Thiochrome Enhances Acetylcholine Affinity at Muscarinic M4 Receptors: Receptor Subtype Selectivity via Cooperativity Rather than Affinity

Molecular Pharmacology

Volumn 65, Issue 1, 2004, Pages 257-266

  Lazareno, S ^a   Dolezal V ^b   Popham, A ^a   Birdsall, N J M ^c  

^a MEDICAL RESEARCH COUNCIL   (United Kingdom)

^b INSTITUTE OF PHYSIOLOGY   (Czech Republic)

^c NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINE; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); METHYLSCOPOLAMINE; MUSCARINIC M1 RECEPTOR; MUSCARINIC M2 RECEPTOR; MUSCARINIC M3 RECEPTOR; MUSCARINIC M4 RECEPTOR; MUSCARINIC M5 RECEPTOR; RECEPTOR SUBTYPE; THIAMINE DERIVATIVE; UNCLASSIFIED DRUG;

ACETYLCHOLINE RELEASE; ADOLESCENT; ALLOSTERISM; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BRAIN SLICE; CONTROLLED STUDY; CORPUS STRIATUM; DRUG EFFECT; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG STRUCTURE; HIPPOCAMPUS; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR AFFINITY; SELECTIVE POSITIVE COOPERATIVITY; THIOCHROME;

ACETYLCHOLINE; ANIMALS; CHO CELLS; CRICETINAE; DRUG INTERACTIONS; HUMANS; MALE; RADIOLIGAND ASSAY; RATS; RATS, WISTAR; RECEPTOR, MUSCARINIC M1; RECEPTOR, MUSCARINIC M2; RECEPTOR, MUSCARINIC M4; THIAMINE;

EID: 1642454572     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.65.1.257     Document Type: Article

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