G-protein-coupled receptor allosterism: The promise and the problem(s)

Biochemical Society Transactions

Volumn 32, Issue 5, 2004, Pages 873-877

  Christopoulos, A ^a   May, L T ^a   Avlani, V A ^a   Sexton, P M ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Allosteric interaction; Drug discovery; G protein coupled receptor; Kinetics; Ternary complex model

Indexed keywords

ACETYLCHOLINE; ALCURONIUM; CYCLIC AMP; FORSKOLIN; G PROTEIN COUPLED RECEPTOR; GALLAMINE; METHYLSCOPOLAMINE; MUSCARINIC M2 RECEPTOR; OXOTREMORINE; TRITIUM;

ALLOSTERISM; ANIMAL CELL; BINDING AFFINITY; BINDING SITE; CHO CELL; CONFERENCE PAPER; DISSOCIATION CONSTANT; DRUG ANTAGONISM; DRUG RESEARCH; GUINEA PIG; NONHUMAN; PRIORITY JOURNAL;

ALCURONIUM; ALLOSTERIC SITE; ANIMALS; BINDING SITES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; HUMANS; KINETICS; LIGANDS; MODELS, CHEMICAL; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, G-PROTEIN-COUPLED; SIGNAL TRANSDUCTION;

ANIMALIA; CAVIA PORCELLUS; SUS SCROFA;

EID: 8744219619     PISSN: 03005127     EISSN: None     Source Type: Journal    
DOI: 10.1042/BST0320873     Document Type: Conference Paper

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