GPCR drug discovery through the exploitation of allosteric drug binding sites

Receptors and Channels

Volumn 8, Issue 5-6, 2002, Pages 261-268

  Rees, Stephen ^a   Morrow, Dwight ^b   Kenakin, Terry ^b  

^a GLAXOSMITHKLINE   (United Kingdom)

^b GLAXOSMITHKLINE   (United States)

Author keywords

Allosteric ligand; GPCR; Ionchannel

Indexed keywords

2 AMINO 4,5 DIMETHYL 3 (3 TRIFLUOROMETHYLBENZOYL)THIOPHENE; 2 METHYL 6 (2 PHENYLVINYL)PYRIDINE; 2 METHYL 6 (PHENYLETHYNYL)PYRIDINE; 4 AMINOBUTYRIC ACID RECEPTOR; ADENOSINE A1 RECEPTOR; ALCURONIUM; ALKALINE PHOSPHATASE; ANTIARRHYTHMIC AGENT; ANTICONVULSIVE AGENT; ANTIHYPERTENSIVE AGENT; BETA GALACTOSIDASE; CARBACHOL; CHEMOKINE RECEPTOR CCR5; CHLORAMPHENICOL ACETYLTRANSFERASE; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; FLECAINIDE; FORSKOLIN; G PROTEIN COUPLED RECEPTOR; GLUTAMATE RECEPTOR; GLYCOPROTEIN GP 120; LAMOTRIGINE; LIDOCAINE; LIGAND; MIBEFRADIL; MUSCARINIC M2 RECEPTOR; MUSCARINIC RECEPTOR BLOCKING AGENT; NIMODIPINE; PHENYTOIN; UNINDEXED DRUG; CELL SURFACE RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; ION;

ALLOSTERISM; BINDING COMPETITION; DOSE RESPONSE; DRUG BINDING SITE; DRUG CLASSIFICATION; DRUG DETERMINATION; DRUG EFFICACY; DRUG IDENTIFICATION; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG TARGETING; HUMAN; LIGAND BINDING; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN INTERACTION; REVIEW; BINDING SITE; BIOCHEMISTRY; CHEMISTRY; DRUG DESIGN; IC 50; METABOLISM; METHODOLOGY; PROTEIN BINDING;

ALLOSTERIC SITE; BINDING SITES; BIOCHEMISTRY; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; GTP-BINDING PROTEINS; INHIBITORY CONCENTRATION 50; IONS; LIGANDS; PROTEIN BINDING; RECEPTORS, CELL SURFACE;

EID: 0036453601     PISSN: 10606823     EISSN: None     Source Type: Journal    
DOI: 10.1080/10606820214640     Document Type: Review

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