Middle east respiratory syndrome coronavirus causes multiple organ damage and lethal disease in mice transgenic for human dipeptidyl peptidase 4

Journal of Infectious Diseases

Volumn 212, Issue 11, 2015, Pages 712-722

  Li, Kun ^a   Wohlford Lenane, Christine ^a   Perlman, Stanley ^a,b,c   Zhao, Jincun ^b   Jewell, Alexander K ^a   Reznikov, Leah R ^b   Gibson Corley, Katherine N ^b   Meyerholz, David K ^b   McCray, Paul B ^a,b  

^a UNIVERSITY OF IOWA   (United States)

^b Department of Microbiology ^*  (United States)

^c UNIVERSITY OF IOWA   (United States)

Author keywords

DPP4 CD26.; MERS; Transgenic mice

Indexed keywords

CYTOKERATIN 18; DIPEPTIDYL PEPTIDASE IV; PROTEIN C; VIRUS RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY TITER; ARTICLE; BRAIN DISEASE; BRAIN STEM; BRAIN TISSUE; CELL INFILTRATION; CLINICAL TRIAL (TOPIC); CONTROLLED STUDY; DISEASES; EMBRYO; HUMAN; HUMAN CELL; INFECTION SENSITIVITY; LETHAL DISEASE; LUNG EDEMA; LUNG PARENCHYMA; MICROTHROMBUS; MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS; MONONUCLEAR CELL; MOUSE; MULTIPLE ORGAN FAILURE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; THALAMUS; TRANSGENIC MOUSE; ANIMAL; CENTRAL NERVOUS SYSTEM INFECTION; CORONAVIRUS INFECTION; GENE EXPRESSION REGULATION; GENETICS; ISOLATION AND PURIFICATION; METABOLISM; MORTALITY; PATHOLOGY; PHYSIOLOGY; VIROLOGY;

ANIMALS; CENTRAL NERVOUS SYSTEM VIRAL DISEASES; CORONAVIRUS INFECTIONS; DIPEPTIDYL PEPTIDASE 4; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; MICE; MICE, TRANSGENIC; MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS; RNA, VIRAL;

EID: 84958639382     PISSN: 00221899     EISSN: 15376613     Source Type: Journal    
DOI: 10.1093/infdis/jiv499     Document Type: Article

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