The Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Does Not Replicate in Syrian Hamsters

PLoS ONE

Volumn 8, Issue 7, 2013, Pages

  de Wit, Emmie ^a   Prescott, Joseph ^a   Baseler, Laura ^a   Bushmaker, Trenton ^a   Thomas, Tina ^a   Lackemeyer, Matthew G ^b   Martellaro, Cynthia ^a   Milne Price, Shauna ^a   Haddock, Elaine ^a   Haagmans, Bart L ^c   Feldmann, Heinz ^a,d   Munster, Vincent J ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^c ERASMUS MEDICAL CENTER   (Netherlands)

^d UNIVERSITY OF MANITOBA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

AEROSOL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORONAVIRUS; DISEASE ASSOCIATION; DISEASE SEVERITY; DISEASE TRANSMISSION; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; INOCULATION; MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS; NONHUMAN; PATHOGENESIS; SEROCONVERSION; SYRIAN HAMSTER; VIRUS REPLICATION;

ANIMALS; BODY TEMPERATURE; BODY WEIGHT; CORONAVIRUS; CORONAVIRUS INFECTIONS; CRICETINAE; DIPEPTIDYL PEPTIDASE 4; DISEASE MODELS, ANIMAL; HOST-PATHOGEN INTERACTIONS; HUMANS; IMMUNOHISTOCHEMISTRY; MESOCRICETUS; MIDDLE EAST; RESPIRATORY TRACT INFECTIONS; SYNDROME; VIRUS REPLICATION;

ANIMALIA; CORONAVIRUS; MESOCRICETUS AURATUS;

EID: 84879760362     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0069127     Document Type: Article

References (16)

1. de Groot RJ, Baker SC, Baric RS, Brown CS, Drosten C, et al. (2013) Middle East Respiratory Syndrome Coronavirus (MERS-CoV); Announcement of the Coronavirus Study Group. J Virol.
2. van Boheemen S, de Graaf M, Lauber C, Bestebroer TM, Raj VS, et al. (2012) Genomic characterization of a newly discovered coronavirus associated with acute respiratory distress syndrome in humans. MBio 3.
3. Zaki AM, van Boheemen S, Bestebroer TM, Osterhaus AD, Fouchier RA, (2012) Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia. N Engl J Med 367: 1814-1820. doi:10.1056/NEJMoa1211721. PubMed: 23075143.
4. WHO (2013) Coronavirus infections. http://www.who.int/csr/don/archive/disease/coronavirus_infections/en/index.html.
5. Annan A, Baldwin HJ, Corman VM, Klose SM, Owusu M, et al. (2013) Human betacoronavirus 2c EMC/2012-related viruses in bas, Ghana and Europe. Emerg Infect Dis 19: 456-459. doi:10.3201/eid1903.121503. PubMed: 23622767.
6. Anthony SJ, Ojeda-Flores R, Rico-Chavez O, Navarette-Macias I, Zambrana-Torrelio CM, et al. (2013) Coronaviruses in bats from Mexico. J Gen Virol. doi:10.1099/vir.0.049759-0.
7. Muller MA, Raj VS, Muth D, Meyer B, Kallies S, et al. (2012) Human coronavirus EMC does not require the SARS-coronavirus receptor and maintains broad replicative capability in mammalian cell lines. MBio 3.
8. Peiris JS, Yuen KY, Osterhaus AD, Stohr K, (2003) The severe acute respiratory syndrome. N Engl J Med 349: 2431-2441. doi:10.1056/NEJMra032498. PubMed: 14681510.
9. Roberts A, Vogel L, Guarner J, Hayes N, Murphy B, et al. (2005) Severe acute respiratory syndrome coronavirus infection of golden Syrian hamsters. J Virol 79: 503-511. doi:10.1128/JVI.79.1.503-511.2005. PubMed: 15596843.
10. Roberts A, Lamirande EW, Vogel L, Jackson JP, Paddock CD, et al. (2008) Animal models and vaccines for SARS-CoV infection. Virus Res 133: 20-32. doi:10.1016/j.virusres.2007.03.025. PubMed: 17499378.
11. Hartings JM, Roy CJ, (2004) The automated bioaerosol exposure system: preclinical platform development and a respiratory dosimetry application with nonhuman primates. J Pharmacol Toxicol Methods 49: 39-55. doi:10.1016/j.vascn.2003.07.001. PubMed: 14670693.
12. Alexander DJ, Collins CJ, Coombs DW, Gilkison IS, Hardy CJ, et al. (2008) Association of Inhalation Toxicologists (AIT) working party recommendation for standard delivered dose calculation and expression in non-clinical aerosol inhalation toxicology studies with pharmaceuticals. Inhal Toxicol 20: 1179-1189. doi:10.1080/08958370802207318. PubMed: 18802802.
13. Corman VM, Eckerle I, Bleicker T, Zaki A, Landt O, et al. (2012) Detection of a novel human coronavirus by real-time reverse-transcription polymerase chain reaction. Euro Surveill 17.
14. Zivcec M, Safronetz D, Haddock E, Feldmann H, Ebihara H, (2011) Validation of assays to monitor immune responses in the Syrian golden hamster (Mesocricetus auratus). J Immunol Methods 368: 24-35. doi:10.1016/j.jim.2011.02.004. PubMed: 21334343.
15. Haller O, Stertz S, Kochs G, (2007) The Mx GTPase family of interferon-induced antiviral proteins. Microbes Infect 9: 1636-1643. doi:10.1016/j.micinf.2007.09.010. PubMed: 18062906.
16. Raj VS, Mou H, Smits SL, Dekkers DH, Muller MA, et al. (2013) Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC. Nature 495: 251-254. doi:10.1038/nature12005. PubMed: 23486063.