Genetically engineering a susceptible mouse model for MERS-CoV-induced acute respiratory distress syndrome

Methods in Molecular Biology

Volumn 2099, Issue , 2020, Pages 137-159

  Leist, Sarah R ^a   Cockrell, Adam S ^b  

^a University of North Carolina at Chapel Hill   (United States)

^b NONE   (United States)

Author keywords

Cas9; Clustered regularly interspaced short palindromic repeats; Middle East respiratory syndrome coronavirus; Mouse; Pathogenesis

Indexed keywords

ADENOSINE DEAMINASE; DIPEPTIDYL PEPTIDASE IV; DPP4 PROTEIN, HUMAN; DPP4 PROTEIN, MOUSE;

ADULT RESPIRATORY DISTRESS SYNDROME; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; C57BL 6 MOUSE; CONTROLLED STUDY; CRISPR-CAS9 SYSTEM; DISEASE PREDISPOSITION; FEMALE; GENE EDITING; GENE EXPRESSION PROFILING; GENE MUTATION; GENE OVEREXPRESSION; GENETIC ENGINEERING; HEK293T CELL LINE; IMMUNOREGULATION; LUNG HEMORRHAGE; LUNG INFECTION; LUNG LAVAGE; MIDDLE EAST RESPIRATORY SYNDROME; MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS; MORBIDITY; MORTALITY; MOUSE; NIH 3T3 CELL LINE; NONHOMOLOGOUS END JOINING REPAIR; NONHUMAN; PHENOTYPE; RESPIRATORY TRACT DISEASE; VERO CELL LINE; VIRAL PLAQUE ASSAY; VIRUS CELL INTERACTION; VIRUS REPLICATION; ANIMAL; C57BL MOUSE; CORONAVIRUS INFECTION; CRISPR CAS SYSTEM; DISEASE MODEL; GENETICS; HUMAN; LUNG; MALE; METABOLISM; PATHOLOGY; PHYSIOLOGY; VIROLOGY;

ANIMALS; CORONAVIRUS INFECTIONS; CRISPR-CAS SYSTEMS; DIPEPTIDYL PEPTIDASE 4; DISEASE MODELS, ANIMAL; DISEASE SUSCEPTIBILITY; FEMALE; GENETIC ENGINEERING; HUMANS; LUNG; MALE; MICE; MICE, INBRED C57BL; MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS; RESPIRATORY DISTRESS SYNDROME, ADULT;

EID: 85077343901     PISSN: 10643745     EISSN: 19406029     Source Type: Book Series    
DOI: 10.1007/978-1-0716-0211-9_12     Document Type: Chapter

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