Allosteric site on muscarinic acetylcholine receptors: Identification of two amino acids in the muscarinic M2 receptor that account entirely for the M2/M5 subtype selectivities of some structurally diverse allosteric ligands in N-methylscopolamine-occupied receptors

Molecular Pharmacology

Volumn 64, Issue 1, 2003, Pages 21-31

  Voigtländer, Uta ^a   Jöhren, Kirstin ^b   Mohr, Marion ^a   Raasch, Alexandra ^a   Tränkle, Christian ^a   Buller, Stefan ^a,c   Ellis, John ^c   Höltje, Hans Dieter ^b   Mohr, Klaus ^a  

^a UNIVERSITY OF BONN   (Germany)

^b HEINRICH HEINE UNIVERSITY   (Germany)

^c PENN STATE COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; EPITOPE; LIGAND; METHYLSCOPOLAMINE; MUSCARINIC AGENT; MUSCARINIC M2 RECEPTOR; MUSCARINIC M5 RECEPTOR; MUSCARINIC RECEPTOR; RECEPTOR SUBTYPE;

ALLOSTERISM; AMINO ACID SEQUENCE; ARTICLE; BINDING SITE; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; LIGAND BINDING; POINT MUTATION; PRIORITY JOURNAL; RECEPTOR AFFINITY; RECEPTOR INTRINSIC ACTIVITY; SEQUENCE ANALYSIS; SIMULATION;

ALLOSTERIC REGULATION; ALLOSTERIC SITE; AMINO ACIDS; ANIMALS; COS CELLS; HUMANS; LIGANDS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; N-METHYLSCOPOLAMINE; PARASYMPATHOLYTICS; RECEPTOR, MUSCARINIC M2; RECEPTORS, MUSCARINIC;

EID: 0038237079     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.64.1.21     Document Type: Article

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