Bactrian camels shed large quantities of Middle East respiratory syndrome coronavirus (MERS-CoV) after experimental infection*

Emerging Microbes and Infections

Volumn 8, Issue 1, 2019, Pages 717-723

  Adney, Danielle R ^a   Letko, Michael ^b   Ragan, Izabela K ^a   Scott, Dana ^b   van Doremalen, Neeltje ^b   Bowen, Richard A ^a   Munster, Vincent J ^b  

^a Department of Ecosystem Science and Sustainability   (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

Bactrian camel; dromedary camel; MERS CoV; natural reservoir; virus shedding

Indexed keywords

DIPEPTIDYL PEPTIDASE IV; NEUTRALIZING ANTIBODY;

ADULT; AMINO ACID SEQUENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASIA; BACTRIAN CAMEL; DISEASE PREDISPOSITION; DROMEDARY; EXPERIMENTAL INFECTION; HUMAN; HUMAN TISSUE; MALE; MIDDLE EAST RESPIRATORY SYNDROME; MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS; NONHUMAN; PRIORITY JOURNAL; VIRUS SHEDDING; VIRUS TITRATION; ANIMAL; CAMEL; CORONAVIRUS INFECTION; DISEASE CARRIER; DISEASE TRANSMISSION; GROWTH, DEVELOPMENT AND AGING; ISOLATION AND PURIFICATION; RESPIRATORY SYSTEM; VETERINARY MEDICINE; VIROLOGY;

ANIMAL EXPERIMENTATION; ANIMALS; ASIA; CAMELUS; CORONAVIRUS INFECTIONS; DISEASE RESERVOIRS; DISEASE TRANSMISSION, INFECTIOUS; MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS; RESPIRATORY SYSTEM; VIRUS SHEDDING;

EID: 85066395287     PISSN: None     EISSN: 22221751     Source Type: Journal    
DOI: 10.1080/22221751.2019.1618687     Document Type: Article

References (26)

1. Zaki AM, van Boheemen S, Bestebroer TM, et al. Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia. N Engl J Med. 2012;367:1814–1820. doi:10.1056/NEJMoa1211721.
2. Azhar EI, et al. Evidence for camel-to-human transmission of MERS coronavirus. N Engl J Med. 2014;370:2499–2505. doi:10.1056/NEJMoa1401505.
3. Conzade R, et al. Reported direct and Indirect contact with dromedary camels among laboratory-confirmed MERS-CoV cases. Viruses. 2018;10; doi:10.3390/v10080425.
4. Haagmans BL, et al. Middle East respiratory syndrome coronavirus in dromedary camels: an outbreak investigation. Lancet Infect Dis. 2014;14:140–145. doi:10.1016/s1473-3099(13)70690-x.
5. Hemida MG, et al. MERS coronavirus in dromedary camel Herd, Saudi Arabia. Emerging Infect Dis. 2014;20; doi:10.3201/eid2007.140571.
6. Memish ZA, et al. Human infection with MERS coronavirus after exposure to infected camels, Saudi Arabia, 2013. Emerging Infect Dis. 2014;20:1012–1015. doi:10.3201/eid2006.140402.
7. Meyer B, et al. Antibodies against MERS coronavirus in dromedary camels, United Arab Emirates, 2003 and 2013. Emerging Infect Dis. 2014;20:552–559. doi:10.3201/eid2004.131746.
8. Muller MA, et al. MERS coronavirus neutralizing antibodies in camels, Eastern Africa, 1983-1997. Emerging Infect Dis. 2014;20:2093–2095. doi:10.3201/eid2012.141026.
9. de Wit E, van Doremalen N, Falzarano D, et al. SARS and MERS: recent insights into emerging coronaviruses. Nat Rev Microbiol. 2016;14:523–534. doi:10.1038/nrmicro.2016.81.
10. Adney DR, et al. Replication and shedding of MERS-CoV in upper respiratory tract of inoculated dromedary camels. Emerg Infect Dis. 2014;20:1999–2005. doi:10.3201/eid2012.141280.
11. Khalafalla AI, et al. MERS-CoV in upper respiratory tract and lungs of dromedary camels, Saudi Arabia, 2013-2014. Emerging Infect Dis. 2015;21:1153–1158. doi:10.3201/eid2107.150070.
12. van Doremalen N, et al. High Prevalence of Middle East respiratory coronavirus in Young dromedary camels in Jordan. Vector Borne Zoonotic Dis. 2017;17:155–159. doi:10.1089/vbz.2016.2062.
13. Adney DR, et al. Efficacy of an adjuvanted Middle East respiratory syndrome coronavirus spike Protein Vaccine in dromedary camels and alpacas. Viruses. 2019;11; doi:10.3390/v11030212.
14. Haagmans BL, et al. An orthopoxvirus-based vaccine reduces virus excretion after MERS-CoV infection in dromedary camels. Science. 2016;351:77–81. doi:10.1126/science.aad1283.
15. Adney DR, Bielefeldt-Ohmann H, Hartwig AE, et al. Infection, replication, and transmission of Middle East respiratory syndrome coronavirus in alpacas. Emerging Infect Dis. 2016;22:1031–1037. doi:10.3201/2206.160192 doi: 10.3201/eid2206.160192
16. Vergara-Alert J, et al. Livestock susceptibility to infection with Middle East respiratory syndrome coronavirus. Emerging Infect Dis. 2017;23:232–240. doi:10.3201/eid2302.161239.
17. Mammal Species of the World. A taxonomic and geographic reference. https://www://www.departments.bucknell.edu/biology/resources/msw3/browse.asp?id=14200112 (2005).
18. Imamura K, et al. The distribution of the Two Domestic camel species in Kazakhstan caused by the demand of industrial stockbreeding. J Arid Land Stud. 2017;26:233–236. doi:10.14976/jals.26.4_233.
19. Chan SM, et al. Absence of MERS-coronavirus in Bactrian camels, southern Mongolia, November 2014. Emerging Infect Dis. 2015;21:1269–1271. doi:10.3201/eid2107.150178.
20. Liu R, et al. Absence of Middle East respiratory syndrome coronavirus in Bactrian camels in the West Inner Mongolia Autonomous Region of China: surveillance study results from July 2015. Emerg Microbes Infect. 2015;4:e73, doi:10.1038/emi.2015.73.
21. Miguel E, et al. Absence of Middle East respiratory syndrome coronavirus in Camelids, Kazakhstan, 2015. Emerging Infect Dis. 2016;22:555–557. doi:10.3201/eid2203.151284.
22. Corman V, et al. Detection of a novel human coronavirus by real-time reverse-transcription polymerase chain reaction. Euro Surveill. 2012;17:1–9.
23. van Doremalen N, et al. Host species restriction of Middle East respiratory syndrome coronavirus through its receptor, dipeptidyl peptidase 4. J Virol. 2014;88:9220–9232. doi:10.1128/jvi.00676-14.
24. Aly M, Elrobh M, Alzayer M, et al. Occurrence of the Middle East respiratory syndrome coronavirus (MERS-CoV) across the Gulf Corporation Council countries: Four years update. PloS one. 2017;12:e0183850), doi:10.1371/journal.pone.0183850.
25. de Wit E, et al. Domestic Pig Unlikely reservoir for MERS-CoV. Emerging Infect Dis. 2017;23:985–988. doi:10.3201/eid2306.170096.
26. Adney DR, et al. Inoculation of Goats, sheep, and horses with MERS-CoV does Not result in productive viral shedding. Viruses. 2016;8; doi:10.3390/v8080230.