
-
Zauberman, A., Lupo, A. and Oren, M. (1995a) Identification of p53 target genes through immune selection of genomic DNA: the cyclin G gene contains two distinct p53 binding sites. Oncogene, 10, 2361-2366.
-
(1995)
Oncogene
, vol.10
, pp. 2361-2366
-
-
Zauberman, A.1
Lupo, A.2
Oren, M.3
-
97
-
-
0029131447
-
A functional p53-responsive intronic promoter is contained within the human mdm-2 gene
-
Zauberman, A., Flusberg, D., Haupt, Y., Barak, Y. and Oren, M. (1995b) A functional p53-responsive intronic promoter is contained within the human mdm-2 gene. Nucleic Acids Res., 23, 2584-2592.
-
(1995)
Nucleic Acids Res.
, vol.23
, pp. 2584-2592
-
-
Zauberman, A.1
Flusberg, D.2
Haupt, Y.3
Barak, Y.4
Oren, M.5
-
98
-
-
0028266265
-
Wild-type p53 is required for apoptosis induced by growth factor deprivation in factor-dependent leukaemic cells
-
Zhu, Y.M., Bradbury, D.A. and Russell, N.H. (1994) Wild-type p53 is required for apoptosis induced by growth factor deprivation in factor-dependent leukaemic cells. Br. J. Cancer. 69, 468-472.
-
(1994)
Br. J. Cancer.
, vol.69
, pp. 468-472
-
-
Zhu, Y.M.1
Bradbury, D.A.2
Russell, N.H.3
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