Application of a Kinetic Model to the Apparently Complex Behavior of Negative and Positive Allosteric Modulators of Muscarinic Acetylcholine Receptors

Journal of Pharmacology and Experimental Therapeutics

Volumn 308, Issue 3, 2004, Pages 1062-1072

  Avlani, Vimesh ^a   May, Lauren T ^a   Sexton, Patrick M ^a   Christopoulos, Arthur ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ALCURONIUM; BROMINE DERIVATIVE; G PROTEIN COUPLED RECEPTOR; GALLAMINE; HEPTANE 1,7 BIS(DIMETHYL 3 PHTHALIMIDOPROPYL)AMMONIUM BROMIDE; METHYLSCOPOLAMINE; MUSCARINIC M2 RECEPTOR; N METHYLSCOPOLAMINE H 3; RADIOLIGAND; UNCLASSIFIED DRUG;

ALLOSTERISM; ANIMAL CELL; ARTICLE; BINDING ASSAY; DISSOCIATION; DRUG RECEPTOR BINDING; KINETICS; MATHEMATICAL ANALYSIS; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BINDING;

ALLOSTERIC REGULATION; ANIMALS; BINDING SITES; CHO CELLS; CRICETINAE; HUMANS; KINETICS; MODELS, BIOLOGICAL; N-METHYLSCOPOLAMINE; RECEPTOR, MUSCARINIC M2; RECEPTORS, MUSCARINIC; TRITIUM;

EID: 1342323325     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.103.059840     Document Type: Article

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