Adenosine deaminase acts as a natural antagonist for dipeptidyl peptidase 4-mediated entry of the middle East respiratory syndrome coronavirus

Journal of Virology

Volumn 88, Issue 3, 2014, Pages 1834-1838

  Stalin Raj, V ^a   Smits, Saskia L ^a,b   Provacia, Lisette B ^a   van den Brand, Judith M A ^a   Wiersma, Lidewij ^a   Ouwendijk, Werner J D ^a   Bestebroer, Theo M ^a   Spronken, Monique I ^a   van Amerongen, Geert ^a   Rottier, Peter J M ^c   Fouchier, Ron A M ^a   Bosch, Berend Jan ^c   Osterhaus, Albert D M E ^a,b   Haagmans, Bart L ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b ViroClinics Biosciences   (Netherlands)

^c UTRECHT UNIVERSITY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE DEAMINASE; AMINO ACID; DIPEPTIDYL PEPTIDASE IV;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING SITE; CONTROLLED STUDY; CORONAVIRUS; CORONAVIRUS INFECTION; ENZYME BINDING; FERRET; HUMAN; IN VIVO STUDY; MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS; MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS INFECTION; MUTAGENESIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; VIRUS ATTACHMENT; VIRUS ENTRY; VIRUS REPLICATION; VIRUS RESISTANCE;

ADENOSINE DEAMINASE; AMINO ACID SEQUENCE; ANIMALS; CORONAVIRIDAE; CORONAVIRIDAE INFECTIONS; DIPEPTIDYL PEPTIDASE 4; DISEASE MODELS, ANIMAL; FERRETS; HUMANS; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; RECEPTORS, VIRUS; SEQUENCE ALIGNMENT; SPIKE GLYCOPROTEIN, CORONAVIRUS; VIRUS INTERNALIZATION;

EID: 84892463403     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.02935-13     Document Type: Article

References (20)

1. van Boheemen S, de Graaf M, Lauber C, Bestebroer TM, Raj VS, Zaki AM, Osterhaus AD, Haagmans BL, Gorbalenya AE, Snijder EJ, Fouchier RA. 2012. Genomic characterization of a newly discovered coronavirus associated with acute respiratory distress syndrome in humans. mBio 3:e00473-12. http://dx.doi.org/10.1128/mBio.00473-12.
2. Zaki AM, van Boheemen S, Bestebroer TM, Osterhaus AD, Fouchier RA. 2012. Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia. N. Engl. J. Med. 367:1814-1820. http://dx.doi.org/10.1056/NEJMoa1211721.
3. World Health Organization. 2013. Middle East respiratory syndrome coronavirus (MERS-CoV)-update 2013/10/04. World Health Organization, Geneva, Switzerland.
4. Ithete NL, Stoffberg S, Corman Cottontail VMVM, Richards LR, Schoeman MC, Drosten C, Drexler JF, Preiser W. 2013. Close relative of human middle East respiratory syndrome coronavirus in bat, South Africa. Emerg. Infect. Dis. 19:1697-1699. http://dx.doi.org/10.3201/eid1910 .130946.
5. Memish ZA, Mishra N, Olival KJ, Fagbo SF, Kapoor V, Epstein JH, AlHakeem R, Durosinloun A, Al Asmari M, Islam A, Kapoor A, Briese T, Daszak P, Al Rabeeah AA, Lipkin WI. November 2013. Middle East respiratory syndrome coronavirus in bats, Saudi Arabia. Emerg. Infect. Dis. http://dx.doi.org/10.3201/eid1911.131172.
6. Chan JF, Chan KH, Choi GK, To KK, Tse H, Cai JP, Yeung ML, Cheng VC, Chen H, Che XY, Lau SK, Woo PC, Yuen KY. 2013. Differential cell line susceptibility to the emerging novel human betacoronavirus 2c EMC/ 2012: implications for disease pathogenesis and clinical manifestation. J. Infect. Dis. 207:1743-1752. http://dx.doi.org/10.1093/infdis/jit123.
7. de Wit E, Prescott J, Baseler L, Bushmaker T, Thomas T, Lackemeyer MG, Martellaro C, Milne-Price S, Haddock E, Haagmans BL, Feldmann H, Munster VJ. 2013. The Middle East respiratory syndrome coronavirus (MERS-CoV) does not replicate in Syrian hamsters. PLoS One 8:e69127. http://dx.doi.org/10.1371/journal.pone.0069127.
8. Raj VS, Mou H, Smits SL, Dekkers DH, Muller MA, Dijkman R, Muth D, Demmers JA, Zaki A, Fouchier RA, Thiel V, Drosten C, Rottier PJ, Osterhaus AD, Bosch BJ, Haagmans BL. 2013. Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC. Nature 495:251-254. http://dx.doi.org/10.1038/nature12005.
9. Belser JA, Katz JM, Tumpey TM. 2011. The ferret as a model organism to study influenza A virus infection. Dis. Model. Mech. 4:575-579. http://dx .doi.org/10.1242/dmm.007823.
10. Martina BE, Haagmans BL, Kuiken T, Fouchier RA, Rimmelzwaan GF, Van Amerongen G, Peiris JS, Lim W, Osterhaus AD. 2003. Virology: SARS virus infection of cats and ferrets. Nature 425:915. http://dx.doi.org/10.1038/425915a.
11. Boonacker E, Van Noorden CJ. 2003. The multifunctional or moonlighting protein CD26/DPPIV. Eur. J. Cell Biol. 82:53-73. http://dx.doi.org/10 .1078/0171-9335-00302.
12. Bosch BJ, Raj VS, Haagmans BL. 2013. Spiking the MERS-coronavirus receptor. Cell Res. 23:1069-1070. http://dx.doi.org/10.1038/cr.2013.108.
13. Lu G, Hu YQ, Wang J, Qi F, Gao Y, Li Y, Zhang W, Zhang Y, Yuan J, Bao B, Zhang Y, Shi J, Yan G, Gao F. 2013. Molecular basis of binding between novel human coronavirus MERS-CoV and its receptor CD26. Nature 500:227-231. http://dx.doi.org/10.1038/nature12328.
14. Wang N, Shi X, Jiang L, Zhang S, Wang D, Tong P, Guo D, Fu L, Cui Y, Liu X, Arledge KC, Chen YH, Zhang LH, Wang X. 2013. Structure of MERS-CoV spike receptor-binding domain complexed with human receptor DPP4. Cell Res. 23:986-993. http://dx.doi.org/10.1038/cr.2013.92.
15. Ohnuma K, Haagmans BL, Hatano R, Raj VS, Mou H, Iwata S, Dang NH, Bosch BJ, Morimoto C. 25 September 2013. Inhibition of Middle East respiratory syndrome coronavirus (MERS-CoV) infection by anti-CD26 monoclonal antibody. J. Virol. http://dx.doi.org/10.1128/JVI02448-13.
16. Weihofen WA, Liu J, Reutter W, Saenger W, Fan H. 2004. Crystal structure of CD26/dipeptidyl-peptidase IV in complex with adenosine deaminase reveals a highly amphiphilic interface. J. Biol. Chem. 279: 43330-43335. http://dx.doi.org/10.1074/jbc.M405001200.
17. Cristalli G, Costanzi S, Lambertucci C, Lupidi G, Vittori S, Volpini R, Camaioni E. 2001. Adenosine deaminase: functional implications and different classes of inhibitors.Med.Res. Rev. 21:105-128. http://dx.doi.org/10.1002/1098-1128(200103)21:2105::AID-MED10023.0.CO;2-U.
18. Mou H, Raj VS, van Kuppeveld FJ, Rottier PJ, Haagmans BL, Bosch BJ. 2013. The receptor binding domain of the new Middle East respiratory syndrome coronavirus maps to a 231-residue region in the spike protein that efficiently elicits neutralizing antibodies. J. Virol. 87:9379-9383. http://dx.doi.org/10.1128/JVI.01277-13.
19. Van der Weyden MB, Kelley WN. 1976. Human adenosine deaminase. Distribution and properties. J. Biol. Chem. 251:5448-5456.
20. Pacheco R, Martinez-Navio JM, Lejeune M, Climent N, Oliva H, Gatell JM, Gallart T, Mallol J, Lluis C, Franco R. 2005. CD26, adenosine deaminase, and adenosine receptors mediate costimulatory signals in the immunological synapse. Proc. Natl. Acad. Sci. U.S.A. 102:9583-9588. http://dx.doi.org/10.1073/pnas.0501050102.